97results about How to "Easy to administer" patented technology

The invention provides a recombinant collagen ionic liquid composition as well as a preparation method and application thereof, and relates to the technical field of cosmetics. The recombinant collagen ionic liquid composition provided by the invention is prepared from the following components in parts by mass: 19.8 to 79.99 parts of lysine citric acid ionic liquid, 20 to 80 parts of glycerol and 0.01 to 0.2 part of recombinant collagen, the lysine citric acid ionic liquid is mainly composed of lysine and citric acid, and the molar ratio of the lysine to the citric acid is (4-1): (2-1). The recombinant collagen ionic liquid composition is good in solubility, high in transdermal efficiency, small in irritation, short in preparation period, simple in process and capable of being continuously produced.

The invention provides a meibomian gland dysfunction treatment composition based on chlorella, the composition comprises sodium hyaluronate gel and drug-loaded chlorella powder, and the drug-loaded chlorella powder comprises chlorella and loaded drug components. The invention also provides a preparation method of the meibomian gland dysfunction treatment composition based on chlorella, which comprises the following steps: (1) dispersing a chlorella suspension in a sodium hydroxyethyl cellulose solution, and adding the medicinal components in the stirring process; (2) carrying out ultrasonic treatment and freeze drying to obtain drug-loaded chlorella powder; and (3) resuspending the drug-loaded chlorella powder, and adding sodium hyaluronate to form the gelatinous composition. The invention also provides application of the composition in preparation of medicines for treating meibomian glands. The composition not only can deliver active ingredients of the medicine in a targeted manner, but also can supplement lipid components lacking in meibomian glands, so that meibomian gland dysfunction is effectively treated.

The invention discloses a medicine for treating autism, application of the medicine for treating autism in preparation of a medicine for improving social competence damage of autism animals or people, and application of the medicine for treating autism in preparation of a medicine for improving anxiety behaviors of autism animals or people. When the high-dose vitamin D is used for intervening autism mice, the method has the advantages of being economical, convenient to take and good in effect, animal experiment evidence is provided for supplementing large-dose VD to intervene autism spectrum disorders in the early stage of clinical experiments, and a new thought is provided for early prevention and treatment of neurodevelopment disorders of clinical children.

The invention discloses a lactoferrin and antibacterial peptide bifunctional hydrogel dressing as well as a preparation method and application thereof. The hydrogel dressing is prepared by mixing lactoferrin, antibacterial peptide NZ2114, a magnesium lithium silicate gel matrix and water. The hydrogel dressing provided by the invention has the following advantages: 1) the hydrogel dressing is simple to prepare, low in cost and suitable for batch production; 2) the gel is convenient to apply, has a moisturizing effect, is long in residence time, good in biocompatibility, small in irritation, safe and reliable, or is accurately injected to the wound, moisturizes, slowly releases and efficiently improves the compliance of the body, and 3) the gel is good in antibacterial and anti-inflammatory effects, good in biocompatibility, free of irritation and capable of promoting wound healing, and only needs to be smeared on the surface of the wound.

The invention belongs to the technical field of biological medicines, and particularly relates to application of divalent metal lactate in a product for promoting tissue regeneration, growth, healing and damage repair. Preferably, the divalent metal lactate comprises one or a combination of more of calcium lactate, magnesium lactate, zinc lactate and ferrous lactate. The invention provides a new treatment mode for tissue injury and repair, and prevention and treatment of tissue fibrosis and / or scar tissue generation, and has wide application prospects in the aspects of injury treatment and repair of tissues such as skin, connective tissues, tendons, fascia and the like.

The utility model relates to the technical field of urethral catheters, and discloses a urethral catheter which comprises a first inflation urethral catheter guide wire and a urethral catheter body, the first inflation urethral catheter guide wire is arranged on the urethral catheter body, a first inflation urethral catheter head is arranged at the top end of the urethral catheter body, and a second inflation urethral catheter head is arranged at the bottom end of the urethral catheter body. According to the utility model, through the arrangement of the catheter flushing cavity inlet and the catheter flushing cavity screw cap, when the bladder is continuously flushed, the catheter flushing cavity inlet is communicated with the first inflating catheter head through an infusion apparatus, and the first inflating catheter head is communicated with the first inflating catheter head through the first inflating catheter head fixer and the first inflating catheter head fixer, and the first inflating catheter head fixer and the first inflating catheter head fixer are fixedly connected with the catheter body through the soft silica gel fixer. Bladder flushing fluid is input into the first catheter flushing cavity, enters the catheter flushing cavity from the catheter flushing cavity inlet and directly reaches the bladder, flows into the catheter main drainage cavity after flushing, flows out of the catheter main drainage cavity outlet and enters a drainage bag, and therefore bladder flushing of a user is safer and more convenient.

The invention discloses a method for treating pulmonary arterial hypertension through miR-142-3p and application, and belongs to the field of biological medicines.The treatment method specifically comprises the following steps that firstly, lentivirus is prepared, and a pre-transfection experiment is conducted; iI, detecting the influence of the lentivirus on the proliferation efficiency and migration activity of the hPASMCs cells; iII, selecting and culturing multiple groups of male SD rats to prepare PH model rats; iV, carrying out a hemodynamic experiment on the PH model rat; v, performing histomorphological analysis on the PH model rats after the experiment; vI, collecting and recording hemodynamic experiment and histomorphological analysis results; the miR-142-3p has good treatment and prevention effects, can well reduce right ventricular pressure, has no obvious systemic toxic effect, can be administered in an injection or nasal drop mode according to different purposes, is harmless to a human body, is easy to synthesize and administrate, is simple and feasible, and has low production cost.

The present invention relates to the technical field of concentrated solution preparation, and in particular to a concentrated solution preparation process after the extraction of mogrosides, a concentrated solution, and an application. The concentrated solution preparation process after the extraction of mogrosides comprises the following steps: S1. The mogroside aqueous solution passes through an adsorption resin column, and the chromatographic solution discharged from the adsorption resin column is collected; S2. The chromatographic solution is concentrated by vacuum decompression to obtain a semi-finished concentrated solution with a specific gravity of 1.12-1.39; S3. The semi-finished concentrated solution is sterilized and cooled to obtain the concentrated solution. The eluate discharged from the mogroside adsorption resin column is used as a raw material, and one fruit is used for multiple purposes, which increases the added value of monk fruit, reduces the raw material purchase cost at the breeding end, and is beneficial to the investment in the breeding industry; the preparation process is simple, and the discharged concentrated steam has no impact on the environment, saving process equipment investment and production costs; the above-mentioned concentrated solution has an outstanding use effect in breeding, and when the addition amount is only 0.1%-0.5%, it has a good improvement on the breeding effect.

The invention belongs to the technical field of pharmaceutical preparations, and provides a skin external preparation for treating dysmenorrhea and a preparation method and application thereof. According to the invention, folium artemisiae argyi, rhizoma cyperi, fructus evodiae, cortex cinnamomi, radix angelicae sinensis, radix astragali, radix paeoniae alba and the like are used as raw materials, and a transdermal preparation which takes effect quickly, is low in dosage, is higher in safety and is convenient to use is obtained through prescription optimization, extraction process, effective part screening and preparation research of the raw materials. The traditional Chinese medicine composition can significantly treat or relieve dysmenorrhea symptoms, and provides an effective, stable, safe and reliable solution for treating dysmenorrhea and other symptoms. According to the invention, the optimal alcohol extraction of the whole prescription is determined through research, different extraction treatments are not required to be carried out on different medicines, and it is found that the stability, applicability and effectiveness of the medicine can be remarkably improved by modifying oral administration into an external preparation, the process is simple, the cost is reduced, and the preparation is suitable for industrial expanded production.

The invention belongs to the technical field of pharmaceutical preparations, and particularly relates to a preparation method and application of a nepafenac and quercetin sustained-release gel preparation, and the nepafenac and quercetin sustained-release gel preparation comprises the following components in parts by mass: 5-75 parts of nepafenac; 3 to 60 parts of quercetin; 100 to 500 parts of a biological carrier; 15 to 350 parts of a viscosity reducing agent; and 50 to 200 parts of a non-aqueous solvent. The composition can relieve pain and resist inflammation, can promote tissue repair and growth, can effectively realize a slow release effect, and is convenient and long-acting in administration. The invention also provides a preparation method and application thereof.

The invention discloses a series of polymers with acid-sensitive degradation and temperature-sensitive properties and a drug-loading composition thereof, the polymers have a structure represented by a formula (1), and have degradation and temperature-sensitive properties in a physiological environment, i.e., the polymers are in a solid state below a phase-transition temperature, are in a liquid state above the phase-transition temperature, are in a stable state in a low-temperature environment of a storage condition, and are in an acid-sensitive degradation and temperature-sensitive state. The polymer has a good fluidity state in a use environment, good drug release property and degradability are maintained, stability during storage and needle passing performance during injection are taken into consideration, and the invention also discloses a preparation method of the polymer and a pharmaceutical composition containing the polymer. # imgabs0 #

The present application relates to a kind of dolasetron mesylate suppositories, it is characterized in that, component includes: dolasetron mesylate, cyclodextrin or its derivative, shell matrix, hardness regulator, gel matrix, water;The gel matrix includes polyacrylic acid derivative grafted chitosan in it.The present application uses polyacrylic acid derivative grafted chitosan and cyclodextrin to prepare dolasetron mesylate liquid gel, significantly improve the stability and bioavailability of suppository;And can achieve the purpose of quick effect and slow release long-acting simultaneously.The suppository of the present application is very convenient for old people, children or patients who cannot be administered orally, and the treatment population of the product belongs to the patient who is inconvenient to swallow.

The present application relates to a kind of soluble microneedle patch of semaglutide peptide and its preparation method and purposes.The soluble microneedle patch of semaglutide peptide includes drug-loaded needle tip layer and back plate layer;Wherein, the drug-loaded needle tip layer includes semaglutide and needle tip layer matrix material;With the total weight of the drug-loaded needle tip layer 100% as 100%, the weight percentage of semaglutide is 85%~99%, and the weight percentage of the needle tip layer matrix material is 1%~15%.The needle type of the soluble microneedle patch of semaglutide is excellent, and the mechanical strength and skin puncture performance are superior, and the safety is high, and drug release and penetration rate are fast, and drug penetration rate is high, with excellent drug utilization and bioavailability;Its preparation method is simple, and controllability is good, and it is suitable for large-scale production.In addition, the soluble microneedle patch of semaglutide is convenient and fast, and patient compliance is high, with wide clinical application prospect.

The utility model provides a dosing device for water pollution control, which relates to the technical field of water pollution control and comprises a shell, a driving mechanism is fixedly mounted on the inner bottom wall of the shell, and two dosing mechanisms are arranged above the driving mechanism. According to the chemical dosing device for water pollution treatment, a feeding motor drives a feeding plate to move up and down by utilizing a lifting block, so that chemical powder in a chemical dosing box can be pushed out through the up-and-down movement of the feeding plate, the effect of automatic chemical dosing is achieved, the chemical dosing amount of the device can be controlled according to the chemical loading capacity of the chemical dosing box, and the chemical dosing efficiency is improved. The device has the advantage of being simpler to use, the eccentric wheel is driven by the motor to rotate, the two medicine feeding boxes can be sequentially pushed out from the interior of the shell through rotation of the eccentric wheel, and therefore the effect of convenient medicine feeding is achieved, the medicine feeding boxes after feeding can be reset into the shell again by arranging the reset springs, and the use is more convenient. And the medicine powder can be conveniently refilled for next dosing.

The application provides a preparation of gramicidin and an antibacterial hydrogel preparation of the gramicidin, and discloses medical uses of the gramicidin, and provides a recombinant gramicidin, heterologous expression of the gramicidin is realized by constructing a Pichia pastoris recombinant strain, and the antibacterial activity of the gramicidin is retained, and the method has the advantages of simplicity and rapidness. Meanwhile, the hydrogel preparation of the gramicidin provided by the application shows good potential for treating wound infection of a diabetic mouse, and has the performance of rapid adhesion and hemostasis, lays a foundation for development of a new antibacterial drug, and provides a new direction for treatment of chronic inflammatory wounds and open bleeding.

The utility model relates to the technical field of nasopharyngeal airway, and discloses a jet type oxygen supply humidifying nasopharyngeal airway, which comprises a main airway, a breathing machine joint limiting baffle is sleeved on the main airway, and an oxygen supply structure is mounted on the main airway. According to the utility model, oxygen enters from the oxygen supply inlet tube, and liquid medicine or normal saline flows into the branch tube through the infusion needle on the rubber cap and then enters the oxygen supply inlet tube, so that the oxygen is humidified, the use comfort of a patient is improved, and meanwhile, the asthma patient is conveniently dosed; oxygen and liquid medicine or normal saline enter the oxygen supply extension tube after being filtered at the same time, so that impurities are prevented from being mixed in the oxygen and the liquid medicine or normal saline, and the clean quality of the oxygen and the liquid medicine or normal saline is guaranteed; oxygen and liquid medicine or normal saline are input to the nasopharynx part of a patient from one end of the conical tube, and the oxygen supply extension tube is matched with the conical tube, so that a channel for conveying the oxygen tends to be thin gradually, the pressure intensity is increased, the spraying distance of the oxygen is enlarged, and the oxygen supply quality is improved.

The utility model relates to the technical field of drug delivery devices, and provides a treatment drug delivery device, which is convenient for expanding the oral cavity of a child patient, observing the wound and delivering drugs, and comprises a drug box, an air bag, a one-way assembly, a conical tube, a fixed frame, an opposite assembly, a bent tube, a rotation driving assembly and a handheld handle, an air hole is formed in the air bag, the one-way assembly is arranged on the connecting channel and used for preventing medicine powder from entering the air bag, the conical pipe communicates with the medicine box, the fixing frame fixedly sleeves the conical pipe and is fixedly connected with a sliding barrel through a fixing plate, the sliding barrel is slidably sleeved with two sliding rods, and the sliding rods are fixedly connected with a nozzle expanding plate; the opposite assembly is arranged on the fixing frame and used for driving the two nozzle expanding plates to move oppositely, the conical pipe is rotationally sleeved with the bent pipe, the rotation driving assembly is arranged on the conical pipe and used for driving the bent pipe to rotate, and the handheld handle is fixedly connected to the medicine box.

The utility model discloses a gastrostomy tube which comprises a tube body, and an anti-seepage base is arranged on the surface of the tube body in a sleeved mode. The pipeline main body comprises an outer pipe, and an inner pipe is mounted in the outer pipe; the anti-seepage base comprises a flexible base body arranged on the surface of the outer pipe in a sleeving mode, a plurality of waterproof breathable films are installed on the flexible base body in a surrounding mode, waterproof dressing is attached to the front side and the rear side of the right side of the flexible base body, and an adhesion layer is arranged on the left side of the waterproof dressing. The gastrostomy tube has the advantage of being good in protection performance, and the problems that in the using process of an existing gastrostomy tube, the protection performance on the connecting position of a fistula and an abdominal incision of a patient is low, liquid leakage of the connecting position is likely to happen, and the infection risk of the patient is increased are solved.

The invention provides an ophthalmic preparation of sivimeline and pharmaceutically acceptable salt or stereoisomer thereof, and a preparation method and application thereof. The ophthalmic preparation only contains sivimeline, chloride ions and sodium ions, is free of preservatives, complexing agents, excipients for increasing viscosity and other auxiliary materials, is purely natural, green and additive-free eye drops, and has a good curative effect on prevention and treatment of eye diseases such as presbyopia, ocular hypertension and xerophthalmia.

The utility model relates to the technical field of ear-nose-throat department nursing, and discloses an intelligent nasal cavity irrigation and administration integrated device which comprises a fixator, an irrigation pipe is slidably connected to the interior of the fixator, and a fixing ring, a camera, a handheld pipe and a water guide pipe are connected to one end of the irrigation pipe in an inserted mode. By means of the fixing ring and the flushing pipe, the stability when the flushing pipe is pushed can be guaranteed, the flushing pipe cannot touch the side wall of the nasal cavity, by means of the camera, the focus position can be visualized, the focus condition can be fed back in real time, cleaning and medicine feeding on the focus position are greatly facilitated, a certain impulsive force can be guaranteed during flushing through the water pump A, and the flushing effect is good. The device is simple in structure and convenient to use, secretions and scabs are easily and thoroughly removed, waste water is prevented from being poured at will through the water guide pipe and the waste water bag, the working environment is guaranteed, secondary pollution can be avoided, and the device can be in butt joint with collection through the Bluetooth module so that images can be checked in real time. Meanwhile, the medicine can be efficiently and accurately sprayed to the paranasal sinus administration position.

The invention relates to the field of traditional Chinese medicines, in particular to a traditional Chinese medicine composition for treating xerostomia, which comprises the following raw material medicines: adenophora tetraphylla, radix pseudostellariae, rehmannia, astragalus membranaceus, dendrobe, radix ophiopogonis, medlar, stiff silkworm (stir-fried with bran), selfheal, Huai wheat, Chinese date and liquorice. The traditional Chinese medicine composition has the effects of nourishing yin and moistening dryness, nourishing yin and clearing heat, replenishing qi and strengthening the spleen, and moistening the lung and promoting salivation, can promote salivary secretion of patients and relieve the dry mouth symptom of the patients, and is mainly used for treating the dry mouth symptom caused by various factors. The preparation process is simple and convenient, the toxic and side effects are small, the administration is convenient, the effects of regulating and balancing the body immunity, relieving the dry mouth symptom, relieving the oral gland injury and the like are achieved in the treatment of the dry mouth symptom, and the life quality of a patient with the dry mouth symptom can be obviously improved.

The present invention relates to a bispecific antibody comprising a first antigen binding site capable of binding to Factor VII(a) and a second antigen binding site capable of binding to TLT-1, a pharmaceutical preparation comprising such a bispecific antibody and uses thereof.

The invention discloses histamine oxidase protein and application thereof. The amino acid sequence of the histamine oxidase protein is shown as SEQ ID NO. 1. The histamine oxidase protein PAO can be used for preparing the medicine for treating allergic rhinitis; according to the invention, histamine is locally degraded through nasal mucosa, so that local histamine aggregation of nasal mucosa is reduced, symptoms such as sneezing and the like of allergic rhinitis are improved, and nasal 2-type inflammatory response is relieved, so that a treatment effect on allergic rhinitis is achieved, and a brand-new view angle and target spot are provided for treatment of allergic rhinitis.

The invention provides a drug intervention comprehensive treatment device which comprises a bottom plate, a fixing plate and a fixing frame and further comprises a first driving piece, a second driving piece, a first connecting piece and a second connecting piece. The adjusting assembly is arranged on the outer side of the first driving part and comprises a supporting frame. According to the drug intervention comprehensive treatment device, through cooperative use of the adjusting assembly, the supporting piece, the lifting assembly and the adjusting piece, the angles of the fixing frame and the intervention assembly can be conveniently adjusted, the height of the fixing plate can be conveniently adjusted, then the device can be conveniently used by different people, the practicability of the device is improved, and the device is worthy of popularization and application. By arranging the drug administration assembly, drug administration can be conveniently carried out on the intervention assembly, effusion in the body of the patient can be conveniently stored, and by arranging the intervention assembly, intervention can be conveniently carried out in the body of the patient, and meanwhile body fluid in the body of the patient can be conveniently extracted.

The invention discloses a composite Chinese medicine preparation for chronic osteomyelitis, and its raw materials include: Wuwei Xiaoduyin extractant, sodium alginate, p-toluenesulfonic acid, cyclodextrin, 1-ethyl-(3-dimethylaminopropyl) carbodiimide hydrochloride, emulsifier, chitosan, sodium chloride, calcium chloride; the mass ratio of Wuwei Xiaoduyin extractant, sodium alginate, p-toluenesulfonic acid, cyclodextrin, 1-ethyl-(3-dimethylaminopropyl) carbodiimide hydrochloride, emulsifier, chitosan, sodium chloride, and calcium chloride is 10-20: 1-3: 0.1-0.2: 2-8: 0.01-0.1: 0.1-0.2: 1-2: 0.1-0.2: 0.1-0.2. The invention also discloses a preparation method of the composite Chinese medicine preparation for chronic osteomyelitis. The present invention can not only solve the disadvantage that antibiotics are difficult to penetrate into the bone to form an effective antibacterial concentration, but also the method is easy to implement, simple to prepare, and convenient to use.

Disclosed is a pharmaceutical composition which can provide a tablet capable of maintaining the shape of the tablet for a long period of time after administration while suppressing the content of polyvinyl alcohol. The pharmaceutical composition contains a polyvinyl alcohol-based resin (A), a polyphenol compound (B), and amorphous silica (C). The content of the amorphous silica (C) is 0.1-20 parts by mass with respect to 100 parts by mass of the polyvinyl alcohol-based resin. Further disclosed is a tablet which comprises a pharmaceutical composition as a matrix composition (I) and an active pharmaceutical ingredient (II) dispersed in the matrix composition (I), the active pharmaceutical ingredient (II) being contained in an amount of 30-90 mass% inclusive.

This invention provides a circRNA-LNP delivery system for in vivo induction of iTregs, its preparation method, and its applications. The delivery system includes circRNA encoding human TGF-β1, lipid nanoparticles encapsulating the circRNA, and IL-2 modified on the surface of the lipid nanoparticles. This invention synergistically combines retinoic acid as a functional immunomodulatory small molecule with five lipids, significantly improving the uptake efficiency of Treg precursor cells and the induction efficiency of iTregs. It can also efficiently increase the proportion of functional iTregs in diseased tissues in vivo, demonstrating excellent therapeutic effects on immunomodulatory diseases such as ulcerative colitis, and providing a novel technical pathway for the radical treatment of autoimmune and inflammatory diseases.

The invention relates to composite self-gelling powder as well as a preparation method and application thereof, and belongs to the technical field of preparation of composite biological materials. The preparation method of the composite self-gel powder comprises the following steps: mixing 1, 3, 5-tri (4-aminophenyl) benzene, 2, 5-dimethoxy terephthalaldehyde, acetonitrile, acetic acid and iron phthalocyanine, reacting, centrifuging, collecting precipitate, and drying to obtain COF-Fe; the COF-Fe is calcined, and CCOF-Fe is obtained; the preparation method comprises the following steps: mixing CCOF-Fe, polyacrylic acid, polyacrylamide and water, freeze-drying, and grinding to obtain composite self-gel powder; the composite self-gel powder can reduce wound inflammatory response, promote healing of infectious wounds and growth of fibroblasts and realize rapid repair of the infectious wounds, and has the advantages of convenience in administration, high adhesion, high stability and good antibacterial performance.

The utility model discloses an ear canal dosing device for ear-nose-throat department nursing, which relates to the technical field of ear-nose-throat department and comprises a squeezing bottle, a connecting tube is fixed at the upper end of the squeezing bottle, a bottom plate is fixed at the bottom of the connecting tube, and a side plate is fixed at the upper end of the bottom plate. A lower one-way valve and an upper one-way valve are arranged on the surface of the bottom plate and the surface of the side plate respectively, an air bag is connected between the lower one-way valve and the upper one-way valve, a push rod is fixed to the other end, opposite to the air bag, of the upper one-way valve, a limiting plate is fixed to the other end, opposite to the upper one-way valve, of the push rod, and a spring is fixed to the surface of the limiting plate. Through the air bag connected with the upper one-way valve and the lower one-way valve, the amount of extruded liquid medicine is fixed, so that the liquid medicine can be applied to the interior of the auditory meatus without causing discomfort caused by water blockage of the auditory meatus due to excessive liquid medicine, and medical staff can conveniently apply the medicine to the auditory meatus.

The utility model relates to the field of medical instruments, in particular to a balloon catheter for trifurcate microballoon compression surgery, which comprises a catheter body and a balloon arranged outside the head end of the catheter body, two conveying chambers are formed in the catheter body through a separator, and the conveying chambers are respectively and correspondingly communicated with a bifurcate joint at the tail end of the catheter body. The conveying chamber comprises a radiography chamber and a liquid suction chamber, and the radiography chamber and the liquid suction chamber are not communicated with each other. A liquid suction hole is formed in the head end of the liquid suction cavity, a plurality of supporting protrusions are arranged at the position, away from the balloon section, of the inner side of the tail end of the liquid suction cavity, and the four sets of supporting protrusions are symmetrically arranged in the radial direction of the inner side of the liquid suction cavity and distributed at equal intervals in the axial direction of the liquid suction cavity. By means of the double-cavity balloon catheter, the synchronous surgery process of balloon filling and cerebrospinal fluid extraction in radiography is achieved, and the technical problems of pollution and mutual influence caused by re-puncture and implementation of the two processes in the same channel are solved. The structure is reasonable in design, convenient to operate and high in practicability.