1213results about How to "Easy to administer" patented technology

A computer executable "aggregate" task is processed by dividing it into subtasks and distributing the subtasks "on demand" to remotely located subscribing computers via a computer network. The aggregate task originates at a coordinating computer, coupled to one or more peripheral computers by appropriate communications links. The coordinating computer divides the aggregate task into multiple independent subtasks. Each peripheral computer begins to "subscribe" to the coordinating computer's aggregate task by obtaining an "idle time activation program" from the coordinating computer, and then installing the program locally. The idle time activation program which may include a screen saver, activates automatically when the subscribing computer is inactive. Continuing the subscription process, each peripheral computer requests a subtask from the coordinating computer. In response, the coordinating computer distributes different subtasks among the subscribing computers, completing the subscription process. The subscribing computers automatically work on their respective subtasks whenever they are idle, as directed by the local idle time activation program. When a subscribing computer completes its subtask, it transmits results back to the coordinating computer. When results of all subtasks have been received from subscribing computers, the coordinating computer compiles and stores these results, concluding the aggregate task.

The invention relates to pharmaceutical compositions and methods of treating inflammatory-related diseases associated with pro-inflammatory cytokine expression and / or reduced expression of anti-inflammatory cytokines. The method typically comprises administration of one or more compounds selected from isoindigo, indigo, indirubin, or derivatives thereof, such as, Meisoindigo and NATURA. Preferably the pharmaceutical composition comprises one or more compounds selected from isoindigo, indigo, indirubin, or derivatives thereof, an anti-inflammatory agent, and a pharmaceutically acceptable carrier.

The invention discloses a traditional Chinese medicine preparation for treating depressive disorder and anxiety disorder and a preparation method thereof. The preparation comprises the following components in portion by weight: 10 to 30 portions of prepared rhizome of rehmannia, 10 to 30 portions of Flos Albiziae, 10 to 30 portions of shelled cedar seed, 10 to 30 portions of rhizoma cyperi, 10 to 30 portions of bupleurum, 10 to 30 portions of Chinese yam, 10 to 30 portions of prepared fleece-flower root, 10 to 30 portions of gynostemma pentaphylla, 10 to 30 portions of gardenia, 10 to 30 portions of radix codonopsitis, 10 to 30 portions of angelica, 10 to 30 portions of unprocessed oyster, 10 to 30 portions of hoantchy root, 10 to 30 portions of schisandra, 10 to 30 portions of epimedium, 10 to 30 portions of spina date seed, 10 to 30 portions of milkwort, 10 to 30 portions of phellodendron amurense, 10 to 30 portions of anoectochilus formosanus, and 10 to 30 portions of uncaria. The traditional Chinese medicine preparation utilizes the efficacy of each drug to generate synergic action, and has the efficacies of relieving restlessness and soothing the nerves, nourishing the mind and replenishing the deficiency, soothing the nerves and benefitting the intelligence, reducing phlegm and dredging acupuncture points, nourishing the mind and protecting the liver, promoting Qi circulation and removing obstruction in the collateral, and relieving melancholy, anxiety and insomnia so as to effectively treat the depressive disorder and the anxiety disorder.

A method of inhibiting angiogenesis in a mammal is disclosed, which employs a pharmaceutically acceptable composition containing a selective inhibitor of protein kinase CK2 (also known as casein kinase II) enzymatic activity, such as emodin, aloe-emodin, 5,6-dichloro-1-beta-D-ribofuranosylbenzimidazole (DRB), and 4,5,6,7-tetrabromobenzotriazole (TBB). Also disclosed is a use of a selective inhibitor of protein kinase CK2 enzymatic activity in the manufacture of a medicament for inhibiting angiogenesis. An in vitro method of screening a potential antiangiogenic agent is also disclosed. A kit for the treatment of a disease by inhibiting angiogenesis is disclosed that contains the pharmaceutically acceptable composition containing a selective inhibitor of protein kinase CK2 enzymatic activity.

A method for commissioning a collection of electronic locks by inserting the same electronic key into each of the locks and recording in the electronic key and internal code unique to that lock which identifies the lock and is needed to open the lock and a method for biometrically permitted controlled secure access to a container having one of the commissioned electronic locks. A data processing machine is configured to make biometric identifications, credential identifications and input identifications to verify users using the system and control and regulate user access to locks or electronic cylinders.

The invention relates to pharmaceutical compositions and methods of treating inflammatory-related diseases associated with pro-inflammatory cytokine expression and / or reduced expression of anti-inflammatory cytokines. The method typically comprises administration of one or more compounds selected from isoindigo, indigo, indirubin, or derivatives thereof, such as, Meisoindigo and NATURA. Preferably the pharmaceutical composition comprises one or more compounds selected from isoindigo, indigo, indirubin, or derivatives thereof, an anti-inflammatory agent, and a pharmaceutically acceptable carrier.

The invention concerns a pharmaceutical and / or food composition comprising a suitable pharmaceutical and / or food vehicle and a heat shock protein and at least conformation or sequential epitopes of an antigenic structure inducing a graft versus host, an allergic or autoimmune reaction.

The external plaster for treating baby's heat cough is developed based on the pathological features and the pathological cause of baby's heat cough. It is prepared with 17 kinds of Chinese medicinal materials including forsythia, sweet wormwood herb, skullcap root, bitter orange, etc. and through decoction, concentration, crushing, mixing and other steps. The external plaster for treating baby's heat cough has the functions of dispelling wind, clearing away heat, promoting lung-Qi flow, eliminating phlegm, etc. and is used mainly for treating baby's heat cough caused by different reasons. The medicine has convenient use and obvious effect, and the preparation process is suitable for industrial production.

The invention discloses a traditional Chinese medicine composition for treating dermatitis and eczema of infants, which consists of oral medicines and externally applied medicines, the oral medicines include 5 to 10 parts of red-rooted salvia root, 5 to 10 parts of suberect spatholobus stem, 5 to 10 parts of the seed of Job stears, 5 to 10 parts of Chinese angelica, 5 to 10 parts of astragalus root, 5 to 15 parts of bighead atractylodes rhizome, 5 to 10 parts of glabrous greenbrier rhizome, 5 to 10 parts of honeysuckle flower, 5 to 10 parts of Philippine violet herb, 5 to 10 parts of Japanese honeysuckle stem, 5 to 10 parts of Chinese wolfberry root bark, 5 to 10 parts of Chinese starjasmine stem and 5 to 15 parts of whiteflower patrinia herb, and the externally applied medicines include 5 to 15 parts of common cnidium fruit, 5 to 15 parts of natural indigo, 10 to 15 parts of spreading hedyotis herb, 10 to 15 parts of cortex dictamnt, 5 to 15 parts of clematis root, 5 to 15 parts of parslane herb, 5 to 15 parts of lightyellow sophora root, 10 to 15 parts of redroot gromwell root, 5 to 15 parts of dried alum, 10 to 15 parts of heartleaf houttuynia herb and 5 to 15 parts of amur corktree bark. The traditional Chinese medicine composition can be easily prepared, the cost is low, the Chinese medicinal materials with different medicinal properties are adopted and scientifically prepared, and the traditional Chinese medicine composition does not have any stimulating effect on the intestines, stomachs and skin of infants, and is safe and effective.

The invention discloses a stable liquid preparation of a recombinant anti-PD-L1 whole-human monoclonal antibody. The liquid preparation is prepared from a recombinant anti-PD-L1 whole-human monoclonal antibody, a buffer solution, a stabilizing agent, an osmotic pressure regulator and a surfactant, wherein the buffer solution is a histidine-histidine hydrochloride buffer solution; the stabilizing agent is mannitol; the osmotic pressure regulator is sodium chloride; the surfactant is polysorbate 80. The liquid preparation of the recombinant anti-PD-L1 whole-human monoclonal antibody has superior stability, and can be stored stably at the temperature of 5+ / -3 DEG C for at least 24 months.

A forward proxy can perform identity substitutions and related services. The user provides the forward proxy with identity information, and the forward proxy presents itself to remote Internet sites on behalf of the user in the guize of the specified identity. From the remote site's point of view, the forward proxy is the machine being used by the user; the identity of the actual user machine can be hidden. Cookies are thus stored and updated at the forward proxy instead of being stored and updated at the user computer as they would be if a conventional forward proxy had been used. This helps preserve user privacy. The use of group identities, which are shared by multiple users, are also facilitated.

The invention provides an in situ eye gel preparation of penciclovir. The compositions and weight percentages thereof are 0.01-2.0wt% of penciclovir, 5-40wt% of poloxamer, 0.1-5wt% of tackifier high polymer base, 0.8-10wt% of osmotic regulation agent, 0.001-0.5wt% of antiseptics and the rest is distilled water. Meanwhile, the preparation method is also provided. The in situ gel preparation has good biocompatibility and glutinousness; compared with a liquid preparation, the invention can increase retention time of drug in the eyes and delay elimination, thus improving the bioavailability of the eyes and reducing the times of administration; meanwhile, the invention avoids weaknesses that operation is inconvenient during gel administration, the preparation is not easy to spread in eyes, the dosage can not be controlled accurately, etc.

The invention belongs to the field of medicinal preparation, relates to a co-feeding delivery system, and particularly relates to a co-feeding lipid nano-delivery system for entrapping anticancer polypeptide and gene or chemotherapeutics or radiopharmaceutical simultaneously. The delivery system consists of a target searching material, a lipid component and medicaments, ensures that different medicaments are entrapped to the lipid nano-delivery system together by sufficiently utilizing character difference among components or entrapping through static electricity or a method of passively combining and actively carrying, and can simultaneously deliver the anticancer polypeptide and genetic medicament capable of restoring activity of tumor suppressor protein p53 or chemotherapeutics or radiopharmaceutical into a target cell so as to achieve the aim of co-therapy. By virtue of in-vitro activity evaluation, the system is proved to be superior to that of delivering single component at the same time, the anticancer activity of the system is remarkably improved, and the system has definite co-therapy effect.

The externally applied plaster for treating infantile fever is developed on the infantile physiological and pathological characteristics and fever cause and is prepared with 18 kinds of Chinese medicinal materials, including sweet wormwood, eucalyptus leaf, mint, schizonepta, etc. and through decoction, concentration, crushing, mix and other steps. It has the functions of dispelling wind and other pathogenic evil, clearing away heat and toxic material, resolving stagnation and alleviating mental depression, is used to treat infantile fever diseases, and has obvious curative effect and high safety.

The invention provides a traditional Chinese medicine composition for treating colpitis mycotica, wherein the oral medicines are: 10-20 parts of viscum album, 10-20 parts of angelica, 10-20 of bighead atractylodes rhizome, 10-20 parts of motherwort, 10-20 of astragalus root, 10-20 parts of fructus zizyphi sativae, 10-20 parts of semen cuscutae, 10-20 parts of fruit of glossy privet, 10-20 of mulberry, 10-20 parts of rhizoma anemarrhenae, 10-20 of fructus rubi, 10-20 parts of Chinese magnoliavine fruit, 10-20 parts of scutellaria baicalensis, and 10-20 parts of patrinia; the external medicines are: 10-30 parts of root of Chinese pulsatilla, 10-30 parts of golden cypress, 10-30 parts of radix sophorae flavescentis, 10-30 parts of fructus cnidii, 10-30 parts of cortex dictamni, 10-30 parts of folium artemisiae argyi, 10-30 parts of clove, 10-30 parts of Chinese prickly ash, 10-30 parts of smoked plum, 10-30 parts of rhizoma smilacis glabrae, 10-30 parts of borneol, 10-30 parts of herba, and 10-30 parts of mint. The composition has fast effects of relieving itching, killing insect and degerming, strongly diminishes inflammation antibiotic property, and is high in bacteriostasis ratio, convenient for administration, easy for manufacturing and low in cost.

The invention belongs to the technical field of medicines, and provides a propranolol hydrochloride (PPL.HCL) gel which can be externally used for treating infant superficial hemangioma. The propranolol hydrochloride gel is mainly prepared from propranolol hydrochloride, gel matrix, a percutaneous penetration enhancer, a preservative, a humectant and the like. By using the propranolol hydrochloride gel, adverse reactions such as decreased heart rate, cyanosis, airway hyperresponsiveness, shortage of granular leukocytes, diarrhoea, sleep change and blood sugar reduction caused by orally taking propranolol by hemangioma patients can be reduced and even avoided, and the problems that oral dosage is not easy to control, infants inconveniently take medicines and the like are solved.

A composition which can be used as platform for transdermal administration of therapeutically active compounds and / or nutrients. The composition comprises at least one therapeutically active compound and / or at least one nutrient, and a non-oily emulsion.

This invention discloses methods and systems for diagnosing glaucoma by combining diagnostic parameters derived from optical coherence tomography images of three different anatomic regions of the eye, including the macular ganglion cell complex (mGCC), the peripapillary nerve fiber layer (ppNFL), and the optic nerve head (ONH). The combined diagnostic parameters form a reduced set of global parameters, which are then fed to pre-trained machine classifiers as input to arrive at a single diagnostic indicator for glaucoma. Also disclosed are methods for training a machine classifier to be used in methods and systems of this invention.

An improved drug delivery composition and method of use is disclosed. The composition comprises one or more biodegradable block copolymer drug carriers; and a reconstitution enhancing and enabling agent comprising polyethylene glycol (PEG), a PEG derivative or a mixture of PEG and a PEG derivative. The composition can be administered as is or after being be dissolved or rapidly reconstituted in an aqueous vehicle to afford a homogeneous solution or uniform colloidal systems.

A temp-sensitive slow-release gel for local injection features that when its temp is lower than that of human body, it exists in liquid state and after it is injected into human body, it becomes gel for slowly releasing its medicine component. Its preparing process includes such steps preparing the temp-sensitive polymer as carrier from PLGA-PEG-PLGA block copolymer, PEG-PLGA-PEG block copolymer and poloxamer, dissolving it in water, and dissolving or dispersing the medicine in said aqueous solution.

A food composition including a fish oil containing omega-3 fatty acids, a food grade acid and a flavoring agent, the food grade acid and flavoring agent neutralizing the aroma and / or flavor of the fish oil. Lemonade flavoring can be added to the composition to further neutralize the fish oil aroma and / or flavor. The food grade acid can be citric acid present in an amount of about 0.8% to about 4% by weight of the composition. The flavoring agent can be a lemon flavor ingredient present in an amount of about 0.02% to about 2% by weight, and / or a mango flavoring present in an amount of about 0.5% to about 3% by weight. The optional lemonade flavoring agent can be present in an amount of about 0.5% to about 3.5% by weight. The fish oil can be encapsulated and further immobilized in a gelatin matrix of a gummi-type product to further eliminate the fish aroma and / or flavor.

The invention discloses an external preparation for treating vitligo and a preparation and using method thereof. The external preparation comprises the following components in portion by weight: 10 to 30 portions of radix salviae miltiorrhizae, 10 to 30 portions of rhizoma drynariae, 10 to 30 portions of herba ecliptae, 10 to 30 portions of angelica, 10 to 30 portions of dodder, 10 to 30 portions of white fructus tribuli, 10 to 30 portions of purslane, 10 to 30 portions of dark plum, 10 to 30 portions of cnidium fruit, 10 to 30 portions of prepared fleece-flower root, 10 to 30 portions of safflower, 10 to 30 portions of black sesame, 10 to 30 portions of szechuan lovage rhizome, 10 to 30 portions of gromwell root, 10 to 30 portions of honeysuckle, 10 to 30 portions of malaytea scurfpea fruit, 2 to 8 portions of radix euphorbiae ebractealatae, 10 to 15 portions of toad shell and 2 to 8 portions of chilopod. The external preparation can invigorate blood circulation and eliminate freckles, inhibit epidermis sulphydryl and melatonin, and activate the activity of tyrosinase so as to recover or accelerate the generation and the transfer of melanin and recover the color element of pathological skin; and the preparation method is simple, and can obtain good economic benefit.

Sustained release compositions in tablet or multiparticulate forms comprising (a) an active ingredient, (b) a primary sustain release agent, (c) a wax-like agent, and (d) a bulking or spheronizing agent are provided. The compositions are chewable and / or taste masked. Oral dosage forms comprising such compositions and methods for preparing and using such compositions and dosage forms are also provided.

The invention discloses a nano-particle containing docetaxel and vitamin E TPGS (d-alpha tocopheryl polyethylene glycol 1000 succinate) and a preparation method thereof. The nano-particle containing docetaxel and vitamin E TPGS comprises the following components in parts by weight: 2-10 parts of docetaxel, 1-15 parts of vitamin E TPGS, 20-65 parts of albumin, 5-50 parts of cryoprotectant, and 2-20 parts of acidic buffer salt. Relative to an existing docetaxel commercial preparation, the nano-particle containing docetaxel and vitamin E TPGS is good in drug entrapping performance, small in toxic and side effect, high in stability, good in anti-tumor curative effect and convenient to administer; the preparation method is simple, and the production cost is low.

The invention discloses a Chinese medicinal preparation for treating anemia and a preparation method thereof. The preparation comprises the following raw materials in part by weight: 10 to 20 parts of Chinese angelica, 10 to 20 parts of root of red-rooted salvia, 10 to 20 parts of coix seed, 10 to 20 parts of dodder seed, 10 to 20 parts of prepared fleece-flower root, 10 to 20 parts of medlar, 10 to 20 parts of Chinese date, 10 to 20 parts of white paeony root, 10 to 20 parts of Chinese yam, 10 to 20 parts of yerbadetajo herb, 10 to 20 parts of suberect spatholobus stem, 10 to 20 parts of black sesame, 10 to 20 parts of mulberry, 10 to 20 parts of motherwort, 10 to 20 parts of prepared rhizome of rehmannia, 10 to 20 parts of large-headed atractylodes rhizome and 10 to 20 parts of astragalus root. Compared with the prior art, the preparation for treating the anemia has the effects of strengthening spleen and stomach, tonifying qi and producing blood. The preparation has the advantages of convenient administration, easy manufacture, low cost and the like. Because the adopted Chinese medicinal materials with different medicinal properties are scientifically compatible, the preparation can achieve the ideal treatment effect, and has the advantages of safety, low toxic and side effect and convenient use.

A liquid medicine in the form of oral liquid or injection contains coenzyme Q10, liposome and buffer liquid proportional. It has high stability and biologic utilization rate.

A buccal microneedle patch may be provided for vaccination. The buccal microneedle patch may include at least one of microneedles. The at least one microneedles may be configured to contain a predetermined vaccine and to penetrate an outside layer of a buccal mucosa for promptly delivering the predetermined vaccine.

A strip, which is both edible and dissolvable, is provided comprising a film and a dosage of at least 2% of the reference daily intake (RDI) of at least one dietary supplement for malnutrition or to prevent / treat alcohol induced hangovers. A method for treating malnutrition and / or preventing and treating alcohol-induced hangovers using a dissolvable orally administered strip.

The invention discloses a tacrolimus eye ointment for cornea transplantation and a preparation method thereof, belongs to the field of pharmaceutical preparation and particularly relates to a tacrolimus eye precursor vesicle capsule for cornea transplantation and a preparation method thereof. The precursor vesicle capsule comprises the following raw materials in percentage by weight: 0.04-0.8% of tacrolimus, 4.0-41.0% of surfactant, 1.6-8.0% of cholesterol, 4.0-41.0% of lecithin, 1.2-30.% of alcohol, and the balance of water or 0,1% of glycerol aqueous solution or phosphate buffer with PH of 7.4, wherein the surfactant is one of span, tween, polyoxyethylene ether castor oil and poloxamer, and the alcohol is one of ethanol, isopropanol, butanol and propanol. The tacrolimus precursor vesicle capsule has limited moisture, and the storage stability of the preparation can be improved; the product organically combines the advantages of the precursor vesicle capsule, the characteristics of an eye dosing system and the indication disease of the tacrolimus drugs, so as to achieve the advantages of improving the curative effect, reducing the side effect, and bringing convenience in administration; and the preparation technique is simple and convenient and is suitable for industrial production.