55 results about "Drug dosing" patented technology

The invention discloses an intelligent anesthesia depth regulation and control system based on a multi-modal biological signal, which relates to the technical field of anesthesia depth regulation and control and comprises a multi-modal biological signal acquisition module, a signal fusion processing module, an intelligent anesthesia depth analysis module, an intelligent regulation and control decision module and an intelligent control terminal. Multi-modal biological signals of a patient are collected in real time, multi-modal physiological signals such as electroencephalogram, electrocardio and blood oxygen are fused, intelligent analysis is performed in combination with a deep learning model and a fuzzy PID control algorithm, and in combination with a pharmacokinetic model, the individual difference of the patient can be considered, the anesthesia depth of the patient is accurately evaluated, and the accuracy of anesthesia is improved. Individual anesthetic dosage adjustment is completed, a basis is provided for accurate regulation and control of anesthetic, accurate closed-loop regulation and control of anesthesia depth are achieved, physiological changes of a patient can be responded in real time, the anesthetic dosage can be adjusted in time, and compared with a traditional manual regulation and control mode, the risk of knowing and excessive anesthesia in an operation can be reduced.

The invention relates to the technical field of water treatment, and provides a chemical adding control method and device in a water treatment process, a product and equipment. The method comprises the following steps: acquiring inlet water parameters, and determining a target water quality category to which the inlet water parameters belong according to an inlet water quality classification model; determining a first dosage prediction feature and a second dosage prediction feature corresponding to the target water quality category according to a preset mapping relation; inputting the characteristic value of the first dosage prediction characteristic into a dosage regression prediction model corresponding to the target water quality category to obtain a first dosage prediction value; inputting the characteristic value of the second dosage prediction characteristic into a dosage classification prediction model corresponding to the target water quality category to obtain a first dosage prediction grade; and according to the overlapping relationship between the first dosage predicted value and the first dosage predicted grade, determining a target dosage predicted value, and controlling the dosage in the water treatment process based on the target dosage predicted value. According to the scheme, the dosing prediction efficiency and accuracy can be improved.

The invention relates to the technical field of treatment of chronic diseases of old people, and discloses a metabolic characteristic-based medicine dosage optimization method for chronic diseases of old people. The method comprises the following steps: acquiring drug metabolism parameters (including a plasma concentration peak value, a half-life period curve and the like) and organ function data (including a hepatocyte metabolism rate, a glomerular filtration rate and the like) of a plurality of monitoring nodes, arranging the drug metabolism parameters and the organ function data into a time sequence input vector, and extracting a dynamic feature vector by using a time convolution network and an adaptive filter network; performing feature crossing, pharmacokinetic constraint correction and feature enhancement processing, performing fusion to generate a joint feature vector, inputting the joint feature vector into a dose decision model to obtain an adjustment coefficient, and generating a drug dose interval with a safety threshold in combination with a historical drug use record. According to the method, multi-dimensional data integration and dynamic modeling are realized, the accuracy and safety of chronic disease medication of old people are improved, and the method is suitable for individualized treatment.

A novel embodiment of a pump system, for example, of the type that would be used in a wearable drug delivery system, comprises dual linear-actuated plungers disposed in a pump chamber. The plungers are coupled to a leadscrew having both left-hand and right-hand threads such that rotation of leadscrew in a first direction moves the plungers together and rotation of leadscrew in a second, opposite direction moves the plungers apart. Movement of the plungers away from each other draws one or more doses of a liquid drug from a reservoir into the pump chamber, while movement of the plungers together forces liquid drug to a patient interface for delivery to the patient.

A computer-implemented method for treating a patient suffering from Type I Diabetes (T1D). The method can include quantifying physical activity (PA) of the patient; calculating an accumulated PA periodically based on the quantified PA, the accumulated PA indicating an aggregate of the PA; and generating an activity informed insulin bolus by adjusting a prevalent functional insulin therapy bolus with a previous activity component, wherein the previous activity component is based on the accumulated daily PA, an activity profile, and an activity factor of the patient. The method can include determining an additional glucose uptake within a time period, the additional glucose uptake being caused by a PA; translating the additional glucose uptake into a number of insulin units with a same BG lowering impact; and generating an activity informed insulin bolus by adjusting a prevalent functional insulin therapy bolus with the insulin units.

The invention relates to the technical field of water treatment, and provides a chemical adding control method and device in a water treatment process, a product and equipment. The method comprises the steps that characteristic values of dosage prediction characteristics in the water treatment process are obtained, and the dosage prediction characteristics comprise floc characteristics, water inlet parameter characteristics and water outlet parameter characteristics; inputting the characteristic value of each dosage prediction characteristic into a dosage regression prediction model taking the dosage prediction characteristic as single input to obtain a first dosage prediction value corresponding to each dosage prediction characteristic; inputting the characteristic value of each dosage prediction characteristic into a dosage classification prediction model taking the dosage prediction characteristic as single input to obtain a first dosage prediction grade corresponding to each dosage prediction characteristic; and controlling the dosage in the water treatment process based on the first dosage prediction value and the first dosage prediction grade corresponding to each dosage prediction feature. The control accuracy of the dosage can be improved.

The invention discloses a vitamin K3 oxidation waste liquid recovery device based on glucose reduction, and relates to the technical field of waste liquid recovery, the recovery device comprises a tank body, a stirring device, a detection device, a comparison device, a medicament adding pipe, a glucose adding pipe and a waste liquid adding pipe, the tank body is connected with the stirring device, the tank body is connected with the detection device, and the tank body is connected with the comparison device. The tank body is connected with the comparison device, the comparison device is connected with the stirring device, the tank body is communicated with the agent feeding pipe, the tank body is communicated with the glucose feeding pipe, the tank body is communicated with the waste liquid feeding pipe, the comparison device is connected with the agent feeding pipe, the stirring device is arranged in the tank body, the detection devices and the comparison devices are arranged on the tank body, and a discharging pipe is arranged on the tank body. And the detection device is connected with the medicament adding pipe and the comparison device.

The invention provides an optimal administration method for promoting cervical maturation by misoprostol based on a PopPK model, and belongs to the technical field of drug administration scheme optimization, the method comprises the following steps: constructing the PopPK model for oral administration of misoprostol by a pregnant woman in late pregnancy, the PopPK model is a model structure containing absorption lag time zero-order-first-order absorption parallel, one-atrioventricular distribution and first-order elimination, and the PopPK model is a model structure containing absorption lag time zero-order-first-order absorption parallel, one-atrioventricular distribution and first-order elimination; the PopPK model comprises two absorption chambers and one central chamber; and based on the PopPK model, determining a staged administration scheme through simulation optimization. The limitation of a traditional fixing scheme is effectively overcome, and the safety, effectiveness and clinical practicability of drug administration are considered.

The invention provides a precise dosing method and system based on an intelligent valve, and relates to the technical field of intelligent control, and the method comprises the steps: collecting multi-source sensor data of a dosing system in real time; preprocessing the data of the multi-source sensor, and outputting standardized process parameters; based on the standardized process parameters, the deviation between a dosing flow measured value and a set value is calculated; when the deviation exceeds a preset threshold value, a valve opening control quantity is generated according to a PID control algorithm and a water inlet flow-dosing flow mapping model, and feedforward compensation is carried out in combination with a water inlet flow variable quantity; and outputting a valve opening control signal and a dosing pump frequency control signal, and driving an execution mechanism to adjust the dosage of the medicament. According to the precise dosing method and system provided by the invention, through high-precision hardware and an intelligent algorithm, the operation cost and the manual dependence are remarkably reduced, and the harsh requirements of the high-end manufacturing industry and the water environment treatment field on precise control are met.

The invention relates to the field of control, in particular to an infusion pump drug dosage control method and system fusing clinical decision support, and the method comprises the steps: monitoring at least two physiological parameters in real time, including a main treatment index and a side effect precursor index; for each parameter, calculating the parameter credibility based on the parameter signal fluctuation characteristic and the deviation degree of the parameter signal fluctuation characteristic and the predicted value of the PK-PD model, and during state updating, weighting the monitoring data by using the parameter credibility to correct the state of the patient; in the constraint conditions, a multi-dimensional safety state space formed by the main treatment indexes and the side effect precursor indexes is defined, and boundaries are adjusted according to the credibility of the side effect precursor indexes; in the cost function, the length of a prediction time window and the asymmetric penalty weight of a prediction track deviating from a target are adjusted according to the credibility of main treatment indexes, a model prediction control problem is solved to obtain an optimal administration dosage sequence, and a first control instruction is output to an infusion pump to be executed.

A system for medicament infusion may include an infusion pump and a mobile device associated with a user. The mobile device is configured to determine an online dosing model and an offline model. The infusion pump is configured to determine an operation mode of the infusion pump based on a connection status between the mobile device and the infusion pump. The operation mode comprises an online mode when the infusion pump is connected to the mobile device and an offline mode when the infusion pump is not connected to the mobile device. The infusion pump is also configured to deliver a dose of medicament to the user based on the online dosing model or the offline dosing model, in accordance with a determination that the infusion pump is in an online mode or an offline mode.

The present invention discloses a drug inhalation device. The inhalation device includes a drug dosing chamber, a push button, and a suction nozzle. The drug dosing chamber includes at least one drug dosing chamber body, which has drug dosing side walls and a drug dosing bottom surface, forming a capsule-receiving cavity. The drug dosing side walls have an inner surface and an outer surface, and the inner surface has a curvature. The drug dosing side walls are provided with at least two drug dosing air channels, each having a first air channel side wall and a second air channel side wall. The first air channel side wall is disposed opposite the second air channel side wall, the first air channel side wall is tangent to the inner surface, and the angle between the second air channel side wall and the first air channel side wall is 1 to 10 degrees. The push button includes a push button body and a puncture unit. The puncture unit is connected to the push button body and can enter the capsule-receiving cavity to puncture the drug capsule. The suction nozzle includes a suction nozzle channel, which is connected to the capsule-receiving cavity and the drug dosing air channel. This inhalation device can reduce the resistance when a user inhales drug powder.

The application provides a misoprostol cervical ripening optimization dosing method based on a PopPK model, belongs to the technical field of drug dosing scheme optimization, and comprises the following steps: constructing a PopPK model of oral misoprostol for pregnant women in the third trimester of pregnancy, the PopPK model is a model structure containing zero-order-first-order absorption in parallel, one-compartment distribution and first-order elimination, the PopPK model comprises two absorption compartments and one central compartment; and determining a phased dosing scheme based on the PopPK model through simulation optimization. The method effectively overcomes the limitations of traditional fixed schemes, and takes into account the safety, effectiveness and clinical practicability of dosing.

Cardiopulmonary resuscitation demands rapid and precise responses, particularly in hospital emergency departments. The "Automated Resuscitation Trolley Alert and Drug Dosage System" is designed as an add-on compatible with various resuscitation trolleys. The system features a powerful central processing unit, a liquid-resistant capacitive touchscreen, an audio-visual alert system with high-power LEDs, and communication modules for hospital network integration. It uses artificial intelligence and machine learning algorithms to calculate drug dosages based on patient information and monitoring data. The audio-visual alert system reduces medical team response times in emergencies. Connectivity to hospital information systems enables quick access to patient data and automatic logging of actions. By enhancing precision and speed in drug administration, minimizing human errors, and improving team coordination, this invention significantly improves the quality of emergency services and the success rate of resuscitation procedures.

The invention relates to the technical field of medical instruments, in particular to a medical medicine quantitative infusion device which comprises an intravenous needle, a Luer taper liquid medicine filter, a bottle stopper puncture outfit, a Murphy type drip chamber, an infusion hose and a flow rate adjusting mechanism. An automatic liquid stopping mechanism is arranged in the Murphy type drip chamber and comprises a cylindrical shell fixedly connected to the inner bottom wall of the Murphy type drip chamber. By arranging the flow speed adjusting mechanism, the abutting arc block can be driven to stably move along the guide rod by rotating a flow speed adjusting knob, an infusion hose is accurately extruded to change the diameter of a pipeline, fine adjustment of the infusion flow speed of liquid medicine is achieved, and compared with a traditional speed regulator, the self-locking characteristic is better; the problem that the infusion speed is too high or too low due to poor stability of a speed regulator is effectively solved, the infusion speed can be flexibly set according to the medicine type, the illness state of a patient and the tolerance degree, the accuracy of the medicine infusion dosage and speed is guaranteed, and the medicine treatment effect is improved.

An approach to supplementing or replacing at least one of a prescribed pharmaceutical can include receiving a usage agreement, executed by at least one of the subject or a medical professional, to use an inert substance according to a treatment regimen. A name or description of at least one health improvement product or protocol can be received, as well as an indication of a downtitration of the pharmaceutical. A treatment regimen can be determined, including an administration of the inert substance to the subject following the downtitration, including notifying the subject that the inert substance is not pharmacologically active.

A system for medicament infusion may include an infusion pump and a mobile device associated with a user. The mobile device is configured to determine an online dosing model and an offline model. The infusion pump is configured to determine an operation mode of the infusion pump based on a connection status between the mobile device and the infusion pump. The operation mode comprises an online mode when the infusion pump is connected to the mobile device and an offline mode when the infusion pump is not connected to the mobile device. The infusion pump is also configured to deliver a dose of medicament to the user based on the online dosing model or the offline dosing model, in accordance with a determination that the infusion pump is in an online mode or an offline mode.

The utility model discloses a polyaluminum ferric chloride liquid adding and backwashing system, which comprises a medicine inlet pipeline, a washing pipeline and a water drainage pipeline, the medicine inlet pipeline (1) comprises a medicine inlet pipe, a medicine storage tank and a medicine adding pipeline, the medicine inlet pipe is connected with a main medicine storage tank and a standby medicine storage tank, and the washing pipeline is connected with the medicine adding pipeline; the water inlet end of the chemical adding pipeline is connected with the main chemical storage tank and the standby chemical storage tank, and the water outlet end of the chemical adding pipeline is connected to the source water pipe; (2) a flushing pipeline which is mainly a high-pressure backwashing pipe, a water supply pipe inputs high-pressure water which just leaves a factory as flushing water to the high-pressure backwashing pipe and the chemical storage tank, and the high-pressure backwashing pipe is communicated with the chemical adding pipeline, so that the flushing water is backflushed into the chemical adding pipeline; one end of the drainage pipeline is connected with the chemical storage tank and the chemical adding pipeline, and the other end of the drainage pipeline is connected with a drainage sewage pipe network. The utility model provides a polyaluminum ferric chloride liquid adding and backwashing system, which can be used for respectively washing a medicine storage tank and each section of medicine adding pipeline while adding medicine without stopping a pump, preventing the pipeline from being blocked, reducing the fault, not influencing the production, and reducing the production cost. Meanwhile, the operation intensity of maintenance personnel is relieved, and the working efficiency is improved.

The invention discloses a cardiovascular drug dose regulation and control system based on reinforcement learning, and relates to the technical field of medical artificial intelligence, and the system comprises a data acquisition module which collects physiological data, metabolic parameters, a drug interaction matrix and a current drug combination of a patient in real time; the adjustment factor calculation module calculates a drug metabolism rate adjustment factor through a pharmacokinetic model; the interaction modulation module adjusts the interaction intensity according to the adjustment factor; the risk score calculation module calculates the adverse reaction risk of the patient based on the adjusted interaction matrix, the drug combination and the physiological data; the first processing module judges whether the risk score exceeds the standard or not, and if yes, the risk is reduced through medicine replacement or dosage reduction; if the risk score is lower than a second threshold value, the second processing module maintains the current dose, otherwise, a dose adjustment strategy is optimized based on reinforcement learning; according to the method, the medicine dosage adjustment can be more fit with the actual metabolic characteristics of the patient, and the accuracy and individualization degree of treatment are improved.

The invention discloses an industrial sewage plant intelligent dosing control method and system based on multi-parameter self-adaption, and relates to the technical field of industrial sewage control. Through a water quality monitoring device arranged in a sewage treatment multi-parameter acquisition position group Pos, an original multi-parameter feature vector group Vec is constructed; and on this basis, a regional drug effect incomplete factor matrix Mat is obtained through calculation, so that quantitative identification of a drug response failure region in an industrial sewage treatment space structure is realized, a reaction failure region proportion Rtd is calculated in combination with a preset response failure judgment threshold Tau, a quantitative index is provided for identification of a local drug adding invalid or low-efficiency region, and the quantitative identification of the drug response failure region in the industrial sewage treatment space structure is realized. According to the method, the regional efficacy incomplete factor matrix Mat is utilized to perform differential correction on the original dosing plan dose vector Cref, and a corrected dose vector Adj is generated, so that spatial differential dosing regulation and control in a real sense are realized, and resource waste and treatment efficiency reduction caused by non-uniform dosing diffusion in a traditional scheme are effectively avoided.

The invention relates to the technical field of medical care informatics, and discloses a multi-mode osteoporosis layered early warning system, which comprises a data interface module, a prescription gradient monitoring module, a semantic feature mapping module, a time sequence feature coding module, a cross attention fusion module and a risk calculation module, the change gradient of the analgesic drug dosage is calculated in real time through the prescription gradient monitoring module, and when physical image data is missing and the drug dosage gradient is abnormal, a high-risk proxy vector is forcibly called as morphological feature input, so that an image diagnosis blind area is filled with treatment behavior data, and the diagnosis accuracy is improved. The technical problem that a traditional system cannot effectively warn the hidden fracture risk in the absence of images is solved, and the logical continuity and the acute risk capturing capability of the system under the working condition of incomplete multi-modal data are ensured.

A novel embodiment of a pump system, for example, of the type that would be used in a wearable drug delivery system, comprises dual linear-actuated plungers disposed in a pump chamber. The plungers are coupled to a leadscrew having both left-hand and right-hand threads such that rotation of leadscrew in a first direction moves the plungers together and rotation of leadscrew in a second, opposite direction moves the plungers apart. Movement of the plungers away from each other draws one or more doses of a liquid drug from a reservoir into the pump chamber, while movement of the plungers together forces liquid drug to a patient interface for delivery to the patient.

The utility model particularly relates to a biological membrane cleaning device applicable to aerators, which comprises a main air pipe, an aeration group connected with the main air pipe, a dosing box and a dosing pump, the dosing box is connected with the dosing pump, an output port of the dosing pump is provided with a drug delivery pipe, the drug delivery pipe is connected with the main air pipe, and the aeration group is provided with a plurality of aerators. The chemical conveying pipe is connected with a chemical adding valve, the main air pipe is provided with an air valve, the air valve is connected with the chemical adding valve, the aeration set is further connected with an emptying pipe, and the emptying pipe is connected with an emptying valve. The device disclosed by the utility model has the beneficial effects that a bactericide solution is output to the aeration group through the combination of the dosing box and the dosing pump, and a biological membrane attached to an aeration head is quickly and effectively eliminated by utilizing online treatment of the bactericide solution, so that the maintenance efficiency is improved, and the production is not influenced.

The disclosure relates to a dosage measurement system for a medicament delivery device. The medicament delivery device includes a medicament reservoir and a dispensing mechanism. The dispensing mechanism includes a dispensing member that is moveable axially to dispense medicament from the medicament reservoir. The dosage measurement system includes a sensor unit and a processor. The sensor unit is configured to measure the axial displacement of the dispensing member. The processor is configured to determine a dosage dispensed from the medicament reservoir based on the measured axial displacement of the dispensing member.

A device may include a dispensing device configured to contain a medicine. A device may include a visual dosing aid on a surface of the dispensing device, the visual dosing aid comprising a plurality of dosing segments, wherein: the visual dosing aid is correlated with a physical parameter, the plurality of dosing segments correspond to a particular volume of the medicine; and the particular volume of the medicine matches a medication dose associated with the physical parameter.

Provided herein are neuromodulation leads and systems including the leads that can be used to both detect chemical analytes in the brain and stimulate the brain. The neuromodulation leads described herein can detect chemical analytes by measuring an electrochemical signal, for example, in response to an applied energy waveform. The systems described herein can utilize a two-electrode and / or three-electrode sensing electrode arrangement to measure electrochemical signals. Moreover, various measuring modalities, such as impedance, amperometry, potentiometry, and / or cyclic voltammetry can be used to measure electrochemical signals. Based on the measured electrochemical signal, the concentration of the chemical analytes in the brain can be determined. The determination of the chemical analytes present in the tissue, including the concentration of the chemical analytes, can be used to inform stimulation parameters of the neuromodulation therapy, exogenous drug dosing, and / or diagnosis chronic diseases.

The invention discloses an individualized administration dosage optimization method based on deep learning, and the method comprises the following steps: collecting multi-source medical data of a patient, and carrying out the preprocessing; modeling an association relationship between the individual features of the patient and the drug dose response based on the graph structure, and generating a preliminary dose prediction vector; performing time sequence feature extraction on the blood concentration feature vector and the physiological sign feature vector to form a self-organizing critical feature vector; calculating a comprehensive criticality score value based on the self-organizing criticality feature vector, dividing a drug dose reaction critical interval, and generating a critical state detection vector; and based on the critical state detection vector, correcting and updating the initial dose prediction vector, and generating a dynamic optimization dose recommendation result. According to the method, improved Grapher is adopted for modeling multi-source medical features, individualized administration dosage optimization is achieved, and the method has the advantages of being high in accuracy, high in safety and good in adaptability.

The invention discloses an efficient heat exchange unit with an automatic dosing function, and relates to the technical field of heat exchange units, and the efficient heat exchange unit with the automatic dosing function is characterized by comprising a mixing device, a stirring mechanism is arranged in the mixing device, the front end of the mixing device is fixedly communicated with a heat exchange unit, and the front end of the mixing device is fixedly communicated with the heat exchange unit. The quantitative powder adding device is arranged on one side of the top end of the mixing device, and the quantitative liquid adding device is arranged on the other side of the top end of the mixing device, so that through the arrangement of the mixing device, the two stirring shafts are effectively driven to rotate and stir by virtue of the sliding chute, and meanwhile, the reciprocating motion can be performed, and the mixing efficiency is improved; the quantitative medicine feeding effect is effectively improved, too much or too little medicine is prevented from being added, by arranging the quantitative liquid adding device, liquid medicine in the liquid adding pipe can be added into the tank body, liquid medicine is added into the tank body, and quantitative conveying of the liquid medicine is effectively achieved.

A powdered medicine administration device (1) comprises a lock mechanism that restricts switching to a medicine fill position or a medicine administration position due to a rotation operation of a movable body (3), from a condition in which a counter (14), which comprises an annular body rotatably retained by a body section (2) and is marked with a scale (26) indicating the remaining number of administrations of the medicine, has rotated a prescribed amount in a feed direction, specifically to a position where the administration of the medicine has been completed a prescribed number of times.

This utility model relates to the field of wastewater technology and discloses a pretreatment device for oily wastewater that facilitates drug dosing. The device includes: a cylindrical body; a switching section located inside the cylindrical body; and a metering section located at the top of the cylindrical body. The drug is placed inside a storage tank and then transported downwards through a conveying pipe into the metering cylinder. A second motor drives two metering plates to rotate. When metering plate one no longer obstructs the bottom of the metering cylinder, the drug inside the cylinder falls, thus achieving a metered drug output. As metering plates one and two rotate, when metering plate one obstructs the bottom of the metering cylinder, metering plate two does not obstruct the bottom of the conveying pipe, allowing the drug to be transported into the metering cylinder. By adjusting the height of metering plate two, the sliding cylinder slides upwards under the transmission of an "L"-shaped connecting rod, achieving adjustable metering transmission.