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Compound Atenolol-Nifedipine slow releasing prepn

The technology of a sustained-release preparation and nifedipine, which is applied to the application of compound sustained-release preparations in medical treatment and the field of compound sustained-release preparations, can solve problems such as the cost of missed doses, and achieve the effects of convenient administration, ideal effect, and prolonged storage period.

Inactive Publication Date: 2003-11-05
GUANGZHOU PUIS PHARMA FACTORY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The compound preparations currently on the market abroad are all regular-release preparations, which are taken twice a day. Although there are many conveniences compared with single use of atenolol or nifedipine, there are still inconveniences such as missed doses and higher costs.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0032] Embodiment 1: the preparation of tablet

[0033] Prescription: (1000 tablets dosage)

[0034] Atenolol 100g

[0035] Nifedipine 30g

[0036] HPMC K100M) 50.5g

[0037] HPMC K15M 42.5g

[0038] Microcrystalline Cellulose 45g

[0039] Lactose 30g

[0040] Magnesium Stearate 2.2g

[0041] 10% PVP solution appropriate amount

[0042] Process:

[0043] Weigh Atenolol 100g, HPMC k100M 20.5g, HPMC K15M 20g, microcrystalline cellulose 20g, lactose 15g, mix evenly, add appropriate amount of 10% PVP solution, wet granulate, the obtained granules are dried to a certain degree, add a certain amount of lubricant, and press into tablets with suitable specifications and sizes.

[0044] Weigh 30g of nifedipine, HPMC K100M 30g, HPMC K15M 22.5g, microcrystalline cellulose 10g, lactose 15g, mix evenly, add appropriate amount of 10% PVP solution, wet granulation, the obtained granules are dried to a certain degree, add a certain amount of l...

Embodiment 2

[0045] Embodiment 2: the preparation of tablet

[0046] Prescription: (1000 tablets dosage)

[0047] Atenolol 120g

[0048]Nifedipine 40g

[0049] HPMC K100M) 55g

[0050] HPMC K15M 45g

[0051] Microcrystalline Cellulose 55g

[0052] Lactose 20g

[0053] Magnesium Stearate 3.2g

[0054] 10% PVP solution appropriate amount

[0055] Process:

[0056] Weigh prescription amounts of atenolol, nifedipine, HPMC k100M 、HPMC K15M , microcrystalline cellulose, and lactose, mixed evenly, adding an appropriate amount of 10% PVP solution, wet granulation, drying the obtained granules to a certain degree, adding lubricant, and pressing into tablets with suitable specifications and sizes.

Embodiment 3

[0057] Embodiment 3: the preparation of capsule

[0058] Ball core:

[0059] Atenolol 100g

[0060] Nifedipine 30g

[0061] Microcrystalline Cellulose 80g

[0062] Lactose 50g

[0063] 10% PVP appropriate amount

[0064] Slow release layer:

[0065] Eudragi t NE 30D 20g

[0066] Talc powder 2.5g

[0067] Pure water 190ml

[0068] Process:

[0069] Weigh 100 g of atenolol, 30 g of microcrystalline cellulose, and 20 g of lactose, mix well, add a certain amount of 10% PVP solution, and prepare drug-containing pellets with a diameter of about 2 mm by extrusion / spheronization. Separately weigh 8.5 g of Eudragi tNE30D, 1.0 g of talcum powder, and 80 ml of pure water to prepare a sustained-release coating solution, and coat the obtained coating solution on the drug-containing pellets prepared above to obtain atenolol sustained-release pellets.

[0070] Weigh 30 g of nifedipine, 50 g of microcrystalline cellulose, and 30 g of lactose candy, mix them evenly, add a certain amo...

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PUM

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Abstract

The present invention relates to compound slow-release Atenolol-Nifedipine preparation and its medical application. The compound delayed preparation has active components Atenolol and Nifedipine anddelaying material for delayed release. The preparation includes also pharmacologically acceptable carrier.

Description

Technical field: [0001] The invention relates to a compound drug sustained-release preparation, in particular to a compound sustained-release preparation composed of atenolol and nifedipine, and the application of the compound sustained-release preparation in medical treatment. Background technique: [0002] Atenolol, a beta-receptor antagonist, acts by inhibiting beta-receptors, which have an effect on cardiac beta 1 Receptors have obvious blocking effect, but bronchial and vascular smooth muscle β 2 Receptor blockade is minimal. In the cardiovascular field, it is currently mainly used for the treatment of hypertension and coronary heart disease, and also for arrhythmias caused by sympathetic nerve stimulation or increased catecholamines. [0003] Nifedipine, a calcium ion influx blocker or slow channel blocker, blocks calcium ions from entering the cell through the channel on the membrane surface of myocardial or smooth muscle cells, thereby causing vascular tension in b...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/22A61K9/52A61K31/4422A61P9/10A61P9/12
Inventor 贝庆生
Owner GUANGZHOU PUIS PHARMA FACTORY
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