Method for preparing calcium chitosan and itsuse for wound hemostasis

A technology of chitosan and calcium gluconate, which is applied in the directions of blood diseases, extracellular fluid diseases, drug combinations, etc., can solve problems such as complicated preparation process, and achieve the effects of simple preparation method, convenient use and promotion of wound healing.

Inactive Publication Date: 2006-08-09
刘万顺
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The preparation process is complicated in the reports of these related chitosan hemostatic materials

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0008] (1) Preparation of chitosan: Take crab shells or shrimp shells and grind them into 10-mesh coarse powder, and process them according to the following steps.

[0009] ① Decalcification of crab or shrimp shells: Weigh 100g of crab or shrimp shells, add 500ml of 1.0mol / L hydrochloric acid, stir for 0.5-3 hours to decalcify, filter to obtain solids. Then add 800 ml of 0.5 mol / L hydrochloric acid, and repeat the above process to obtain a solid. Wash the solid matter with deionized water to pH 5-7, and filter to obtain decalcified crab shells or decalcified shrimp shells.

[0010] The concentration of the hydrochloric acid aqueous solution used in the decalcification of the crab shell or shrimp shell may be 0.5-2.0 mol / L, and the dosage may be 400ml-1000ml.

[0011] ② Deproteinization and depigmentation: Put the above-mentioned decalcified crab shells or decalcified shrimp shells into a beaker, add 600ml of 0.5mol / L sodium hydroxide aqueous solution, heat and react at 90°C f...

Embodiment 2

[0019] (1) Preparation of chitosan: the same as the step of (1) in Example 1.

[0020] (2) Preparation of chitosan calcium: Weigh 0.5g of calcium chloride, put it in a beaker, add 200ml of deionized water, stir and dissolve to obtain an aqueous solution of calcium chloride. Weigh 10 g of chitosan powdery solid, pour it into an aqueous calcium chloride solution, stir at room temperature for 0.5 hour, and filter to obtain a solid. The solid was washed 3 times with deionized water for 20 minutes each time, and filtered to obtain the solid. Then dehydrate with 95% ethanol aqueous solution and filter to obtain a solid. The solid matter is dried at 60-70°C, crushed, 60 Co irradiation sterilization, chitosan calcium.

[0021] The chitosan used has a molecular weight range of 10KD-1000KD and a deacetylation degree of 60%-100%. The weight ratio of chitosan and calcium chloride may be 10:0.01-2. Changing calcium chloride to calcium acetate or calcium gluconate or calcium lactate or...

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PUM

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Abstract

This invention relates to a preparation method for calcium chitin characterizing in mixing the chitin with powder of CaCl2, calcium acetate, calcium gluconate, calcium lactate, calcium maltate or citrate calcium malate to be reacted, filtered, cleaned, dewatered, dried, crushed and virus eliminated to get the calcium chitin, which is a new type of hemostatic by acting on the red blood cells in the blood, suppressing soluble fiber protein and activating thrombin so as to arrest bleeding.

Description

technical field [0001] The invention relates to a preparation method of chitosan calcium, which is used for wound or operation hemostasis. Background technique [0002] Chitosan is a natural polymer polycation polysaccharide, which has good biocompatibility, no immunogenicity, no toxic side effects, and has hemostatic, antibacterial, anti-infection effects, and can promote wound healing. Good properties of sugar for use as a hemostatic dressing or hemostat. It has been reported that chitosan is used as one of the raw materials to prepare wound hemostatic materials, mainly by compounding chitosan or chitosan derivatives with other materials to make hemostatic sponge or hemostatic film. The preparation process in the reports of these related chitosan hemostatic materials is complicated. Contents of the invention [0003] The purpose of this invention is to provide a preparation method of hemostatic agent chitosan calcium and the application of the hemostatic agent in traum...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08B37/08A61K31/722A61P7/04
Inventor 刘万顺韩宝芹顾其胜
Owner 刘万顺
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