594 results about "Alimentary tracts" patented technology

The invention provides a plant lactobacillus KSFY202408 strain and application thereof, and belongs to the technical field of microorganisms. The preservation number of the plant lactobacillus KSFY202408 provided by the invention is CGMCC (China General Microbiological Culture Collection Center) No. 31102. The survival rate of the strain in artificial gastric juice with the pH value of 3.0 can reach 55.2%, the survival rate of the strain in artificial gastric juice with the pH value of 2.5 can reach 33.2%, the activity of a helicobacter pylori strain can be remarkably inhibited, formation of a helicobacter pylori thallus biological membrane can be inhibited, and the activity of helicobacter pylori metabolite urease can be reduced. Meanwhile, the bacterial strain can remarkably protect cell membrane integrity and cell viability of gastric mucosa epithelial cells, and has important significance on prevention or treatment of gastritis, gastric ulcer and other digestive tract diseases caused by helicobacter pylori.

The invention discloses a livestock feed proportioning method based on livestock growth, and relates to the technical field of feed proportioning, and the livestock feed proportioning method comprises the following steps: collecting the body temperature and motion track data and environmental temperature and humidity data of livestock individuals, monitoring the concentration of amino acids in digestive tracts, preprocessing the collected data, and generating a standardized biological data set; analyzing the compensation amount of vitamins and trace elements according to the metabolic fingerprint spectrum, and constructing a multi-objective optimization function in combination with an individual growth curve; solving the multi-objective optimization function through a quantum annealing algorithm, and matching local raw material inventory data of block chain evidence storage to generate an optimization strategy; and executing the optimization strategy and detecting the mixing uniformity, and when the mixing uniformity index exceeds a preset mixing uniformity threshold, starting the compensation device to adjust the optimization strategy. According to the invention, through a cooperation mechanism of dynamic nutritional requirement identification and multi-constraint optimization, the precise regulation and control capability of livestock breeding is significantly improved.

The invention belongs to the field of bioactive peptides. The invention provides an angiotensin converting enzyme inhibitory peptide as well as a screening method and application thereof. The amino acid sequence of the inhibitory peptide is GKGLW and / or GDGLKW. According to the screening method of the ACE inhibitory peptide, the soybean protein is taken as a raw material, and the ACE inhibitory peptide is prepared and screened by adopting a targeted alkaline protease and chymotrypsin double-enzymolysis technology, so that rapid screening of the ACE inhibitory peptide is realized, and an experimental basis is provided for the structure-function relationship of the ACE inhibitory peptide. The inhibitory peptide provided by the invention has strong antihypertensive activity, high safety and no toxic or side effect. Digestive tract stability determination shows that the inhibitory peptide has good gastrointestinal tract stability in gastrointestinal tract digestion, and can still keep good activity after entering blood.

The invention relates to the technical field of feed products, in particular to a fatty acid composition and application thereof in preparation of products for improving intestinal health. The fatty acid composition comprises arachidonic acid, docosahexaenoic acid, eicosapentaenoic acid, butyric acid and lauric acid, or a precursor substance capable of releasing the fatty acid in the digestive tract, and the mass of the fatty acid composition is calculated according to the mass of the arachidonic acid, the mass of the docosahexaenoic acid, the mass of the eicosapentaenoic acid, the mass of the butyric acid and the mass of the lauric acid. The additive is prepared from the following components in parts by weight: 7-10 parts of arachidonic acid, 3-7 parts of docosahexaenoic acid, 3-7 parts of eicosapentaenoic acid, 2-5 parts of butyric acid and 1-3 parts of lauric acid. The composition can effectively relieve inflammation and diarrhea, regulate intestinal flora and improve intestinal health, and drug resistance is not prone to being generated.

The invention discloses a data analysis system for early diagnosis of digestive tract diseases, relates to the field of medical health, and constructs a multi-level digestive tract disease risk assessment model through machine learning and deep learning technologies. In the preliminary evaluation stage, oral cavity gas data in the standard data set C is trained by using a support vector machine (SVM), a preliminary digestive tract risk score D1 is generated, and the preliminary digestive tract risk score D1 is compared with a preset preliminary risk threshold value T1 to judge whether a patient has a digestive tract disease risk or not. And when the score D1 exceeds the initial threshold value T1, the system automatically starts a deep learning model such as an LSTM network to carry out more accurate secondary evaluation, and calculates and outputs a deep digestive tract risk score D2. By extracting big data and analyzing medical record data, the model is further optimized, a secondary risk threshold T2 is set, and finally, real-time examination prompts such as gastroscope or blood examination are sent to a doctor or an automatic system through linkage of the system and a diagnosis and treatment server.

The invention relates to digestive tract mucosa protective agent powder as well as a preparation method and application thereof, and the digestive tract mucosa protective agent powder contains gel and a cross-linking agent, the gel comprises any one or a combination of at least two of cellulose, modified cellulose, alginate, modified alginate, sodium polyglutamate, modified sodium polyglutamate, starch, modified starch, sodium hyaluronate, modified sodium hyaluronate, pectin or modified pectin, and the cross-linking agent comprises an ionic cross-linking agent or a nonionic cross-linking agent. The powder protective agent provided by the invention is convenient to produce and simple to use, can be adhered to the surface of a mucous membrane wound surface only through simple spraying operation, forms a hydrogel protective layer under the action of gastric juice, intestinal juice or other liquid on the surface of the wound surface, plays a role of a physical barrier, and has a good application prospect. The continuous erosion of digestible liquid or pathogenic microorganisms on the surface of the wound surface to the wound surface is effectively blocked.

The invention relates to the technical field of nutritional supplements. A traditional fat reducing method mainly comprises dieting, high-intensity exercise, medicine weight losing and the like. However, dieting may lead to malnutrition; high-intensity sports are difficult to insist, and sports injury is easily caused; in order to solve the technical problems, the invention discloses a fat-reducing nutritional composition capable of improving metabolism, and the fat-reducing nutritional composition can be used for solving the technical problems of severe side effects such as tachycardia, insomnia and the like caused by medicine weight loss. The composition comprises the following components in parts by weight: 13-21 parts of a bitter gourd extract, 15-31 parts of a garcinia cambogia extract, 13-17 parts of oat fibers, 17-23 parts of whey protein powder, 7-9 parts of linseed oil, 6-14 parts of a green tea extract, 9-15 parts of a calcium supplement and 15-19 parts of a purple perilla seed extract, and can provide energy for a user, supplement immune globulin, lactoferrin and a calcium source, improve the immunity of the user and improve the immunity of the user. The body metabolism level and immunocompetence are improved, absorption of fat in digestive tracts can be effectively inhibited, storage of fat in the body is reduced, fat consumption is promoted, and the fat reducing effect is achieved.

The invention discloses a strain of lactobacillus plantarum, which is named as L.plantarum ZW1, and the preservation number of the lactobacillus plantarum is CGMCC (China General Microbiological Culture Collection Center) 26685. The lactobacillus plantarum provided by the invention is a lactic acid bacterium with relatively strong broad-spectrum inhibition capability, and after the interference of organic acid and hydrogen peroxide is eliminated and protease treatment verification is carried out, the strain is determined to have relatively strong bacteriocin production capability. Probiotic performance evaluation shows that the strain has good digestive tract fluid tolerance, and the L.plantarum CGMCC26685 has good intestinal tract probiotic characteristics, can significantly enrich mouse intestinal flora in an in-vitro intestinal flora fermentation model, increase the relative abundance of the phylum of thick-walled bacteria, reduce the relative abundance of the phylum of proteobacteria, proteusbacillus and shigella, and improve the intestinal tract fluid resistance of mice. The number of flora OTU is obviously higher than that of lactobacillus rhamnosus LGG and lactobacillus plantarum L.plantarum PL4 group which does not produce bacteriocin, and the Chao1 index, the Shannon index and the Simpson index are obviously improved compared with those of a control group. It is shown that the L.plantarum CGMCC26685 has good intestinal tract beneficial activity, and has the potential of further performance excavation and application expansion.

The invention discloses a compound feed additive as well as preparation and application thereof, and belongs to the technical field of feeds. The additive comprises a first composition and a second composition, the first composition comprises microcapsules formed by coating short-chain fatty acid and / or short-chain fatty acid derivatives with triglyceride carrying beta-glucuronide residues, and the second composition comprises microcapsules formed by coating short-chain fatty acid and / or short-chain fatty acid derivatives with triglyceride carrying beta-glucuronide residues. The second composition comprises medium-chain fatty acid and / or medium-chain fatty acid derivatives, and microcapsules formed by coating short-chain fatty acid and / or short-chain fatty acid derivatives with long-chain fatty acid and / or long-chain fatty acid derivatives. The invention effectively solves the problem that short-chain fatty acids and derivatives thereof are decomposed in advance before reaching target sites of intestinal tracts, so that the short-chain fatty acids and derivatives thereof can be transported to the whole course of digestive tracts, realize precise metabolism of parts in colon positions, and are suitable for balance of long-chain, medium-chain and short-chain fatty acids in intestines and stomachs of piglets. The feed can achieve the positive effects of promoting growth, improving the digestibility of nutrient substances, improving intestinal health and the like, and has a good application prospect in animal breeding.

The invention discloses animal combined lactobacillus D27 as well as a screening method and application thereof, and relates to the technical field of microorganisms, and the key points of the technical scheme are as follows: the animal combined lactobacillus D27 is preserved in China General Microbiological Culture Collection Center (CGMCC) on May 9, 2024, and the preservation number is CGMCC No.30561. The animal combined lactobacillus D27 has the advantages that the animal combined lactobacillus D27 can be used for screening the animal combined lactobacillus D27; the animal combined lactobacillus D27 provided by the invention is a strain with excellent performance screened from the digestive tract of the calf, has the characteristics of stronger acid resistance, cholate resistance, strong adhesiveness, high lactic acid production and the like, and provides an excellent strain resource for the development of probiotics for preventing and treating calf diarrhea.

The invention discloses an integrated front-end driving, active steering and visual digestive tract catheterization system, which belongs to the field of medical apparatus and instruments, and comprises a guide arm comprising a pull wire and an elastic arm, the guide arm is provided with a first end and a second end deviating from each other, and one end of the pull wire is fixedly connected to the first end; the lens is arranged at the first end; the driving part comprises a first annular balloon, a second annular balloon and a cylindrical balloon, and the first annular balloon and the second annular balloon are fixedly connected to the two sides of the cylindrical balloon in the axial direction respectively; when the annular balloon is full, the outer wall expands in the radial direction; when the cylindrical balloon is full, the outer wall extends in the axial direction; the fixing sleeve comprises a flexible sleeve and a connecting base which are fixedly connected, the connecting base is connected with the second end of the guide arm and the first annular balloon, and the end, deviating from the connecting base, of the flexible sleeve penetrates through the driving part and extends in the direction deviating from the guide arm. Through the arrangement, the front end of the nasointestinal tube can be guided and driven at the epiglottis of the nasal cavity and the upper and lower digestive tracts.

The invention discloses a targeted drug delivery capsule robot based on a soluble film. The targeted drug delivery capsule robot comprises a soft capsule shell, a magnetic control module, a camera module, a drug storage cavity, a release channel and the soluble film covering an outlet of the release channel. The capsule robot has the advantages that by means of the transparent design of the soft capsule shell, the intuition and safety of the drug delivery process are guaranteed, the targeted drug delivery mechanism is located at one end of the capsule robot, drug release is controlled by a soluble film, accurate response can be conducted according to the environmental conditions (such as pH value, temperature or enzyme concentration) of different parts of the digestive tract, and the targeted drug delivery mechanism is suitable for being applied to the digestive tract. Therefore, targeted release of the drug is realized. Due to the linkage design of the magnetic control system and the oscillation module, the capsule robot can be rapidly positioned to a target area in a complex alimentary canal environment, and the accuracy and reliability of targeted drug delivery are improved. Compared with a traditional medicine release mode, the structure remarkably reduces medicine waste and systemic side effects, and meanwhile the efficient treatment requirement of minimally invasive medical treatment is met.

The invention provides a digestive tract hemorrhage risk assessment method and system based on capsule gastroscopy results. The method comprises the following steps: acquiring a gastrointestinal image of a patient, processing to obtain image feature data, performing lesion quantity evaluation according to lesion feature data, obtaining a gastrointestinal tract lesion quantity index, obtaining examination process data and examination technical parameter data of capsule gastroscopy, and processing in combination with the gastrointestinal feature data to obtain a gastroscopy correction coefficient. The method comprises the following steps: acquiring and processing arteriovenous blood vessel feature data and personal data of a patient, acquiring and processing blood vessel diameter quantized value data, acquiring and processing clinical data, acquiring high-risk factors of gastrointestinal hemorrhage, and finally performing risk assessment in combination with several indexes and factors to obtain risk indexes of gastrointestinal hemorrhage; and comparing the risk value with a preset risk threshold value, and obtaining a corresponding preset treatment scheme according to a comparison result to guide treatment of the patient, so that a digestive tract hemorrhage risk assessment technology based on a capsule gastroscopy result is realized.

The invention belongs to the technical field of probiotic particles, and particularly relates to probiotic particles for improving intestinal functions as well as a preparation method and application of the probiotic particles. The probiotic particles capable of improving the intestinal function comprise a probiotic core, a first embedding layer, a second embedding layer and a third embedding layer, the probiotic inner core is prepared from plant lactobacillus, bifidobacterium animalis, lactobacillus acidophilus, bifidobacterium longum, lactobacillus paracasei, lactobacillus rhamnosus, lactobacillus fermentum, lactobacillus helveticus, streptococcus thermophilus, plant lactobacillus, lactobacillus helveticus and lactobacillus rhamnosus. According to the present invention, the twelve probiotics are contained, and the latest three-layer embedding technology is adopted so as to enhance the storage property and the digestive tract tolerance, such that the product can maintain the beneficial bacterium activity for a long time without refrigeration, and the product is suitable for the crowd with the alteration of the intestinal flora.

The present application relates to the technical field of small molecule drugs, in particular to a isoquinoline drug and its application in improving or treating digestive tract tumors, and aims to provide a compound, a pharmaceutical composition containing the compound and its application in treating colorectal cancer and gastric cancer, and provides a 3,13-position substituted berberine derivative, the drug itself has less toxicity and does not affect the growth of normal human cells, and has a good application prospect in the development of novel antitumor drugs, especially in the development of anti-digestive tract tumor drugs.

The invention discloses a follow-up visit management system for an inflammatory bowel disease patient, and relates to the technical field of medical management. Comprising a patient management module which is in dynamic butt joint with a hospital information system, synchronizes patient data and endoscopic examination results in real time through an HL7 protocol, and establishes an electronic file containing an inflammatory bowel disease specificity tag; the diagnosis and treatment result module is used for storing structured data with temporal markers, including medication time sequences recorded by three groups of timestamps, administration routes and drug categories, auxiliary examination results accompanied with digestive tract pathological section images and hidden space feature vectors extracted from the images through a convolutional neural network; and the diet module is used for carrying out multi-level classification on diet photos uploaded by the patient through an image recognition unit based on MobileNetV3, and outputting food types and intake estimated values. According to the invention, by integrating the multi-dimensional data of the patient, the disease development trend is predicted, and personalized follow-up visit management is provided.

The invention relates to the technical field of biological genetic engineering, in particular to construction of recombinant lactobacillus plantarum of an African swine fever virus antigen, and the method comprises the following steps: constructing a lactobacillus plantarum shuttle vector containing different ASFV antigen genes; and referring to a genome sequence of a Chinese isolate CADCHN09 of ASFV disclosed in GenBank. The method has the advantages that an inducer is not needed, antigen protein is efficiently expressed, the dendritic cell (DC) binding peptide for enhancing immune cell uptake and processing is subjected to fusion expression, the oral immunization mode is simple, mucosal immunity is stimulated, and ASFV infection is effectively prevented and controlled; probiotics, namely lactobacillus plantarum, which naturally exist in animal intestinal tracts and can be colonized and copied in digestive tracts for a long time are used as a carrier; key epitopes of proteins such as nucleocapsid protein p72, outer envelope protein CD2v, inner envelope protein p54, p22, pE199L and pE248R, which play an important role in adsorption, internalization, endocytosis and membrane fusion of ASFV, are preferably fused with dendritic cell binding peptide and then are displayed on the surface of lactobacillus plantarum.

The invention discloses a preparation process and application of magnolol-loaded plant exosomes, and relates to the technical field of plant exosomes. Magnolol is extracted from a magnolia officinalis plant material through ultrasonic assistance, the plant exosomes are obtained from fresh ginger by using an ultracentrifugation method, and the plant exosomes are further modified through palmitic acid and polyethylene glycol, so that the magnolol-loaded plant exosomes are obtained. And finally, preparing the magnolol-loaded plant exosome by virtue of an incubation method. The magnolol can be protected from being damaged by gastric acid and digestive enzymes through membrane structure wrapping of the plant exosome, the stability of the magnolol in the digestive tract is improved, and it is further verified through mouse experiments that the magnolol-loaded plant exosome can be beneficial to regulation of intestinal flora.

The present disclosure provides methods of treating inflammation of the upper gastrointestinal tract, especially the esophagus, by administering an oral corticosteroid. In some cases, the methods include treating eosinophilic esophagitis (EoE) by administering an oral corticosteroid in an induction phase and a maintenance phase to improve peak eosinophilic counts and symptoms. In embodiments, the methods include treating EoE by administering the oral corticosteroid at nighttime and / or while the patient is lying down.

The invention belongs to the technical field of detection methods, and provides a method for determining the content of amino acid in chyme in digestive tracts of livestock and poultry, which comprises the following steps: mixing a sample and a peroxyformic acid solution, and reacting to obtain an oxidation system; mixing the oxidation system, a hydrochloric acid solution and a chelating agent solution, and hydrolyzing to obtain a hydrolysis system; mixing the hydrolysis system and alkali liquor, then adjusting the pH value, and then mixing with acid liquor to obtain liquid to be detected; centrifuging the to-be-measured liquid, filtering, injecting a filtering system and the mixed amino acid standard liquid into an automatic amino acid analyzer, and measuring. According to the method, a certain amount of disodium ethylene diamine tetraacetate is added to chelate heavy metals in chyme in digestive tracts of livestock and poultry, and meanwhile, the heavy metals and redundant impurities are removed by adopting the steps of centrifuging, filtering and the like, so that the accuracy of amino acid detection is ensured, and the addicability of digestible amino acid content in daily ration is better. The hydrolysate is treated by adopting simple steps such as pH regulation and centrifugation, so that the operation process is simplified, and the operation error is reduced.

Disclosed in the present invention is a lesion feature recognition system for gastrointestinal endoscopy. By utilizing the system, the accuracy and efficiency of lesion feature recognition under gastrointestinal endoscopy can be improved, and the shortcomings including limited recognition capability, poor anti-interference performance, high demand for computing power, high misdiagnosis rate and the like under conventional AI-assisted endoscope inspection technology are overcome.

The invention discloses an anti-flocculation defoaming agent for digestive tract mucosa in gastroscopy and a preparation method of the anti-flocculation defoaming agent, and relates to the technical field of medicines, and the anti-flocculation defoaming agent comprises simethicone emulsion, sodium bicarbonate and sterilized water for injection. 80mg of simethicone emulsion is combined with 40ml of 2.5% sodium bicarbonate solution (containing 1000mg of sodium bicarbonate) to be used for preparation before gastroscopy, flocculent precipitation can be prevented and the gastric mucosa cleaning effect can be improved by using a small dose of simethicone emulsion, and the simethicone emulsion is simple to use, can be rapidly prepared, is low in cost and high in cost performance, and reduces the medical cost.

The invention provides application of pediococcus pentosaceus in preparation of a product for improving pork quality and intestinal flora, and relates to the technical field of animal feeding. The pediococcus pentosaceus disclosed by the invention is pediococcus pentosaceus LL2018368, is separated from the digestive tract of a Diqing Tibetan pig and is preserved in the China General Microbiological Culture Collection Center (CGMCC), and the preservation number is CGMCC No.18709. The pediococcus pentosaceus disclosed by the invention has the advantages that the pediococcus pentosaceus can be used for preparing the pediococcus pentosaceus; the pediococcus pentosaceus LL2018368 is added into drinking water of the Du-Si pigs, the influence of the pediococcus pentosaceus LL2018368 on archaea, meat quality, tissue fat-soluble vitamins and excrement metabolite composition in the excrement of the Du-Si pigs is studied, and the result shows that the pediococcus pentosaceus LL2018368 enables the species of the archaea in the excrement to tend to be consistent, so that the content of the archaea in the excrement of the Du-Si pigs in the excrement of the Du-Si pigs in the excrement of the Du-Si pigs is increased. The contents of vitamin A and all-trans-retinol in kidney tissues are increased, and the probiotic functions of amino acid and fat metabolism related bacteria and enzymes are improved.

The application provides an extendable digestive tract cannula and application thereof, and relates to the technical field of medical devices. The application comprises a first cannula, a second cannula and a degradable material. Opposite ends of the first cannula are a proximal end and a distal end, respectively. The first cannula is sleeved with the second cannula, and a double-layer structure is formed at the distal end of the first cannula. The double-layer structure is fixed by the degradable material. When the degradable material degrades, the second cannula moves towards the end face of the distal end of the first cannula. By setting the movable second cannula, the second cannula moves backward after the degradable material degrades, so that the length of the digestive tract cannula is extended. Since the length of the digestive tract cannula is increased, the area of intestinal absorption is also increased, the compensatory absorption function of the intestine at the distal end of the digestive tract cannula is weakened, the isolation effect of chyme and the intestine is improved, and the digestion and absorption effect of the intestine can be reduced for a long time.

The invention belongs to the field of biology, and discloses lactobacillus mucosa which is preserved in China General Microbiological Culture Collection Center (CGMCC), the preservation number is CGMCC30899, and the preservation address is Institute of Microbiology, Chinese Academy of Sciences, No.3, No.1 Yard, Beichen West Road, Chaoyang District, Beijing. The lactobacillus is separated from small intestines of piglets, is one of main lactobacillus in digestive tracts of the piglets, and has certain cholate tolerance. The lactobacillus mucosa and the composition can promote the weight, the average daily gain and the weaning weight of 14-day-old suckling piglets by regulating the breast milk of the sows, promote the development of an ileum structure and the secretion of gastric mucus and gastric acid, regulate the 5-HT metabolism of intestinal tracts, and improve the immunity of the piglets. The expression of the HTR subtype in the stomach, the jejunum, the ileum and the colon is differentially regulated, and the indole level is increased by regulating tryptophan metabolism of microorganisms in the stomach, the ileum and the colon to play a role. Meanwhile, the invention further discloses application of the lactobacillus mucosa and the composition.

The invention relates to the technical field of probiotics, in particular to lactobacillus salivarius and application of the lactobacillus salivarius in regulating flora balance of digestive tracts of mutton sheep. The invention provides a lactobacillus salivarius KS1018, and the preservation number of the lactobacillus salivarius KS1018 is CCTCC (China Center for Type Culture Collection) NO: M 2025020. The lactobacillus salivarius KS1018 is a strain which is separated from dolang sheep rumen fluid and has the characteristics of high temperature resistance, acid resistance and cholate resistance, and has the advantages of low immunogenicity and high safety when being applied to mutton sheep. Due to the high-temperature-resistant characteristic, high stability can be kept in the feed mixing and processing process, and the application effect is further improved. The acid-resistant and cholate-resistant characteristics can reduce the influence of the digestive tract on the activity of the feed additive, so that the feed additive effectively plays a role in the digestive tract of the ruminant. The strain is good in palatability after being fed, and can effectively regulate digestive tract flora of ruminants, restore digestive tract flora balance and improve the disease-resistant potential of the ruminants.

The invention discloses a fermented feed for improving intestinal health and a preparation method thereof, and relates to the technical field of feed processing. The fermented feed for improving intestinal health is prepared from ZIF-8 ocimum gratissimum oil nanoparticles, porphyra polysaccharide active traditional Chinese medicine composite gel, corn flour, soybean meal, grass meal, bacillus subtilis, saccharomycetes and papain. The porphyra polysaccharide active traditional Chinese medicine composite gel is prepared from porphyra polysaccharide, chitosan, compound traditional Chinese medicine superfine powder and citric acid, the ZIF-8-coated ocimum gratissimum oil nanoparticles and the porphyra polysaccharide active traditional Chinese medicine composite gel are combined, and then the fermented feed is coated, so that the fermented feed is effectively isolated from the external environment, the activity of microorganisms in the fermented feed is maintained, the stability of the feed is improved, harmful substances in the feed can be adsorbed, the adverse effect on digestive tracts is reduced, and the feed is safe and reliable. The intestinal health is obviously improved, so that the digestive absorption is promoted, and the growth performance of animals is favorably improved.

The present invention discloses a nasogastric feeding device for nursing the digestive tract with anti-backflow, which relates to the field of nasogastric feeding technology, including a feeding device and a hose, wherein the feeding device includes a driving rod and a housing, the upper and lower ends of the housing are respectively provided with end caps and a sleeve, a pressing plate and a mesh plate are installed inside the housing, a cavity is formed between the end cap and the sleeve, a four-way pipe is installed on the end cap, an air pump and a control valve are installed inside the four-way pipe, the pressing plate and the mesh plate are provided with a driving rod, and the four ports of the four-way pipe are respectively connected to the external environment, the cavity, the air pump and the space inside the housing. The present invention performs air extraction before food processing to prevent the liquid food from carrying a large amount of air into the patient's stomach during the infusion period, thereby preventing the patient from experiencing bloating. At the same time, the hose is provided with an anti-backflow mechanism to prevent the phenomenon of gastric fluid backflow due to the patient's body posture.

A digestive tract sampling capsule includes a capsule shell and a sampling chamber disposed in the capsule shell, wherein the capsule shell is provided with a sampling port, and the sampling chamber is provided with an injection port, wherein the injection port and the sampling port can be selectively aligned or misaligned, and further includes a driving component disposed in the capsule shell, wherein the injection port is blocked by a dissolving material, and the driving component drives the injection port or the sampling port to transform between two states relative to the sampling chamber, wherein in a first state, the sampling port is misaligned with the injection port; in a second state, the sampling port is aligned with the injection port, and the dissolving material contacts the sample and dissolves under the action of the sample to open the injection port for sampling. The digestive tract sampling capsule of the present invention adopts a mode combining active and passive trigger sampling, which can achieve accurate sampling and improve the success rate of sampling.

Disclosed herein are systems and methods related to a capsule endoscopy, where a patient can swallow an ingestible capsule that records images of digestive tract, and a new in-body positioning system can precisely localize the capsule's position. Implementations include a new frequency-division multiplexing-based magnetic localization (FDMML) approach which leverages a higher frequency carrier in the low MHz range. The approach significantly reduces the reference excitation coil sizes and decreases the required excitation current by three orders of magnitude compared to prior work, making it practical for wearable systems. A fully integrated wireless receiver prototype is implemented in 180 nm bulk CMOS and packaged in an ingestible pill form factor. The new scheme achieves the best experimentally demonstrated tracking accuracy in both 2D and 3D localization experiments, achieving a sub-mm mean absolute position error and consuming only 247 pW while running at 100% duty cycle.