16 results about "Tumor biopsy" patented technology

The invention discloses a digestive tract tumor biopsy sampling device convenient for puncture and sampling for medical oncology, which relates to the technical field of tumor biopsy sampling and comprises a biopsy device, a limiting seat and a base. According to the alimentary canal tumor biopsy sampling device convenient to puncture and sample for the medical oncology, tumor tissue can be accurately contained through the sampling groove, fragmentation of a tumor tissue sample is avoided, it is guaranteed that the tissue sample meets the tissue form needed by detection, the sample quality is guaranteed, the outer sleeve needle covers the sampling groove after sampling, the sample can be fixed and cannot fall off, and the sampling efficiency is improved. The tissue is prevented from remaining in the body or being polluted during withdrawing, and meanwhile the risks of bleeding and tissue damage in the puncture process are reduced; enough samples can be obtained through one-time operation, the repeated puncture frequency is reduced, the operation time is shortened, the pain of a patient is relieved, and the operation efficiency is improved; and the modularized puncture needle design allows medical staff to quickly adjust the puncture depth according to individual differences, and the flexibility is high.

Immunohistochemistry (INC) and in situ hybridization (ISH) methods are used for the targeted detection and localization of biomolecules (e.g., proteins and miRNAs) in tissues or cells, for research applications and clinical applications such as those of pathologists (e.g., biomarker analysis of resected tumors or tumor biopsies). These methods include mass spectrometry imaging (MSI) as a mode for detecting and localizing biomolecules in tissues or cells. The methods employ optically cleavable mass-tagged reagents linked to probes such as antibodies and nucleic acids and used to enable multiplexed immunohistochemistry and in situ hybridization, with MSI as the detection / readout mode. The methods also include multi-omics MSI procedures in which MSI of optically cleavable mass-tagged probes is combined with other MSI modes, such as direct label-free MSI of endogenous biomolecules from biological samples (e.g., tissues).

The invention relates to the technical field of sampling devices, and discloses a medical clinical tumor biopsy sampling device which comprises a sleeve and further comprises a sampling part arranged on the sleeve; the lifting part is arranged in the sleeve; the limiting part is arranged at the top of the sleeve; the sampling part comprises a sampling assembly; the sampling assembly is mounted on the sleeve; the rotary cutting assembly is mounted on the sleeve; the sampling assembly comprises two sampling openings formed in the outer wall of the sleeve, the bottom end of the sleeve is fixedly connected with a puncture head, the outer wall of the puncture head is fixedly connected with an umbrella-shaped annular knife, and a sampling bin is formed in the top of the puncture head. According to the tumor biopsy sampling device, by arranging the sampling part, the problems that according to an existing tumor biopsy sampling device, a sample is not prone to remaining on the sampling device, the sample falls off, the accuracy and timeliness of follow-up pathological detection are affected, and finally the overall working efficiency of clinical biopsy is reduced are solved.

The present invention belongs to the technical field of immune cell culture, and specifically relates to a composition and kit for expanding tumor infiltrating lymphocytes, and an expansion method therefor. Provided is a composition for expanding tumor infiltrating lymphocytes for a trace amount of tumor tissue, i.e., a tumor biopsy sample, to perform the expansion of tumor infiltrating lymphocytes, which solves the problem that a large amount of a tumor tissue sample is required for tumor infiltrating lymphocytes, and is suitable for patients who cannot undergo surgical resection to obtain tumor tissue. In addition, by means of optimizing the combination and working concentration of antibody stimulants, a process flow for expanding tumor infiltrating lymphocytes on the basis of biopsy samples is established, such that the stemness of the expanded tumor infiltrating lymphocytes is maintained, and the killing ability is improved, thereby ensuring the anti-tumor efficacy after reinfusion into the body.

This invention discloses an intelligent digestive tract tumor biopsy sampler and system, belonging to the field of medical device technology. It includes a puncture cone, shaft, end cap, annular blade, motor, and lead screw. A cutting opening is formed between two annular walls. The motor drives the lead screw to move the annular blade up and down for sampling. The device is equipped with stepless speed control buttons, a stroke limit structure, status indicator lights, a negative pressure adsorption component, and an ergonomic non-slip handle. This invention integrates a pressure sensor, an AI module, a storage module, and a wireless transmission module, allowing connection to remote devices. The device supports both manual and intelligent working modes. It relies on the pressure sensor to collect cutting resistance in real time, and the AI ​​adaptively adjusts the cutting speed and stroke. It features fault self-diagnosis, audible and visual prompts, remote parameter updates, and algorithm upgrades. This invention has a compact structure, can seal and preserve samples, produces a regular cutting surface, effectively prevents sample detachment and contamination, reduces reliance on operational experience, and improves sampling accuracy and surgical safety.

The application discloses a kind of negative pressure suction gun, manual negative pressure suction method, it is related to biomedical engineering technical field, the gun handle of negative pressure suction gun is reciprocated and opened and closed to drive suction pumping section to reciprocate in negative pressure sedimentation cavity Negative pressure suction and extrusion pumping, negative pressure sedimentation cavity can pass through liquid suction pipe one-way liquid suction when negative pressure suction, negative pressure sedimentation cavity can be one-way liquid delivery to the liquid storage part when extrusion pumping, so as to be used for suction liquid and soft solid tissue in liquid by setting negative pressure sedimentation cavity, then by adjusting increase negative pressure suction force, the viscosity of solid tissue that can be sucked is also greater, so that the negative pressure suction gun of the application can not only be used for endometrial gynecological field liquid suction and solid tissue sampling, but also can be used for closed narrow space tumor biopsy, brain tissue and other solid-liquid components suction, during suction process, by rotating liquid suction pipe, the inlet slope of liquid suction pipe is realized 360 degree rotation, to avoid suction dead angle.

The invention belongs to the technical field of immune cell culture, and particularly relates to a tumor infiltration lymphocyte amplification composition, a kit and an amplification method thereof. The invention provides the tumor infiltration lymphocyte amplification composition aiming at a trace amount of tumor tissue, namely a tumor puncture sample, the tumor infiltration lymphocyte amplification composition is used for amplifying the tumor infiltration lymphocyte, the problem that the tumor tissue sample size required by the tumor infiltration lymphocyte is large is solved, and the tumor infiltration lymphocyte amplification composition is suitable for a patient who cannot receive the tumor tissue obtained by surgical excision. Besides, by optimizing the antibody stimulant combination and the working concentration and establishing the technological process for amplifying the tumor infiltration lymphocytes based on the puncture sample, the dryness of the tumor infiltration lymphocytes obtained through amplification is maintained, the lethality is improved, and therefore the anti-tumor curative effect after the tumor infiltration lymphocytes are infused back into the body is guaranteed.

A kind of skin scale for operation, mainly by the transverse scale plate and longitudinal scale plate connected with each other vertically, is connected with detachable bandage by connecting block.The wire mesh structure with adjustable spacing is arranged between scale plate, including transverse and longitudinal arrangement of metal wire.Scale plate surface is provided with accurate scale, to facilitate direct measurement.Longitudinal metal wire spacing is controlled by screw adjusting mechanism, and transverse metal wire adopts magnetic type sliding fixing device to realize quick positioning.Bandage realizes quick disassembly and assembly by buckle type connector.The present application is manufactured by medical grade material, with good biocompatibility and perspective development nature.The device solves the measurement error problem caused by body position change, skin stretching and other factors in traditional operation positioning, and can provide stable and reliable body surface positioning reference.It has simple structure, convenient operation, and can be widely applied to orthopedic surgery, tumor biopsy and other medical operations requiring accurate body surface positioning.

To provide a method for treating malignant tumors.SOLUTION: A method of treating a malignancy in a patient, the method comprising: (a) analyzing a tumor biopsy from the patient to characterize a tumor microenvironment; and (b) administering to the patient an effective dose of a T cell comprising one or more chimeric receptors, wherein the effective dose is determined using the characteristics of the tumor microenvironment.SELECTED DRAWING: Figure 1

The field of this invention relates to immunohistochemistry (IHC) and in situ hybridization (ISH) for the targeted detection and mapping of biomolecules (e.g., proteins and miRNAs) in tissues or cells for example, for research use and for clinical use such by pathologists (e.g., biomarker analyses of a resected tumor or tumor biopsy). In particular, the use of mass spectrometric imaging (MSI) as a mode to detect and map the biomolecules in tissues or cells for example. More specifically, the field of this invention relates to photocleavable mass-tag reagents which are attached to probes such as antibodies and nucleic acids and used to achieve multiplex immunohistochemistry and in situ hybridization, with MSI as the mode of detection / readout. Probe types other than antibodies and nucleic acids are also covered in the field of invention, including but not limited to carbohydrate-binding proteins (e.g., lectins), receptors and ligands. Finally, the field of the invention also encompasses multi-omic MSI procedures, where MSI of photocleavable mass-tag probes is combined with other modes of MSI, such as direct label-free MSI of endogenous biomolecules from the biospecimen (e.g., tissue), whereby said biomolecules can be intact or digested (e.g., chemically digested or by enzyme).

Methods, devices and systems are provided to analyze the immunologic response of patients at various times before, during and / or after immunomodulating therapy, particularly treatment with specialized pulsed electric field energy. In some embodiments, such methods, devices and systems include a laboratory developed test that utilizes a patient tumor biopsy sample and a series of blood draws to determine whether the locoregional therapy (with or without additional systemic therapies, or systemic therapies-alone) was sufficient to facilitate an increase in tumor-specific antibody production. In some embodiments, the focus is on evaluation of baseline antibody levels, prior to any treatment, and changes in levels of antibodies to given antigens, especially in response to a given therapy treatment. In such embodiments, this antibody testing is performed prior to treatment. The treatment, such as delivery of specialized PEF energy to a target tissue, is then performed and antibody levels are checked at one or more later timepoints to detect changes in the presence of antibodies and therefore response to therapy.

The field of this invention relates to immunohistochemistry (IHC) and in situ hybridization (ISH) for the targeted detection and mapping of biomolecules (e.g., proteins and miRNAs) in tissues or cells for example, for research use and for clinical use such by pathologists (e.g., biomarker analyses of a resected tumor or tumor biopsy). In particular, the use of mass spectrometric imaging (MSI) as a mode to detect and map the biomolecules in tissues or cells for example. More specifically, the field of this invention relates to photocleavable mass-tag reagents which are attached to probes such as antibodies and nucleic acids and used to achieve multiplex immunohistochemistry and in situ hybridization, with MSI as the mode of detection / readout. Probe types other than antibodies and nucleic acids are also covered in the field of invention, including but not limited to carbohydrate-binding proteins (e.g., lectins), receptors and ligands. Finally, the field of the invention also encompasses multi-omic MSI procedures, where MSI of photocleavable mass-tag probes is combined with other modes of MSI, such as direct label-free MSI of endogenous biomolecules from the biospecimen (e.g., tissue), whereby said biomolecules can be intact or digested (e.g., chemically digested or by enzyme).

This invention belongs to the field of medical device technology and discloses a tumor puncture biopsy positioning device, including a base, a suction cup connected to the base, two mutually perpendicular connecting arms, a lead screw connected to each connecting arm, a groove formed in the connecting arm, a slider connected to the lead screw via a thread, a telescopic component connected to the slider, and a puncture control component connected to the telescopic component. The puncture control component includes an outer housing, a guide cylinder connected to the outer housing, and a pair of speed control components. The speed control component includes a rotating shaft and an inner housing, the rotating shaft connected to a conical cylinder and a rotating wheel, the rotating wheel being located inside the inner housing, and the inner housing containing a shear-thickening fluid. This invention utilizes the suction cup to fix the entire positioning device, resulting in good fixation and precise positioning; the puncture control component controls the puncture of the puncture device, reducing the risk of damage to normal tissue surrounding the lesion and reducing the sharp pain experienced by the patient during the puncture.

1. Name of the product in this design: Tumor puncture sampler. 2. Purpose of this design: Medical device for tumor biopsy. 3. The key design feature of this product is its shape. 4. The image or photograph that best illustrates the design's key points: a 3D model.

The invention discloses a bone tumor biopsy positioning device, and relates to the technical field of medical biopsy instruments, the bone tumor biopsy positioning device comprises a biopsy medical bed, the top of the biopsy medical bed is movably provided with a bed plate, and two sides of the biopsy medical bed are fixedly provided with slide rails. After a driving motor at the end of a supporting plate is started, the motor drives a threaded rod to rotate, through the thread meshing effect of the threaded rod and a threaded block, the threaded block is pushed to move in the axial direction of the supporting plate, the height of a positioning frame is adjusted, and then a rotating shaft extending to the side face of an assembling block is rotated; through the meshing effect of a rotating gear at the end of a rotating shaft and a transmission ring in the positioning frame, the transmission ring is driven to rotate around the axis of the transmission ring, then the internal clamping plate is driven to synchronously rotate to be matched with the clamping angle, the clamping plate can flexibly rotate along with the transmission ring, and the clamping angle can be adjusted according to the growth direction of bone tumors and the optimal angle of biopsy puncture; the limitation of fixed-angle clamping is broken through, the biopsy operation requirements of tumors at different anatomical positions are met, and the reasonability of a puncture path is improved.