13results about How to "Easy to administer" patented technology

The present application relates to a kind of dolasetron mesylate suppositories, it is characterized in that, component includes: dolasetron mesylate, cyclodextrin or its derivative, shell matrix, hardness regulator, gel matrix, water;The gel matrix includes polyacrylic acid derivative grafted chitosan in it.The present application uses polyacrylic acid derivative grafted chitosan and cyclodextrin to prepare dolasetron mesylate liquid gel, significantly improve the stability and bioavailability of suppository;And can achieve the purpose of quick effect and slow release long-acting simultaneously.The suppository of the present application is very convenient for old people, children or patients who cannot be administered orally, and the treatment population of the product belongs to the patient who is inconvenient to swallow.

The present application relates to a kind of soluble microneedle patch of semaglutide peptide and its preparation method and purposes.The soluble microneedle patch of semaglutide peptide includes drug-loaded needle tip layer and back plate layer;Wherein, the drug-loaded needle tip layer includes semaglutide and needle tip layer matrix material;With the total weight of the drug-loaded needle tip layer 100% as 100%, the weight percentage of semaglutide is 85%~99%, and the weight percentage of the needle tip layer matrix material is 1%~15%.The needle type of the soluble microneedle patch of semaglutide is excellent, and the mechanical strength and skin puncture performance are superior, and the safety is high, and drug release and penetration rate are fast, and drug penetration rate is high, with excellent drug utilization and bioavailability;Its preparation method is simple, and controllability is good, and it is suitable for large-scale production.In addition, the soluble microneedle patch of semaglutide is convenient and fast, and patient compliance is high, with wide clinical application prospect.

The application provides a preparation of gramicidin and an antibacterial hydrogel preparation of the gramicidin, and discloses medical uses of the gramicidin, and provides a recombinant gramicidin, heterologous expression of the gramicidin is realized by constructing a Pichia pastoris recombinant strain, and the antibacterial activity of the gramicidin is retained, and the method has the advantages of simplicity and rapidness. Meanwhile, the hydrogel preparation of the gramicidin provided by the application shows good potential for treating wound infection of a diabetic mouse, and has the performance of rapid adhesion and hemostasis, lays a foundation for development of a new antibacterial drug, and provides a new direction for treatment of chronic inflammatory wounds and open bleeding.

The invention discloses histamine oxidase protein and application thereof. The amino acid sequence of the histamine oxidase protein is shown as SEQ ID NO. 1. The histamine oxidase protein PAO can be used for preparing the medicine for treating allergic rhinitis; according to the invention, histamine is locally degraded through nasal mucosa, so that local histamine aggregation of nasal mucosa is reduced, symptoms such as sneezing and the like of allergic rhinitis are improved, and nasal 2-type inflammatory response is relieved, so that a treatment effect on allergic rhinitis is achieved, and a brand-new view angle and target spot are provided for treatment of allergic rhinitis.

The invention provides a drug intervention comprehensive treatment device which comprises a bottom plate, a fixing plate and a fixing frame and further comprises a first driving piece, a second driving piece, a first connecting piece and a second connecting piece. The adjusting assembly is arranged on the outer side of the first driving part and comprises a supporting frame. According to the drug intervention comprehensive treatment device, through cooperative use of the adjusting assembly, the supporting piece, the lifting assembly and the adjusting piece, the angles of the fixing frame and the intervention assembly can be conveniently adjusted, the height of the fixing plate can be conveniently adjusted, then the device can be conveniently used by different people, the practicability of the device is improved, and the device is worthy of popularization and application. By arranging the drug administration assembly, drug administration can be conveniently carried out on the intervention assembly, effusion in the body of the patient can be conveniently stored, and by arranging the intervention assembly, intervention can be conveniently carried out in the body of the patient, and meanwhile body fluid in the body of the patient can be conveniently extracted.

Disclosed is a pharmaceutical composition which can provide a tablet capable of maintaining the shape of the tablet for a long period of time after administration while suppressing the content of polyvinyl alcohol. The pharmaceutical composition contains a polyvinyl alcohol-based resin (A), a polyphenol compound (B), and amorphous silica (C). The content of the amorphous silica (C) is 0.1-20 parts by mass with respect to 100 parts by mass of the polyvinyl alcohol-based resin. Further disclosed is a tablet which comprises a pharmaceutical composition as a matrix composition (I) and an active pharmaceutical ingredient (II) dispersed in the matrix composition (I), the active pharmaceutical ingredient (II) being contained in an amount of 30-90 mass% inclusive.

This invention provides a circRNA-LNP delivery system for in vivo induction of iTregs, its preparation method, and its applications. The delivery system includes circRNA encoding human TGF-β1, lipid nanoparticles encapsulating the circRNA, and IL-2 modified on the surface of the lipid nanoparticles. This invention synergistically combines retinoic acid as a functional immunomodulatory small molecule with five lipids, significantly improving the uptake efficiency of Treg precursor cells and the induction efficiency of iTregs. It can also efficiently increase the proportion of functional iTregs in diseased tissues in vivo, demonstrating excellent therapeutic effects on immunomodulatory diseases such as ulcerative colitis, and providing a novel technical pathway for the radical treatment of autoimmune and inflammatory diseases.

The present application belongs to the technical field of pharmaceutical chemistry, and particularly relates to a crystal form of lamivudine salt of m-hydroxybenzoic acid and a preparation method thereof. The crystal form has an X-ray diffraction spectrum expressed by 2theta using Cu-Kalpha radiation, and has characteristic peaks at least at 9.26+ / -0.2, 12.56+ / -0.2, 13.05+ / -0.2, 14.59+ / -0.2, 17.45+ / -0.2, 20.30+ / -0.2, 21.76+ / -0.2, 23.37+ / -0.2, 25.05+ / -0.2 and 27.58+ / -0.2; the crystal form is composed of a molecule of lamivudine, a molecule of m-hydroxybenzoic acid and a molecule of n-butanol as a basic unit; meanwhile, the crystal form has good solubility, provides ideal raw material for preparing parenteral dosage forms which are convenient to administer and have rapid effect, and thus better meets the requirements of clinical application.

The invention discloses an application of sotrasturin, or a stereoisomer of sotrasturin, or a raceme of sotrasturin, or a pharmaceutically acceptable salt of sotrasturin, or a solvate of sotrasturin in the development of a medicine for preventing or treating TRPM8 related diseases. Particularly, sotratolin is disclosed as a TRPM8 agonist, and a good prevention or treatment effect can be obtained when sotratolin is used for preventing or treating xerophthalmia; in a mouse xerophthalmia model induced by a benzalkonium chloride solution, sotratoline has a remarkable improvement effect.

The invention discloses a traditional Chinese medicine oral prescription for preventing and treating influenza A and improving digestive tract diseases, and belongs to the technical field of traditional Chinese medicines. The prescription is prepared from kudzuvine root, radix bupleuri, moutan bark, peach kernel, scutellaria baicalensis, raw rhubarb, pinellia ternate, fructus forsythiae, mirabilite, mangnolia officinalis, immature bitter orange, poria cocos, bighead atractylodes rhizome, rhizoma alismatis, white paeony root, Chinese date and ginger which are strictly matched according to a specific weight ratio and are prepared by a specific water decoction process. The traditional Chinese medicine oral prescription can effectively prevent and treat influenza A through the synergistic effect of the components, has a remarkable improvement effect on most of digestive tract diseases, is simple in preparation process, convenient to take and high in safety, avoids the problems of poor curative effect, obvious side effect or narrow application range and the like of related medicines in the prior art, and has a wide application prospect. And a new effective choice is provided for prevention and treatment of influenza A and improvement of digestive tract diseases.

The application discloses a small-molecule inhibitor targeting NID1 and application, and relates to the technical field of biological medicines.The application selects W-5 hydrochloride as a small molecule for specifically inhibiting the function and activity of NID1 by molecular docking prediction and function verification from existing small-molecule drugs, and finds and verifies for the first time that W-5 can directly combine and inhibit NID1 protein.Starting from the core pathological link of "NID1-CSCs-resistance / metastasis", it is verified through experiments that W-5 hydrochloride can effectively combine with NID1, and can inhibit lung adenocarcinoma cell stemness, invasion and drug resistance by inhibiting the function of NID1 in lung adenocarcinoma.The application not only provides a clear orientation and a solid foundation for chemical optimization, structure modification, dosage form development and pharmacokinetics / toxicology (ADMET) research of a clear mechanism of directly targeting NID1, but also discovers new medicinal value of W-5 hydrochloride.

The invention discloses an application of an RAR alpha specific antagonist in prevention and treatment of porcine reproductive and respiratory syndrome. According to the application, the fact that the RAR alpha specific antagonist ER 50891 has the anti-PRRSV effect is found for the first time, it is shown that the ER 50891 can remarkably inhibit replication and proliferation of the PRRSV, inhibit PRRSV N protein expression and reduce the PRRSV titer and has the remarkable antiviral effect, and the effect of the ER 50891 is dose-dependent. Meanwhile, the ER 50891 has a broad-spectrum antiviral effect on the PRRSV, and still has a relatively good antiviral effect on different strains and the high-pathogenicity PRRSV (HP-PRRSV). The invention discloses the new application of the ER 50891 in the anti-PRRSV aspect for the first time, a new candidate compound is provided for research and development of anti-PRRSV drugs, and a new strategy and means are also provided for clinical prevention and treatment of porcine reproductive and respiratory syndrome.

The utility model discloses an arm support frame capable of adjusting an inclination angle during an operation, and particularly relates to the technical field of medical instruments, the arm support frame comprises a first support plate and a second support plate which are used for supporting an arm of a patient, and one end of the first support plate is connected with one end of the second support plate through an inclination adjusting mechanism; the bottom of the first supporting plate is rotationally connected with a base through a rotating shaft, the base is connected with a sickbed through a buckle, and a clamping mechanism is arranged between the bottom of the first supporting plate and the base. By arranging the inclination adjusting mechanism, the included angle between the first supporting plate and the second supporting plate is changed, so that the lifting arm of a patient is supported, medical staff can conveniently observe the venipuncture part, intraoperative dosing can be carried out without connecting an extension tube, dosing delay is avoided, and dosing is convenient; the bed is fixed beside a bed, an additional supporting frame is not needed, the operation of a doctor is not affected, meanwhile, the inclined second supporting plate also guarantees the normal physiological curvature of the arm of the patient, and the comfort level of the patient is guaranteed.