The utility model relates to the technical field of vehicles, in particular to a wire harness fixing device and a vehicle. In the embodiment of the invention, the wire harness fixing device at least comprises a body and a plurality of ribbons, and the body comprises a first side wall, a second side wall, a third side wall and a fourth side wall. The body is arranged to be of a structure with four side walls, so that the body is roughly of a square structure, further, open holes are formed in the first side wall, the second side wall, the third side wall and the fourth side wall, and the open holes in the side walls are formed in the longitudinal direction of the body at intervals; therefore, the ribbon can flexibly form corresponding fixing spaces in the first direction, the second direction and the lengthwise direction of the body. Therefore, a plurality of wire harnesses are more flexibly separated and arranged in different directions, so that the interference among the wire harnesses is improved, the installation is convenient, and the safety and the aesthetic property are also improved.