Targeted drug delivery capsule robot based on soluble film

Abstract

The invention discloses a targeted drug delivery capsule robot based on a soluble film. The targeted drug delivery capsule robot comprises a soft capsule shell, a magnetic control module, a camera module, a drug storage cavity, a release channel and the soluble film covering an outlet of the release channel. The capsule robot has the advantages that by means of the transparent design of the soft capsule shell, the intuition and safety of the drug delivery process are guaranteed, the targeted drug delivery mechanism is located at one end of the capsule robot, drug release is controlled by a soluble film, accurate response can be conducted according to the environmental conditions (such as pH value, temperature or enzyme concentration) of different parts of the digestive tract, and the targeted drug delivery mechanism is suitable for being applied to the digestive tract. Therefore, targeted release of the drug is realized. Due to the linkage design of the magnetic control system and the oscillation module, the capsule robot can be rapidly positioned to a target area in a complex alimentary canal environment, and the accuracy and reliability of targeted drug delivery are improved. Compared with a traditional medicine release mode, the structure remarkably reduces medicine waste and systemic side effects, and meanwhile the efficient treatment requirement of minimally invasive medical treatment is met.

Description

Technical Field

[0001] The invention relates to a capsule robot, in particular to a targeted drug delivery capsule robot based on a soluble film, belonging to the technical field of medical equipment. Background Art

[0002] With the continuous development of society and the continuous improvement of human production and living standards, the gastrointestinal tract of most people is in a sub-healthy state. Therefore, it is increasingly important to carry out early inspections of gastrointestinal safety. Although conventional gastroscopy technology has a relatively high inspection accuracy and is more accurate in judging the condition, it will cause discomfort to the patient during the inspection. When passing through the throat, there will be pain for a few seconds and the desire to vomit. Some people will feel bloating and nausea because of the air entering the stomach through the tube. Although ultrasound detection methods can greatly reduce the patient's discomfort, the gastrointestinal tract is a hollow organ and is often affected by gas. It is not easy to obtain satisfactory sonograms from the surface of the body, which sometimes affects the accuracy of the diagnosis.

[0003] As a new type of medical device, the capsule robot can perform inspection and treatment in the digestive tract in a non-invasive manner. In the prior art, a new type of magnetically controlled anti-interference targeted drug delivery capsule robot disclosed in publication number CN115814247A is driven by an external magnetic field generated by an external permanent magnet, and the internal embedded targeted drug delivery mechanism enables the robot to have two functional modes, which can perform targeted drug treatment on the lesions of the constantly moving human intestine. The robot has a built-in targeted drug delivery mechanism consisting of an arc-shaped slide disc, an anchoring slide, four anchoring tentacles and a fixing rod, which is fixed to a radially magnetized O-type permanent magnet. The functional mode is switched by an external permanent magnet. When the robot rotates axially, it is in a motion mode, which can realize flexible movement in a constantly peristaltic fluid environment. When the robot rotates radially, it is in a targeted drug delivery mode, which can realize the function of anchoring in the intestine for targeted drug delivery treatment, ensuring sufficient drug concentration in the lesion site and the treatment effect is not affected by intestinal peristalsis. However, the current capsule robot still has the following deficiencies in terms of drug delivery function: low drug release accuracy, drug release is difficult to accurately correspond to the specific lesion location in the digestive tract, which easily leads to drug waste or poor treatment effect; the release method is not flexible; traditional drug release designs are mostly mechanically driven or timed release, which is difficult to adapt to complex environmental changes in the digestive tract (such as different pH values, temperatures); the structural integration is limited, and the existing drug release module design usually occupies the internal space of the capsule, resulting in restrictions on other functional modules of the robot. Based on this, the present invention proposes a targeted drug delivery capsule robot based on a soluble film. Summary of the invention

[0004] The purpose of the present invention is to provide a targeted drug delivery capsule robot based on a soluble film in order to solve at least one of the above-mentioned technical problems. The targeted drug delivery mechanism of the soluble film is integrated at one end of the capsule robot, and precise targeted drug release is achieved through external magnetic control and internal environmental response mechanism.

[0005] The present invention achieves the above-mentioned purpose through the following technical solutions: A targeted drug delivery capsule robot based on a soluble film comprises a soft capsule shell, the interior of the soft capsule shell is divided into a plurality of functional module areas by a partition; A drug outlet is provided at the front end of the shell body of the soft capsule shell, a drug storage cavity is provided at the front end of the shell body of the soft capsule shell, the drug outlet is connected with the drug storage cavity, a port of the drug outlet is covered with a soluble film, a first permanent magnetic ring and a second permanent magnetic ring are embedded in the shell body of the soft capsule shell, and a drug delivery module is placed in the drug storage cavity.

[0006] As a further solution of the present invention: the shell of the soft capsule shell is made of gastric acid resistant material.

[0007] As a further solution of the present invention: the soluble film is made of a specific pH-responsive material, and the drug in the drug storage cavity includes but is not limited to liquid, gel or particle forms.

[0008] As a further solution of the present invention: the drug delivery module includes a retractable piston and a sealing sleeve, the retractable piston is movably arranged in the drug storage cavity, the sealing sleeve is arranged on the retractable piston, and the sealing sleeve is placed on the inner wall of the drug storage cavity, and the retractable piston is made of ferromagnetic material that is linked to the magnetic field.

[0009] As a further solution of the present invention: a battery module is fixedly installed in the shell of the soft capsule, and the installation position of the battery module is located on a side close to the drug storage cavity.

[0010] As a further solution of the present invention: a radio module is fixedly installed in the shell of the soft capsule, and the radio module is located on one side of the battery module.

[0011] As a further solution of the present invention: a camera module is fixedly installed in the shell of the soft capsule, and the camera module is located on one side of the radio module.

[0012] The beneficial effects of the present invention are: 1) The present invention uses the responsiveness of the soluble film to the digestive tract environment, and the drug delivery mechanism can achieve precise drug release at the lesion location, effectively reducing drug waste and side effects; the drug delivery mechanism is highly integrated, installed at one end of the capsule robot, does not occupy the internal space, and is highly integrated with imaging, sensing and other functional modules, and has strong adaptability. The soluble film material can be designed in a variety of ways to meet the treatment needs of different parts and complex diseases; the operation is simple, and unlike conventional medical methods, no mechanical drive or complex operation is required. The magnetically controlled telescopic piston is used instead of complex motors or other drive systems, reducing the complexity of the system and production costs; 2) The transparent design of the soft capsule shell ensures the intuitiveness and safety of the drug delivery process. The targeted drug delivery mechanism is located at one end of the capsule robot, and its drug release is controlled by a soluble film, which can accurately respond to environmental conditions (such as pH, temperature or enzyme concentration) in different parts of the digestive tract, thereby achieving targeted drug release. The linkage design of the magnetic control system and the oscillation module enables the capsule robot to quickly locate the target area in a complex digestive tract environment, improving the accuracy and reliability of targeted drug delivery. Compared with traditional drug release methods, this structure significantly reduces drug waste and systemic side effects, while meeting the efficient treatment needs of minimally invasive medical care. BRIEF DESCRIPTION OF THE DRAWINGS

[0013] Figure 1 It is a schematic diagram of the cross-sectional structure of the present invention; Figure 2 This is a schematic diagram of the drug administration process of the present invention; In the figure: 1. soft capsule shell, 2. first permanent magnetic ring, 3. second permanent magnetic ring, 4. drug storage cavity, 5. drug outlet, 6. soluble film, 7. retractable piston, 8. sealing sleeve, 9. battery module, 10. radio module, 11. camera module. DETAILED DESCRIPTION

[0014] The following will be combined with the drawings in the embodiments of the present invention to clearly and completely describe the technical solutions in the embodiments of the present invention. Obviously, the described embodiments are only part of the embodiments of the present invention, not all of the embodiments. Based on the embodiments of the present invention, all other embodiments obtained by ordinary technicians in this field without creative work are within the scope of protection of the present invention.

[0015] Embodiment 1, as Figure 1 As shown, a targeted drug delivery capsule robot based on a soluble film comprises a soft capsule shell 1, the interior of the soft capsule shell 1 is divided into a plurality of functional module areas by a partition to ensure the independence and functional stability of different modules; A drug outlet 5 is provided at the front end of the shell body of the soft capsule shell 1, and a drug storage cavity 4 is provided at the front end of the shell body of the soft capsule shell 1. The drug outlet 5 is connected to the drug storage cavity 4, and the port of the drug outlet 5 is covered with a soluble film 6. A first permanent magnetic ring 2 and a second permanent magnetic ring 3 are embedded in the shell body of the soft capsule shell 1, and a drug delivery module is arranged in the drug storage cavity 4. The capsule robot can be directionally controlled under the guidance of the external magnetic field through the built-in first permanent magnetic ring 2 and the second permanent magnetic ring 3 and the external magnetic field, so that it can accurately reach a specific position in the stomach, further improving the targeting and accuracy of drug delivery. The drug storage cavity 4 can be used to place therapeutic drugs. When the capsule robot enters the patient's stomach with a pH value of 1-3, the soluble film 6 gradually dissolves, opening the drug outlet 5, and the drug delivery module pushes out the drugs in the drug storage cavity 4 to achieve drug release.

[0016] Embodiment 2: In addition to all the technical features of Embodiment 1, this embodiment also includes: the shell of the soft capsule shell 1 is made of gastric acid-resistant material, which has corrosion resistance and biocompatibility, ensuring the safe operation of the robot in the gastric environment.

[0017] The soluble film 6 is made of a specific pH-responsive material, and the drug in the drug storage cavity 4 includes but is not limited to liquid, gel or particle forms to meet different types of treatment needs.

[0018] Dissolvable Film 6 The type of film can be selected according to the specific conditions (such as pH, temperature, enzyme concentration) in different parts of the digestive tract: Gastric soluble film: Rapidly degrades in the acidic environment of the stomach (pH < 3.5), suitable for targeted drug delivery to the stomach; Enteric film: dissolves in the alkaline environment of the small intestine (pH > 6.5), suitable for administration in the small intestine; Delayed-degradation film: By adjusting the film thickness or composite structure, the timed release function is achieved, which is suitable for colon or other delayed treatment scenarios.

[0019] The drug storage cavity 4 is made of acid- and alkali-resistant medical polymer materials to ensure stable storage of drugs in the complex environment of the digestive tract.

[0020] The drug delivery module includes a retractable piston 7 and a sealing sleeve 8. The retractable piston 7 is movably arranged in the drug storage chamber 4. The sealing sleeve 8 is sleeved on the retractable piston 7, and the sealing sleeve 8 is placed on the inner wall of the drug storage chamber 4. The retractable piston 7 is made of ferromagnetic material linked to the magnetic field. The retractable piston 7 can be driven by an external magnetic control device to realize linear motion, gradually push the drug out of the drug storage chamber 4, complete the drug delivery, and ensure the thoroughness and uniformity of drug release.

[0021] A battery module 9 is fixedly mounted in the soft capsule shell 1. The battery module 9 is installed at a side close to the drug storage cavity 4. The battery module 9 can provide the required electrical energy for other components during the operation of the capsule robot.

[0022] A radio module 10 is fixedly installed in the soft capsule shell 1. The radio module 10 is located on one side of the battery module 9. The external control and data transmission functions are realized by the set radio module 10. At the same time, the pictures taken by the robot can be transmitted to the external control platform.

[0023] A camera module 11 is fixedly installed in the soft capsule shell 1. The camera module 11 is located on one side of the radio module 10. The camera module 11 is used to shoot the real-time situation inside the gastrointestinal tract during the operation of the capsule robot.

[0024] Embodiment three, as Figure 2 As shown, a targeted drug delivery capsule robot based on a soluble film, the drug delivery process of the capsule robot in the digestive tract is as follows: Startup and activation,The gel robot capsule robot enters the human body with water or other media, and activates the radio module 10 and the magnetic control device through external magnetic control; In the positioning stage, the external magnetic control system is started to adjust the movement path of the capsule robot in the stomach by controlling the first permanent magnetic ring 2 and the second permanent magnetic ring 3; the radio module 10 is used to feedback the position information to ensure that the capsule robot reaches the target position; During the stabilization phase, the capsule robot stops in the target area and maintains stability through the magnetic control device to avoid deviation caused by gastric peristalsis; the target position is confirmed through the radio module, 1 sending a feedback signal; Drug release preparation, drug delivery module starts, and the internal retractable piston 7 is ready to work; Drug delivery, through the gradual advancement of the magnetically controlled piston, accurately pushes the drug from the drug storage cavity 4 to the targeted part of the stomach wall; Feedback on drug administration completion: After drug release is completed, the capsule robot sends a drug administration completion signal through the radio module 10 to ensure a smooth drug administration process; During the excretion stage, after the capsule robot completes its task, the flexible capsule shell is naturally excreted through gastrointestinal peristalsis.

[0025] The drug storage cavity 4 can be used to place therapeutic drugs. Under the guidance of the external magnetic field, the capsule robot is directionally controlled to accurately reach a specific position in the stomach, further improving the targeting and accuracy of drug delivery. When the capsule robot enters the patient's stomach at a pH value of 1-3, the soluble film 6 gradually dissolves, opening the drug outlet 5. The retractable piston 7 is driven by an external magnetic control device to achieve linear motion, gradually pushing the drug out of the drug storage cavity 4 to complete the drug delivery. During the drug delivery process of the capsule robot, the battery module 9 can provide the required electrical energy for the operation of other components during the operation of the capsule robot. The radio module 10 can realize external control and data transmission functions. At the same time, the pictures taken by the robot can be transmitted to the external control platform. The camera module 11 can be used to shoot the real-time situation inside the gastrointestinal tract during the operation of the capsule robot.

[0026] It will be apparent to those skilled in the art that the invention is not limited to the details of the exemplary embodiments described above and that the invention can be implemented in other specific forms without departing from the spirit or essential features of the invention. Therefore, the embodiments should be considered exemplary and non-limiting in all respects, and the scope of the invention is defined by the appended claims rather than the foregoing description, and it is intended that all variations falling within the meaning and scope of the equivalent elements of the claims be included in the invention. Any reference numeral in a claim should not be considered as limiting the claim to which it relates.

[0027] In addition, it should be understood that although the present specification is described according to implementation modes, not every implementation mode contains only one independent technical solution. This description of the specification is only for the sake of clarity. Those skilled in the art should regard the specification as a whole. The technical solutions in each embodiment may also be appropriately combined to form other implementation modes that can be understood by those skilled in the art.

Claims

1. A targeted drug delivery capsule robot based on a soluble film, comprising a soft capsule shell (1), characterized in that: The interior of the soft capsule shell (1) is divided into a plurality of functional module areas by partitions; The front end of the shell body of the soft capsule shell (1) is provided with a drug outlet (5), the front end of the shell body of the soft capsule shell (1) is provided with a drug storage cavity (4), the drug outlet (5) is connected to the drug storage cavity (4), the port of the drug outlet (5) is covered with a soluble film (6), the shell body of the soft capsule shell (1) is embedded with a first permanent magnetic ring (2) and a second permanent magnetic ring (3), and a drug delivery module is arranged in the drug storage cavity (4).

2. The targeted drug delivery capsule robot based on soluble film according to claim 1, characterized in that: The shell of the soft capsule shell (1) is made of a gastric acid-resistant material.

3. The targeted drug delivery capsule robot based on soluble film according to claim 1, characterized in that: The soluble film (6) is made of a specific pH-responsive material, and the drug in the drug storage cavity (4) includes but is not limited to liquid, gel or microparticle forms.

4. The targeted drug delivery capsule robot based on soluble film according to claim 1, characterized in that: The drug delivery module comprises a retractable piston (7) and a sealing sleeve (8); the retractable piston (7) is movably arranged in the drug storage chamber (4); the sealing sleeve (8) is sleeved on the retractable piston (7), and the sealing sleeve (8) is placed on the inner wall of the drug storage chamber (4); the retractable piston (7) is made of a ferromagnetic material that is linked to a magnetic field.

5. The targeted drug delivery capsule robot based on soluble film according to claim 1, characterized in that: A battery module (9) is fixedly mounted inside the soft capsule shell (1), and the battery module (9) is installed at a side close to the drug storage cavity (4).

6. The targeted drug delivery capsule robot based on soluble film according to claim 5, characterized in that: A radio module (10) is fixedly mounted inside the soft capsule shell (1), and the radio module (10) is located on one side of the battery module (9).

7. The targeted drug delivery capsule robot based on soluble film according to claim 6, characterized in that: A camera module (11) is fixedly mounted inside the soft capsule shell (1), and the camera module (11) is located on one side of the radio module (10).

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