216 results about "Grafted chitosan" patented technology

The invention discloses a biomedical material and a product thereof. The biomedical material has main characteristic that a compound having a catechol group structure is grafted on chitosan to form a chitosan biomedical material having the catechol group structure; or the grafted chitosan is cross-linked to prepare a novel macromolecular biomedical material. The catechol has cell adhesion, so that tissue adhesiveness of the chitosan can be changed, and blood cells can be adsorbed on the material surface to achieve better bleeding-steeping effect. By virtue of the mediation, performance of the chitosan is improved, and tissue affinity is improved. The material is prepared into a novel bleeding-stopping sponge by freeze-drying, and prepared into novel dressing by spinning or prepared into powder dressing by reverse flocculating.

The invention relates to a preparation method of a polyether-grafted chitosan derivative crude oil desalting demulsifier. The preparation method comprises the following specific steps: firstly, performing formylation modification on polyethylene glycol monoethylether; secondly, preparing glycidyl dimethyl alkyl ammonium chloride; thirdly, preparing quaternarization carboxyalkyl chitosan; fourthly, enabling formylation modified polyethylene glycol monoethylether to react with carboxy alkyl chitosan to obtain the polyether-grafted chitosan derivative crude oil desalting demulsifier. The polyether-grafted chitosan derivative crude oil desalting demulsifier disclosed by the invention is prepared by taking chitosannatural polymeric compounds as raw materials, and has the advantages of wide sources, naturalness, no toxicity, sustainability, good biocompatibility of a product, degradability and the like. The prepared demulsifier is good in demulsifying and dehydrating effect; meanwhile, a demulsifying molecule contains a large amount of carboxyalkyl groups and quaternary ammonium salt groups which have strong combining capacity to metal cation, ions with negative electricity such as naphthenic acid radicals as well as particles of which the surfaces are electronegative, so the polyether-grafted chitosan derivative crude oil desalting demulsifier has capacity of removing oil-soluble salts while demulsifying.

The invention discloses a method for preparing a contamination-resistant composite reverse osmosis membrane. The method comprises the steps of (a) preparing a polysulfone support membrane; (b) preparing an aromatic polyamide reverse osmosis composite membrane by using the polysulfone support membrane obtained in Step (a); and (c) grafting chitosan on the surface of the aromatic polyamide reverse osmosis composite membrane obtained in Step (b). According to the method for preparing a contamination-resistant composite reverse osmosis membrane, chitosan is grafted on the surface of the polyamide reverse osmosis composite membrane through a chemical treatment method, so that hydrophilicity of the surface of the membrane as well as the water flux of the membrane is improved; meanwhile, contaminations such as hydrophobic organic matters and transition metal ions can be prevented from being absorbed on the surface of the membrane, thereby greatly improving the anti-pollution capability of the membrane; in addition, chitosan has broad-spectrum antibacterial property, so that the resistance of the membrane against microbial contamination is improved.

The invention discloses a chitosan-grafted beta-cyclodextrin bonded silica gel absorbent as well as a preparation method and application of the chitosan-grafted beta-cyclodextrin bonded silica gel absorbent, and belongs to the technical field of the absorbent material preparation. The preparation method of the chitosan-grafted beta-cyclodextrin bonded silica gel absorbent comprises the steps of (1) activating silica gel, (2) bonding the silica gel with gamma-aminopropyl, (3) carrying out silica gel formyl group modification reaction, and (4) bonding chitosan with glutaraldehyde and grafting beta-cyclodextrin with the chitosan. According to the chitosan-grafted beta-cyclodextrin bonded silica gel absorbent provided by the invention, the activated silica gel surface is chemically modified by gamma aminopropyl triethoxy silane, and then, cyclodextrin-grafted chitosan is taken as a functional monomer to compound a solid-phase extraction material. By combining cyclodextrin recognition performance and a chitosan absorbing function, the chitosan-grafted beta-cyclodextrin bonded silica gel absorbent has the advantages of firmness in bonding, stable property, favorable reproducibility and selection, and large enrichment multiple, and the chitosan-grafted beta-cyclodextrin bonded silica gel absorbent can be used in a wide pH scope. The absorbent can be used in the enrichment pretreatment of trace Cu (I) and Cd (II) in an environmental water sample.

The invention discloses a hyperbranched polyamide-grafted chitosan adsorbent and its preparation method and use and belongs to the field of adsorption material preparation. The preparation method comprises 1, amino-terminated hyperbranched polymer synthesis and 2, amino-terminated hyperbranched polyamide-modified chitosan synthesis. Under cross-linking action of glutaraldehyde as a cross-linking agent, amino-terminated hyperbranched polyamide is carried by chitosan as a carrier so that the solid phase extraction material is obtained. Through introduction of a lot of nitrogen-containing groups to chitosan, active group content is improved, adsorbent adsorption performances are improved, bonding strength is improved, properties are stable, reappearance is good and enrichment multiple is large. The hyperbranched polyamide-grafted chitosan adsorbent can be used for adsorption of heavy metal copper ions and dye in an environment sample.

The invention relates to PEI (Polyetherimide) modified chitosan triply compound gene vector coated with RGD (Arginyl-Glycyl-Aspartic acid)-chondroitin sulfate and a preparation method and application thereof. The triply compound gene vector is formed by mixing RGD polypeptide modified chondroitin sulfate, pDNA and PEI grafted chitosan in the mass ratio of 15:1:4. The transfection efficiency of a chitosan vector is improved by using a PEI grafting method; by using a coating method of electronegative chondroitin sulfate, red cells in blood plasma and plasma protein can be prevented from being adsorbed and reduced and the stability of blood circulation can be enhanced; in addition, by using the special targeted RGD polypeptide to modify the chondroitin sulfate, the transmembrane capability of compound particles can be enhanced. A triply gene delivery system can be constructed by taking the PEI grafted chitosan and DNA compound particles as the core and the RGD-modified chondroitin sulfate as the casing. The preparation method is simple and convenient and has mild conditions; the modified chitosan is used as a gene vector, so that the transfection efficiency is high and the cytotoxicity is low; in addition, the invention can effectively prevent the adsorption to the red cells and electronegative macromolecules, has favorable body fluid circulating stability and is hopeful to be used for gene treatment clinical experiments.

The invention discloses protein-grafted natural polysaccharide, a preparation method and an application thereof, and concretely relates to bio-protein-grafted chitosan oligosaccharide, a preparation method and an application, which belongs to the high-molecular modification field. The bio-protein-grafted chitosan oligosaccharide is obtained by dissolved chitosan oligosaccharide and a bio-protein solution under effect of a catalyst microbial transglutaminase. According to the invention, reaction condition is mild, technology is simple, and the reaction substances are natural macromolecule with characteristics of environmental protection. The prepared water-soluble chitosan oligosaccharide bio-protein copolymer has good film forming ability, moisture-absorption effect, moisture-retention effect and antioxidation effect.

The invention provides a preparation method of polyamine compound-modified magnetic chitosan and an application thereof. The preparation method comprises the following steps: firstly swelling chitosan with a 2% acetic acid solution, then connecting triethylene tetramine to the chitosan molecules by epoxy chloropropane, performing carboxymethylation of the above product by chloroacetic acid, and finally introducing magnetic ferroferric oxide into the triethylene tetramine-grafted chitosan molecules by using N,N'-dicyclohexyl carbimide with N,N-dimethyl formamide as a solvent, so as to obtain a target adsorbent. The adsorbent of the invention is mainly used for adsorption treatment of heavy metal ion-polluted waste water, not only can be used for adsorption recovery of single heavy metal ion, but also can be used for adsorption treatment of waste water polluted by a plurality of heavy metal ions, has the advantages of good adsorption effect, no secondary pollution, easy separation, recyclability, cheap and easily available raw materials, and the like, and is a potential heavy metal waste water treating agent.

The invention relates to the field of daily use chemicals and in particular relates to a facial cleanser for effectively preventing haze hazards. The facial cleanser comprises the following raw materials in parts by weight: 0.1-10 parts of chitosan and derivatives thereof, 5-25 parts of an amino acid-based surfactant and 0.2-3 parts of a thickening agent, wherein the chitosan and derivatives thereof are selected from one or more in chitosan, water-soluble chitosan, N-trimethyl chitosan, N-malely chitosan, carboxymethyl chitosan, hydroxypropyl chitosan or beta-cyclodextrin grafted chitosan; and the deacetylation degree of the chitosan and derivatives thereof is 60-99 percent. The chitosan and derivatives thereof are added into the amino acid-based facial cleanser, and the slightly acidic facial cleanser disclosed by the invention is rich in foam, high in stability, mild and non-irritating, has the effects of inhibiting bacteria and chelating heavy metals and is applied to skin care in hazy weather.

The invention discloses an expansion fiber anti-cracking waterproofing agent. The expansion fiber anti-cracking waterproofing agent is prepared from the following raw materials in percentage by mass:10 to 30 percent of an anti-cracking expansion agent, 20 to 40 percent of micro-bead powder, 30 to 45 percent of coal gangue, 0.5 to 5 percent of modified basalt fiber, 0.4 to 2 percent of cellulose grafted chitosan, 1 to 2 percent of an early strength agent, 0.5 to 1.0 percent of a water reducer and 0.1 to 0.2 percent of a defoamer, the sum of mass percentage of the the raw materials is 100%. Theexpansion fiber anti-cracking waterproofing agent provided by the invention has dual anti-cracking and water-proofing functions. The anti-cracking expansion agent, the modified basalt fiber and the cellulose grafted chitosan in the composite material can improve the dispersion of the anti-cracking waterproofing agent in concrete, and play the role of superposition shrinkage compensation in concrete, thereby effectively avoiding micro-cracks caused by different reasons at different concrete ages, preventing and restraining the occurrence and development of cracks, and improving the rupture strength, impermeability and frost resistance of concrete.

The invention relates to a nanometer photosensitizer for photodynamic antisepsis, a preparation method and an application thereof. According to the invention, a photosensitizer grafted chitosan or a derivative thereof is acquired through the chemical coupling reaction of a photosensitizer and chitosan or chitosan derivative; such amphiphilic polymer can be self-assembled to form the nanometer photosensitizer; the hydrophobicity of a prototype photosensitizer is improved by the nanometer photosensitizer and the stability and biocompatibility thereof can be promoted; besides, the nanometer photosensitizer with positive charges is formed in a physiological solution by the photosensitizer grafted chitosan or the derivative thereof, pathogenic microorganisms can be better taken under the effectof electrostatic interaction, oxygen molecules in surroundings are converted into singlet oxygen under the effect of visible light/near-infrared light, and the singlet oxygen can be used for photodynamic antisepsis.

The invention discloses an anionic polymer grafted chitosan magnetic composite microsphere and a preparation method and application. The compound takes a chitosan magnetic composite microsphere as a core and a grafted anionic polymer as a brush. The preparation method comprises the following steps: preparing the chitosan and an Fe3O4 nanoparticle into a chitosan magnetic composite microsphere by using a reverse emulsion crosslinking method, and then performing copolymerization on the chitosan magnetic composite microsphere and an anionic monomer to generate the anionic polymer grafted chitosan magnetic composite microsphere. The anionic polymer grafted chitosan magnetic composite microsphere prepared by the preparation method provided by the invention can effectively remove a cationic dye and has the advantages of large adsorption capacity, easy separation under an external magnetic field, repeated use after desorption and no influence on adsorption effect. The preparation method is simple to operate, and the cost is low.

The invention provides a preparation method of citric acid grafted chitosan beads. The preparation method comprises the following steps: 1) preparation of chitosan-citric acid gel: adding chitosan into a citric acid solution, and stirring uniformly to obtain the chitosan-citric acid gel; 2) preparation of citric acid grafted chitosan wet gel beads: pouring the chitosan-citric acid gel obtained inthe step 1 into a burette, dripping the chitosan-citric acid gel into a sodium hydroxide solution with magnetic stirring, and collecting to obtain citric acid grafted chitosan wet gel beads; 3) preparation of citric acid grafted chitosan beads: performing freeze drying treatment on the citric acid grafted chitosan wet gel beads obtained in the step 2) to obtain chitosan-citric acid beads. The invention belongs to the technical field of heavy metal adsorbents. By adopting the preparation method, the adsorption performance of the citric acid grafted chitosan beads is improved, the biocompatibility is taken into consideration, and the stability is improved. The citric acid grafted chitosan beads can be widely applied to adsorption of heavy metals such as copper ions.

The invention discloses a preparation method of an amino-terminated hyper-branched polymer grafted chitosan microsphere adsorbent (the simple formula is represented by figure I), and belongs to the field of preparation processes of adsorbing materials. According to the present invention, a hyper-branched polymer is cross-linked in a chitosan structure through succinic anhydride by using the rich nitrogen-containing groups (primary amino group, amide group and secondary amino group) in the hyper-branched polymer based on the highly-reactive amino group in the molecular structure of chitosan toprepare the amino-terminated hyper-branched polymer grafted chitosan solid-phase adsorbing material having a specific structure, wherein the adsorbing material is used for formaldehyde adsorption; a large amount of the nitrogen-containing groups are introduced on the chitosan so as to increase the content of the active groups, such that the formaldehyde adsorption capacity can be significantly improved; and by using the ionic liquid as the reaction medium for cross-linking the hyper-branched polymer and the chitosan, the reaction rate can be significantly increased, the cross-linking proportion can be increased, and the ionic liquid can be recycled so as to achieve the environmental protection.

The invention provides a triphenylphosphine-stearic acid grafted chitosan drug-loading micelle. The triphenylphosphine-stearic acid grafted chitosan drug-loading micelle is prepared through a two-stepamide method as follows: grafting tetracarboxybutyl triphenylphosphine to stearic acid grafted chitosan to obtain triphenylphosphine-stearic acid grafted chitosan having a mitochondrion targeting function; and performing coating of an antitumor drug amycin through a dialysis method to obtain the mitochondrion-targeting triphenylphosphine-stearic acid grafted chitosan drug-loading micelle. The drug-loading micelle provided by the invention has an efficient mitochondrion targeting function, and the coated drug amycin can maximally reduce the leakage of the amycin in normal tissues and non-target parts, thereby reducing the toxic or side effect; and meanwhile, a large amount of amycin can be accurately delivered to tumor cell mitochondria in a targeting manner, so that the concentration of the amycin in the tumor cell mitochondria is increased, apoptosis of the tumor cells is induced, and the antitumor curative effect is greatly improved.

The invention discloses a method for modifying polyester fiber through polyethylene glycol grafted chitosan, and belongs to the technical field of textile chemicals. The method comprises the process of pretreating the polyester fiber, the process of preparing a polyethylene glycol grafted chitosan derivative and the process of modifying the polyester fiber through the polyethylene glycol grafted chitosan. After the polyester fiber is modified through a sodium hydroxide solution, the fiber surface is roughed, adhesion of the chitosan derivative in the later period is facilitated, cyanuric acid is added for modifying amidation chitosan to obtain cyanuric acid modified amidation chitosan, the modified chitosan can better have a grafting reaction with polyethylene glycol, the flexibility and hydrophilic performance are more excellent, the modified chitosan can carry out grafting and adsorption on polyester fiber to improve the hydrophilic performance and anti-static performance of polyester molecules, the hand feel of a polyester fiber fabric is improved to a certain degree, the polyester fiber fabric has the certain antibacterial performance, and meanwhile the polyester fiber fabric is firm in grafting, good in water resistance, high in economic benefit and wide in industrial popularization prospect.

The invention discloses anti-infective, safe and efficient hemostatic aerogel which is prepared by supercritical drying after hydrogel is prepared from 8-O-acetyl saponin methyl ester-grafted chitosan, sodium alginate, gellan gum and water; the 8-O-acetyl saponin methyl ester-grafted chitosan is prepared by grinding for 20-30 minutes under infrared light after chitosan salt is mixed with 8-O-acetyl shanzhiside methyl ester according to the mass ratio of (5-8):l; the molecular weight of the chitosan salt is 50-100 kDa, and the degree of deacetylation is 90-100 percent; the chitosan salt is at least one of hydrochloride, acetate and lactate. The 8-O-acetyl saponin methyl ester is grafted to the chitosan, the hydrogel is prepared by the coordination of the sodium alginate, the water and the gellan gum, and the aerogel is obtained by supercritical drying; the prepared hemostatic aerogel is good in swelling property, strong in adhesiveness and quick in hemostasis, difficultly enters blood to cause the thrombosis risk, has an anti-infective effect and is particularly suitable for quick hemostasis of severe bleeding such as deep acute trauma and arterial rupture.

The present invention provides a PEGylated and fatty acid grafted chitosan oligosaccharide comprising a structural unit represented by the following Formula (I) and a structural unit represented by the following Formula (II) and synthesize method, wherein the chitosan oligosaccharide has a molecular weight of less than 200,000 Da, and a degree of deacetylation of 70%-100%, and part of free amino groups of chitosan oligosaccharide chain are replaced by a fatty acid or PEG, where n refers to degree of polymerization of the PEG, and R is an alkyl group having 11-21 carbon atoms. The grafting ratio of fatty acids is 1%-50%, and the grafting ratio of PEG is 0.05%-50%. The present invention also comprise a pharmaceutical composition comprising the PEGylated and fatty acid grafted chitosan oligosaccharide as a carrier, and use of the PEGylated and fatty acid grafted chitosan oligosaccharide in preparation of a pharmaceutical composition.

The invention discloses an adhesive for plywood and relates to the technical field of plywood preparation. The adhesive is prepared from the following components: konjaku flour, vanillic aldehyde grafted chitosan, acrylate crosslinked polyvinyl alcohol, glacial acetic acid, filler and water. The adhesive for plywood provided by the invention has high bonding strength, excellent ageing resistance and water resistance and capability of effectively prolonging the service life.

The invention discloses a multifunctional traditional Chinese medicine organic acid grafted chitosan quaternary ammonium salt broad-spectrum antibacterial agent and a preparation method thereof. Under the action of EDC/NHS, a traditional Chinese medicine organic acid reacts with chitosan quaternary ammonium salt molecules to synthesize the traditional Chinese medicine organic acid-chitosan quaternary ammonium salt broad-spectrum antibacterial agent with antibacterial, anti-inflammatory and antioxidant properties. The method is simple and convenient in steps, low in investment, high in output and suitable for large-scale production and use. Through the synergistic effect of the traditional Chinese medicine organic acid and the chitosan quaternary ammonium salt, the broad-spectrum antibacterial property superior to that of the chitosan quaternary ammonium salt is obtained; through parameter optimization, the obtained traditional Chinese medicine organic acid-chitosan quaternary ammonium salt antibacterial agent has no cytotoxicity; on the other hand, the traditional Chinese medicine organic acid endows the antibacterial agent with good anti-inflammatory performance and oxidation resistance; and due to no cytotoxicity and multi-functionalization, the traditional Chinese medicine organic acid-chitosan quaternary ammonium salt broad-spectrum antibacterial agent has a wider application prospect.

The invention discloses a method for preparing a chitosan grafted cyclodextrin derivative with a water pollutant adsorption function and belongs to the field of an adsorption material preparation technology. The adsorbent is prepared by direct chemical grafting between aldehyde cyclodextrin and chitosan. The preparation process of the polymer is as follows: cyclodextrin containing active aldehyde group and chitosan with amino active functional group are dissolved in a solvent to undergo a Schiff's base reaction at a certain temperature, and chemical grafting of cyclodextrin and chitosan is completed to prepare the graft polymer. The adsorbent has cyclodextrin identification performance and chitosan adsorption performance, has stable performance, has low toxicity, is green and environmentally friendly, and is degradable. The adsorbent can be used in enrichment pretreatment of pollutants in a water body and also can be used in the fields of drug release and molecular recognition. The adsorbent has a wide application prospect.

The invention relates to a surface antibacterial modification method for a non-woven fabric by plasma grafted chitosan oligosaccharide and a derivative thereof. The method comprises the steps of taking the chitosan oligosaccharide and the derivative thereof as surface grafting materials of a non-woven fabric; carrying out surface modification on the non-woven fabric by stopping discharge plasma through an atmospheric air medium; and then combining the chitosan oligosaccharide with the derivative thereof by covalent bonds.

The invention relates to an alginate embedded type hydrogel microsphere carrier having the interior containing a galactosyl chitosan molecule and a preparation method thereof. A galactosyl group is grafted onto a chitosan molecule by an amidation reaction, and hepatocytes are cultured in microcapsules jointly formed by chitosan and alginic acid. Experiments prove that the microcapsules jointly prepared by the galactosyl-grafted chitosan and alginic acid are used for culturing primary hepatocytes of rats, and the activity and function of the hepatocytes are well maintained.