The invention discloses a topical spray for treating intractable skin ulcer. The topical spray is prepared from puerarin, sophora flavescens, golden cypress, golden larch bark, oldenlandia diffusa, gallnut, divaricate saposhnikovia roots, borneol and recombinant human basic fibroblast growth factor powder. The topical spray is prepared by the following steps of firstly crushing the raw materials and then adding 95% ethanol for percolation to prepare a traditional Chinese medicine extract solution; adding the recombinant human basic fibroblast growth factor powder for mixing evenly; dissolving taken menthol by using 75% ethanol to serve as a corrigent; and adding tween-80 for solubilizing and then mixing evenly to obtain a finished product spray. An advanced modern medicine preparation technology is used, new components are scientifically added on the basis of reserving effective components of a traditional Chinese medicine preparation, traditional dosage and ratios of the raw materials are changed, the new components are matched with the added oldenlandia diffusa, gallnut, divaricate saposhnikovia roots and the like, so that the therapeutic effects of resisting bacteria, relieving pain, clearing heat and dry dampness of the topical spray are strengthened; and meanwhile, western medicine components are added, so that the prepared topical spray is more convenient to use, fast to take effect and more lasting in medicinal effect.