Nifedipine sustained-release tablet

A nifedipine, gentle technology, applied in cardiovascular system diseases, pharmaceutical formulations, drug combinations, etc., can solve problems such as unavoidable side effects

Inactive Publication Date: 2011-07-20
上海中邦斯瑞生物药业技术有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Common preparations need to be administered at least 3 times a day, and side effects caused by rapid expansion of short-term arterioles cannot be avoided

Method used

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  • Nifedipine sustained-release tablet

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0023] Nifedipine 15g

[0024] Lactose 30g

[0025] PVP k29 / 32 10g

[0026] Low-substituted hypromellose 30g

[0027] Sodium Alginate 60g

[0028] Magnesium Stearate 4g

[0029] Preparation: Grind the remaining excipients of nifedipine separately, pass through 80 mesh sieve; mix nifedipine and sodium alginate evenly; granulate with PVP K29 / 30 ethanol solution, dry, and granulate with 14 mesh sieve; The rest of the excipients are mixed evenly; compressed into tablets.

Embodiment 2

[0031] Nifedipine 30g

[0032] Lactose 40g

[0033] PVP k29 / 32 10g

[0034] Crosslinked PVP 34g

[0035] Hydroxypropyl Methyl Cellulose 50g

[0036] Magnesium Stearate 6g

[0037] Preparation: Grind the remaining excipients of nifedipine separately, pass through 80 mesh sieve; mix nifedipine and hydroxypropyl methylcellulose evenly; granulate with PVP K29 / 30 ethanol solution, dry, and pass through 14 mesh sieve Whole grain; mixed with other excipients; compressed into tablets.

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PUM

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Abstract

The invention provides a nifedipine sustained-release tablet which contains a physiological effective dose of nifedipine and release blocker and a pharmaceutically acceptable excipient, wherein the nifedipine is dispersed in the release blocker; the release blocker is selected from macromolecular substances which can be swelled in water, such as hydroxypropyl methyl cellulose, sodium alginate, carboxymethyl cellulose, methyl cellulose and xanthan gum, and the amount of the used release blocker is 5-30 percent of the weight of the sustained-release tablet; and the nifedipine sustained-release tablet contains 15-30mg of nifedipine and also contains several of filler, a disintegrating agent, a surfactant, an adhesive, a lubricant and a glidant as the excipient. The nifedipine sustained-release tablet can be used for treating hypertension and angina pectoris.

Description

technical field [0001] The invention belongs to the field of pharmaceutical preparations, and in particular relates to a slow-release tablet of nifedipine and a preparation method thereof. Background technique [0002] Nifedipine, the English name nifedipine, is one of the calcium antagonists, and its molecular structure is shown in the figure below. Nifedipine has a strong expansion of coronary arteries and peripheral arteries, and can significantly inhibit vasospasm. It is the drug of choice for variant angina pectoris. It is clinically suitable for the prevention and treatment of angina pectoris caused by coronary heart disease, especially for variant angina pectoris and coronary artery spasm. Angina. It is suitable for various types of hypertension, and has a good effect on intractable and severe hypertension. Because it can reduce afterload, it also has good curative effect on refractory congestive heart failure and is suitable for long-term use. In addition, it is a...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/22A61K31/4422A61K47/36A61K47/38A61P9/08A61P9/10A61P9/12
Inventor 丁杰
Owner 上海中邦斯瑞生物药业技术有限公司
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