Lurasidone hydrochloride orally disintegrating tablet and preparation method thereof

A technology of lurasidone hydrochloride and orally disintegrating tablets, which is applied in the direction of pharmaceutical formulas, medical preparations with no active ingredients, medical preparations containing active ingredients, etc., which can solve the problem of complex operation process and lack of rapid oral disintegration , Dissolution decline and other issues, to achieve the effect of simple operation of the production process, increase of bioavailability, and improvement of dissolution rate
CN106539768AActive Publication Date: 2017-03-29CHENGDU KANGHONG PHARMA GRP
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
CHENGDU KANGHONG PHARMA GRP
Publication Date
2017-03-29

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Abstract

The invention provides a lurasidone hydrochloride orally disintegrating tablet containing indissolvable drugs. The lurasidone hydrochloride orally disintegrating tablet comprises 8%-24% of lurasidone hydrochloride, 8%-48% of a carrier, 0.8%-4% of adhesive, 24%-76.2% of filler, 4%-10% of a disintegrating agent, 2%-6% of flavoring agent and 1%-4% of a lubricating agent. The lurasidone hydrochloride orally disintegrating tablet can be disintegrated quickly, and convenience is provided for medicine taking of patients particularly like the aged, children, coma patients and the patients who cannot take water conveniently. Moreover, the dissolving-out rate can reach 85% or above within 5 minutes. In addition, the lurasidone hydrochloride orally disintegrating tablet can be disintegrated and absorbed quickly in the oral cavity, so that the bioavailability is greatly improved. Operation is easy in production technology, the production cost is low, and the lurasidone hydrochloride orally disintegrating tablet is suitable for industrial mass production.
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Description

technical field

[0001] The invention belongs to the field of pharmaceutical preparations, and relates to a lurasidone hydrochloride orally disintegrating tablet and a preparation method thereof. Background technique

[0002] Schizophrenia (schizophrenia) is a psychiatric disease. It is a persistent and usually chronic major mental illness. It is the most serious type of mental illness. Environmental disharmony is the most common type of mental illness, and it usually occurs in young and middle-aged people, which in turn affects behavior and emotion. The main symptom of schizophrenia is considered to be a fragmentation of basic thinking structures and cognition. This dissociation creates thought-form disorders and leads to an inability to distinguish between inner and outer experience. People with schizophrenia may report hallucinations themselves, or others may find that their performance is affected by hallucinations. Patients may also express overtly delusional beliefs....

Claims

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