31 results about "Drug dosing" patented technology

The invention provides an optimal administration method for promoting cervical maturation by misoprostol based on a PopPK model, and belongs to the technical field of drug administration scheme optimization, the method comprises the following steps: constructing the PopPK model for oral administration of misoprostol by a pregnant woman in late pregnancy, the PopPK model is a model structure containing absorption lag time zero-order-first-order absorption parallel, one-atrioventricular distribution and first-order elimination, and the PopPK model is a model structure containing absorption lag time zero-order-first-order absorption parallel, one-atrioventricular distribution and first-order elimination; the PopPK model comprises two absorption chambers and one central chamber; and based on the PopPK model, determining a staged administration scheme through simulation optimization. The limitation of a traditional fixing scheme is effectively overcome, and the safety, effectiveness and clinical practicability of drug administration are considered.

The invention relates to the field of control, in particular to an infusion pump drug dosage control method and system fusing clinical decision support, and the method comprises the steps: monitoring at least two physiological parameters in real time, including a main treatment index and a side effect precursor index; for each parameter, calculating the parameter credibility based on the parameter signal fluctuation characteristic and the deviation degree of the parameter signal fluctuation characteristic and the predicted value of the PK-PD model, and during state updating, weighting the monitoring data by using the parameter credibility to correct the state of the patient; in the constraint conditions, a multi-dimensional safety state space formed by the main treatment indexes and the side effect precursor indexes is defined, and boundaries are adjusted according to the credibility of the side effect precursor indexes; in the cost function, the length of a prediction time window and the asymmetric penalty weight of a prediction track deviating from a target are adjusted according to the credibility of main treatment indexes, a model prediction control problem is solved to obtain an optimal administration dosage sequence, and a first control instruction is output to an infusion pump to be executed.

A system for medicament infusion may include an infusion pump and a mobile device associated with a user. The mobile device is configured to determine an online dosing model and an offline model. The infusion pump is configured to determine an operation mode of the infusion pump based on a connection status between the mobile device and the infusion pump. The operation mode comprises an online mode when the infusion pump is connected to the mobile device and an offline mode when the infusion pump is not connected to the mobile device. The infusion pump is also configured to deliver a dose of medicament to the user based on the online dosing model or the offline dosing model, in accordance with a determination that the infusion pump is in an online mode or an offline mode.

The application provides a misoprostol cervical ripening optimization dosing method based on a PopPK model, belongs to the technical field of drug dosing scheme optimization, and comprises the following steps: constructing a PopPK model of oral misoprostol for pregnant women in the third trimester of pregnancy, the PopPK model is a model structure containing zero-order-first-order absorption in parallel, one-compartment distribution and first-order elimination, the PopPK model comprises two absorption compartments and one central compartment; and determining a phased dosing scheme based on the PopPK model through simulation optimization. The method effectively overcomes the limitations of traditional fixed schemes, and takes into account the safety, effectiveness and clinical practicability of dosing.

Cardiopulmonary resuscitation demands rapid and precise responses, particularly in hospital emergency departments. The "Automated Resuscitation Trolley Alert and Drug Dosage System" is designed as an add-on compatible with various resuscitation trolleys. The system features a powerful central processing unit, a liquid-resistant capacitive touchscreen, an audio-visual alert system with high-power LEDs, and communication modules for hospital network integration. It uses artificial intelligence and machine learning algorithms to calculate drug dosages based on patient information and monitoring data. The audio-visual alert system reduces medical team response times in emergencies. Connectivity to hospital information systems enables quick access to patient data and automatic logging of actions. By enhancing precision and speed in drug administration, minimizing human errors, and improving team coordination, this invention significantly improves the quality of emergency services and the success rate of resuscitation procedures.

The invention relates to the technical field of medical instruments, in particular to a medical medicine quantitative infusion device which comprises an intravenous needle, a Luer taper liquid medicine filter, a bottle stopper puncture outfit, a Murphy type drip chamber, an infusion hose and a flow rate adjusting mechanism. An automatic liquid stopping mechanism is arranged in the Murphy type drip chamber and comprises a cylindrical shell fixedly connected to the inner bottom wall of the Murphy type drip chamber. By arranging the flow speed adjusting mechanism, the abutting arc block can be driven to stably move along the guide rod by rotating a flow speed adjusting knob, an infusion hose is accurately extruded to change the diameter of a pipeline, fine adjustment of the infusion flow speed of liquid medicine is achieved, and compared with a traditional speed regulator, the self-locking characteristic is better; the problem that the infusion speed is too high or too low due to poor stability of a speed regulator is effectively solved, the infusion speed can be flexibly set according to the medicine type, the illness state of a patient and the tolerance degree, the accuracy of the medicine infusion dosage and speed is guaranteed, and the medicine treatment effect is improved.

An approach to supplementing or replacing at least one of a prescribed pharmaceutical can include receiving a usage agreement, executed by at least one of the subject or a medical professional, to use an inert substance according to a treatment regimen. A name or description of at least one health improvement product or protocol can be received, as well as an indication of a downtitration of the pharmaceutical. A treatment regimen can be determined, including an administration of the inert substance to the subject following the downtitration, including notifying the subject that the inert substance is not pharmacologically active.

A system for medicament infusion may include an infusion pump and a mobile device associated with a user. The mobile device is configured to determine an online dosing model and an offline model. The infusion pump is configured to determine an operation mode of the infusion pump based on a connection status between the mobile device and the infusion pump. The operation mode comprises an online mode when the infusion pump is connected to the mobile device and an offline mode when the infusion pump is not connected to the mobile device. The infusion pump is also configured to deliver a dose of medicament to the user based on the online dosing model or the offline dosing model, in accordance with a determination that the infusion pump is in an online mode or an offline mode.

The utility model discloses a polyaluminum ferric chloride liquid adding and backwashing system, which comprises a medicine inlet pipeline, a washing pipeline and a water drainage pipeline, the medicine inlet pipeline (1) comprises a medicine inlet pipe, a medicine storage tank and a medicine adding pipeline, the medicine inlet pipe is connected with a main medicine storage tank and a standby medicine storage tank, and the washing pipeline is connected with the medicine adding pipeline; the water inlet end of the chemical adding pipeline is connected with the main chemical storage tank and the standby chemical storage tank, and the water outlet end of the chemical adding pipeline is connected to the source water pipe; (2) a flushing pipeline which is mainly a high-pressure backwashing pipe, a water supply pipe inputs high-pressure water which just leaves a factory as flushing water to the high-pressure backwashing pipe and the chemical storage tank, and the high-pressure backwashing pipe is communicated with the chemical adding pipeline, so that the flushing water is backflushed into the chemical adding pipeline; one end of the drainage pipeline is connected with the chemical storage tank and the chemical adding pipeline, and the other end of the drainage pipeline is connected with a drainage sewage pipe network. The utility model provides a polyaluminum ferric chloride liquid adding and backwashing system, which can be used for respectively washing a medicine storage tank and each section of medicine adding pipeline while adding medicine without stopping a pump, preventing the pipeline from being blocked, reducing the fault, not influencing the production, and reducing the production cost. Meanwhile, the operation intensity of maintenance personnel is relieved, and the working efficiency is improved.

The invention discloses a cardiovascular drug dose regulation and control system based on reinforcement learning, and relates to the technical field of medical artificial intelligence, and the system comprises a data acquisition module which collects physiological data, metabolic parameters, a drug interaction matrix and a current drug combination of a patient in real time; the adjustment factor calculation module calculates a drug metabolism rate adjustment factor through a pharmacokinetic model; the interaction modulation module adjusts the interaction intensity according to the adjustment factor; the risk score calculation module calculates the adverse reaction risk of the patient based on the adjusted interaction matrix, the drug combination and the physiological data; the first processing module judges whether the risk score exceeds the standard or not, and if yes, the risk is reduced through medicine replacement or dosage reduction; if the risk score is lower than a second threshold value, the second processing module maintains the current dose, otherwise, a dose adjustment strategy is optimized based on reinforcement learning; according to the method, the medicine dosage adjustment can be more fit with the actual metabolic characteristics of the patient, and the accuracy and individualization degree of treatment are improved.

The invention relates to the technical field of medical care informatics, and discloses a multi-mode osteoporosis layered early warning system, which comprises a data interface module, a prescription gradient monitoring module, a semantic feature mapping module, a time sequence feature coding module, a cross attention fusion module and a risk calculation module, the change gradient of the analgesic drug dosage is calculated in real time through the prescription gradient monitoring module, and when physical image data is missing and the drug dosage gradient is abnormal, a high-risk proxy vector is forcibly called as morphological feature input, so that an image diagnosis blind area is filled with treatment behavior data, and the diagnosis accuracy is improved. The technical problem that a traditional system cannot effectively warn the hidden fracture risk in the absence of images is solved, and the logical continuity and the acute risk capturing capability of the system under the working condition of incomplete multi-modal data are ensured.

A novel embodiment of a pump system, for example, of the type that would be used in a wearable drug delivery system, comprises dual linear-actuated plungers disposed in a pump chamber. The plungers are coupled to a leadscrew having both left-hand and right-hand threads such that rotation of leadscrew in a first direction moves the plungers together and rotation of leadscrew in a second, opposite direction moves the plungers apart. Movement of the plungers away from each other draws one or more doses of a liquid drug from a reservoir into the pump chamber, while movement of the plungers together forces liquid drug to a patient interface for delivery to the patient.

The disclosure relates to a dosage measurement system for a medicament delivery device. The medicament delivery device includes a medicament reservoir and a dispensing mechanism. The dispensing mechanism includes a dispensing member that is moveable axially to dispense medicament from the medicament reservoir. The dosage measurement system includes a sensor unit and a processor. The sensor unit is configured to measure the axial displacement of the dispensing member. The processor is configured to determine a dosage dispensed from the medicament reservoir based on the measured axial displacement of the dispensing member.

A device may include a dispensing device configured to contain a medicine. A device may include a visual dosing aid on a surface of the dispensing device, the visual dosing aid comprising a plurality of dosing segments, wherein: the visual dosing aid is correlated with a physical parameter, the plurality of dosing segments correspond to a particular volume of the medicine; and the particular volume of the medicine matches a medication dose associated with the physical parameter.

The invention discloses an individualized administration dosage optimization method based on deep learning, and the method comprises the following steps: collecting multi-source medical data of a patient, and carrying out the preprocessing; modeling an association relationship between the individual features of the patient and the drug dose response based on the graph structure, and generating a preliminary dose prediction vector; performing time sequence feature extraction on the blood concentration feature vector and the physiological sign feature vector to form a self-organizing critical feature vector; calculating a comprehensive criticality score value based on the self-organizing criticality feature vector, dividing a drug dose reaction critical interval, and generating a critical state detection vector; and based on the critical state detection vector, correcting and updating the initial dose prediction vector, and generating a dynamic optimization dose recommendation result. According to the method, improved Grapher is adopted for modeling multi-source medical features, individualized administration dosage optimization is achieved, and the method has the advantages of being high in accuracy, high in safety and good in adaptability.

The invention discloses an efficient heat exchange unit with an automatic dosing function, and relates to the technical field of heat exchange units, and the efficient heat exchange unit with the automatic dosing function is characterized by comprising a mixing device, a stirring mechanism is arranged in the mixing device, the front end of the mixing device is fixedly communicated with a heat exchange unit, and the front end of the mixing device is fixedly communicated with the heat exchange unit. The quantitative powder adding device is arranged on one side of the top end of the mixing device, and the quantitative liquid adding device is arranged on the other side of the top end of the mixing device, so that through the arrangement of the mixing device, the two stirring shafts are effectively driven to rotate and stir by virtue of the sliding chute, and meanwhile, the reciprocating motion can be performed, and the mixing efficiency is improved; the quantitative medicine feeding effect is effectively improved, too much or too little medicine is prevented from being added, by arranging the quantitative liquid adding device, liquid medicine in the liquid adding pipe can be added into the tank body, liquid medicine is added into the tank body, and quantitative conveying of the liquid medicine is effectively achieved.

A powdered medicine administration device (1) comprises a lock mechanism that restricts switching to a medicine fill position or a medicine administration position due to a rotation operation of a movable body (3), from a condition in which a counter (14), which comprises an annular body rotatably retained by a body section (2) and is marked with a scale (26) indicating the remaining number of administrations of the medicine, has rotated a prescribed amount in a feed direction, specifically to a position where the administration of the medicine has been completed a prescribed number of times.

This utility model relates to the field of wastewater technology and discloses a pretreatment device for oily wastewater that facilitates drug dosing. The device includes: a cylindrical body; a switching section located inside the cylindrical body; and a metering section located at the top of the cylindrical body. The drug is placed inside a storage tank and then transported downwards through a conveying pipe into the metering cylinder. A second motor drives two metering plates to rotate. When metering plate one no longer obstructs the bottom of the metering cylinder, the drug inside the cylinder falls, thus achieving a metered drug output. As metering plates one and two rotate, when metering plate one obstructs the bottom of the metering cylinder, metering plate two does not obstruct the bottom of the conveying pipe, allowing the drug to be transported into the metering cylinder. By adjusting the height of metering plate two, the sliding cylinder slides upwards under the transmission of an "L"-shaped connecting rod, achieving adjustable metering transmission.

The invention relates to the technical field of tumor chemotherapy drug sensitivity detection, and discloses a tumor chemotherapy drug sensitivity detection kit and a detection method.The tumor chemotherapy drug sensitivity detection kit comprises a kit body, two driving mechanisms and two equivalent dosing mechanisms and further comprises a kit cover installed on one side of the kit body through a hinge; the six groups of sample injectors are distributed at the bottom of the equivalent dosing mechanism in an annular array manner; according to the technical scheme, through the arrangement of the technical characteristics of the gear transmission assembly, the spline transmission assembly and the bevel gear linkage assembly, the gear transmission assembly drives the rack lifting frame to move downwards through rotation to drive the sample injector to be pushed into the test tube, so that the effects of accurately controlling the injection speed and the consistent stroke are achieved; therefore, the equivalence of the amount of chemotherapeutic drugs or lysate injected into each test tube is ensured, the dosing or liquid adding amount of six groups of detection samples is equivalently controlled, the consistency of reaction conditions is ensured, and the reliability of the sensitivity detection result of the tumor chemotherapeutic drugs is improved.

An approach to supplementing or replacing at least one of a prescribed pharmaceutical can include receiving a usage agreement, executed by at least one of the subject or a medical professional, to use an inert substance according to a treatment regimen. A name or description of at least one health improvement product or protocol can be received, as well as an indication of a downtitration of the pharmaceutical. A treatment regimen can be determined, including an administration of the inert substance to the subject following the downtitration, including notifying the subject that the inert substance is not pharmacologically active.

The present invention relates to a triple combination drug dosing therapy for head and neck cancer treatment and, more specifically, to a therapeutic method for the treatment of head and neck cancer by dosing an anti-PD1 antibody, a human papilloma virus (HPV) vaccine, and a long-lasting recombinant IL-7 fusion protein. The present invention exhibits a remarkable effect in the treatment of intractable head and neck cancer that has been difficult to treat with existing therapeutic agents.

The present invention relates inter alia to a drug dosing device comprising a dose scale having a plurality of different visual symbols representing a series of increasing dose unit settings in a number of consecutive dose unit settings defined by a dose increment between two consecutive dose unit settings. A first dose increment between two consecutive higher dose unit settings is selected so that dosing ranges of the two higher dose unit settings do not overlap, and a second dose increment between two consecutive lower dose unit settings is selected so that dosing ranges of the two lower dose unit settings do not overlap. The invention also relates to a dose scale.

A method for controlling dosing of droplet delivery device includes providing a droplet delivery device, such as an inhaler, to a user, verifying a location of the user with the droplet delivery device, such as by GPS, and enabling dosing of the drug in droplets ejected from the device based on the verifying of the location of the user.

The invention discloses a direct-drive type medicine dosing mechanism which comprises a dose setting knob, a driving mechanism and a driving mechanism. The dose setting knob is connected to a shell or a fixing component in a screwing-in and screwing-out mode through threads and provided with a meshing face. The button is arranged on the dose setting knob in an axial pressing manner; the clutch rod is inserted into the dose setting knob, and an elastic positioning structure and meshing teeth are arranged on the clutch rod; the push rod can axially move and is inserted into the clutch rod in a relative rotation limited manner, and a driving thread is arranged on the push rod; a fixed guide thread is arranged in the shell or on the fixed part; and the push rod is matched and connected with the guide thread through the driving thread. The liquid medicine distribution rod of the dosing mechanism adopts a direct drive mode, so that the transmission structure is simplified, the transmission parts and the transmission stage number are reduced, the dosing precision and the dosing stability are improved, the use of matching parts among the transmission parts is reduced, the overall structure of the injection pen is simplified, and the assembly difficulty is reduced.

This invention relates to a drug dosing system, aiming to solve the technical problem that current drug dosing equipment, which mostly uses metering pumps (diaphragm pumps) and screw pumps to regulate the drug, generates unstable factors such as pulses and vibrations that affect the stability of drug dosing. The main components include a vacuum generator, a storage tank A, a storage tank B, and a dosing control unit. The drug solution is introduced through vacuum negative pressure to avoid pulses and vibrations during device operation (there is slight vibration from the opening and closing of the solenoid valve). A drug dosing system mainly consists of a pressure tank, a check valve C, an exhaust valve B, a solenoid valve C, and multiple liquid level sensors. When the liquid level in the storage tank is higher than that in the pressure tank, it will be filled. The solenoid valve C controls the opening of the compressed air pipeline to add air to the pressure tank, thereby achieving ultra-high liquid drug delivery.

The invention relates to the technical field of thermal power plant water treatment and automatic control, and discloses a thermal power plant lime softening system multi-agent intelligent collaborative dosing method and system.The method comprises the steps that firstly, a digital twin simulation environment coupling lime softening and coagulating sedimentation mechanisms is constructed, and a virtual interaction platform is formed; and on the basis, three independent agents are trained by using a multi-agent depth deterministic strategy gradient algorithm, the addition of lime, polyferric chloride and polyacrylamide is controlled respectively, and the learning of a collaborative strategy meeting the standard water quality and the optimal cost is guided through a maximized collaborative reward function. During online application, the dosing instruction set generated by the agent must be verified by the security constraint module embedded with the pH security boundary and the agent proportion rule, and only the verified instruction is issued to the execution unit. The method effectively solves the problem of nonlinear strong coupling of multi-agent addition, ensures that the hardness, alkalinity and turbidity of effluent stably reach the standard, and reduces the comprehensive agent consumption and operation risk.

A monitoring system comprises:a first device (2) configured tocapture an image of a medicament dosage indicated by a medicament dispensing device by an image capturing component of the first device;display the image of the medicament dosage on a display (21) of the first device; andtransmit data representing the image of the medicament dosage to a second device; andcomputer code that when executed by a second device causes the second device (100) to:receive the data representing the image of the medicament dosage sent by the first device (2);perform optical character recognition on the data of the medicament dosage thereby to identify the dosage indicated by the medicament dispensing device; andmake a non-transient record of dosage information based at least in part on the identified medicament dosage.

A computer-implemented method determines an optimal drug dosing regimen to treat a patient against a drug-sensitive pathogenic agent responsible for infection. The method obtains patient data and drug data, including the drug, administration route, adaptation type (priori or posteriori), and a drug treatment regimen. The method includes determining values for pharmacokinetic parameters for efficacy (PPE) and pharmacokinetic parameters for toxicity (PPT) from the patient and drug data using population pharmacokinetic models when PPE and PPT are not obtained directly from measurement concentration(s). The method includes obtaining infection data, including parameters selected from the documentation of infection, localization, infection type, identified pathogen, susceptibility, and minimum inhibitory concentration. The method includes determining an efficacy target for the drug from the infection data and a target at risk of toxicity. The method includes determining an optimal dosing regimen by comparing PPE with the efficacy target and PPT with the risk of toxicity target.

A computer-implemented method for treating a patient suffering from Type I Diabetes (T1D). The method can include quantifying physical activity (PA) of the patient; calculating an accumulated PA periodically based on the quantified PA, the accumulated PA indicating an aggregate of the PA; and generating an activity informed insulin bolus by adjusting a prevalent functional insulin therapy bolus with a previous activity component, wherein the previous activity component is based on the accumulated daily PA, an activity profile, and an activity factor of the patient. The method can include determining an additional glucose uptake within a time period, the additional glucose uptake being caused by a PA; translating the additional glucose uptake into a number of insulin units with a same BG lowering impact; and generating an activity informed insulin bolus by adjusting a prevalent functional insulin therapy bolus with the insulin units.

The utility model belongs to the technical field of pharmacy, particularly relates to a medicine dosage distributor, and aims to solve the problems of inaccurate quantification, low working efficiency, complicated operation and the like when the existing medicine dosage distributor is used, and provides the following scheme: the medicine dosage distributor comprises a shell, and a plurality of fixed cylinders are fixedly mounted on the inner wall of the bottom of the shell; the plurality of fixing cylinders are used for storing and quantifying to-be-distributed medicines; the medicine dose distributor comprises a plurality of fixed cylinders, the fixed cylinders are arranged in the fixed cylinders, partition buckets are fixedly installed in the fixed cylinders, the partition buckets divide the interiors of the corresponding fixed cylinders into storage cavities and quantitative cavities, the storage cavities are located above the partition buckets, and the quantitative cavities are located below the partition buckets. Effective separation and storage of medicines are realized; the quantitative assembly is ingeniously combined with the separation hopper, so that a user can accurately control the medicine distribution amount, it is guaranteed that the doses distributed every time are consistent, medical risks are reduced, operation is easy, and user experience is improved.