Nifedipine double-layer osmotic pump tablet and preparation method thereof

Abstract

The invention provides a nifedipine double-layer osmotic pump tablet. The nifedipine double-layer osmotic pump tablet includes a medicated-layer tablet core, a boosting-layer tablet core, a semipermeable membrane and single drug-releasing holes arranged in the surface of the semipermeable membrane at one side of a medicated layer. The nifedipine double-layer osmotic pump tablet is simple in preparation process and low in cost and has stable drug-releasing rate; zero-level release is basically realized in 416 hours, and the the drug release is basically complete; the purpose of administration of preparation once per day is achieved, and the compliance of a patient is improved. The invention provides a preparation method of a nifedipine controlled-release tablet.

Description

technical field

[0001] The invention belongs to the technical field of pharmaceutical preparations, and in particular relates to a double-layer osmotic pump tablet of an antihypertensive drug nifedipine and a preparation method thereof. Background technique

[0002] Nifedipine (Nifedipine) is the first dihydropyridine calcium ion channel blocker, the chemical name is 2,16-dimethyl-4(2-nitrophenyl)-1,4-dihydro-3 , dimethyl 5-pyridinedicarboxylate, used for the prevention and treatment of angina pectoris caused by coronary heart disease, especially variant angina pectoris and angina pectoris caused by coronary artery spasm; it has no adverse effect on respiratory function, so it is suitable for angina pectoris with obstructive airway diseases In addition, nifedipine still has anti-atherosclerosis, inhibits vascular smooth muscle hyperplasia, protects the integrity of the structure and function of vascular endothelial cells, and resists platelet aggregation; Dipine can signifi...

Images