53 results about "Alimentary tracts" patented technology

This invention discloses a method for identifying lesion regions in gastrointestinal images based on a visual language model. It combines the cross-modal feature alignment capability of the visual language model, a medical semantic guidance mechanism, and a data imbalance handling strategy. By constructing a matching relationship between images and corresponding text categories, it achieves the identification of gastrointestinal lesions. This method introduces a bidirectional contrastive learning loss, enhancing the discriminative ability of different lesion categories while maintaining consistency between image features and text semantics. Furthermore, to address the uneven distribution of lesion categories in the training data, this invention introduces a category weighting mechanism and sampling strategy, allowing minority class samples to obtain higher weights or higher frequencies during training, effectively improving the identification accuracy and model stability of minority class lesions. During the inference stage, classification is completed by calculating the similarity between the image and all categories of text features, achieving the identification and classification of various gastrointestinal endoscopic images without the need for additional labeled data or complex training.

The present invention relates to an artificial digestive tract tissue for training in endoscopic submucosal dissection (ESD) and a method for manufacturing the same. Specifically, the invention relates to an artificial digestive tract tissue configured to mimic the mucosal layer, submucosal layer, and muscle layer constituting the human digestive tract tissue in a multilayer structure, such that swelling occurs upon liquid injection and a color change occurs due to changes in salt concentration, and to a casting and curing-based hydrogel molding process for manufacturing the same. According to the present invention, the problems associated with existing animal tissue-based ESD training simulators can be resolved, repeated use is possible, and training tailored to the structural characteristics of specific organs (stomach, large intestine, small intestine, etc.) is possible.

The application provides a kind of based on digestive tract tissue protein expression abundance determination method and system, applied to digestive tract tissue image processing technical field. Including: based on the PVDF membrane image after color development of digestive tract tissue acquisition in vitro, contain at least one protein standard band and the protein band of multiple target proteins;When determining the presence of electrophoresis distortion according to the band of target protein standard, construct pixel space coordinate system;The target image is obtained by angle correction and linear repair to PVDF membrane image, and the protein band corresponding to multiple target proteins in target image is in horizontal alignment state under pixel space coordinate system;Determine the development area of each target protein in target image and the irregular region of interest wrapped the protein band corresponding to multiple target proteins, and for each target protein, the expression abundance of target protein is obtained by analyzing the development area and the irregular region of interest, and the accuracy of the protein expression abundance is higher.

This invention discloses a low glycemic index (GI) Hericium erinaceus (monkey head mushroom) steamed bun, belonging to the field of food processing and functional food applications. By weight, it is prepared from the following raw materials: 45-55 parts all-purpose flour, 28-35 parts Hericium erinaceus extract powder, 0.3-0.35 parts yeast, 15-18 parts water, 0.3-0.6 parts oil, and 0.7-0.9 parts sugar. This invention partially replaces the flour with Hericium erinaceus extract powder, fully utilizing the multiple mechanisms of action of Hericium erinaceus polysaccharides in forming a viscous gel in the digestive tract to slow down the contact between amylase and substrate, inhibiting α-amylase and α-glucosidase activity, and improving intestinal microecology and enhancing insulin sensitivity through dietary fiber. This allows the product to meet the low-GI food standard (GI<55), effectively filling the gap in low-GI steamed buns with Hericium erinaceus functional components as the core active ingredient. It has significant application value in the fields of diabetes management, weight control, and healthy staple foods.

The application discloses application of Gastrodia elata extract in preparation of a feed additive for resisting Aeromonas hydrophila infection, and belongs to the technical field of water animal disease prevention and treatment. The application first finds that the Gastrodia elata extract has a significant effect of inhibiting Aeromonas hydrophila infection. After the Gastrodia elata extract is added into water animal feed as a feed additive and is fed to the water animal, the Gastrodia elata extract is absorbed into blood circulation system through a digestive tract, up-regulates intestinal immunoglobulin gene expression, improves serum immunoglobulin level, enhances intestinal barrier function, improves animal activity, effectively resists Aeromonas hydrophila infection, reduces disease occurrence, and improves yield and quality of animal breeding. Therefore, the Gastrodia elata extract has a good application prospect.

An endoscope auxiliary device for gastrointestinal polyp measurement mainly comprises a polyp scale, a pushing tube and an operating handle, overcomes the estimation error caused by the fish-eye lens distortion and zoom of the existing technology, and fills the technical gap of accurate physical measurement of polyp shape. At the same time, in addition to being used for physical measurement of the size of polyps in the digestive tract under the endoscope, the device can also be combined with the endoscope administration tube to realize the clinical functions including polyp measurement, lavage, spraying of liquid medicine and contrast.

The present invention provides a temperature-corrected analyte detection method, and relates to the following steps: after a series of analyte calibrators with different concentrations are added into an immunoassay test strip, using an optical analyzer to measure, at each segmented temperature point, a signal value generated after the analyte calibrator of each concentration is captured on a detection pad of the immunoassay test strip; drawing a corresponding equation by taking a T / C value at each segmented temperature point as an X axis and the concentration of the analyte calibrator as a Y axis; and then, performing temperature segmentation according to n selected segmented temperature points, and in different temperature segments, using different formulas to perform calculation. The temperature-corrected analyte detection method can be used for more accurately detecting myocardial markers, upper respiratory tract viral infections, metabolic hormones, gastrointestinal panel markers, allergens, and the like on the basis of time-resolved fluorescence immunoassay.

This invention discloses an inference method and system for gastrointestinal endoscopic images based on a multimodal large model. The method includes: removing redundant background from the gastrointestinal endoscopic image input to the visual encoder in the multimodal large model based on the sparsity of feature distribution; calculating the local probability density, self-information, and global dependency score of the visual token in the gastrointestinal endoscopic image; calculating the retained score vector of the visual token by weighting the self-information and global dependency score; performing a first pruning process on the gastrointestinal endoscopic image based on the retained score vector; and inputting the pruned gastrointestinal endoscopic image and text information into the decoder in the multimodal large model for decoding to obtain the inference result of the gastrointestinal endoscopic image. This invention improves inference performance by pruning the gastrointestinal endoscopic image and extracting effective information before inference.

1. Name of the product in this design: Suction connector (2). 2. Purpose of this design: To connect the suction connector (2) to the suction tube of the suction device when there is gastrointestinal bleeding. 3. The key design feature of this product is its shape. 4. The image or photograph that best illustrates the design's key points: a 3D model.

To provide a pediatric surgical device for removing metal objects from the digestive tract. [Solution] The pediatric surgical device has an adjustable frame 1, with position-limiting rings 2 fixedly connected to both the left and right side walls of the adjustable frame, a contact plate 3 provided above the adjustable frame, a sliding rod 4 fixedly connected to the lower end of the contact plate, the lower end of the sliding rod passing through the upper side wall of the adjustable frame and fixedly connected to a traction rope 7, an elastic storage mechanism 6 provided at the lower end of the extension outer tube 5, and a clamping mechanism provided at the lower end of the traction rope. By installing the elastic storage mechanism, the entire foreign object is softly encased after being clamped, preventing the corners of the foreign object or the edges of the instrument from injuring the gastrointestinal mucosa, thereby significantly improving the safety of pediatric surgical procedures.

This invention relates to a device for electric field therapy of the human digestive tract, comprising: an inner guide rod, an outer sleeve, a rotating ring, and a supporting component, with an electrode array membrane spirally wound around the supporting component. When the supporting component is in a radially contracted state, the invention can be placed within the surgical instrument channel of a commonly used gastroscopy. When the supporting component is in a radially expanded state, it supports the electrode array membrane, enabling accurate electric field therapy of the upper digestive tract, particularly the inner wall of the duodenum.

The present invention relates to the field of probiotics, in particular to an Akkermansia muciniphila MG784 for alleviating constipation, promoting defecation, improving intestinal barrier function and intestinal immunity, and its uses. The Akkermansia muciniphila MG784 provided by the present invention has the deposition number DSM 35549. The Akkermansia muciniphila MG784 provided by the present invention can increase the levels of motilin (MTL), gastrin (GAS), and acetylcholine in the gastrointestinal tract, promote intestinal peristalsis, improve the small intestine propulsion rate, and ameliorate defecation time and fecal output. Furthermore, Akkermansia muciniphila MG784 can also alleviate colonic mucosal inflammation, improve the thickness of the digestive tract muscular layer, modulate the structure of the intestinal microbiota, significantly increase the abundance of beneficial bacteria, and decrease the abundance of harmful bacteria.

The application provides a digestive tract hemorrhage locator, and relates to the field of medical devices, which comprises a probe-in mechanism; an inner part of the probe-in mechanism is fixedly connected with a monitoring structure, a driving mechanism, a second sliding mechanism and a storage mechanism, one side of the monitoring structure is fixedly connected with a first sliding mechanism and a control mechanism, the first sliding mechanism is movably connected with a rotating structure and the driving mechanism, the rotating structure is movably connected with the probe-in mechanism and the monitoring structure, the control mechanism is movably connected with the second sliding mechanism, and the storage mechanism comprises a medicine storage box, a protection box, an extension rod and a partition plate; the protection box is fixedly connected in the inner part of the medicine storage box, the extension rod is fixedly connected in the protection box, one end of the extension rod is fixedly connected with the partition plate through the protection box, and the partition plate is movably connected in the medicine storage box; the medicine storage box can effectively store the powdered medicine, and after the partition plate is lifted through the extension rod, the medicine can be discharged into the patient's body through the hollow slot B and the hollow slot A.

The application discloses a kind of integrated full solid-state antimony microelectrode's intelligent digestive tract vibration capsule, comprising: capsule shell, inner support, vibration motor, main control module, battery, pH sensor, data wireless transmission module, temperature sensor and pressure sensor;Inner support is arranged in capsule shell, vibration motor, main control module, battery, pH sensor, data wireless transmission module, temperature sensor and pressure sensor are all arranged in inner support;Vibration motor, pH sensor, data wireless transmission module, temperature sensor and pressure sensor are connected with main control module, and are controlled by main control module;Main control module is connected with battery, and is powered by battery;The sensing end of pH sensor is worn out capsule shell, and the cladding material of reference electrode is provided with microchannel.The application can detect in-vivo health condition, start vibration for abnormal area, solve the problem of constipation and other problems, solve the problem of transition treatment or insufficient treatment, and will not cause impact to healthy area.

This invention relates to the application of a melanin-catalase nanocomposite (MAC) targeting intestinal mucosal neutrophils in the preparation of drugs for treating inflammatory bowel disease, belonging to the field of novel applications of nanomedicine. It addresses the challenges of catalase oral delivery being easily degraded and inactivated by gastrointestinal proteases and difficult to precisely target neutrophils. This invention is the first to discover a MAC prepared by in-situ polymerization of dopamine on the surface of catalase, which can be used for the treatment of inflammatory bowel disease. This nanocomposite, through oral delivery, precisely targets intestinal mucosal infiltrating neutrophils and maintains structural stability in the gastrointestinal fluid environment, effectively protecting catalase activity. It actively targets intestinal mucosal infiltrating neutrophils through the high affinity of melanin for dopamine D2 receptors, synergistically exerting a triple effect of hydrogen peroxide decomposition, hypochlorous acid scavenging, and iron ion chelation, effectively inhibiting the formation of extracellular traps in neutrophils.

A device for ablation treatment of a digestive tract and a system comprising the same, comprising: an inner tube; an outer tube sleeved outside the inner tube; a rotating tube, the rotating tube being rotatably sleeved outside the inner tube; an electrode film having a contracted state of being radially reduced and an expanded state of being radially increased, the electrode film having an inner electrode film end and an outer electrode film end in a winding direction of the electrode film, the outer electrode film end being fixedly arranged with the outer tube, and the inner electrode film end being fixedly arranged with the rotating tube; and an expandable member having a contracted state of being radially reduced and an expanded state of being radially increased, the expandable member being completely located on one side of the inner tube; when the expandable member is in the contracted state, the electrode film is also in the contracted state, the expandable member is located between the outermost electrode film and the next outermost electrode film, and each layer of electrode film inside the next outermost electrode film is spirally wound on the rotating tube; when the expandable member is in the expanded state, the electrode film is expanded to the expanded state by the expandable member.

The invention discloses a compound preparation suitable for traditional Chinese medicine constitution conditioning and a preparation method thereof. The compound preparation comprises a stepped ternary-quaternary-quinary compound preparation. The ternary complex is based on hydroxypropyl methyl cellulose, fumed silica and silicified microcrystalline cellulose, and digestive tract mucosa protection and body safety tolerance establishment are achieved; in the quaternary compound, resistant dextrin is added on the basis of the ternary compound, so that the digestion function and the defecation rhythm are stable; l-glutamine is further added to the quinary compound on the basis of a quaternary compound, so that the whole body state is harmonized, and nine constitutions in traditional Chinese medicine are balanced. The three components strictly follow a ternary-quaternary-quinary sequence for use, and a complete conditioning path from safe tolerance establishment to intestinal environment regulation to whole body consolidation is formed. The invention provides a preparation process which is high in forming rate, good in stability, resistant to moisture absorption, excellent in reconstituability and suitable for industrial large-scale production.

This invention discloses a method for preparing and applying an antioxidant and intestinal-delivered astaxanthin-loaded microalgae. First, hyaluronic acid-modified astaxanthin liposomes with controlled intestinal release are synthesized. Then, the carboxyl groups on the astaxanthin liposomes are activated using EDC / NHS reagents to couple with the amino groups on Chlorella. After oral administration, this drug-loaded microalgae can effectively remain in the intestinal tract and gradually degrade, slowly releasing astaxanthin. This significantly increases the astaxanthin concentration in the intestine, maximizing astaxanthin absorption and utilization while minimizing astaxanthin loss through the digestive tract. The astaxanthin released by this drug-loaded microalgae after simulated gastrointestinal digestion exhibits strong free radical scavenging and antioxidant capabilities in its polar ketone structure, showing broad application prospects in health and nutrition aspects such as anti-inflammation, photoprotection, immune enhancement, and anti-aging.

This invention discloses a selenium-enriched feed additive for beef cattle and its feeding method, belonging to the field of animal nutrition and feed technology. It comprises the following raw materials in parts by weight: 12-22 parts yeast selenium, 5-10 parts nano selenium, 8-15 parts L-selenomethionine, 3-8 parts methionine o-selenoclidinium, 300-400 parts fermented puffed corn flour, 150-200 parts fermented wheat bran, 10-15 parts vitamin E, 20-30 parts L-lysine salt, 15-25 parts DL-methionine, 150-200 parts compound minerals, 0.5-1.5 parts antifungal agent, and 0.1-0.5 parts antioxidant. This invention uses methionine o-selenoclidinium to bind and target the selenium source, synergistically combining the advantages of three selenium sources to solve the problems of low selenium bioavailability, poor digestive tract stability, and insufficient targeted deposition in muscle, thereby improving absorption efficiency, ensuring processing stability, and optimizing selenium deposition and safety in meat products.

The application relates to the technical field of medical devices, and particularly discloses a transnasal digestive tract exploration device, which can wipe and remove mucus, digestive juice, food residues and secretions attached to the outer wall of a guide member in real time during the process of extracting the guide member from the human digestive tract through an integrated clean interface assembly, so as to prevent pollutants from dropping along the outer wall of the guide member to the face, lips and clothes of a patient, and to effectively protect the clean dignity and clinical operation neatness of the patient. The transnasal digestive tract exploration device comprises a guide member and a clean interface assembly. The guide member is used for being placed into the human digestive tract through the nasal cavity. The clean interface assembly is movably sleeved outside the guide member and detachably connected with the guide member. A clean interface piece is detachably arranged on the inner side of the clean interface assembly. The clean interface piece is attached to the outer wall of the guide member and used for wiping and removing the attachments on the outer wall of the guide member when the guide member is extracted from the human digestive tract.

The utility model relates to a kind of for gastrointestinal tract's frozen balloon ablation device and ablation system, the ablation device includes elongated carrier, balloon carried by the elongated carrier, and refrigerant pipe for input refrigerant, wherein, the balloon has the balloon cavity capable of swelling, the refrigerant pipe has refrigerant outlet, and the refrigerant outlet is communicated the balloon cavity.When the ablation device is used for the ablation treatment of gastrointestinal tract, after the balloon is sent into the treatment site of gastrointestinal tract by elongated carrier, the balloon is inflated, refrigerant is injected into refrigerant pipe, the refrigerant can be vaporized to form low temperature after entering balloon cavity, so that surrounding tissue is frozen, thereby reaching the purpose of ablation treatment. The ablation device can be used in combination with endoscope, and both can enter or exit from gastrointestinal tract in human body, which is more convenient to operate.

The application relates to the technical field of feed additives, in particular to a feed additive for degrading vomitoxin and application, wherein the feed additive for degrading vomitoxin is composed of, in percentage by weight, Bacillus altitudinis G-1 bacterial liquid: 10-30%; solid carrier: 70-90%. Efficient and stress-resistant Bacillus altitudinis G-1 is obtained through screening, the fermentation liquor is mixed with the treated solid carrier, and low-temperature or spray drying is adopted for shaping. The strain can secrete specific degradation enzyme system to efficiently convert vomitoxin, and can maintain activity in processing and digestive tract environment by virtue of wide temperature range and wide pH tolerance characteristics; in combination with the protection and slow-release effect of the carrier, efficient degradation of vomitoxin and synchronous inhibition of mold growth are realized, and the problems of limited efficiency of existing degradation strains, unstable activity in complex environment and lack of mold regeneration inhibition capacity are solved.

This invention provides a triple-coupled SERS substrate, its preparation method, and its applications. This triple-coupled SERS substrate achieves excellent signal amplification and can acquire rich SERS bands for both single and multi-component components. A robust machine learning classifier is used to identify and analyze the acquired serum metabolic Raman spectral features, demonstrating high clinical accuracy, sensitivity, and specificity in differentiating between gastrointestinal malignancies and healthy human samples. Serum metabolic analysis based on the triple-coupled SERS substrate constructed in this invention provides a promising solution to the clinical challenge of differentiating gastrointestinal malignancies and can be further expanded into clinical cancer detection based on other biological fluids.

The application provides a traditional Chinese medicine external application composition for treating benign breast disease and preparation and application thereof, and belongs to the technical field of traditional Chinese medicine compositions, and is used for solving the problems of slow effect, large side effect and poor compliance of existing drugs for treating benign breast disease. The composition is composed of Tribulus terrestris 8-12 parts, Taraxacum officinale 8-12 parts, Pheretima 2-4 parts, Cornu Cervi 8-12 parts, mirabilite 16-24 parts, Pericarpium Citri Reticulatae Viride 10-14 parts, Swertia 8-12 parts, Ophiocordyceps sinensis 2-4 parts and borneol 1-3 parts. The medicinal materials are prepared into an external application powder, and the breast part is externally applied before sleep, and the application time is more than 6 hours each time. The application adopts external use and transdermal administration, has fast effect, no digestive tract stimulation and liver and kidney burden, is convenient to use, has high compliance, and is clinically verified to have exact curative effect on mastalgia, breast hyperplasia and benign breast nodules (including BI-RADS 3 and 4a nodules), has high safety, and is suitable for long-term conditioning of benign breast disease.

This invention proposes a multi-degree-of-freedom gastrointestinal surgical robot system, belonging to the field of medical robot technology. It includes a platform with a pair of guide rails on its end face; a main arm drive device mounted on the platform, its output end connected to one end of the main arm to provide power to the main arm, which is hollow inside; a deployment mechanism mounted on the other end of the main arm away from the platform; two sub-arm drive devices respectively mounted on the platform and slidably connected to the guide rails; the output ends of the two sub-arm drive devices pass through the main arm and extend into the deployment mechanism to provide power to the deployment mechanism; the deployment mechanism includes a snake-bone tube and a force-sensitive elastomer clamping unit. The snake-bone tube includes several sequentially arranged rotary joints, adjacent rotary joints are hinged together, the interior of the first rotary joint communicates with a channel inside the main arm, and the last rotary joint is connected to the force-sensitive elastomer clamping unit. Clamping force and three-dimensional force sensing are achieved through inverse kinematics calculation.

This invention relates to the field of feed additive technology, and discloses a pet compound probiotic preparation rich in functional nutrients and its application. The pet compound probiotic preparation comprises the following components in parts by weight: compound matrix powder: 38.0-50.0 parts; Enterococcus faecium freeze-dried powder: 4.0-5.2 parts; Lactobacillus plantarum freeze-dried powder: 7.8-8.2 parts; trisodium citrate: 3.0-3.5 parts; L-glutamine: 16.5-20.0 parts; β-glucan: 12.4-15.0 parts; the compound matrix powder is made from sodium alginate 25.0-30.0 parts, betaine 5.0-8.0 parts, and calcium carbonate 8.0-12.0 parts. This invention's preparation can resist gastric acid and target intestinal release according to the digestive tract environment, effectively solving the problem of clumping when mixed with high-moisture food, and simultaneously achieving pet microecological regulation and damaged mucosal repair.

The application provides a mass spectrum processing method and system based on digestive tract tissues, and is applied to the technical field of mass spectrum data processing. By acquiring mass spectrum of each digestive tract tissue; the retention time and mass-to-charge ratio information of each main peak in the mass spectrum are automatically extracted to obtain a core feature vector representing the protein abundance of the digestive tract tissue; and the protein identity information associated with the index of the core feature vector is determined; according to the core feature vector of the healthy digestive tract tissue, a first protein abundance is determined; and according to the core feature vector of each of the multiple diseased digestive tract tissues, multiple second protein abundances are determined; the fold change and the significant difference value are calculated according to the first protein abundance and the multiple second protein abundances; the target protein abundance corresponding to the fold change and the significant difference value satisfying the preset condition is determined; and according to the protein identity information corresponding to the target protein abundance, a protein differential quantification list is output. It has high credibility and data traceability.

The application relates to the field of medical systems, in particular to a gastrointestinal hemorrhage prediction analysis system and method based on information planning, which analyzes the damage of food to the digestive tract and the influence of gastrointestinal hemorrhage abnormalities on the food through a multi-source data fusion method, judges the damage risk of food to the digestive tract, improves the edible safety of food, analyzes the chewing habit through a multi-layer perception machine neural network model, evaluates the influence of chewing on food, and then judges the damage of food to the digestive tract after chewing, and improves the accuracy of the damage risk judgment of food to the digestive tract.

The application discloses a kind of extraction determination methods of soil nematode digestive tract microorganism, belong to the field of microbial detection technology. Including the following steps: (1) separation extraction nematode: shallow dish method is used to separate nematode in soil, in turn through washing and screening, shallow dish standing, starvation treatment, concentration and preservation operation;(2) digestive tract microorganism extraction: after species identification to nematode, select the nematode individual of specific nutrition group, after surface microorganism elution treatment, extract digestive tract microorganism DNA;(3) DNA amplification: using primer to the V3-V4 region of digestive tract bacteria 16S rRNA gene and the ITS region of fungal ITS gene is carried out PCR amplification;(4) sequencing and data analysis: after purification and quantification to PCR amplification product, using Illumina MiSeq platform carries out double-end sequencing, original data is split, quality filtering, sequence splicing, chimeric sequence removal, ASV clustering and species annotation processing.

1. Name of the product in this design: Air Pump. 2. Purpose of this design: To inject carbon dioxide gas into the upper and lower digestive tracts during endoscopic diagnosis, treatment, and surgery. 3. The key design feature of this product is its shape. 4. The image or photograph that best illustrates the design's key points: a 3D model.