The invention belongs to the technical field of polymer materials processing, which particularly relates to a method for producing biological fully-degradable environmental-friendly hot melt adhesive. Biological fully-degradable environmental-friendly hot melt adhesive is manufactured through modifying cornstarch and a process technique which is squeezed through blending. The method comprises the following steps: mixing and adding cornstarch and plasticizing agent, obstructing agent, reinforcing agent, lubricating agent and filling material in a stirrer according to proportion, stirring under 80 DEG C and 1000-3000rpm, preparing modified fecula, utilizing a double screw extrusion machine to blend and extrude after modified fecula, biodegradable polyester, plastisol, viscosity modifier, plasticizing agent, antioxidant and filling material are mixed, wherein the temperature of an extrusion machine is 100-180 DEG C, and number of revolution of a screw bolt is 40-200rpm, wherein modified fecula is 40-60%, biodegradable polyester is 0-30%, plastisol is 20-30%, viscosity modifier is 5-10%, plasticizing agent is 0-10%, antioxidant is 0.5-1%, and filling material is 0-10%. Hot melt adhesive which is got by the invention has the advantages of excellent compatibility, uniform products, low production cost, excellent initial viscosity and fully-degradable biology, which can be widely used in the fields such as cartons, unsewn binding of books, nonwoven manufacture and the like.