12results about How to "Improves transdermal penetration" patented technology

The invention discloses a nano composition with a deep acne removal effect and a preparation method and application thereof.The preparation method includes the steps that a straight-chain alkane structural unit (containing six or more carbon atoms) is adopted as an initiator to initiate a hydrophilic polymeric monomer to be subjected to a polymerization reaction, an amphiphilic polymer is prepared, acne removal active ingredients are entrapped, and the nano composition with the deep acne removal effect is obtained; the obtained nano composition has high encapsulation efficiency, and the encapsulation efficiency can reach 53.8% or above, and even can reach 80% or above. Meanwhile, the acne-removing nano composition has good percutaneous permeability and antibacterial effect and can be used for preparing acne-removing products, and the acne-removing effect of the acne-removing nano composition is remarkably superior to that of other acne-removing products.

This invention discloses a Tibetan bath composition compound and its preparation method, relating to the field of daily chemical products technology. The Tibetan bath composition compound consists of a ternary complex of scutellaria baicalensis hydroxypropyl-β-cyclodextrin nanoshell powder, Bacillus subtilis, Tibetan medicine composition, starch, anhydrous citric acid, sodium bicarbonate, calcium citrate, crospovidone, and magnesium stearate. Bacillus subtilis is used to ferment the ternary complex of scutellaria baicalensis hydroxypropyl-β-cyclodextrin nanoshell powder to obtain a fermentation-modified porous carrier, which is then loaded with the Tibetan medicine composition to form a Tibetan medicine inclusion powder. This not only achieves efficient drug delivery through a triple mechanism of biomodification, metabolite synergy, and structural optimization, but also forms a quaternary system with Terminalia chebula. The effervescent effect also enhances the penetration of Tibetan medicine components, which is beneficial for better exerting the antibacterial and anti-inflammatory effects of active substances, and significantly improving fungal infections and eczema-related skin problems.

The embodiment of the invention discloses Chinese herbal medicine freckle-removing cream and a preparation method thereof. The Chinese herbal medicine freckle-removing cream is prepared from Chinese herbal medicine decoction liquor and a natural oil-in-water emulsion system, and the Chinese herbal medicine decoction liquor comprises the following medicinal materials: rehmannia, radix polygonati officinalis, Chinese waxgourd seed, stiff silkworm, caltrop, hawthorn, hairyvein agrimony, allium macrostemon, vine of multiflower knotweed, cortex albiziae, platycladi seed, lalang grass rhizome, perilla leaf, pepper and magnolia bark; the natural oil-in-water emulsifying system comprises the following raw materials: olive oil emulsifying wax, shea butter, jojoba oil, grape seed oil and vitamin E. Human body trials prove that the Chinese herbal medicine freckle-removing cream is fine and moist in skin feeling and not greasy after being smeared, and skin irritation reactions such as stabbing pain, redness and pruritus do not exist in the using process; after continuous use for 3 months, chloasma, sunburn and other color spots are obviously faded, the skin glossiness and fineness are obviously improved, and no obvious rebound occurs after the use is stopped; the composition is suitable for dry, oily, mixed and sensitive skin, and has good safety and tolerance.

The invention provides a traditional Chinese medicine composition for treating intestinal obstruction and a preparation method thereof, and belongs to the technical field of intestinal obstruction treatment. The traditional Chinese medicine composition for treating intestinal obstruction comprises 5-15 parts of rheum officinale, 20-40 parts of radix paeoniae alba, 5-15 parts of radix rehmanniae recen, 20-40 parts of pericarpium arecae, 5-15 parts of fructus cannabis, 20-40 parts of sargentgloryvine stem, 20-40 parts of moutan bark, 20-40 parts of dandelion, 5-15 parts of coptis chinensis, 2-10 parts of semen pharbitidis and 20-40 parts of mirabilite. The traditional Chinese medicine composition for treating intestinal obstruction has the effects of clearing heat, purging pathogenic fire, nourishing blood, regulating menstruation and the like, can improve the functions of intestines and stomach and digestive systems, can effectively treat intestinal obstruction diseases, and promotes defecation of intestinal obstruction patients.

The present invention discloses a supramolecular VC nicotinamide cocrystal and a preparation method and application thereof, which comprises the steps of: adding vitamin C and nicotinamide to a primary reactor of a CO2 supercritical microchannel reaction device, introducing CO2 and an organic solvent, stirring CO2 to a supercritical state, and obtaining a mixed solution of VC and nicotinamide; in a supercritical state, introducing the mixed solution of VC and nicotinamide into a microchannel secondary reactor, and obtaining a supramolecular VC nicotinamide solution after reaction; cooling and crystallizing the supramolecular VC nicotinamide solution, filtering, and drying the supramolecular VC nicotinamide cocrystal. The present invention realizes the efficient preparation of supramolecular VC nicotinamide cocrystal by using a microchannel reactor in a supercritical state process, avoids the problem that the existing cocrystal synthesis method will cause vitamin C to be destroyed, and the method of the present invention can not only enhance the permeability of the skin and improve the bioavailability, but also better exert the whitening and soothing effect, and has super strong antioxidant properties.

The invention relates to the technical field of collapse treatment, and discloses a traditional Chinese medicine rehabilitation collapse treatment device which comprises a collapse barrel and an infrared lamp assembly, water blocking layers are fixedly arranged on the two sides of the collapse barrel respectively, rotating channels are formed in the water blocking layers, collapse treatment assemblies are installed in the rotating channels, and the infrared lamp assembly is fixedly connected with the collapse barrel. The collapse treatment assembly comprises a front group of rotating rings and a rear group of rotating rings which are respectively arranged in the rotating channel, and each rotating ring comprises an upper semi-ring and a lower semi-ring. The driving system drives the rotating ring and the sloughing cloth to rotate, so that the sloughing cloth rotates to the bottom to be in contact with liquid medicine in the water storage cavity, the liquid medicine is quickly supplemented, repeated manual wetting is not needed, and treatment continuity is guaranteed; the length of the collapsed cloth can be matched with the distance between the rotating rings, and the collapsed cloth can be tightly attached to limb affected parts with different thicknesses in cooperation with a balancing weight, an arc-shaped guide frame and other structures, gaps are reduced, uneven liquid medicine distribution is avoided, medicine can directly act on the treated parts, and the medicine effect is enhanced.

The invention discloses an oil-soluble lip plumping composite peptide, which is characterized in that the composite peptide comprises the following components by weight percentage: 0.1-1.0% of active polypeptide, 50-85% of oil phase matrix, 1-20% of emulsifier, 1-20% of auxiliary emulsifier, 1-15% of water, 0.1-1.0% of preservative, and 0.01-0.1% of pH regulator. The active polypeptide comprises a composite of lip plumping / breast plumping peptides, moisturizing peptides and anti-wrinkle and anti-aging peptides. The lip plumping / breast plumping peptides are one or more combinations of palmitoyl tripeptide-1, hexapeptide-3, palmitoyl isoleucine and acetyl hexapeptide-38; the moisturizing peptides are one or more mixtures of acetyl hexapeptide-37 and carnosine; the anti-wrinkle and anti-aging peptides comprise one or more mixtures of acetyl hexapeptide-8, palmitoyl pentapeptide-4, palmitoyl tripeptide-38 and palmitoyl hexapeptide-12; and the sum of the contents of all components is 100%.

The invention discloses a silk fibroin microneedle transdermal patch suitable for psoriasis, the silk fibroin microneedle transdermal patch comprises a matrix layer and a microneedle layer, the microneedle layer comprises a base part and a needle body extending outwards from the base part, and the matrix layer and the base part are attached to each other; the matrix layer contains methotrexate and silk fibroin, and the mass ratio of methotrexate to silk fibroin in the matrix layer is (1-4): 10; the microneedle layer contains methotrexate sodium salt and silk fibroin, and the mass ratio of the methotrexate sodium salt to the silk fibroin in the microneedle layer is (0.2-2): 10. The silk fibroin microneedle patch applicable to psoriasis prepared by the invention can be used for effectively loading a drug and improving the percutaneous penetration of methotrexate, the drug onset concentration can be quickly reached at the initial stage of microneedle release, the methotrexate can be continuously and stably released subsequently, and the drug can be kept at relatively high concentration in vivo for a long time. Meanwhile, the microneedle transdermal patch avoids the first-pass effect of the liver and improves the bioavailability of methotrexate.

The invention relates to the technical field of cosmetics, in particular to ferulic acid ethosome with multiple anti-aging effects, a preparation method and application of the ferulic acid ethosome and a product of the ferulic acid ethosome. The ferulic acid ethosome is prepared from the following components in parts by mass: 80 to 100 parts of soybean lecithin, 5 parts of astragaloside, 5 parts of ceramide and 10 to 15 parts of ferulic acid. The preparation method of the ferulic acid ethosome comprises the following steps: A, mixing soybean lecithin, astragaloside, ceramide and ferulic acid according to the formula dosage to obtain a mixed material, adding absolute ethyl alcohol into the mixed material, and stirring until the absolute ethyl alcohol is dissolved to obtain an organic phase; b, injecting the organic phase obtained in the step A into water, and hydrating to obtain a solution; and C, filtering the solution obtained in the step B to obtain the ferulic acid ethosome. According to the ferulic acid ethosome disclosed by the invention, the risk of cardiovascular and cerebrovascular diseases of an organism is avoided, meanwhile, the carrier stability is also improved, and more skin care effects are brought.

The present disclosure discloses a transdermal drug delivery device, comprising: a device body, wherein a control module, a plasma and electroporation module, an iontophoresis module and a power module are arranged in the device body; wherein the control module is used for converting a first low-voltage direct current signal provided by the power module into a second low-voltage direct current signal for the plasma and electroporation module; the plasma and electroporation module is used for converting the second low-voltage direct current signal provided by the control module into a symmetric oscillation high-voltage pulse signal and introducing the signal into the skin surface through a high-voltage electrode; the iontophoresis module is used for converting the first low-voltage direct current signal provided by the power module into a rectangular pulse signal and introducing the signal into the skin surface through a low-voltage electrode, so as to be coupled with the symmetric oscillation high-voltage pulse signal introduced by the high-voltage electrode to promote the transdermal absorption of the drug; and the control module is further used for controlling the plasma and electroporation module and the iontophoresis module to perform the above actions at different times or simultaneously.

The invention provides a glycyrrhizic acid composition with functions of removing redness and resisting inflammation as well as a preparation method and application of the glycyrrhizic acid composition, and belongs to the technical field of cosmetics. The preparation method comprises the following steps: carrying out enzymolysis, supercritical fluid extraction and precipitation on liquorice to prepare glycyrrhizic acid, coupling glycyrrhizic acid with allantoin to prepare a glycyrrhizic acid-alkaloid conjugate, reacting glycyrrhizic acid with menthol to prepare glycyrrhizic acid menthol ester, adding glycyrrhizic acid menthol ester, the glycyrrhizic acid-alkaloid conjugate, phospholipid and cholesterol into ethanol for dissolving, and carrying out reduced pressure rotary evaporation to remove ethanol, so as to obtain the glycyrrhizic acid menthol ester. Adding an ethanol solution, performing ultrasonic treatment, and filtering with a microfiltration membrane, so as to obtain the glycyrrhizic acid composition with the redness-removing and anti-inflammatory functions. The glycyrrhizic acid composition with the functions of removing redness and resisting inflammation has the effects of removing redness, resisting allergy, diminishing inflammation, resisting bacteria, relieving, moisturizing and the like, the percutaneous infiltration capacity of active ingredients is effectively improved, the water-soluble capacity is improved, the bioavailability of a product is greatly improved, and therefore the application range of the glycyrrhizic acid composition is widened.

The present invention relates to the technical field of cosmetics, and provides a whitening and freckle-removing recombinant collagen cosmetic composition and a preparation method. The components of the cosmetic composition include modified recombinant collagen, glutathione, glycerol, water, vegetable oil, emulsifier, thickener, and preservative. The present invention prepares modified recombinant collagen by introducing butylthionone structure and benzimidazole structure into the peptide chain of recombinant collagen. After adding cosmetics, it can not only accurately promote the transdermal penetration of collagen, but also improve the binding ability of collagen with the copper ion active center of tyrosinase, thereby significantly improving the inhibitory effect of collagen on tyrosinase activity, significantly reducing melanin production, and giving the cosmetic composition better whitening and freckle-removing effect.