9 results about "Digestive tract disease" patented technology

The invention discloses bacillus subtilis for recombinant expression of a hermetia illucens HIAMP0438 gene and a construction method of the bacillus subtilis, and belongs to the technical field of gene engineering. The hermetia illucens recombinant protein used in the invention is obtained by expression of bacillus subtilis WB800N transferred into a pHT43-HIAMP0438 high-efficiency expression vector, and the pHT43-HIAMP0438 high-efficiency expression vector is obtained by a homologous recombination technology, so that high-level expression of the HIAMP0438 gene is realized, the HIAMP0438 gene can be efficiently secreted out of cells, the preparation process of the recombinant protein is greatly simplified, and the production cost is reduced. According to the present invention, the recombinant protein can significantly inhibit the growth of Escherichia coli, Salmonella and Listeria monocytogenes, and the recombinant protein can be used as the animal health product, and can be used for preventing and treating pig and chicken intestinal diarrhea caused by Escherichia coli and Salmonella and food-borne digestive tract diseases caused by Listeria monocytogenes.

The invention discloses medical equipment and a digestive tract three-dimensional model modeling method and device. The method comprises the following steps: acquiring an acquisition pose set and an image data set; calculating a relative pose set according to the image data set; fusing the collection pose set and the relative pose set to obtain an absolute pose set; generating point cloud data of the alimentary canal according to the absolute pose set and the image data set; and generating a three-dimensional model of the alimentary canal according to the point cloud data and the image data set. According to the modeling method of the digestive tract three-dimensional model, the collected pose information and the pose information determined according to the image are fused at the same time, more accurate positioning is carried out by combining information in two dimensions, the precision of the three-dimensional model can be remarkably improved, the diagnosis and treatment quality of digestive tract diseases can be improved, and the modeling method has important social and economic benefits.

This invention discloses a deformable capsule endoscope probe and image fusion system based on multimodal imaging, belonging to the field of medical endoscopy technology. This invention solves the problems of existing capsule endoscope technology, which has relatively limited functionality and a fixed shape, making it difficult to adapt to the complex structure of the digestive tract and resulting in poor imaging effects. By using flexible silicone material to make the capsule endoscope probe's shell and deformable structure, it can automatically adjust its shape according to the shape of the digestive tract lumen, ensuring clear and accurate multimodal images are acquired from different locations. A neural network model accurately identifies potential lesion areas and adaptively adjusts the fusion weights based on the importance of the lesion and tissue characteristics to optimize image quality. Furthermore, a deep learning fusion network generates a comprehensive image, which, after contrast optimization and automatic labeling of lesion areas, provides doctors with clearer and more detailed diagnostic prompts, aiding in the early diagnosis and precise treatment of digestive tract diseases.

The application provides a gold-silver alloy nanoflower SERS substrate and a preparation method and application thereof. 3+ and Ag + The preparation method is as follows: an aluminum foil paper substrate is placed in a growth solution containing Au 3+ and Ag + , a gold-silver alloy nanoflower array pattern layer with a multi-level branch structure is formed on the surface of the aluminum foil paper substrate by a displacement reaction of aluminum and noble metal ions in situ. The gold-silver alloy nanoflower array pattern layer has rich nanotips and a three-dimensional rough structure, can form a large number of electromagnetic 'hot spots', and can significantly enhance the Raman signal intensity. Relying on the excellent SERS enhancement performance, the gold-silver alloy nanoflower SERS substrate is applied to an immune recognition mediated sandwich detection mode, and high-sensitivity and accurate detection of a hidden blood marker in a fecal sample is realized. The preparation process is simple, the cost is low, and complex equipment is not needed; the obtained SERS substrate has strong stability and excellent repeatability, and can meet the needs of early screening and on-site rapid detection of digestive diseases.

The invention discloses a traditional Chinese medicine oral prescription for preventing and treating influenza A and improving digestive tract diseases, and belongs to the technical field of traditional Chinese medicines. The prescription is prepared from kudzuvine root, radix bupleuri, moutan bark, peach kernel, scutellaria baicalensis, raw rhubarb, pinellia ternate, fructus forsythiae, mirabilite, mangnolia officinalis, immature bitter orange, poria cocos, bighead atractylodes rhizome, rhizoma alismatis, white paeony root, Chinese date and ginger which are strictly matched according to a specific weight ratio and are prepared by a specific water decoction process. The traditional Chinese medicine oral prescription can effectively prevent and treat influenza A through the synergistic effect of the components, has a remarkable improvement effect on most of digestive tract diseases, is simple in preparation process, convenient to take and high in safety, avoids the problems of poor curative effect, obvious side effect or narrow application range and the like of related medicines in the prior art, and has a wide application prospect. And a new effective choice is provided for prevention and treatment of influenza A and improvement of digestive tract diseases.

The invention discloses a preparation method of selenium-enriched honeysuckle formula granules. According to the invention, the honeysuckle flower enriched with organic selenium, which is planted in a selenium-rich producing area or irrigated with a selenium-containing culture solution and sprayed with a selenium-rich nutrient solution, is used as a core raw material, and has irreplaceable exclusive value in the field of veterinary drugs: the organic selenium component can improve the activity of immune cells and enhance the disease resistance of the body, and the active component of the honeysuckle flower can directly inhibit virus replication; dual mechanisms cooperate to accurately aim at animal mass-occurring respiratory tract and digestive tract diseases, the morbidity is remarkably reduced, and the immunomodulatory effect can be amplified, virus removal can be accelerated and the dosage of a single drug can be reduced when the composition is combined with an antiviral veterinary drug; the antibiotic dependence can be reduced after long-term use, the antibiotic-free breeding trend is met, the drug residue risk is reduced due to the natural plant source characteristic, and the animal-derived food safety is guaranteed; meanwhile, the animal production performance can be improved, breeding enterprises are assisted to enhance product competitiveness, and unification of economic and social benefits is achieved.

This invention provides a gold-silver alloy nanoflower SERS substrate, its preparation method, and its application. The preparation method involves placing an aluminum foil paper substrate in an Au-containing... 3+ and Ag + In a growth solution, a gold-silver alloy nanoflower array pattern layer with a multi-level branched structure is grown in situ on the surface of an aluminum foil substrate using a displacement reaction between aluminum and noble metal ions. This gold-silver alloy nanoflower array pattern layer has abundant nano-tip and three-dimensional rough structure, which can form a large number of electromagnetic "hot spots" and significantly enhance the Raman signal intensity. Based on its excellent SERS enhancement performance, this gold-silver alloy nanoflower SERS substrate is applied to the immune recognition-mediated sandwich detection mode to achieve highly sensitive and accurate detection of occult blood markers in fecal samples. The preparation process of this invention is simple, low-cost, and requires no complex equipment. The resulting SERS substrate has strong stability and excellent repeatability, which can meet the needs of early screening and rapid on-site detection of digestive tract diseases.

This invention discloses a macro- and micro-image feature fusion and classification method based on the identification of the same lesion. It not only adaptively designs spatial and channel attention mechanisms to extract macro- and micro-features respectively, taking into account the visual characteristics of different modalities, but also introduces a cross-modal feature fusion and bias reconciliation mechanism. By quantifying cross-modal semantic consistency, it dynamically extracts and suppresses systematic bias components. At the same time, it performs deep difference reconciliation and residual compensation on bimodal features in local and global receptive fields, breaking through the performance bottleneck of traditional multimodal direct stitching. It achieves efficient and accurate fusion of macro-morphological and micro-cellular features, and can perform intelligent identification of digestive tract diseases based on the macro- and micro-features and their fused features. It has stronger robustness and accuracy, significantly improves the accuracy of lesion identification, and helps doctors obtain more accurate diagnostic results.

The present application relates to a kind of layered microbial fermentation bed manufacturing process for livestock and poultry and fermentation bed, belong to the field of breeding. Oxygen supply is ensured by optimizing layered structure, using efficient complex microbial population, realizing the rapid, complete aerobic decomposition of excrement, basically eliminating the source of ammonia, hydrogen sulfide and other foul-smelling gas. Significantly reduce the humidity, harmful gas concentration, dust in the house, provide a drier, cleaner, more comfortable living environment. Improve animal health: reduce ammonia stimulation, reduce respiratory diseases; pathogenic bacteria are reduced, reduce digestive diseases, reduce the incidence of skin disease, parasitic disease, reduce drug costs.