4 results about "Central compartment" patented technology

The invention provides an optimal administration method for promoting cervical maturation by misoprostol based on a PopPK model, and belongs to the technical field of drug administration scheme optimization, the method comprises the following steps: constructing the PopPK model for oral administration of misoprostol by a pregnant woman in late pregnancy, the PopPK model is a model structure containing absorption lag time zero-order-first-order absorption parallel, one-atrioventricular distribution and first-order elimination, and the PopPK model is a model structure containing absorption lag time zero-order-first-order absorption parallel, one-atrioventricular distribution and first-order elimination; the PopPK model comprises two absorption chambers and one central chamber; and based on the PopPK model, determining a staged administration scheme through simulation optimization. The limitation of a traditional fixing scheme is effectively overcome, and the safety, effectiveness and clinical practicability of drug administration are considered.

The application provides a misoprostol cervical ripening optimization dosing method based on a PopPK model, belongs to the technical field of drug dosing scheme optimization, and comprises the following steps: constructing a PopPK model of oral misoprostol for pregnant women in the third trimester of pregnancy, the PopPK model is a model structure containing zero-order-first-order absorption in parallel, one-compartment distribution and first-order elimination, the PopPK model comprises two absorption compartments and one central compartment; and determining a phased dosing scheme based on the PopPK model through simulation optimization. The method effectively overcomes the limitations of traditional fixed schemes, and takes into account the safety, effectiveness and clinical practicability of dosing.

A three-compartment water-soluble capsule, each compartment containing a portion of a liquid cleaning agent composition, the compartments being arranged side-by-side to provide a central compartment side-by-side by a first side compartment and a second side compartment on respective sides, the capsule being formed of two water-soluble films sealed together to form a sealing mesh surrounding each compartment, the sealing mesh being located within a sealing plane, each of the three compartments extending at a maximum equal distance above and below the sealing plane, wherein the sealing mesh includes an annular sealing mesh defining the periphery of the capsule, and two inner sealing meshes, each extending through the capsule, each inner sealing mesh serving to connect the central compartment to the adjacent side compartment and to separate its contents, wherein each inner sealing mesh has a continuously curved shape.

A hand-held case is provided. In some embodiments, the hand-held case may include a central compartment defined by an outer wall, a top lid with a cover for covering the central compartment, the top lid movable from a closed position to an open position, a bottom lid for covering a bottom compartment, wherein the top lid attached to the wall with a hinge, and wherein when the top lid is in a closed position, the hinge sits flush against the outer wall.