21results about How to "Easy to administer" patented technology

The present invention relates to the technical field of concentrated solution preparation, and in particular to a concentrated solution preparation process after the extraction of mogrosides, a concentrated solution, and an application. The concentrated solution preparation process after the extraction of mogrosides comprises the following steps: S1. The mogroside aqueous solution passes through an adsorption resin column, and the chromatographic solution discharged from the adsorption resin column is collected; S2. The chromatographic solution is concentrated by vacuum decompression to obtain a semi-finished concentrated solution with a specific gravity of 1.12-1.39; S3. The semi-finished concentrated solution is sterilized and cooled to obtain the concentrated solution. The eluate discharged from the mogroside adsorption resin column is used as a raw material, and one fruit is used for multiple purposes, which increases the added value of monk fruit, reduces the raw material purchase cost at the breeding end, and is beneficial to the investment in the breeding industry; the preparation process is simple, and the discharged concentrated steam has no impact on the environment, saving process equipment investment and production costs; the above-mentioned concentrated solution has an outstanding use effect in breeding, and when the addition amount is only 0.1%-0.5%, it has a good improvement on the breeding effect.

The present application relates to a kind of dolasetron mesylate suppositories, it is characterized in that, component includes: dolasetron mesylate, cyclodextrin or its derivative, shell matrix, hardness regulator, gel matrix, water;The gel matrix includes polyacrylic acid derivative grafted chitosan in it.The present application uses polyacrylic acid derivative grafted chitosan and cyclodextrin to prepare dolasetron mesylate liquid gel, significantly improve the stability and bioavailability of suppository;And can achieve the purpose of quick effect and slow release long-acting simultaneously.The suppository of the present application is very convenient for old people, children or patients who cannot be administered orally, and the treatment population of the product belongs to the patient who is inconvenient to swallow.

The present application relates to a kind of soluble microneedle patch of semaglutide peptide and its preparation method and purposes.The soluble microneedle patch of semaglutide peptide includes drug-loaded needle tip layer and back plate layer;Wherein, the drug-loaded needle tip layer includes semaglutide and needle tip layer matrix material;With the total weight of the drug-loaded needle tip layer 100% as 100%, the weight percentage of semaglutide is 85%~99%, and the weight percentage of the needle tip layer matrix material is 1%~15%.The needle type of the soluble microneedle patch of semaglutide is excellent, and the mechanical strength and skin puncture performance are superior, and the safety is high, and drug release and penetration rate are fast, and drug penetration rate is high, with excellent drug utilization and bioavailability;Its preparation method is simple, and controllability is good, and it is suitable for large-scale production.In addition, the soluble microneedle patch of semaglutide is convenient and fast, and patient compliance is high, with wide clinical application prospect.

The utility model provides a dosing device for water pollution control, which relates to the technical field of water pollution control and comprises a shell, a driving mechanism is fixedly mounted on the inner bottom wall of the shell, and two dosing mechanisms are arranged above the driving mechanism. According to the chemical dosing device for water pollution treatment, a feeding motor drives a feeding plate to move up and down by utilizing a lifting block, so that chemical powder in a chemical dosing box can be pushed out through the up-and-down movement of the feeding plate, the effect of automatic chemical dosing is achieved, the chemical dosing amount of the device can be controlled according to the chemical loading capacity of the chemical dosing box, and the chemical dosing efficiency is improved. The device has the advantage of being simpler to use, the eccentric wheel is driven by the motor to rotate, the two medicine feeding boxes can be sequentially pushed out from the interior of the shell through rotation of the eccentric wheel, and therefore the effect of convenient medicine feeding is achieved, the medicine feeding boxes after feeding can be reset into the shell again by arranging the reset springs, and the use is more convenient. And the medicine powder can be conveniently refilled for next dosing.

The application provides a preparation of gramicidin and an antibacterial hydrogel preparation of the gramicidin, and discloses medical uses of the gramicidin, and provides a recombinant gramicidin, heterologous expression of the gramicidin is realized by constructing a Pichia pastoris recombinant strain, and the antibacterial activity of the gramicidin is retained, and the method has the advantages of simplicity and rapidness. Meanwhile, the hydrogel preparation of the gramicidin provided by the application shows good potential for treating wound infection of a diabetic mouse, and has the performance of rapid adhesion and hemostasis, lays a foundation for development of a new antibacterial drug, and provides a new direction for treatment of chronic inflammatory wounds and open bleeding.

The utility model discloses a gastrostomy tube which comprises a tube body, and an anti-seepage base is arranged on the surface of the tube body in a sleeved mode. The pipeline main body comprises an outer pipe, and an inner pipe is mounted in the outer pipe; the anti-seepage base comprises a flexible base body arranged on the surface of the outer pipe in a sleeving mode, a plurality of waterproof breathable films are installed on the flexible base body in a surrounding mode, waterproof dressing is attached to the front side and the rear side of the right side of the flexible base body, and an adhesion layer is arranged on the left side of the waterproof dressing. The gastrostomy tube has the advantage of being good in protection performance, and the problems that in the using process of an existing gastrostomy tube, the protection performance on the connecting position of a fistula and an abdominal incision of a patient is low, liquid leakage of the connecting position is likely to happen, and the infection risk of the patient is increased are solved.

The invention discloses histamine oxidase protein and application thereof. The amino acid sequence of the histamine oxidase protein is shown as SEQ ID NO. 1. The histamine oxidase protein PAO can be used for preparing the medicine for treating allergic rhinitis; according to the invention, histamine is locally degraded through nasal mucosa, so that local histamine aggregation of nasal mucosa is reduced, symptoms such as sneezing and the like of allergic rhinitis are improved, and nasal 2-type inflammatory response is relieved, so that a treatment effect on allergic rhinitis is achieved, and a brand-new view angle and target spot are provided for treatment of allergic rhinitis.

The invention provides a drug intervention comprehensive treatment device which comprises a bottom plate, a fixing plate and a fixing frame and further comprises a first driving piece, a second driving piece, a first connecting piece and a second connecting piece. The adjusting assembly is arranged on the outer side of the first driving part and comprises a supporting frame. According to the drug intervention comprehensive treatment device, through cooperative use of the adjusting assembly, the supporting piece, the lifting assembly and the adjusting piece, the angles of the fixing frame and the intervention assembly can be conveniently adjusted, the height of the fixing plate can be conveniently adjusted, then the device can be conveniently used by different people, the practicability of the device is improved, and the device is worthy of popularization and application. By arranging the drug administration assembly, drug administration can be conveniently carried out on the intervention assembly, effusion in the body of the patient can be conveniently stored, and by arranging the intervention assembly, intervention can be conveniently carried out in the body of the patient, and meanwhile body fluid in the body of the patient can be conveniently extracted.

The invention discloses a composite Chinese medicine preparation for chronic osteomyelitis, and its raw materials include: Wuwei Xiaoduyin extractant, sodium alginate, p-toluenesulfonic acid, cyclodextrin, 1-ethyl-(3-dimethylaminopropyl) carbodiimide hydrochloride, emulsifier, chitosan, sodium chloride, calcium chloride; the mass ratio of Wuwei Xiaoduyin extractant, sodium alginate, p-toluenesulfonic acid, cyclodextrin, 1-ethyl-(3-dimethylaminopropyl) carbodiimide hydrochloride, emulsifier, chitosan, sodium chloride, and calcium chloride is 10-20: 1-3: 0.1-0.2: 2-8: 0.01-0.1: 0.1-0.2: 1-2: 0.1-0.2: 0.1-0.2. The invention also discloses a preparation method of the composite Chinese medicine preparation for chronic osteomyelitis. The present invention can not only solve the disadvantage that antibiotics are difficult to penetrate into the bone to form an effective antibacterial concentration, but also the method is easy to implement, simple to prepare, and convenient to use.

Disclosed is a pharmaceutical composition which can provide a tablet capable of maintaining the shape of the tablet for a long period of time after administration while suppressing the content of polyvinyl alcohol. The pharmaceutical composition contains a polyvinyl alcohol-based resin (A), a polyphenol compound (B), and amorphous silica (C). The content of the amorphous silica (C) is 0.1-20 parts by mass with respect to 100 parts by mass of the polyvinyl alcohol-based resin. Further disclosed is a tablet which comprises a pharmaceutical composition as a matrix composition (I) and an active pharmaceutical ingredient (II) dispersed in the matrix composition (I), the active pharmaceutical ingredient (II) being contained in an amount of 30-90 mass% inclusive.

This invention provides a circRNA-LNP delivery system for in vivo induction of iTregs, its preparation method, and its applications. The delivery system includes circRNA encoding human TGF-β1, lipid nanoparticles encapsulating the circRNA, and IL-2 modified on the surface of the lipid nanoparticles. This invention synergistically combines retinoic acid as a functional immunomodulatory small molecule with five lipids, significantly improving the uptake efficiency of Treg precursor cells and the induction efficiency of iTregs. It can also efficiently increase the proportion of functional iTregs in diseased tissues in vivo, demonstrating excellent therapeutic effects on immunomodulatory diseases such as ulcerative colitis, and providing a novel technical pathway for the radical treatment of autoimmune and inflammatory diseases.

The invention relates to composite self-gelling powder as well as a preparation method and application thereof, and belongs to the technical field of preparation of composite biological materials. The preparation method of the composite self-gel powder comprises the following steps: mixing 1, 3, 5-tri (4-aminophenyl) benzene, 2, 5-dimethoxy terephthalaldehyde, acetonitrile, acetic acid and iron phthalocyanine, reacting, centrifuging, collecting precipitate, and drying to obtain COF-Fe; the COF-Fe is calcined, and CCOF-Fe is obtained; the preparation method comprises the following steps: mixing CCOF-Fe, polyacrylic acid, polyacrylamide and water, freeze-drying, and grinding to obtain composite self-gel powder; the composite self-gel powder can reduce wound inflammatory response, promote healing of infectious wounds and growth of fibroblasts and realize rapid repair of the infectious wounds, and has the advantages of convenience in administration, high adhesion, high stability and good antibacterial performance.

The present application belongs to the technical field of pharmaceutical chemistry, and particularly relates to a crystal form of lamivudine salt of m-hydroxybenzoic acid and a preparation method thereof. The crystal form has an X-ray diffraction spectrum expressed by 2theta using Cu-Kalpha radiation, and has characteristic peaks at least at 9.26+ / -0.2, 12.56+ / -0.2, 13.05+ / -0.2, 14.59+ / -0.2, 17.45+ / -0.2, 20.30+ / -0.2, 21.76+ / -0.2, 23.37+ / -0.2, 25.05+ / -0.2 and 27.58+ / -0.2; the crystal form is composed of a molecule of lamivudine, a molecule of m-hydroxybenzoic acid and a molecule of n-butanol as a basic unit; meanwhile, the crystal form has good solubility, provides ideal raw material for preparing parenteral dosage forms which are convenient to administer and have rapid effect, and thus better meets the requirements of clinical application.

The invention discloses an application of sotrasturin, or a stereoisomer of sotrasturin, or a raceme of sotrasturin, or a pharmaceutically acceptable salt of sotrasturin, or a solvate of sotrasturin in the development of a medicine for preventing or treating TRPM8 related diseases. Particularly, sotratolin is disclosed as a TRPM8 agonist, and a good prevention or treatment effect can be obtained when sotratolin is used for preventing or treating xerophthalmia; in a mouse xerophthalmia model induced by a benzalkonium chloride solution, sotratoline has a remarkable improvement effect.

The invention provides a child oral administration device convenient to operate, and belongs to the technical field of administration devices. The child oral cavity drug delivery device convenient to operate comprises a first fixing cylinder and a drug delivery mechanism, a second fixing cylinder is arranged on the right side of the first fixing cylinder, a cleaning mechanism is installed in an inner cavity of the first fixing cylinder, a connecting mechanism is arranged on the right side of the first fixing cylinder, and a supporting mechanism is arranged on the surface of the second fixing cylinder; the administration cylinder is installed in an inner cavity of the second fixing cylinder, the administration rod is inserted into an inner cavity of the administration cylinder, the administration pipe communicates with the right side of the administration cylinder, and the medicine spraying head is installed on the right side of the administration pipe. The oral cavity of the child patient can be cleaned through the cleaning mechanism in the inner cavity of the first fixing cylinder before administration, and then the situation that saliva or food residues secreted in the oral cavity of the child patient affect normal administration is avoided.

The invention discloses a traditional Chinese medicine oral prescription for preventing and treating influenza A and improving digestive tract diseases, and belongs to the technical field of traditional Chinese medicines. The prescription is prepared from kudzuvine root, radix bupleuri, moutan bark, peach kernel, scutellaria baicalensis, raw rhubarb, pinellia ternate, fructus forsythiae, mirabilite, mangnolia officinalis, immature bitter orange, poria cocos, bighead atractylodes rhizome, rhizoma alismatis, white paeony root, Chinese date and ginger which are strictly matched according to a specific weight ratio and are prepared by a specific water decoction process. The traditional Chinese medicine oral prescription can effectively prevent and treat influenza A through the synergistic effect of the components, has a remarkable improvement effect on most of digestive tract diseases, is simple in preparation process, convenient to take and high in safety, avoids the problems of poor curative effect, obvious side effect or narrow application range and the like of related medicines in the prior art, and has a wide application prospect. And a new effective choice is provided for prevention and treatment of influenza A and improvement of digestive tract diseases.

The application discloses a small-molecule inhibitor targeting NID1 and application, and relates to the technical field of biological medicines.The application selects W-5 hydrochloride as a small molecule for specifically inhibiting the function and activity of NID1 by molecular docking prediction and function verification from existing small-molecule drugs, and finds and verifies for the first time that W-5 can directly combine and inhibit NID1 protein.Starting from the core pathological link of "NID1-CSCs-resistance / metastasis", it is verified through experiments that W-5 hydrochloride can effectively combine with NID1, and can inhibit lung adenocarcinoma cell stemness, invasion and drug resistance by inhibiting the function of NID1 in lung adenocarcinoma.The application not only provides a clear orientation and a solid foundation for chemical optimization, structure modification, dosage form development and pharmacokinetics / toxicology (ADMET) research of a clear mechanism of directly targeting NID1, but also discovers new medicinal value of W-5 hydrochloride.

The present application relates to an anesthesia device. The anesthesia device of the present application includes: a medicine feeding component, which is used to feed anesthetics to a living being; a dosing unit, the dosing unit includes an air inlet and an air outlet, the air outlet of the dosing unit is connected to the medicine feeding component, and the dosing unit is used to provide a preset dose of anesthetics to anesthetize the living being; and an oxygen supply unit, the oxygen supply unit includes a first supply port, the first supply port is connected to the air inlet of the dosing unit, and is used to provide oxygen, and the anesthetics produced by the dosing unit is delivered to the medicine feeding component to be fed to the living being, and the oxygen supply unit is also used to dilute the anesthetic. The anesthesia device can control the dosage of the medicine to the living being, and the dosing is convenient and will not cause harm to the living being.

The invention discloses an application of an RAR alpha specific antagonist in prevention and treatment of porcine reproductive and respiratory syndrome. According to the application, the fact that the RAR alpha specific antagonist ER 50891 has the anti-PRRSV effect is found for the first time, it is shown that the ER 50891 can remarkably inhibit replication and proliferation of the PRRSV, inhibit PRRSV N protein expression and reduce the PRRSV titer and has the remarkable antiviral effect, and the effect of the ER 50891 is dose-dependent. Meanwhile, the ER 50891 has a broad-spectrum antiviral effect on the PRRSV, and still has a relatively good antiviral effect on different strains and the high-pathogenicity PRRSV (HP-PRRSV). The invention discloses the new application of the ER 50891 in the anti-PRRSV aspect for the first time, a new candidate compound is provided for research and development of anti-PRRSV drugs, and a new strategy and means are also provided for clinical prevention and treatment of porcine reproductive and respiratory syndrome.

The invention discloses an oral hepatitis B vaccine and a preparation method thereof. The preparation method comprises the following steps: preparing a milk exosome; construction and purification of hepatitis B surface antigen; and encapsulating the purified hepatitis B surface antigen into the milk exosome by adopting a membrane fusion method to obtain the oral hepatitis B vaccine. In the preparation method of the oral hepatitis B vaccine provided by the invention, the exosome is extracted and separated from fresh milk through a mechanical separation method and sucrose density gradient centrifugation and is used as an oral drug delivery carrier; secondly, inserting the hepatitis B virus surface antigen gene into engineered yeast, and expressing hepatitis B virus surface antigen protein; subsequently, mixing the purified hepatitis B surface antigen with cationic liposome, encapsulating the hepatitis B surface antigen into exosome by using a membrane fusion method, and carrying out characterization and activity test to obtain the oral hepatitis B vaccine. The oral hepatitis B vaccine prepared by the preparation method of the oral hepatitis B vaccine provided by the invention can tolerate the gastrointestinal tract environment in the body of an experimental mouse, can penetrate through the intestinal epithelial barrier, and finally stimulates the body to generate a hepatitis B antibody.

The utility model discloses an arm support frame capable of adjusting an inclination angle during an operation, and particularly relates to the technical field of medical instruments, the arm support frame comprises a first support plate and a second support plate which are used for supporting an arm of a patient, and one end of the first support plate is connected with one end of the second support plate through an inclination adjusting mechanism; the bottom of the first supporting plate is rotationally connected with a base through a rotating shaft, the base is connected with a sickbed through a buckle, and a clamping mechanism is arranged between the bottom of the first supporting plate and the base. By arranging the inclination adjusting mechanism, the included angle between the first supporting plate and the second supporting plate is changed, so that the lifting arm of a patient is supported, medical staff can conveniently observe the venipuncture part, intraoperative dosing can be carried out without connecting an extension tube, dosing delay is avoided, and dosing is convenient; the bed is fixed beside a bed, an additional supporting frame is not needed, the operation of a doctor is not affected, meanwhile, the inclined second supporting plate also guarantees the normal physiological curvature of the arm of the patient, and the comfort level of the patient is guaranteed.