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31 results about "Tumor penetration" patented technology
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Furthermore, tumor penetration of nanomedicines is significantly influenced by physicochemical characteristics, such as size, surface chemistry, and shape. The effect of size on tumor penetration has been exploited to design nanomedicines with switchable size to tackle this challenge.
Method of treatment using ligand-immunogen conjugates
InactiveUS7033594B2Improve recognitionEnhance endogenous immune response-mediated eliminationAntibacterial agentsBiocideBinding siteCytotoxicity
A method and pharmaceutical composition are provided for enhancing the endogenous immune response-mediated elimination of a population of pathogenic cells in a host animal wherein the pathogenic cells preferentially express, uniquely express, or overexpress a binding site for a particular ligand. The invention comprises administering the ligand conjugated to an immunogen to a host animal harboring the population of pathogenic cells. Antibodies, preexisting or administered to the host animal to establish a passive immunity, directed against the immunogen bind to the ligand-immunogen conjugate resulting in elimination of the pathogenic cells by the host's immune response. At least one additional therapeutic factor is administered selected from the group consisting of a cell killing agent, a tumor penetration enhancer, a chemotherapeutic agent, antimicrobial agent, a cytotoxic immune cell, and a compound capable of stimulating an endogenous immune response wherein the compound does not bind to the ligand-immunogen conjugate.
Owner:PURDUE RES FOUND INC
Method of treatment using ligand-immunogen conjugates
InactiveUS20060067946A1Improve recognitionEnhance endogenous immune response-mediated eliminationAntibacterial agentsBiocideBinding siteCytotoxicity
A method and pharmaceutical composition are provided for enhancing the endogenous immune response-mediated elimination of a population of pathogenic cells in a host animal wherein the pathogenic cells preferentially express, uniquely express, or overexpress a binding site for a particular ligand. The invention comprises administering the ligand conjugated to an immunogen to a host animal harboring the population of pathogenic cells. Antibodies, preexisting or administered to the host animal to establish a passive immunity, directed against the immunogen bind to the ligand-immunogen conjugate resulting in elimination of the pathogenic cells by the host's immune response. At least one additional therapeutic factor is administered selected from the group consisting of a cell killing agent, a tumor penetration enhancer, a chemotherapeutic agent, antimicrobial agent, a cytotoxic immune cell, and a compound capable of stimulating an endogenous immune response wherein the compound does not bind to the ligand-immunogen conjugate.
Owner:PURDUE RES FOUND INC
Environmental response type anti-tumor nanometer medicine with high medicine loading capacity, carrier and preparation method thereof
InactiveCN108066771AHigh embedding rateGood biocompatibilityOrganic active ingredientsNanomedicineFiberPolyethylene glycol
The invention relates to an environmental response type anti-tumor nanometer medicine with high medicine loading capacity, a carrier and a preparation method thereof. The nanometer medicine comprisesan amphiphilic polymer carrier and a medicine prodrug; the amphiphilic polymer carrier comprises a hydrophilic segment and a hydrophobic segment which are connected mutually; the hydrophilic segment comprises polyethylene glycol or poly(N-(2-hydroxypropyl)methacrylamide); the hydrophobic segment comprises D-alpha-tocopherol succinate; the medicine prodrug comprises a medicine for treating tumor aswell as a hydrophobic chain segment which is connected with the medicine through a chemical bond; and the hydrophobic chain segment comprises D-alpha-tocopherol succinate. The nanometer medicine hasthe characteristics of high medicine loading capacity, environmental responsiveness and adjustable and controllable grain size, and can achieve the properties that the tumor penetration ability is high, the tumor cell multidrug resistance is achieved, drug-resistant cells are killed in advance, tumor related fibroblast is not killed and tumor stem cells can be killed effectively according to composition of different polymers and the loaded prodrug molecule types.
Owner:北京思如诺科技有限公司
Nucleic acid-drug-loaded nano material for improving tumor permeability through VEGF response and preparation method and application thereof
ActiveCN112451666AGood biocompatibilitySmall sizeEnergy modified materialsMacromolecular non-active ingredientsAptamerBiocompatibility
The invention discloses a nucleic acid-drug-loaded nano material for improving tumor permeability through VEGF response. The nucleic acid-drug-loaded nano material comprises a drug-loaded nanoparticlecore and a nucleic acid shell, wherein the nucleic acid shell comprises DNA1, DNA2, DNA3 and DNA4, and the DNA3 contains a V7T1 aptamer for specifically recognizing VEGF protein. Due to that the DNA3contains the VEGF aptamer, the VEGF protein overexpressed in a tumor microenvironment can be specifically recognized, so that the DNA3 and the DNA4 fall off from nucleic acid-drug-loaded nanoparticles, and the DNA2 / DNA1 modified albumin drug-loaded nanoparticles are small in particle size and have good tumor permeability; and the whole nucleic acid-drug-loaded nano material is mainly composed ofnucleic acid and protein and has good biocompatibility. The invention further discloses a preparation method and application of the nucleic acid-drug-loaded nano material. The preparation method is simple in operation and low in cost.
Owner:湖南长星生物医药有限公司
Deep-penetrating nano drug delivery system having tumor microenvironment responsiveness
InactiveCN107308457AOrganic active ingredientsPharmaceutical non-active ingredientsTumor targetSide effect
The invention belongs to the field of medicinal preparations and relates to a nano drug delivery system having tumor microenvironment responsiveness and a preparation method and application thereof. The nano drug delivery system consists of biodegradable hyaluronic acid, dendritic polymer and a chemotherapeutic drug. A framework is the hyaluronic acid (HA), and a small-particle-diameter dendritic polymer material is a chemotherapeutic drug carrier. The preparation method of the system comprises the steps of preparation of a dendritic polymer kernel and preparation of responsive tumor-targeted nanoparticles. The HA in the system can achieve tumor targeting, and the toxic and side effects of the drug delivery system on the normal tissues are reduced. In addition, the HA produces responsive particle size degradation under the effect of high-expressed hyaluronidase in a tumor microenvironment, the small-particle-diameter drug delivery nanoparticles are released, deep tumor penetration is achieved, retention and accumulation of drugs at tumor parts are increased, and accordingly the treating effect is improved.
Owner:SICHUAN UNIV
Antibody prodrug conjugate and preparation and use thereof
ActiveCN109939242AStrong penetrating powerSmall toxicityOrganic active ingredientsAntiinfectivesSide effectWilms' tumor
The invention discloses an antibody prodrug conjugate and preparation and application thereof. The antibody prodrug conjugate is formed by coupling an antibody and a prodrug molecule with a protectedfunctional group through a linker responding to a microenvironment, and has a structure shown in the description, wherein Ab is the antibody, L represents a connecting unit for connecting the antibodyand a drug molecule, D represents the drug molecule, X represents the protected functional group on the drug molecule, and Cage represents a protecting group. The antibody prodrug conjugate has enhanced tissue penetration and lower toxic and side effects, and can be used for treating tumors, immune diseases or infectious diseases. In particular, the antibody prodrug conjugate targeting the tumorsis stimulated by a tumor microenvironment to release the prodrug molecule, the prodrug molecule do not kill normal cells and are specifically activated after penetrating into tumor tissues, and compared with existing ADC drug molecules, the antibody prodrug conjugate improves tumor penetration, reduces the toxic and side effects, and has a good tumor treatment effect.
Owner:PEKING UNIV
Construction of drug penetration dynamic model based on three-dimensional cell model and application of drug penetration dynamic model to drug evaluation
The invention creatively discloses a drug penetration dynamic evaluation method based on a three-dimensional cell model. The method comprises the steps that (1) a three-dimensional somatic cell model and a "penetration dynamics" mathematic model are established, the penetration behavior of an antitumor drug in somatic cells and an accumulation process in all layers of cells are described semi-quantitatively, and fitting is performed to obtain corresponding dynamic parameters; (2) drug concentrations in all layers of cells at different time points after the drug is given according to different concentrations can be subjected to backward prediction based on the obtained dynamic parameters, and the prediction result is highly consistent with an experience result; (3) biological factors influencing characteristic dynamic parameters are analyzed, the penetration behavior of the drug in tumor tissue is speculated according to a plasma drug concentration time course, and the speculation result is highly consistent with an experiment result; and (4) the model and the evaluation method are applied to a second-phase clinical drug INNO-206, and reasons for superiority of the clinical effect of the drug to that of doxorubicin are expounded from the aspect of in-tumor penetration, so that the universality of the method is further verified.
Owner:CHINA PHARM UNIV
Polypeptide, targeted drug carrier, preparation method of targeted drug carrier, pharmaceutical composition, and preparation method of pharmaceutical composition
InactiveCN103936829AEfficient targetingStrong tumor penetration abilityOrganic active ingredientsPeptidesOrganic solventMedicine
The invention discloses a polypeptide, which contains an amino acid sequence represented by the SEQ ID No.1. The invention also discloses a targeted drug carrier and a preparation method thereof. The preparation method comprises the following step: contacting the polypeptide provided by the invention with a drug carrier containing a group represented by the formula (1) so as to form a covalent linkage, which is represented by the formula (2), between the polypeptide and the drug carrier. The invention also discloses a pharmaceutical composition and a preparation method thereof. The preparation method comprises the following steps: (1) mixing a hydrophobic drug with a substance containing the targeted drug carrier mentioned above in an organic solvent, drying to remove the organic solvent so as to obtain a dried material; (2) contacting the dried material with a buffer solution. The polypeptide, targeted drug carrier, and pharmaceutical composition all have a high efficient targeting property and a very strong tumor penetrating performance.
Owner:THE NAT CENT FOR NANOSCI & TECH NCNST OF CHINA
Doxorubicin prodrug for combined use of tumor penetration enhanced photo-thermal and chemotherapy and preparation method of doxorubicin prodrug
ActiveCN114209824AGive full play to the effect of chemotherapyImprove drug utilizationOrganic active ingredientsDrug photocleavageChemo therapyTumor cells
The invention discloses an adriamycin prodrug for combined use of tumor penetration enhanced photothermal and chemotherapy and a preparation method of the adriamycin prodrug. The preparation method comprises the following steps: after DOX and NPC-PEG-SH react, connecting a sulfydryl end with a photothermal conversion material to synthesize DOX-photothermal conversion nanoparticles; further, a hydrazone bond is introduced into PEG and PCL to prepare pHPP; finally, the DOX-photothermal conversion nanoparticles are coated with the pHPP, and the DOX prodrug is prepared. The nano-drug prepared by the invention has the characteristic of combined use of photothermal and chemotherapy with enhanced in-tumor permeation, and can more effectively resist tumor cells. The nano-drug has an intelligent size regulation strategy, has a large size in blood to enhance long circulation, is disintegrated into small-size DOX-photothermal conversion nano-particles in a tumor to enhance permeation, and can generate heat under near-infrared illumination to release DOX after penetrating into the deep part of the tumor, so as to achieve the purpose of enhancing the penetration of the DOX-photothermal conversion nano-particles. Therefore, the aim of combining photo-thermal and chemotherapy is fulfilled.
Owner:HUAIYIN INSTITUTE OF TECHNOLOGY
Polylactic acid-polyethylene glycol-tumor penetrating peptide compound, preparation and application thereof
InactiveCN103536930AImprove distributionPowder deliveryEmulsion deliveryTumor targetPolyethylene glycol
The invention relates to a polylactic acid-polyethylene glycol-tumor penetrating peptide compound. The compound is a linear segmented copolymer (PLA-PEG-iNGR for short) composed of polylactic acid (PLA), polyethylene glycol (PEG) and a targeting peptide iNGR with tumor penetration performance which are in covalent linkage; the molar ratio of the polylactic acid to the polyethylene glycol to the targeting peptide is 1:1:1. The invention also provides a preparation method of the polylactic acid-polyethylene glycol-tumor penetrating peptide compound. The polylactic acid-polyethylene glycol-tumor penetrating peptide compound can be applied to preparation of a targeted micelle or nanoparticles with tumor penetration performance; the tumor targeting property and the tumor penetration performance are improved.
Owner:SHANGHAI NAT ENG RES CENT FORNANOTECH
Preparation method and application of shrinking particle size type tumor penetrating nano system sensitive to FAP-Alpha (fibroblast activation protein alpha) enzyme and reducing environment
ActiveCN106729746AOvercoming biological barriersThe synthesis process is simpleOrganic active ingredientsPharmaceutical non-active ingredientsSide effectBiocompatibility Testing
The invention relates to a preparation method and application of a shrinking particle size type tumor penetrating nano system sensitive to FAP-Alpha (fibroblast activation protein alpha) enzyme and reducing environment, and effectively solves the problem that a traditional drug delivery system has poor targeting performance, high toxic and side effects, single functionality, poor penetrating performance and difficulty in overcoming tumor microenvironment bio-barrier. According to the technical scheme to solve the problem, doxorubicin is connected with polyamidoamine through disulfide bonds as linker arms to form reduction-sensitive nanoparticles, the nanoparticles are connected with polypeptides linker arms sensitive to FAP-Alphaj to form the shrinking particle size type tumor penetrating nano system sensitive to FAP-Alpha enzyme and reducing environment; the shrinking particle size type tumor penetrating nano system sensitive to FAP-Alpha enzyme and reducing environment has the advantages of good biocompatibility, sensitiveness to enzymes and reducing environments, and capability to effectively overcome tumor microenvironment bio-barrier, and belongs to innovation on drug preparations for tumor therapy.
Owner:ZHENGZHOU UNIV
Targeted DNA nano-probe and preparation and application thereof
InactiveCN105331613AGood biocompatibilityPrecise size controlIn-vivo testing preparationsDNA preparationBase JA-DNA
The invention discloses a targeted DNA tetrahedron nano-probe and preparation and application thereof. A DNA single chain marked with Cy5 and other three DNA chains with specific base sequences are added to a Tris-MgCl2 solution for mixing and reacting, and a DNA tetrahedron, namely, TDN is obtained; the DNA tetrahedron solution and a tumor penetration peptide solution with certain concentration are mixed, and through a click reaction, a targeted DNA tetrahedron, namely, targeted TDN is synthesized; thirdly, the targeted DNA tetrahedron solution is added to a concentration centrifugal tube, residual micromolecules in reaction liquid are centrifugally removed, precipitate is resuspended in TMbuffer (10mM Tris base, 50mM MgCl2, pH=8), and then the targeted DNA nano-probe can be obtained. Cy5 fluorescent molecules are modified on the DNA tetrahedron and connected with targeted polypeptide, and the probe has targeting and in-vivo near-infrared imaging functions.
Owner:SHANGHAI NAT ENG RES CENT FORNANOTECH
A kind of amphiphilic hydroxyethyl starch coupled cholesterol polymer and nano drug loading system
ActiveCN113105566BGood biocompatibilityUniform particle sizePowder deliveryOrganic active ingredientsHydroxyethyl starchPolymer science
The invention provides an amphiphilic hydroxyethyl starch-coupled cholesterol polymer, which is formed by the acylation reaction of carboxylated cholesterol and aminated hydroxyethyl starch. The invention also provides a Penetrating nano drug-carrying system and its preparation method. An amphiphilic hydroxyethyl starch-coupled cholesterol copolymer provided by the present invention can be prepared into spherical nanoparticles loaded with indocyanine green by ultrasonic emulsification and high-pressure homogenization, and then continue Illuminate it with a near-infrared laser to prepare a "sea urchin-shaped" nanocarrier with stable structure, good biocompatibility, and good deep tumor penetration effect.
Owner:XIEHE HOSPITAL ATTACHED TO TONGJI MEDICAL COLLEGE HUAZHONG SCI & TECH UNIV
Preparation method and application of particle size-shrinking tumor-permeable nanosystem sensitive to fap-α enzyme and reducing environment
ActiveCN106729746BOvercoming biological barriersThe synthesis process is simpleOrganic active ingredientsPharmaceutical non-active ingredientsDisulfide bondingSide effect
Owner:ZHENGZHOU UNIV
Biotin target-modified photosensitizer and quercetin nano-drug delivery system
ActiveCN109908362AGood water solubilityInhibition of tumor thermotoleranceOrganic active ingredientsOrganic chemistrySolubilityPhotosensitizer
The invention relates to the technical field of a nano-drug delivery system, in particular to a biotin target-modified photosensitizer and a quercetin nano-drug delivery system, aiming to overcome thepoor water solubility and the low bioavailability of a photochemotherapy agent and the quercetin, and the defect of tumor tolerance caused by the photosensitizers in the prior art. The biotin-modified IR780 is co-assembled with the quercetin to form a nanosystem for the first time, not only the shortcomings that the quercetin and the IR780 are insoluble in water and the bioavailability is low aresolved, but also the cancer tolerance caused by the photosensitizers is overcome. The prepared B780 / QuNPs nano-assembly with a diameter of 130 nm, conforms to the size range of tumor infiltration andretention effect, and has good passive and active targeting.
Owner:SHANDONG UNIV
CD133 aptamers for detection of cancer stem cells
InactiveUS9840712B2Rapidly internalisedImprove permeabilityOrganic active ingredientsGenetic material ingredientsAptamerCancer cell
Owner:DEAKIN UNIVERSITY
Composite nano-enzyme for tumor targeting as well as preparation method and application thereof
PendingCN113143959AConvenient treatmentEasy to prepareHeavy metal active ingredientsHydrolasesEndoribonucleaseLactate oxidase
The invention belongs to the technical field of tumor treatment, and discloses a composite nano-enzyme for tumor targeting as well as a preparation method and application thereof. The composite nano-enzyme for tumor targeting is prepared from the following components of, in parts by mass, 6-8 parts of lactate oxidase, 3-5 parts of ribonucleic acid endonuclease, 3-6 parts of deoxyribonucleic acid endonuclease, 2-4 parts of human serum albumin, 1-3 parts of glutathione, 3-4 parts of ammonium ferrous sulfate and 1-2 parts of diazo diammonium salt contrast agent. The composite nano-enzyme prepared by the invention can effectively realize tumor penetration; meanwhile, the ammonium ferrous sulfate wrapped in the composite nano-enzyme has an oxygen carrying function, oxygen can be input into a tumor microenvironment, and tumor treatment is facilitated; and meanwhile, the preparation method of the composite nano-enzyme for tumor targeting is simple, no high-temperature or complex equipment or harsh reaction conditions are needed, and the prepared composite nano-enzyme for tumor targeting is uniform in texture and good in tumor treatment effect.
Owner:王胧庆
Multicomponent lipid complex system with controlled particle size and drug release by tumor microenvironment, its preparation method and application
The present invention takes the anti-tumor microemulsion as the core, and co-encapsulates the microemulsion and certain active drugs in liposomes with the help of lipid materials sensitive to the tumor microenvironment, and the formed lipid complex system can Realize the change in size and the gradual release of drugs, transport different types of drugs to different parts, make the core part complete deeper tumor penetration, and finally release anti-tumor components in tumor cells to exert synergistic anti-tumor drug effects.
Owner:JIANGSU PROVINCE INST OF TRADITIONAL CHINESE MEDICINE
A kind of preparation method and application of EPR effect-enhanced combined drug system
ActiveCN108992399BAchieve penetrationImprove the efficiency of tumor treatmentAerosol deliveryOintment deliveryTumor targetHydroxychloroquine
The invention relates to a preparation method and application of an EPR effect-enhanced combined drug system, which can effectively solve the problem of preparation of antitumor drugs. Substrate, Fe 3+ As a cross-linking agent and gating switch, hydroxychloroquine and compretidine are used as model drugs, and compretidine is used as a blood vessel target molecule to construct a nanogel as an anti-tumor delivery system; the preparation process of the invention is simple and stable Reliable, energy-saving and environmentally friendly, the prepared EPR effect-enhanced combined drug system can efficiently accumulate at the tumor target site to achieve long-term controlled release; under the stimulation of the tumor microenvironment, the particle size can be transformed from large to small, and deep tumor penetration can be achieved; activation Endogenous H 2 o 2 →•OH transformation, used for local and efficient treatment of tumors, the combination of anti-angiogenesis and autophagy inhibition can have a synergistic and significant therapeutic effect, providing a new strategy for improving the efficiency of tumor treatment.
Owner:ZHENGZHOU UNIV
A biotin-targeted photosensitizer and quercetin nano-delivery system
ActiveCN109908362BAchieve targetedImprove anti-tumor effectOrganic active ingredientsOrganic chemistryBiotinAqueous solubility
The invention relates to the technical field of a nano-drug delivery system, in particular to a biotin target-modified photosensitizer and a quercetin nano-drug delivery system, aiming to overcome thepoor water solubility and the low bioavailability of a photochemotherapy agent and the quercetin, and the defect of tumor tolerance caused by the photosensitizers in the prior art. The biotin-modified IR780 is co-assembled with the quercetin to form a nanosystem for the first time, not only the shortcomings that the quercetin and the IR780 are insoluble in water and the bioavailability is low aresolved, but also the cancer tolerance caused by the photosensitizers is overcome. The prepared B780 / QuNPs nano-assembly with a diameter of 130 nm, conforms to the size range of tumor infiltration andretention effect, and has good passive and active targeting.
Owner:SHANDONG UNIV
Preparation and application of a sodium alginate-based anti-tumor drug delivery system with variable particle size gating
ActiveCN109091452BHas the ability to transformIncrease loading capacityOrganic active ingredientsAerosol deliveryPeptide ligandChemotherapy combinations
The invention relates to the preparation and application of a sodium alginate-based variable particle size gating antitumor drug delivery system, which can effectively solve the problem of antitumor drug preparation; Peptide ligands were grafted on the sodium acid skeleton, mixed evenly with doxorubicin under ultrasonic conditions, and FeCl was added dropwise 3 A cross-linking agent, which covalently cross-links with -COOH on the molecular skeleton of sodium alginate to form a nano hydrogel, and at the same time packs doxorubicin in the space grid structure of the nano gel, namely; the preparation method of the present invention Simple, energy-saving and environmentally friendly, the prepared anti-tumor drug delivery system has the ability of tumor-triggered phase inversion, which can realize the release of drugs in response to the tumor microenvironment; realize the particle size transformation through the stimulation of the tumor microenvironment, and realize the deep penetration of the tumor; activate endogenous H 2 o 2 →•OH conversion, realize O-free 2 Participating in tumor chemokinetics-chemotherapy combination therapy, providing new ideas for improving the efficiency of chemotherapy drugs for tumor treatment.
Owner:ZHENGZHOU UNIV
Polylactic acid-polyethylene glycol-tumor penetrating peptide compound, preparation and application thereof
The invention relates to a polylactic acid-polyethylene glycol-tumor penetrating peptide compound. The compound is a linear segmented copolymer (PLA-PEG-iNGR for short) composed of polylactic acid (PLA), polyethylene glycol (PEG) and a targeting peptide iNGR with tumor penetration performance which are in covalent linkage; the molar ratio of the polylactic acid to the polyethylene glycol to the targeting peptide is 1:1:1. The invention also provides a preparation method of the polylactic acid-polyethylene glycol-tumor penetrating peptide compound. The polylactic acid-polyethylene glycol-tumor penetrating peptide compound can be applied to preparation of a targeted micelle or nanoparticles with tumor penetration performance; the tumor targeting property and the tumor penetration performance are improved.
Owner:SHANGHAI NAT ENG RES CENT FORNANOTECH
A kind of nucleic acid-drug-loaded nanomaterial that increases tumor permeability in response to vegf and its preparation method and application
ActiveCN112451666BGood biocompatibilitySmall sizeEnergy modified materialsMacromolecular non-active ingredientsAptamerAlbumin
Owner:湖南长星生物医药有限公司
Nano-engineered stem cell anti-tumor targeting drug delivery system as well as preparation method and application thereof
ActiveCN114848844AAvoid degradationIntegrity guaranteedOrganic active ingredientsPharmaceutical non-active ingredientsTumor targetMetformin hcl
The invention discloses a nano-engineered stem cell anti-tumor targeted drug delivery system, a preparation method and application, the targeted drug delivery system is composed of a delivery drug, a nano drug delivery carrier and stem cells, the stem cells are mesenchymal stem cells MSCs, the delivery drug is paclitaxel (PTX) and metformin hydrochloride (MET), the nano drug delivery carrier is a nano-engineered stem cell anti-tumor targeted drug delivery system, and the nano-engineered stem cell anti-tumor targeted drug delivery system is a nano-engineered stem cell anti-tumor targeted drug delivery system. Thioether bonds are covalently bound to the surfaces of MSCs (mesenchymal stem cells) to construct a nanoparticle-mesenchymal stem cell drug delivery system for targeted therapy of spinal glioma; the drug delivery system can retain tumor tropism and tumor infiltration capacity of MSCs, can effectively inhibit tumor cell growth in vivo and in vitro, promotes tumor cell apoptosis, and achieves a good anti-tumor effect.
Owner:CHINA PHARM UNIV
A ferritin nanoparticle of C-terminally modified tumor penetrating peptide rgerppr, its preparation method and application
ActiveCN112426534BStrong targetingStrong cytotoxicityPolypeptide with localisation/targeting motifOrganic active ingredientsPharmaceutical drugDrug targetting
The invention discloses a C-terminally modified tumor-penetrating peptide RGERPPR ferritin nanoparticle, its preparation method and application. The C-terminal modification of the ferritin nanoparticles of the tumor-penetrating peptide RGERPPR connects the tumor-penetrating peptide RGERPPR to the C-terminus of the ferritin through a linker sequence, and the tumor-penetrating peptide RGERPPR is exposed to the outside of the ferritin. The ferritin nanoparticles of the C-terminal modified tumor penetrating peptide RGERPPR of the present invention have strong targeting ability and cell penetrating power, and can have a strong combination with tumor cells, and the prepared antitumor drug has a strong Cytotoxicity provides a very good carrier model for subsequent drug-targeted tumor cell therapy and has a good application prospect.
Owner:埃特尼特(上海)生命科学有限公司
Titanium dioxide-gold nanorod asymmetric nano composite material as well as preparation method and application thereof
PendingCN112316143ASynthetic raw materials are cheapSimple methodMaterial nanotechnologyPhotodynamic therapyHypoxic tumorGold nanorod
The invention discloses a titanium dioxide-gold nanorod asymmetric nano composite material as well as a preparation method and application thereof. The nano composite material has an asymmetric structure that titanium dioxide is in direct contact with one end of a gold nanorod by taking one end of the gold nanorod as a growing point of the nano titanium dioxide, wherein the length-diameter ratio of the gold nanorod is about 2.5-3.5, and the thickness of the titanium dioxide in direct contact is 7-20 nanometers; nano composite particles have relatively good tumor permeability due to small sizeand are absorbed in a near-infrared light region of 650-900 nanometers with relatively strong penetrating power, and PEG and fluorescent molecules-PEG are used for surface modification to enhance thebiocompatibility. The material can be used for near-infrared illumination based suitable photothermal and better photodynamic synergistic treatment of hypoxic tumors; and a synthesis method of the nano composite particles has the advantages of convenience in operation, cheap raw materials, simplicity in separation and the like.
Owner:DALIAN UNIV OF TECH
A chip device and method for simulating tumor penetration in vitro
ActiveCN110938546BHigh Density FeaturesHigh osmotic propertiesBioreactor/fermenter combinationsBiological substance pretreatmentsHigh densityTumor tissue
The invention discloses a chip device and method for simulating tumor penetration in vitro. The chip device includes a chip; the chip is provided with at least one chamber; the chamber is provided with at least one structure for fixing cell spheres and at least one baffle structure, after the fluid flows into the chamber from the fluid inlet of the chamber, the baffle structure Under the barrier of the fixed cell sphere, the fluid flows out of the chamber through the fluid outlet of the chamber; the space size of the chamber is smaller than the space size of the three-dimensional tumor cell sphere at least in one dimension, and can accommodate at least one cell sphere. The chip device of the present invention can simulate the high density and high osmotic pressure characteristics of tumor tissue to a certain extent; can reflect the characteristics of nanoparticles and macromolecules penetrating into the tumor through convective mass transfer on the tumor surface; Predicting the penetration behavior of granular drugs in tumors is of great significance for the development, evaluation and quality monitoring of macromolecular and nanoparticle anti-tumor drugs.
Owner:TSINGHUA UNIV
Method for preparing camptothecin drug nanocrystals by using reversible decomposition method
ActiveCN110759928APreserve antitumor activityImprove permeabilityOrganic active ingredientsPowder deliverySide effectPharmaceutical drug
The invention provides a method for preparing camptothecin drug nanocrystals by using a reversible decomposition method. The nanocrystals provided by the invention are needle-shaped or rod-shaped andcan be free of any auxiliary materials, so that the antitumor activity of the drug is retained, the tumor penetration effect of the drug is enhanced, and the toxic and side effects are reduced; and the preparation process is simple and suitable for industrial production, and has broad application prospects.
Owner:SICHUAN UNIV
Preparation of Camptothecin Drug Nanocrystals by Reversible Decomposition
ActiveCN110759928BPreserve antitumor activityImprove permeabilityOrganic active ingredientsPowder deliverySide effectPharmaceutical Aids
The invention provides a method for preparing camptothecin drug nanocrystals by using a reversible decomposition method. The nano crystal provided by the invention is needle-shaped or rod-shaped, does not contain any auxiliary material, retains the anti-tumor activity of the drug, enhances the tumor penetration effect of the drug, and reduces toxic and side effects. The preparation process is simple, suitable for industrial production, and has broad application prospects.
Owner:SICHUAN UNIV
Complex analysis system of spectrophotometry and ultrasound images and data for automatic early-stage diagnosing of malignant skin tumors
ActiveUS20200390383A1Efficient inspectionSafe wayOrgan movement/changes detectionDiagnostics using spectroscopySurgical removalMalignancy
Disclosed is a system and a method to analyze spectrophotometry and ultrasound images and data in a complex way to diagnose malignant skin tumors in early stages. The system consists of a high-frequency portable ultrasonic imaging device for in vivo skin examinations, an optical spectrophotometer with light sources of different wavelengths for skin chromophore registration, and a complex data processing algorithm providing an advisory diagnostic evaluation. This enables automatically aggregating data and quantitative estimates obtained by different imaging techniques for melanocyte-derived skin tumors, facilitating the decision support for acceptance of the final clinical diagnosis and treatment planning. The system allows simultaneous analysis of images recorded by devices with different physical principles, automatic separation of the tumor area and evaluation the depth of the tumor penetration into the superficial tissue, which is essential for the selection of further testing and treatment tactics, and the planning of surgical removal procedures.
Owner:KAUNO TECHNOLOGIJOS UNIVTAS +1
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