123results about How to "Improves transdermal penetration" patented technology

The invention provides a metal microneedle array which comprises a substrate, a metal sheet fixed on the surface of the substrate, and/or one metal sheet with one side edge embedded into the substrate, and/or at least two metal sheets which are arranged at certain intervals and fixed on the surface of the substrate, and/or at least two metal sheets with one side edge embedded into the substrate, wherein at least two metal sheets with one side edge embedded into the substrate are arranged at certain intervals. A microneedle array protruding outward is arranged on the edge of at least one side of each metal sheet, and at least comprises two microneedles arranged at certain intervals, the microneedles protrude out of the surface of the substrate, the microneedles are perpendicular to the surface of the substrate or the microneedles tilt to the surface of the substrate by the predetermined angle, the microneedles are perpendicular to a principal plane in which a center area of each metal sheet exists, or the microneedles share the same plane with the principal plane, and one end of each mironeedle is a needle point.

The invention discloses an empty micropin array chip which comprises a substrate and an empty micropin, wherein the empty micropin comprises a pin head and a pin rod, the empty micropin is fixed on the substrate through the pin rod and is inclined to the substrate at a certain angle, the pin head is provided with an oval-shaped annular plane, one end of the pin head is a pinpoint, one part of the oval-shaped annular plane is embedded into the substrate, the pin rod is an empty circular pipe which is embedded into the substrate or is penetrated through the substrate, the bottom of the pin rod is parallel with the lower surface of the substrate or is convex or concave, and the empty micropin penetrates through the two sides of the substrate to be formed into the hole-shaped micropin or the bottom of the pin rod is sealed to be formed into a blind hole type micropin. The empty micropin array chip is firm in structure, sharp in pinpoint, convenient in puncture, low in cost, high in yield, and suitable for manufacture in bulk. The micropin in the array has good consistency, is free of pain feel and blooding when in use, and is safe and reliable since the minimally-invasive skin can fast heal after in use.

Methods and apparatus are disclosed for treating physiological problems, and for providing rapid, efficacious transdermal treatment, for example, of muscle sprains, erectile dysfunction, or baldness, without requiring the use of needles or other invasive interventions. A topical therapeutic agent and ultrasound energy are applied to a tissue surface, e.g., the skin, such that the ultrasound enhances transdermal penetration of the agent. The invention is especially useful in localized delivery of a controlled dosage of a therapeutic agent to the small blood vessels and capillaries beneath the skin's surface.

A vehicle for topical delivery which contains a liquid eutectic mixture of hydrophobic compounds.

A vehicle for topical application which contains a liquid eutectic mixture of hydrophobic compounds to improve solubility of pharmaceutically active component and enhance topical and transdermal delivery.

The invention pertains to the field of pharmaceutical technology, which more particularly relates to an elastic nano-vesicle carrier which can transport the active ingredients of the drug to penetrate the natural permeability barrier or pores (such as skin, mucosa, and organs, etc.) and the preparation method, as well as the usage. The vesicle has lipid double molecular layers for transporting one or more active ingredients to penetrate the natural barrier. The vesicle at least contains three dressing components of phospholipid, membrane softener and alcohol, and the three have different physical and chemical properties. The diameter of the typical nano-vesicle is less than 200nm. The vesicle carrier containing the active ingredients of the drug can be applied in the injection, spray and the transdermal preparation.

The invention discloses a metal micro-needle array flexible patch, a transdermal applicator and a transdermal application patch. The metal micro-needle array flexible patch comprises a flexible substrate and at least two metal micro-needle modules which are arranged at certain intervals and fixed on the bottom surface of the flexible substrate or partially inset in the flexible substrate. Each metal micro-needle module is a metal sheet with projecting micro-needles on the edge, or a metal sheet fixed on a needle holder and provided with projecting micro-needles on the edge, or composed of metal micro-needles separately erected and fixed on a needle holder. The micro-needles are perpendicular to the surface of the flexible substrate and are hollow or solid metal micro-needles with a tip pointing out. The micro-needle array is organically combined with the flexible substrate, so that medicine is allowed to directly pass corneum to quickly enter the human body. The metal micro-needle array flexible patch is comfortable to use and evident in efficacy.

The aquogel type thiamazole plaster includes a back lining layer, a medicine matrix layer and a protecting film. The medicine matrix layer contains medicine thiamazole in 0.2-20 wt% of the medicine matrix layer, aquogel type contact adhesive material, cross-linking agent, pH regulator, humectant, tackifier medicine, transdermal promoter and water, . The present invention has high transdermal effect of medicine, good skin compatibility, high air and moisture permeability, lowered toxicity and side effect of medicine and other advantages, and is used for treating hyperthyroidism.

The invention provides a vitamin E nanoemulsion, a nano cream and a preparation method thereof. The vitamin E nanoemulsion is composed of vitamin E, oil phase, main surfactant, cosurfactant and water.The average grain diameter of the vitamin E nanoemulsion is 30-60 nm, and the vitamin E nanoemulsion is an O/W type emulsion and is a uniform system which is transparent or semi-transparent, low in viscosity and good in mobility and has blue opalescence. The method for preparing the vitamin E nanoemulsion includes the steps of mixing an oil phase and vitamin E and performing stirring evenly; sequentially adding the main surfactant and the cosurfactant, and performing stirring evenly; slowly adding distilled water dropwise, performing stirring while adding water, and obtaining the vitamin E nanoemulsion. The vitamin E nano cream is made of the vitamin E nanoemulsion and the O/W type cream substrate, and the manufactured nano cream is white, fine, glossy and good in viscosity. Instruments required for the preparation method and operation steps are simple, and the prepared nano cream is good in stability and high in infiltration capacity and has good application prospect in the directionof cosmetics.

The invention relates to a hydrogel preparation for improving the permeation of an active component glycyrrhetinic acid and/or its salt through a barrier via skins, its preparation method, and its application in the dermatology. The glycyrrhetinic acid hydrogel preparation comprises 0.01-10wt% of the active component glycyrrhetinic acid and/or its salt, 0.01-10wt% of a gel matrix, 0.01-10wt% of a humectant, 0.01-5wt% of an antiseptic, 0.01-5wt% of a pH adjustment agent, and the balance water. The glycyrrhetinic acid hydrogel preparation has the advantages of simple preparation method, good storage stability, substantial improvement of the penetration amount through the skins, no irritation or anaphylaxis, good absorbency, and good safety, and can be used for preparing medicinal preparations for treating dermatoses comprising chronic urticaria, eczema, contact dermatitis and the like through skin administration.

The invention discloses tretinoin ethosomes gel. The particle size of a tretinoin ethosomes in the gel is 130200 nm, and the encapsulation efficiency of the tretinoin ethosomes is higher than 90%. The invention further discloses a preparation method of the gel. The preparation method comprises the specific steps of preparing a coarse tretinoin ethosomes suspension and conducting ultrasonic processing on the coarse tretinoin ethosomes suspension, using 0.22 microns of filter membrane to perform filtration so as to obtain the tretinoin ethosomes, preparing a gel body, mixing the tretinoin ethosomes and the gel body, and performing development to obtain the tretinoin ethosomes gel. The mode that the ethosomes is adopted to wrap tretinoin brings better stability and transdermal absorption compared with the mode that a lipidosome is adopted to wrap the tretinoin, the prepared tretinoin ethosomes gel is an externally-used transdermal delivery preparation, the transdermal permeation effect can be improved while skin irritation is reduced, and a certain amount of permeation promoting agent is contained in the gel, so that the transdermal permeation effect of the tretinoin ethosomes gel is further improved.

The invention belongs to the technical field of daily use care products and discloses polyethylene glycol-modified vitamin E liposome and its preparation method and use. The polyethylene glycol-modified vitamin E liposome comprises 10-100 parts of phosphatidylcholine, 10-100 parts of cholesterol, 10-150 parts of vitamin E, 200-600 parts of sodium cholate, 1000-4000 parts of polyethylene glycol and 400-800 parts of a freeze drying protective agent. The preparation method comprises dissolving phosphatidylcholine, cholesterol, vitamin E and sodium cholate in a mixed solvent of chloroform and methanol, removing the solvent so that a liposome film is obtained, adding the liposome film into a polyethylene glycol solution to obtain a liposome suspension, carrying out ultrasonic dispersion and dialysis on the liposome suspension, adding the freeze drying protective agent into the solution obtained by dialysis, and carrying out freeze drying to obtain the polyethylene glycol-modified vitamin E liposome. The polyethylene glycol-modified vitamin E liposome has good stability and skin permeability, can be used for a skin care product and has effects of removing oxyradical and delaying ageing.

The invention discloses a metal micro-needle array with medicine grooves and a micro-needle percutaneous dosing patch and device. The metal micro-needle array comprises a substrate and a plurality of metal micro-needles. The metal micro-needles are arranged on the substrate at intervals and are made from metal tubes, the medicine grooves are formed by inner cavities of the metal tubes, and part of the metal tubes are removed in the axial direction of the metal tubes, so that the medicine grooves are provided with radial openings facing the metal tubes. According to the metal micro-needle array with the medicine grooves, part of the metal tubes are removed in the axial direction of the metal tubes, so that the metal micro-needles are formed, the sizes of the metal micro-needles are reduced, pain of a user is low in the using process, no blood flows out, and minimally-invasive skin can be quickly self-healed after the metal micro-needle array is used; meanwhile, the medicine grooves with the radial openings serve as medicine storehouses, detection of the filling effect and filling operation of medicine are facilitated, and the probability that medicine is left out of the body in the needle applying process can be greatly decreased.

Mast cell degranulation inhibitors having a carboxyl group have not been developed as external preparations due to the low transdermal permeability thereof. By formulating external preparations thereof, side effects on the internal organs by oral administration can be avoided. Some of the mast cell degranulation inhibitors show drastically inferior photostability, which is also one cause of suppressed development of the drug as an external preparation.

The present invention aims at improving the transdermal permeability and photostability of mast cell degranulation inhibitors by forming a salt of the mast cell degranulation inhibitor with an organic amine. Consequently, an external preparation of a mast cell degranulation inhibitor can be provided and the photostability of the mast cell degranulation inhibitor itself, and a preparation containing same can be improved.

The invention belongs to the technical field of medicines, and particularly provides a long-acting donepezil percutaneous absorption sticking agent. The long-acting donepezil percutaneous absorption patch agent consists of a back lining layer, a drug-containing pressure-sensitive glue layer and an anti-sticking layer, wherein the long-acting donepezil percutaneous absorption sticking agent comprises 5-15 parts of main drug donepezil, 70-95 parts of pressure-sensitive glue and 0.5-15 parts of percutaneous absorption accelerant. The long-acting donepezil percutaneous absorption sticking agent is characterized in that the ingredients of a film selected by the back lining layer comprises polyethylene, polyester and ethylvinylacetate. The donepezil percutaneous absorption sticking agent provided by the invention is stable and durable in curative effect, and each sticking agent has 5 days of effective function. The long-acting donepezil percutaneous absorption sticking agent is characterized in that the back lining layer capable of providing maximum drug-permeable quantity is adopted. The long-acting donepezil percutaneous absorption sticking agent provided by the invention is good in percutaneous permeability, durable and stable in curative effect, and good in skin feeling.

The invention belongs to the field of cosmetics, and specifically relates to a flexible liposome cosmetic containing active polypeptides and a preparation method thereof. Due to barrier effects of cuticle of skin epidermis, the skin is difficult to be penetrated by most of active ingredients of cosmetics containing active polypeptides. In order to solve the problem, the invention provides a flexible liposome cosmetic containing active polypeptides. The flexible liposome cosmetic containing the active polypeptides is prepared by containing active polypeptides in flexible liposomes modified by hydrophobic modifying polypeptides, so that, transmittance of the cosmetic is effectively improved; and thus, the developed cosmetic is easier to absorb as well as better in anti-oxidizing and anti-aging effects. Therefore, the cosmetic has broad application prospects.

The invention discloses a sinomenine vesicle and a preparation method thereof, a preparation containing the sinomenine vesicle and a preparation method of the preparation, which belong to the field of medicament preparations. The sinomenine vesicle is prepared from sinomenine, a nonionic surfactant and an additive. The sinomenine vesicle is preferably prepared into external gel. A sinomenine transdermal administration external preparation has a unique advantage to the medicament. Due to the application of a novel vesicle administration system, transdermal absorption of the medicament is improved, and a clinical curative effect is enhanced. The sinomenine vesicle can be used for treating rheumatism, rheumatoid arthritis, a glomerular disease, hyperosteogeny, spondylitis, arrhythmia, systemic lupus erythematosus, a heroin addict withdrawal symptom and the like.

The invention relates to imiquimod micro emulsion gels for local skin, at least comprising the following ingredients by mass percent: 0.1-2.5 percent of imiquimod, 1-24 percent of solvent, 1-16 percent of surface active agent, 1-12 percent of cosurfactant, 1-20 percent of gelatinizing agent and the remaining water; wherein the imiquimod is 1-isobutyl-1H-imidazole(4,5-C) quinoline-4-amine; the preparation method comprises the following steps: the imiquimod is dissolved in the solvent, the surface active agent and the cosurfactant are added in the solvent dissolved with the imiquimod, and the mixture is dispersed uniformly; water with [roper amount is added in the mixture to form micro emulsion; the gelatinizing agent is swelled by water, so as to prepare the solution with a certain concentration, the gelatinizing agent solution is dropped in the imiquimod micro emulsion dropwise, the stirring is carried out while the gelatinizing agent solution is dropped, the pH value is adjusted by adding triethanolamine, so as to prepare the imiquimod micro emulsion gels; the invention has the advantages that: the thorough dispersity of the micro emulsion to medicines, adhesiveness of gels to the skin and deformation flowability thereof under external force are concentrated, so as to lead the medicine to be applied to the affected part and cause the medicine to pass into internal body and reach target spot through the skin; the medicine effect can act on continuously.

The invention provides a non-steroid anti-inflammatory drug microemulsion-based gel patch with good stability and good permeation promotion effect. The patch contains a non-steroid anti-inflammatory drug microemulsion, a polymer gel skeleton, a cross-linking agent, a tackifier, a humectant, a filler and other pharmaceutically acceptable excipients. The non-steroid anti-inflammatory drug microemulsion contains a non-steroid anti-inflammatory drug, an emulsifier, a co-emulsifier, an oil phase and pharmaceutically acceptable excipients. According to the invention, the oil phase, the emulsifier and the co-emulsifier used for preparing the microemulsion can be used as drug permeation promoters at the same time and are cooperated with the microemulsion to promote percutaneous permeability of the drug, so the percutaneous permeability of the drug is effectively improved; thus, the residual quantity of the drug in the patch is reduced and the utilization degree of the drug is improved.

The invention discloses an aminolevulinic acid hydrochloride temperature-sensitive in-situ gel preparation and belongs to the technical field of medicinal preparations. The preparation consists of aminolevulinic acid hydrochloride solid powder and a gel substrate. During use, the aminolevulinic acid hydrochloride solid powder and the gel substrate are uniformly mixed and then are spread. The invention firstly prepares aminolevulinic acid hydrochloride into temperature-sensitive in-situ gel, the preparation is in a liquid state when the preparation is out of a body, the dose is easy to control, semisolid gel can be quickly formed at an administrated position after administration, the retention time is long, the biocompatibility is good, the use is facilitated, the problems such as low biological utilization rate and inconvenience in use of 5-ALA preparations are solved, and the preparation is applicable to the treatment of various skin diseases such as acnes and actinic keratosis and has a wide clinical application prospect.

The invention discloses modified polyethylene glycol superoxide dismutase (mPEG-SOD) nanoemulsion capable of being directly externally used for skin and a preparation method thereof. The mPEG-SOD nanoemulsion is prepared from the following raw materials in part by weight: 7 parts of isopropyl myristate, 30 parts of caprylocaproyl macrogolglycerides, 10 parts of polyglyceryl-3-dioleate, 50 parts of mPEG-SOD aqueous solution and 3 parts of vitamin E. The mPEG-SOD nanoemulsion solves the problem that the SOD has low stability, is easy to deactivate, and has poor penetrability for external application to the skin. The modified polyethylene glycol superoxide dismutase (mPEG-SOD) nanoemulsion capable of being directly externally used for the skin is a preparation with good stability and capacity of persistently protecting the bioactivity of the SOD, and can quickly penetrate the skin so as to greatly improve the biological effect of the SOD. The preparation method has the advantages of simple preparation process, easy actual operation, no need of special instrument and equipment, and high-efficiency and quick preparation.

A patch for transdermal administration having a sufficiently high transdermal permeation property of a COX-2 inhibitor to exert a superior antiinflammatory effect, the patch for transdermal administration comprising a backing and an adhesive layer which is placed on at least one side of the backing and comprises an adhesive base agent and a drug, wherein the drug is valdecoxib or a pharmaceutically acceptable salt thereof.

The invention provides a Chinese medicine microemulsion preparation with enhanced percutaneous permeability and preparation method thereof, which is characterized in that: the preparation contains the following raw materials in weight ratio: tripterygium alcohol extract 0.1-1.5, mixed oil phase 1-10, mixed surfactant 10-30, cosurfactant 0.1-10 and double distilled water 60-85. The preparation provided by the invention has the advantages of: good percutaneous permeability and good inclusiveness, which cause the Chinese medicine complicated components easy to be molded; thereby avoiding stimulation of oral preparation to gastrointestinal tract and first-pass effect, generating lasting and constant blood concentration, reducing administration frequency, reducing pharmaceutical toxic and side effects. Body surface administration can directly reach focus for resolving patient complaint more quickly, because the medicine can be used conveniently, and is easy to control, paint and clean; the tripterygium microemulsion preparation provided by the invention has a percutaneous permeation rate which is 6.15 times of that of tripterygium ointment with identical drug loading, and conforms to zero level release equation, and reflects high-efficient and constant-speed release characteristics.

The invention provides a compound lidocaine medicine composition. The composition is prepared from lidocaine, prilocaine, an oil phase, a surfactant, a cosurfactant and water. According to the method, a hydrophilic drug prilocaine and a lipophilic drug lidocaine are introduced into a microemulsion system in a reasonable proportion. The system can be used for enhancing the transdermal permeation effect of the two drugs at the same time and greatly shortening the effect of local anaesthesia, can be applied to local cortex before injection to reduce patient pain and improve compliance, and can be applied to patients requiring operation as soon as possible to greatly reduce the waiting time of anaesthesia and shorten the operation time. Furthermore, the pharmaceutical composition has high stability, can be stored for 9 months at 25 DEG C and 40 DEG C, does not contain penetration enhancer, preservative, ionic polymer or other additives, and is simple in composition, high in quality, small in side effect and high in safety.