252 results about "Alimentary tracts" patented technology

The invention discloses an integrated front-end driving, active steering and visual digestive tract catheterization system, which belongs to the field of medical apparatus and instruments, and comprises a guide arm comprising a pull wire and an elastic arm, the guide arm is provided with a first end and a second end deviating from each other, and one end of the pull wire is fixedly connected to the first end; the lens is arranged at the first end; the driving part comprises a first annular balloon, a second annular balloon and a cylindrical balloon, and the first annular balloon and the second annular balloon are fixedly connected to the two sides of the cylindrical balloon in the axial direction respectively; when the annular balloon is full, the outer wall expands in the radial direction; when the cylindrical balloon is full, the outer wall extends in the axial direction; the fixing sleeve comprises a flexible sleeve and a connecting base which are fixedly connected, the connecting base is connected with the second end of the guide arm and the first annular balloon, and the end, deviating from the connecting base, of the flexible sleeve penetrates through the driving part and extends in the direction deviating from the guide arm. Through the arrangement, the front end of the nasointestinal tube can be guided and driven at the epiglottis of the nasal cavity and the upper and lower digestive tracts.

The application provides an extendable digestive tract cannula and application thereof, and relates to the technical field of medical devices. The application comprises a first cannula, a second cannula and a degradable material. Opposite ends of the first cannula are a proximal end and a distal end, respectively. The first cannula is sleeved with the second cannula, and a double-layer structure is formed at the distal end of the first cannula. The double-layer structure is fixed by the degradable material. When the degradable material degrades, the second cannula moves towards the end face of the distal end of the first cannula. By setting the movable second cannula, the second cannula moves backward after the degradable material degrades, so that the length of the digestive tract cannula is extended. Since the length of the digestive tract cannula is increased, the area of intestinal absorption is also increased, the compensatory absorption function of the intestine at the distal end of the digestive tract cannula is weakened, the isolation effect of chyme and the intestine is improved, and the digestion and absorption effect of the intestine can be reduced for a long time.

The invention discloses an intelligent auxiliary diagnosis and grading system for gastrointestinal tumor endoscopic images, which belongs to the technical field of medical image processing and computer-aided diagnosis and comprises a multi-modal image preprocessing and segmentation module, a lesion feature extraction and diagnosis module, a grading and depth evaluation module and a closed-loop feedback optimization module. The system receives white light, a narrow band and an amplified endoscopic image, adaptive segmentation is performed to obtain a lesion area, mucous membrane morphology, capillary and gland features are extracted, Paris classification, Vienna classification and infiltration depth evaluation are realized, and segmentation parameters are subjected to closed-loop optimization according to classification confidence. And intelligent auxiliary support is provided for early diagnosis and treatment decision of gastrointestinal tumors.

An enhanced hydrogel composition, and a preparation method therefor and the use thereof. According to the composition, a hydrogel is formed by means of a physical cross-linking mechanism using the chelation between calcium ions and an alginic acid raw material, with the assistance of a carboxymethyl cellulose raw material to reduce the sensitivity of the chelation. The hydrogel retains a high water absorption rate of media; meanwhile, the elastic modulus of the hydrogel is significantly enhanced by means of the introduction of silicon dioxide. The method for preparing the composition comprises: dispersing the carboxymethyl cellulose raw material, the alginic acid raw material, and the silicon dioxide in a solution, mixing same uniformly, drying the mixture to obtain a material A, and then mixing the material A with a calcium source to obtain the composition. Further provided is the use of the composition in the preparation of a space-occupying product in the digestive tract.

The invention relates to the technical field of computer vision and medical image processing, and discloses a digestive endoscopy report generation method and device based on a multi-modal large language model. The method specifically comprises the following steps: for a plurality of upper gastrointestinal endoscopy images, extracting a first image feature through a visual encoder to perform anatomical part identification; extracting a second image feature from the first image feature by using a self-attention mechanism to perform background gastric mucosa classification; generating description about digestive tract diseases through a large language model, and under the guidance of the description, extracting third image features from the first image features to perform digestive tract disease classification; the constructed text instruction about report generation and the third image feature are combined and then input into a multi-mode decoder, and a digestive endoscopy report is generated. According to the method, a plurality of upper gastrointestinal endoscopy image analysis tasks can be processed at the same time, and a digestive endoscopy report which does not depend on a fixed template and has rich context content can be generated with high efficiency and high accuracy.

The degradable duodenum bypass stent system comprises a tubular grid stent and a bypass membrane tube, one end of the bypass membrane tube is fixed to the tubular grid stent, the other end of the bypass membrane tube is a free end, the bypass membrane tube is communicated with the interior of the tubular grid stent, and the bypass membrane tube is arranged in the tubular grid stent. Anchor thorns capable of being embedded into a duodenum bulbar mucous membrane are arranged on the tubular grid stent; all components of the degradable duodenum bypass stent system are made of materials which can be degraded in the human digestive tract environment. All the components of the degradable duodenum bypass stent system are made of materials which can be degraded in the human digestive tract environment, the degraded components can be discharged out of the body through excrement, and then a secondary endoscopic extraction operation can be avoided.

The invention discloses panda-derived tryptophan-producing streptococcus non-lactolyticus C49 and application thereof, and belongs to the field of microorganisms, the strain is preserved in Guangdong Microbial Culture Collection Center, and the preservation number is GDMCC No: 67209. The strain has good acid-resistant and cholate-resistant characteristics, and can ensure that enough biomass passes through stress of a digestive tract environment; whole genome sequencing finds that C49 is significantly related to the pathway and module of tryptophan biosynthesis. Whole genome sequencing and in-vitro fermentation confirm that C49 has tryptophan biosynthesis capability, and in-vivo animal tests confirm that C49 has synthetic nerve conditioning capability. Therefore, as a probiotic feed additive, the streptococcus non-lactolyticus C49 has a good application prospect in the aspects of improving the feed value, improving the intestinal health of animals, enhancing the immunity of organisms and the like.

Use of a bitter melon exosome and an oral medicament prepared therefrom. The bitter melon exosome obtained from the bitter melon juice can be used for preparing a pharmaceutical formulation embedding a protein, a polypeptide, a small molecule peptide, a nucleic acid, or a small molecule compound. The compositions of the oral medicament of the present invention comprise the bitter melon exosome and an active pharmaceutical ingredient encapsulated in the bitter melon exosome. The bitter melon exosome is suitable for preparing a drug that is easily damaged by the gastrointestinal tract and is mostly administered by means of an injection route into an oral agent, and the oral agent can produce a similar therapeutic effect to that of the injection administration route by oral administration, and is convenient to use. The extraction method for the bitter melon exosome is simple and has a low cost. Moreover, the bitter melon exosome has no immunogenicity, has relatively high biocompatibility and biosafety, and has relatively strong tolerance to gastric acid and digestive tract proteolytic enzymes, and intestinal barrier permeability.

Disclosed herein are methods for administering a dose of a microbiota recovery therapy composition by colonoscopy. The methods disclosed herein are useful for the treatment of diseases and / or conditions of the digestive tract, such as Clostridium difficile infection (GDI), including recurrent GDI, and other gastrointestinal disorders. The method can result in improved quality of life. These methods are capable of altering the gut microbiota composition and / or the gut metabolome composition. The microbiota recovery therapy composition comprises a fecal microbiota suspension comprising: a fecal microorganism derived from a human fecal sample, and a solution of polyethylene glycol and brine.

A magnetically-tracked catheter system having a catheter and a magnetic beacon. The catheter has a proximal end and a distal end. The catheter includes a first magnetic sensor disposed at (i.e., near) the distal end. The magnetic beacon is configured to be disposed external to an individual and in a target zone. An operator interface is in electronic communication with the first magnetic sensor. The catheter may further include a guide lumen (and / or other lumen or lumens) extending between the proximal end and the distal end and the configured for use with a guidewire. The catheter may include an occlusion member configured to occlude a vessel or other passage of an individual (e.g, respiratory tract, gastrointestinal tract, etc.).

The application provides an ultrasonic endoscope for detecting digestive tract walls, which comprises a shell, a conveying device, a liquid storage box, a liquid outlet head, a detachable shell and a camera main body; the conveying device is arranged in the interior of the shell; the liquid storage box is arranged in the interior of the shell and on one side of the conveying device; the liquid outlet head is arranged on one side of the conveying device; the detachable shell is arranged at one end of the shell; and the camera main body is installed in the interior of the detachable shell. The ultrasonic endoscope for detecting digestive tract walls can be quickly disassembled and has liquid medicine convenient to replace, through the detachable structure of the liquid storage box and the mounting bracket; the liquid path can be quickly disassembled and sealed without liquid leakage, through the threaded joint structure of the communication sleeve and the communication head; the liquid can be supplemented without disassembling the liquid storage box, through the use of the filling head structure, and the use convenience is improved; the camera main body can be disassembled and washed and is convenient to disinfect, through the split structure of the detachable shell and the transparent cover; and the liquid is automatically supplied, through the conveying pump.

A medical instrument is used for a device, a system and application of digestive tract electric field treatment and comprises a long and thin rod, a sleeve and an expandable component, the expandable component comprises a plurality of supporting rods and an electrode array film, when the long and thin rod slides forwards to a front limit position relative to the sleeve, the expandable component is in a contraction working state, and when the electrode array film slides forwards to a rear limit position relative to the sleeve, the expandable component is in a contraction working state. Each supporting rod is tightly attached to the outer surface of the slender rod; when the slender rod slides backwards relative to the sleeve from the front limit position, the expandable component is in an expanded working state, the front section supporting rods and the rear section supporting rods are in an unfolded umbrella shape, and the electrode array film is in an unfolded state. The device is used for ablating tissues of the alimentary canal and treating diseases such as diabetes mellitus and obesity.

The invention relates to a colon-targeted micro-ecological regulation composition. The colon-targeted micro-ecological regulation composition is prepared by compounding the following functional components in percentage by weight: 5-95% of a component A, 1-15% of a component B and 4-94% of a component C, the component A is resistant starch, the polymerization degree DP is greater than or equal to 15, and the crystallinity is greater than or equal to 35%; the component B is probiotics and is embedded through a complex coacervation method or an extrusion-gel method, the embedding rate is larger than or equal to 75%, and the particle size is 200-800 microns; the survival rate is greater than or equal to 60% after treatment in simulated gastric juice for 2 hours, and the survival rate is greater than or equal to 50% after treatment in simulated intestinal juice for 4 hours; the component C comprises functional nutritional auxiliary materials, the functional nutritional auxiliary materials comprise prebiotics and a medicinal and edible composition, and the prebiotics comprise rapid fermentation type prebiotics, medium-speed fermentation type prebiotics, slow fermentation type prebiotics and a non-fermentation type water-holding expansion component. By constructing a carbon source slow release-flora orientation-metabolism regulation ternary interaction collaborative network, accurate regulation and multi-target metabolism intervention of the whole digestive tract are realized.

This invention discloses a method for identifying lesion regions in gastrointestinal images based on a visual language model. It combines the cross-modal feature alignment capability of the visual language model, a medical semantic guidance mechanism, and a data imbalance handling strategy. By constructing a matching relationship between images and corresponding text categories, it achieves the identification of gastrointestinal lesions. This method introduces a bidirectional contrastive learning loss, enhancing the discriminative ability of different lesion categories while maintaining consistency between image features and text semantics. Furthermore, to address the uneven distribution of lesion categories in the training data, this invention introduces a category weighting mechanism and sampling strategy, allowing minority class samples to obtain higher weights or higher frequencies during training, effectively improving the identification accuracy and model stability of minority class lesions. During the inference stage, classification is completed by calculating the similarity between the image and all categories of text features, achieving the identification and classification of various gastrointestinal endoscopic images without the need for additional labeled data or complex training.

Systems and methods for objective evaluation of a stool sample to determine whether a patient's lower gastrointestinal tract is sufficiently clean to undergo a successful gastrointestinal visualization procedure with favorable visualization. A method includes collecting a stool sample from a patient and assessing the stool sample to determine whether an intestine of the patient is sufficiently clean for the patient to undergo a successful lower gastrointestinal tract visualization procedure.

The present invention relates to an artificial digestive tract tissue for training in endoscopic submucosal dissection (ESD) and a method for manufacturing the same. Specifically, the invention relates to an artificial digestive tract tissue configured to mimic the mucosal layer, submucosal layer, and muscle layer constituting the human digestive tract tissue in a multilayer structure, such that swelling occurs upon liquid injection and a color change occurs due to changes in salt concentration, and to a casting and curing-based hydrogel molding process for manufacturing the same. According to the present invention, the problems associated with existing animal tissue-based ESD training simulators can be resolved, repeated use is possible, and training tailored to the structural characteristics of specific organs (stomach, large intestine, small intestine, etc.) is possible.

The invention belongs to the technical field of medical instruments, and discloses a gastrointestinal tract magnetic clipping fistulization assembly and application thereof. The assembly comprises at least two magnetic bodies, each magnetic body is provided with a clamping end face, the effective length of each clamping end face is 3-5 cm, the width of each clamping end face is not smaller than 0.2 cm, and a clamping gap of 2-4 mm is formed between the stomach wall and the intestinal wall when the two magnetic bodies are attracted. The assembly can adopt an integral structure, a split structure, a bendable structure or a concave-convex clamping structure, and the magnetic body is provided with a fixing structure and a guide assembly. Laparotomy and minimally invasive implantation are not needed, permanent foreign matter residues are avoided, a stable permanent anastomosis channel can be formed, the risk of complications such as adhesion and leakage is reduced, the device is suitable for patients with refractory digestive tract obstruction, and fistulization safety and success rate are improved.

The invention discloses a piglet anti-diarrhea complete feed formula based on a microecological preparation, and relates to the technical field of animal nutrition and health. The microsphere has a unique three-layer core-shell structure, wherein a core layer is coated with butyric acid producing probiotics and precise prebiotics; the middle layer is a chitosan-gallic acid-vanillin terpolymer with dual functions of strong mucous membrane adsorbability and quorum sensing quenching; and the shell layer is a pH-sensitive slow-release coating and is loaded with an acidifying agent. The structure is constructed through a layer-by-layer coating process, and the technical problems that in the prior art, functional components cannot be delivered in a targeted mode, the synergistic effect is poor, and intestinal barriers cannot be actively repaired are solved. When the microspheres enter animal digestive tracts, the shell layer firstly releases an acidifying agent at the front end to inhibit pathogenic bacteria and clear obstacles for subsequent steps; after entering the small intestine, the middle layer polymer is released, adheres and repairs the damaged intestinal mucosa in the form of a biological bandage, and interferes pathogen communication at the same time.

The application provides a kind of based on digestive tract tissue protein expression abundance determination method and system, applied to digestive tract tissue image processing technical field. Including: based on the PVDF membrane image after color development of digestive tract tissue acquisition in vitro, contain at least one protein standard band and the protein band of multiple target proteins;When determining the presence of electrophoresis distortion according to the band of target protein standard, construct pixel space coordinate system;The target image is obtained by angle correction and linear repair to PVDF membrane image, and the protein band corresponding to multiple target proteins in target image is in horizontal alignment state under pixel space coordinate system;Determine the development area of each target protein in target image and the irregular region of interest wrapped the protein band corresponding to multiple target proteins, and for each target protein, the expression abundance of target protein is obtained by analyzing the development area and the irregular region of interest, and the accuracy of the protein expression abundance is higher.

1. Name of the product in this design: Dynamic in vitro bionic infant gastrointestinal digestive system. 2. Purpose of this design: A device for biomimetic simulation of an infant's gastrointestinal tract, assisting in understanding phenomena such as mixing, digestion, and emptying in the digestive tract. 3. The key design feature of this product is its shape. 4. The image or photograph that best illustrates the design's key points: a 3D model.

The present application relates to a kind of slow-release multi-mineral feed additive and its preparation method applied to the technical field of feed additive, the additive is microsphere with three concentric ball structures, from outside to inside, in turn: outermost layer, include selenium and / or iodine, carrier is enterase sensitive polymer;Middle layer, include zinc and manganese, carrier is the pH-sensitive polymer modified by quaternary ammonium salt;Nucleus, include copper, carrier is slow-release skeleton material.The total particle size of microsphere is 100-200 μm, the thickness ratio of three layers is 1:(1.8-2.2):(1.8-2.2).Its preparation method uses "multi-stage atomization-layer-by-layer self-assembly-ladder temperature drying" integrated process, three layers of slurry are pumped out by coaxial three-channel atomizing nozzle, and are formed by ladder temperature zone drying and solidification.The present application realizes the directional gradient sequential release of mineral elements in the digestive tract of poultry, solves the antagonism problem among minerals, significantly improves the bioavailability, and the middle layer has antibacterial function simultaneously, can improve intestinal health, and is suitable for poultry feed such as laying hens.

The invention relates to a multifunctional capsule robot integrating dual-channel biopsy, drug administration and anchoring functions, which comprises a shell, a capsule, a capsule, a capsule and an anchoring device, wherein a bracket is arranged in the shell; the three-degree-of-freedom magnetic driving assembly is arranged on the bracket, and the three-degree-of-freedom magnetic driving assembly is arranged on the bracket; the tool switching mechanism is used for switching different tool cabins, and the tool switching mechanism is installed on the support; the four tool cabins respectively have the functions of 30G biopsy, 25G biopsy, drug A administration and drug B administration, are used for supporting the realization of double-channel biopsy and double-channel administration, and are mounted on a four-phase tool wheel disc of the tool switching mechanism; and the deformation anchoring mechanism is used for being fixed near a focus, and the deformation anchoring mechanism is connected with the support. The device is used for diagnosis and treatment of human body lumen organs such as digestive tracts, is suitable for multi-part tissue sampling, multi-drug precise administration and stable anchoring operation under the non-invasive or minimally invasive condition, realizes function cooperation through the four-phase tool wheel disc, and flexibly switches the working state between two-channel biopsy and drug administration; and an integrated solution is provided for diagnosis and treatment of intracavity diseases.

This invention discloses a low glycemic index (GI) Hericium erinaceus (monkey head mushroom) steamed bun, belonging to the field of food processing and functional food applications. By weight, it is prepared from the following raw materials: 45-55 parts all-purpose flour, 28-35 parts Hericium erinaceus extract powder, 0.3-0.35 parts yeast, 15-18 parts water, 0.3-0.6 parts oil, and 0.7-0.9 parts sugar. This invention partially replaces the flour with Hericium erinaceus extract powder, fully utilizing the multiple mechanisms of action of Hericium erinaceus polysaccharides in forming a viscous gel in the digestive tract to slow down the contact between amylase and substrate, inhibiting α-amylase and α-glucosidase activity, and improving intestinal microecology and enhancing insulin sensitivity through dietary fiber. This allows the product to meet the low-GI food standard (GI<55), effectively filling the gap in low-GI steamed buns with Hericium erinaceus functional components as the core active ingredient. It has significant application value in the fields of diabetes management, weight control, and healthy staple foods.

The digestive tract dosing device comprises an injection tube and a dosing tube, a piston rod is arranged on the inner side of the injection tube, an injection head is arranged on the top of the injection tube, a dosing port is formed in the top of the rear side of the injection tube, a plug is arranged above the dosing port, a connecting port is formed in one end of the dosing tube, and a plug is arranged on the other end of the dosing tube. When the device is used, medicine is added into the injection tube branch through the medicine adding opening, after medicine adding is completed, the plug is connected with the medicine adding opening, so that the medicine adding opening is closed, medicine feeding is more convenient, and when medicine feeding is carried out, the medicine feeding head is arranged on the outer side of the medicine feeding tube, a spherical table is arranged on the inner side of the medicine feeding head, and a medicine discharging groove is formed in the periphery of the medicine feeding head. The connecting opening is adjusted to be opened and closed through the valve, so that the dosing speed can be adjusted, when the dosing head conducts dosing, medicine drips on the spherical table firstly, flows to the medicine outlet grooves in the periphery through the spherical table and flows out through the medicine outlet grooves, dosing is milder, and a patient feels more comfortable.

According to the digestive tract liquid sampling capsule disclosed by the invention, by arranging a sampling block capable of swelling after absorbing water and a sealing plate structure linked with the sampling block, automatic opening and closing of a sampling hole are realized, the comprehensive performance of the sampling capsule is remarkably improved, a channel can be kept unblocked in the initial sampling stage, and a large amount of liquid can be ensured to quickly enter a sampling cavity; the sampling speed and the sample capacity are effectively improved, when the sampling block absorbs water and expands, the sealing plate is pushed to seal the sampling hole, leakage of the collected sample can be prevented, external pollutants can be prevented from entering, and therefore the sampling success rate and the sample specificity are greatly improved. The capsule structure is simplified, the production cost is reduced, the sampling reliability and applicability are improved, meanwhile, the sampling process is completed in a full-automatic mode, external intervention is not needed, operation is easy and convenient, and popularization to large-scale clinical sampling and experimental research is facilitated.

The application discloses application of Gastrodia elata extract in preparation of a feed additive for resisting Aeromonas hydrophila infection, and belongs to the technical field of water animal disease prevention and treatment. The application first finds that the Gastrodia elata extract has a significant effect of inhibiting Aeromonas hydrophila infection. After the Gastrodia elata extract is added into water animal feed as a feed additive and is fed to the water animal, the Gastrodia elata extract is absorbed into blood circulation system through a digestive tract, up-regulates intestinal immunoglobulin gene expression, improves serum immunoglobulin level, enhances intestinal barrier function, improves animal activity, effectively resists Aeromonas hydrophila infection, reduces disease occurrence, and improves yield and quality of animal breeding. Therefore, the Gastrodia elata extract has a good application prospect.

The utility model discloses a gastrointestinal decompression tube which comprises a tube body, a tube head and a plurality of first side holes formed in the tube body, a coil is arranged at the position of the tube head, and a metal clamp clamps the coil to enter an alimentary canal and is fixed to a mucous membrane on the wound side. The decompression tube can be stably attached to a wound surface or a target part in the gastrointestinal tract, and the risk that the tube body slips off is avoided.

The application discloses a gastrointestinal foreign body taking-out device which comprises a fixing tube provided with a clamping cavity and a wrapping cavity, the wrapping cavity is arranged on one side of the clamping cavity, a clamping assembly is arranged in the clamping cavity, and a jaw in the clamping assembly extends out of the clamping cavity and enters the outside world; a wrapping assembly is arranged in the wrapping cavity, the wrapping assembly comprises an elastic framework and a wrapping film, the elastic framework is provided with a sliding part and a working part connected with the sliding part through a connecting part, the sliding part is slidably connected with a cavity wall of the wrapping cavity and can slide in the axial direction of the fixing tube to the outside world, when the working part is located in the wrapping cavity, the working part is located on the side away from the clamping cavity along the movement path of the sliding part, and the elastic framework is elastically deformed, and when the working part moves out of the wrapping cavity, the working part rotates to the side close to the clamping cavity along the movement path of the sliding part under the action of the elastic deformation of the elastic framework, and the wrapping film can wrap the jaw, so that the foreign body can be safely taken out.

The invention relates to the technical field of medical instruments, in particular to a digestive tract radiography auxiliary examination device which comprises a frame body, an examination plate and a control system used for assisting in obtaining digestive tract radiography, an imager is fixedly connected to the outer wall of the examination plate, and the control system is used for controlling operation of the imager; the frame body is fixedly connected with a connecting plate with the interior and the middle hollow, and the bottom of the connecting plate is fixedly connected with a standing plate. The connecting plate is provided with a rotating assembly used for adjusting the position of the checking plate. The rotating assembly comprises an outer gear ring rotationally connected to the inner wall of the connecting plate, the outer gear ring is meshed with a gear, and the checking plate is fixedly connected to the inner wall of the outer gear ring; the bottom of the connecting plate is fixedly connected with a rotating part; the control system is used for controlling the rotating part to rotate; an output shaft of the rotating piece penetrates through the connecting plate and is coaxially and fixedly connected with the gear. The examination success rate of special groups is remarkably improved, and repeated examination caused by invalid communication or body position deviation can be effectively reduced.

An endoscope auxiliary device for gastrointestinal polyp measurement mainly comprises a polyp scale, a pushing tube and an operating handle, overcomes the estimation error caused by the fish-eye lens distortion and zoom of the existing technology, and fills the technical gap of accurate physical measurement of polyp shape. At the same time, in addition to being used for physical measurement of the size of polyps in the digestive tract under the endoscope, the device can also be combined with the endoscope administration tube to realize the clinical functions including polyp measurement, lavage, spraying of liquid medicine and contrast.