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Superabsorbent silk fibroin hemostatic film and preparation method thereof

A technology of silk fibroin and high liquid absorption, which is applied in the manufacture of rayon, pharmaceutical formulations, conjugated artificial filaments, etc., can solve the problem of long hemostasis time, low immunogenicity of high liquid absorption silk fibroin hemostatic membrane, Insufficient liquid absorption performance, etc.

Inactive Publication Date: 2019-01-25
GUANGDONG TAIBAO MEDICAL SCI TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0004] The purpose of the present invention is to provide a highly liquid-absorbing silk fibroin hemostatic membrane and a preparation method thereof for the existing hemostatic materials with insufficient liquid absorption performance and long hemostasis time. Low immunogenicity, abundant material sources, good biocompatibility and degradability

Method used

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  • Superabsorbent silk fibroin hemostatic film and preparation method thereof
  • Superabsorbent silk fibroin hemostatic film and preparation method thereof
  • Superabsorbent silk fibroin hemostatic film and preparation method thereof

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preparation example Construction

[0029] (1) Preparation of hemostatic membrane spinning material:

[0030] Preparation of S1 silk fibroin / nano-silica spinning solution: weigh a certain amount of silk fibroin according to the formula ratio, dissolve it in trifluoroethanol, prepare a solution with a mass concentration of 10%, and then add it according to the formula ratio Nano silicon dioxide, stirred at room temperature for 2.5h, for subsequent use;

[0031] Preparation of S2 polyethylene oxide / sodium alginate spinning solution: weigh a certain amount of polyethylene oxide and dissolve it in distilled water to prepare a polyethylene oxide solution with a mass concentration of 10%wt; weigh a certain amount of sodium alginate to dissolve In distilled water, configure a sodium alginate solution with a mass concentration of 3%; mix the polyethylene oxide solution and sodium alginate solution according to the convenience of the recipe, stir evenly, and set aside after defoaming;

[0032] (2) Spinning of hemostatic...

Embodiment 1

[0038] The present invention prepares a highly liquid-absorbent silk fibroin hemostatic film according to the above method, wherein the consumption of polyethylene oxide is 5 parts, the consumption of silk fibroin is 50 parts, the consumption of sodium alginate is 15 parts, nano silicon dioxide The dosage is 1 part.

Embodiment 2

[0040]The present invention prepares a highly liquid-absorbent silk fibroin hemostatic membrane according to the above method, wherein the amount of polyethylene oxide is 25 parts, the amount of silk fibroin is 10 parts, the amount of sodium alginate is 5 parts, nano silicon dioxide The dosage is 0.5 parts.

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Abstract

The invention discloses a high-liquid-absorption silk fibroin hemostatic film and a preparation method thereof, wherein the high-liquid-absorption silk fibroin hemostatic film comprises the followingcomponents in parts by weight: polyethylene oxide of 5-25 parts, fibroin of 10-50 parts, sodium alginate of 5-15 parts and nanometer silicon dioxide of 0.5-1 part. The preparation method is realized through the following steps: (1) preparation of a hemostatic membrane spinning material, (2) spinning of the hemostatic membrane, and (3) cross-linking treatment of the hemostatic membrane. The silk fibroin hemostatic membrane with high liquid absorption has good hemostatic effect, can absorb a large amount of wound seepage, and has good air permeability and biocompatibility.

Description

technical field [0001] The invention belongs to the technical field of hemostatic material preparation, and in particular relates to a highly liquid-absorbing silk fibroin hemostatic film and a preparation method thereof. Background technique [0002] Injuries are unavoidable in daily life, and hemostasis is an important step in emergency treatment, especially for sudden trauma in daily life, surgical treatment in hospitals, etc., rapid hemostasis is an indispensable part. However, effective hemostatic agents are usually expensive, have low efficacy or cause various safety problems. Therefore, it is very important to find a new hemostatic material with high efficiency, low cost and no side effects. The hemostasis measure that takes in the past mainly is to use tourniquet or bandage to tie up the wound, then bandage with gauze pressure. These methods of hemostasis have played an important role in rescuing the wounded in a short time. However, because the tourniquet cannot ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L24/08A61L24/10A61L24/06A61L24/02A61L24/00D01F8/16D01F8/18D01F1/10
CPCA61L24/0047A61L24/02A61L24/06A61L24/08A61L24/108A61L2300/236A61L2300/252A61L2400/04D01F1/10D01F8/16D01F8/18C08L89/00C08L71/02C08L5/04
Inventor 卢亢何立彬韦加娜
Owner GUANGDONG TAIBAO MEDICAL SCI TECH
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