7 results about "Central compartment" patented technology

The invention provides an optimal administration method for promoting cervical maturation by misoprostol based on a PopPK model, and belongs to the technical field of drug administration scheme optimization, the method comprises the following steps: constructing the PopPK model for oral administration of misoprostol by a pregnant woman in late pregnancy, the PopPK model is a model structure containing absorption lag time zero-order-first-order absorption parallel, one-atrioventricular distribution and first-order elimination, and the PopPK model is a model structure containing absorption lag time zero-order-first-order absorption parallel, one-atrioventricular distribution and first-order elimination; the PopPK model comprises two absorption chambers and one central chamber; and based on the PopPK model, determining a staged administration scheme through simulation optimization. The limitation of a traditional fixing scheme is effectively overcome, and the safety, effectiveness and clinical practicability of drug administration are considered.

The application provides a misoprostol cervical ripening optimization dosing method based on a PopPK model, belongs to the technical field of drug dosing scheme optimization, and comprises the following steps: constructing a PopPK model of oral misoprostol for pregnant women in the third trimester of pregnancy, the PopPK model is a model structure containing zero-order-first-order absorption in parallel, one-compartment distribution and first-order elimination, the PopPK model comprises two absorption compartments and one central compartment; and determining a phased dosing scheme based on the PopPK model through simulation optimization. The method effectively overcomes the limitations of traditional fixed schemes, and takes into account the safety, effectiveness and clinical practicability of dosing.

A cabinet for a laundry soap dispensing system includes a first compartment, a second compartment, and a central compartment. The first compartment includes at least one first chemical reservoir and a first dispensing manifold. The second compartment includes at least one second chemical reservoir and a second dispensing manifold. The central compartment includes a central passageway extending through the cabinet.

A three-compartment water-soluble capsule, each compartment containing a portion of a liquid cleaning agent composition, the compartments being arranged side-by-side to provide a central compartment side-by-side by a first side compartment and a second side compartment on respective sides, the capsule being formed of two water-soluble films sealed together to form a sealing mesh surrounding each compartment, the sealing mesh being located within a sealing plane, each of the three compartments extending at a maximum equal distance above and below the sealing plane, wherein the sealing mesh includes an annular sealing mesh defining the periphery of the capsule, and two inner sealing meshes, each extending through the capsule, each inner sealing mesh serving to connect the central compartment to the adjacent side compartment and to separate its contents, wherein each inner sealing mesh has a continuously curved shape.

A therapeutic massage system is provided. The system is characterized by a controllable compressed air delivery system and a cushion adapted for operative union with a portion of the air delivery system. The cushion includes a support pad and a therapy pad, the support pad having head and vertebral column supporting portions. The support pad vertebral column supporting portion is characterized by longitudinally extending compartments containing filler material. A central compartment of compartments of the support vertebral column supporting portion having a primary region traversing an axial centerline of said cushion and secondary regions spaced apart from said primary central region. The therapy pad overlays and is affixed to the vertebral column supporting portion of the support pad, the therapy pad including a plurality of fluid fillable channels for receiving a vertebral column wherein select fluid fillable channels of the plurality of fluid fillable channels of the therapy pad are fillable via programmed actuation of an actuatable element of the air delivery system. Filler material of the compartments of the support vertebral column supporting portion are responsive to receipt of body weight upon the cushion and select filling of the plurality of fluid fillable channels of the therapy pad, filler material of the regions of the central compartment being passable throughout segments of same in response to receipt of body weight upon the cushion and select filling of the plurality of fluid fillable channels of the therapy pad.

A hand-held case is provided. In some embodiments, the hand-held case may include a central compartment defined by an outer wall, a top lid with a cover for covering the central compartment, the top lid movable from a closed position to an open position, a bottom lid for covering a bottom compartment, wherein the top lid attached to the wall with a hinge, and wherein when the top lid is in a closed position, the hinge sits flush against the outer wall.

The present invention relates to a method for calculating in silico an arterial input function (AIF), wherein the method comprises selecting a class (CM, CMC) and an order (n) of the pharmacokinetic model. A pharmacokinetic model class is selected from a parallel distribution (CM) model from a central compartment to one or more peripheral compartments or a serial distribution (CMC) model from a central compartment in series through one or more intermediate compartments to one or more peripheral compartments. The order (n) of the pharmacokinetic model is the number of compartments in the selected pharmacokinetic model. In particular, the invention provides a computation of the arterial input function (AIF) at the inlet to the target circulatory area (VOI). The computed arterial input function (AIF) is then used to calculate perfusion and in particular perfusion metrics. In silico computed arterial input functions (AIF) were compared with results obtained in vivo. Consistency was observed between in silico and in vivo results at a level allowing for medical application of the invention. In particular, allowing the determination of perfusion metrics.