Traditional Chinese medicine composition and application thereof

Abstract

The invention discloses a traditional Chinese medicine composition and application thereof. The composition comprises 8-12 parts of agastache rugosus, 4-8 parts of fructus gleditsiae, 8-12 parts of radix angelicae, 8-12 parts of pericarpium citri reticulatae, 4-8 parts of mint, 4-8 parts of liquorice, 8-12 parts of platycodon grandiflorum, 4-8 parts of radix aucklandiae, 8-12 parts of radix saposhnikoviae, 4-8 parts of pinellia ternate, 0.1-0.5 part of realgar, 8-12 parts of radix ampelopsis, 8-12 parts of notopterygium root, 8-12 parts of radix bupleuri, 8-12 parts of scutellaria baicalensis, 4-8 parts of coptis chinensis, 8-12 parts of golden cypress, 8-12 parts of poria cocos, 8-12 parts of rhizoma alismatis, 8-12 parts of fructus aurantii, 8-12 parts of radix scrophulariae and 4-8 parts of The traditional Chinese medicine composition can be used for treating or preventing fever, respiratory tract diseases, digestive tract diseases or myocarditis caused by viruses, bacteria or fungi, and has the advantages of scientific formula and exact curative effect.

Description

Technical Field

[0001] The present invention relates to the field of traditional Chinese medicine compositions, and in particular to a traditional Chinese medicine composition for treating mixed toxins with multiple targets and applications thereof. Background Art

[0002] Viral fevers and the respiratory infections and inflammatory diseases they cause, such as influenza and bronchitis, are common and devastating clinically. Current treatment options primarily include Western medicine antivirals, antibiotics, and glucocorticoids, as well as common traditional Chinese medicines. Among Western medicines, common antiviral drugs such as glucocorticoids are widely used; in severe cases, they suppress excessive inflammation; and antibiotics are used to prevent and treat secondary bacterial infections. Among traditional Chinese medicines, heat-clearing and detoxifying, wind-dispelling and exterior-clearing Chinese medicines, such as Lianhua Qingwen Capsules, are commonly used for conditions like viral influenza and pneumonia. However, these existing treatments also have shortcomings. For one thing, many Western medicines have a single target, making them susceptible to pathogen mutation and drug resistance. While glucocorticoids can alleviate inflammation, they suppress the immune system, and long-term or high-dose use can easily induce or worsen infection. Furthermore, some therapies only alleviate symptoms and lack a comprehensive immune system-modulating effect. Modern medical research has found that the high variability and rapid replication of viruses pose challenges to conventional targeted antiviral drugs; in severe cases, severe cytokine storms can lead to acute respiratory distress syndrome and multi-organ damage; and variants such as Omicron have shown the ability to partially escape the host immune response and are resistant to multiple therapeutic antibodies, further increasing the difficulty of treatment. Traditional Chinese medicine compound prescriptions often have multiple ingredients that work synergistically and can exert comprehensive effects in multiple aspects such as inhibiting viral replication, relieving inflammation, and regulating immunity. They are considered to be an effective way to develop broad-spectrum antiviral drugs. Therefore, there is an urgent need to develop a traditional Chinese medicine composition with a reasonable ingredient ratio, diverse administration forms, and multi-target effects to meet the needs of clinical treatment. Summary of the Invention

[0003] The technical problem to be solved by the present invention is that the existing technology lacks a Chinese herbal compound preparation that can effectively treat diverse symptoms (such as fever, respiratory symptoms, digestive tract symptoms or systemic symptoms) caused by multiple pathogens (such as bacteria, viruses), and lacks specific dosage forms for different symptom types, resulting in poor treatment effects and failure to meet clinical needs.

[0004] In order to solve the above technical problems, the present invention adopts the following technical solutions: A traditional Chinese medicine composition comprising the following raw materials by weight: 8-12 parts of Patchouli, 4-8 parts of Gleditsia sinensis, 8-12 parts of Angelica dahurica, 8-12 parts of dried tangerine peel, 4-8 parts of peppermint, 4-8 parts of liquorice, 8-12 parts of Platycodon grandiflorum, 4-8 parts of costus root, 8-12 parts of siler, 4-8 parts of pinellia tuber, 0.1-0.5 parts of realgar, 8-12 parts of white mulberry, 8-12 parts of notopterygium wilfordii, 8-12 parts of bupleurum, 8-12 parts of scutellaria baicalensis, 4-8 parts of coptis chinensis, 8-12 parts of phellodendron amurense, 8-12 parts of poria, 8-12 parts of oriental rhizome, 8-12 parts of fructus aurantii, 8-12 parts of Radix Dioscoreae, and 4-8 parts of rhubarb. The realgar is water-melted realgar.

[0005] Further optimization also includes 1-3 parts of Asarum.

[0006] Further optimization also includes 0.05-0.2 parts of musk.

[0007] For further optimization, honeysuckle and forsythia were also added.

[0008] The medicinal properties of the raw materials used in the present invention are described as follows: Patchouli is pungent and slightly warm in nature, entering the spleen, stomach, and lung meridians. It has the effects of dispelling dampness, harmonizing the middle-Jiao meridian, and relieving exterior symptoms and summer heat. Modern research indicates that its volatile oil components (such as patchouliol) have antibacterial and antiviral properties, and promote gastrointestinal motility. It is suitable for treating chest tightness and nausea caused by exogenous summer heat and dampness.

[0009] Angelica dahurica is pungent and warm, and enters the lung and stomach meridians. It is traditionally used to dispel wind and dampness, open the orifices and relieve pain. Its active ingredient, angelica dahuricae, has anti-inflammatory and analgesic effects, can inhibit tyrosinase activity, and is effective for rhinitis, headaches, and skin inflammation.

[0010] Saposhnikovia divaricata, pungent, sweet and slightly warm, enters the bladder, liver and spleen meridians. It can dispel wind and relieve exterior symptoms, overcome dampness and relieve pain. Pharmacology shows that it has antipyretic, anti-allergic and immunity-enhancing effects. It is often used for rheumatic pain and urticaria.

[0011] Qianghuo, pungent, pungent and warm, enters the bladder and kidney meridians, can dispel cold and dampness, relieve numbness and relieve pain. Modern research has confirmed its anti-inflammatory, analgesic and microcirculation-improving effects. It is suitable for wind-cold-dampness arthritis and cold pain in the shoulders and back.

[0012] Asarum is pungent and warm, and enters the lung and kidney meridians. It is traditionally used to dispel wind and cold, open the orifices and relieve pain. Its volatile oil (methyl eugenol) has local anesthetic and antitussive effects, but it contains aristolochic acid, so the dosage must be strictly controlled.

[0013] Scutellaria baicalensis is bitter and cold, and enters the lung, gallbladder, spleen, and large intestine meridians. It clears away heat and dampness, and purges fire and detoxifies. Baicalin is its core ingredient, which has broad-spectrum antibacterial, antiviral and antioxidant activities, and is effective in treating lung infections and damp-heat jaundice.

[0014] Coptis chinensis is bitter and cold, and enters the heart, spleen, stomach, and liver meridians. It contains berberine, which can be anti-inflammatory, lower blood sugar, and regulate intestinal flora. It is mainly used to treat damp-heat fullness, diarrhea, abdominal pain, and hyperactivity of heart fire.

[0015] Huang Bo, bitter and cold, enters the kidney and bladder meridians, clears away heat and dampness, purges fire and eliminates steaming. Its alkaloids can inhibit inflammatory factors (such as IL-6 and TNF-α), and are used for thick yellow leucorrhea caused by damp-heat and night sweats due to yin deficiency.

[0016] Rhubarb is bitter and cold, and enters the spleen, stomach, and large intestine meridians. It can attack stagnation, clear away heat and purge fire. Its anthraquinone components (such as rhubarb) stimulate intestinal peristalsis and have antibacterial and anti-thrombotic effects. It is mainly used to treat excess heat constipation and blood stasis.

[0017] Tangerine peel is pungent, spicy and warm, and enters the spleen and lung meridians. It can regulate qi and strengthen the spleen, dry dampness and resolve phlegm. It contains hesperidin, which can regulate gastrointestinal motility and relieve abdominal distension and cough with excessive phlegm.

[0018] Costus root is pungent, pungent and warm in nature, and enters the spleen, stomach and large intestine meridians. It can promote qi circulation, relieve pain, strengthen the spleen and aid food. Its volatile oil (costus lactone) has antispasmodic and anti-ulcer effects. It is mainly used to treat food stagnation, qi stagnation and heaviness after diarrhea.

[0019] Citrus aurantium, bitter, pungent and slightly cold, enters the spleen and stomach meridians, can break up qi and eliminate accumulation, resolve phlegm and relieve abdominal distension, can enhance gastrointestinal contraction and promote bile secretion, and is used for chest and diaphragm fullness and phlegm stagnation and qi obstruction.

[0020] Pinellia ternata is pungent and warm, and enters the spleen, stomach, and lung meridians. It can dry dampness and resolve phlegm, reduce adverse reactions and stop vomiting. It contains alkaloids that can inhibit gastric acid secretion and has a significant antiemetic effect. It is mainly used to treat phlegm, cough, and asthma, and upward flow of stomach qi. Poria cocos, sweet, mild, and neutral, enters the heart, lung, spleen, and kidney meridians. It promotes diuresis and eliminates dampness, strengthens the spleen, and calms the mind. Poria cocos polysaccharide acts as a diuretic and immune-boosting agent, and is used for edema, oliguria, and spleen deficiency and dampness. Alisma orientalis, sweet and cold, enters the kidney and bladder meridians. It promotes diuresis and eliminates dampness, and relieves heat. Its terpenoid component (alismol) can lower blood lipids and combat arteriosclerosis. It is primarily used to treat dysuria and dizziness caused by phlegm and fluid retention.

[0021] Pig's tooth soap is pungent, salty and warm, and enters the lung and large intestine meridians. It can eliminate phlegm, open the orifices, disperse lumps and reduce swelling. Its saponin components can dissolve phlegm mucin, and it is used for coma caused by phlegm congestion and sores.

[0022] Realgar is pungent and warm, and enters the liver and large intestine meridians. It can detoxify, kill insects, dry dampness and eliminate phlegm. It mainly contains arsenic disulfide (As2S2), which is effective against parasites and skin fungi, but it is highly toxic and should be used with caution.

[0023] Musk is pungent and warm, and enters the heart and spleen meridians. It can open the orifices, refresh the mind, promote blood circulation and dredge menstruation. Musk ketone can strengthen the heart, fight inflammation and promote wakefulness. It is used for closed syndrome, coma and amenorrhea. It is prohibited for pregnant women.

[0024] Yuanshen (Scrophulariaceae) is sweet, bitter and cold, and enters the lung, stomach and kidney meridians. It can clear away heat and cool blood, nourish yin and reduce fire. It contains harpagosides that can lower blood sugar and protect the vascular endothelium. It is mainly used to treat febrile diseases that damage yin and sore throat.

[0025] Bletilla striata is bitter, pungent and slightly cold, enters the heart and stomach meridians, clears away heat and toxins, eliminates carbuncles and disperses nodules, has an inhibitory effect on Staphylococcus aureus, and is used for sores, swellings and burns.

[0026] Platycodon grandiflorum is bitter, pungent and neutral in nature. It enters the lung meridian, clears the lungs and eliminates phlegm, relieves sore throat and discharges pus. Platycodon grandiflorum saponins can promote the secretion of respiratory mucus. It is mainly used to treat cough with excessive phlegm and lung abscess with vomiting pus.

[0027] Peppermint is pungent and cool, and enters the lung and liver meridians. It can dispel wind-heat and clear the head. Menthol can relax bronchial smooth muscles and relieve wind-heat headaches and sore throats.

[0028] Licorice is sweet and mild, and enters the heart, lung, spleen, and stomach meridians. It can nourish the spleen and replenish qi, and harmonize various medicines. Glycyrrhizic acid has anti-ulcer and corticosteroid-like effects, and can relieve drug toxicity and spleen and stomach weakness.

[0029] According to the principle of monarch, minister, assistant and envoy in traditional Chinese medicine, the composition and efficacy of the prescription of the present invention are as follows: The main drugs are used to dispel exterior pathogenic factors, eliminate cold, transform dampness and harmonize the middle, targeting the core pathogenesis of exogenous wind-cold-dampness, including Patchouli (aromatic to transform dampness, dispel exterior pathogenic factors and harmonize the middle, targeting exogenous wind-cold-dampness, and is the core drug for transforming dampness and dispelling exterior pathogenic factors), Notopterygium wilfordii (dispels exterior pathogenic factors, eliminates cold, dispels wind and overcomes dampness, is good at treating rheumatic pain in the upper body, and strengthens the effect of dispelling exterior pathogenic factors), Saposhnikovia divaricata (dispels wind and resolves exterior pathogenic factors, overcomes dampness and relieves pain, and works synergistically with Notopterygium wilfordii and Patchouli to enhance the effect of dispelling exterior pathogenic factors), Angelica dahurica (dispels exterior pathogenic factors, dispels cold, unclogs the nasal passages, dries dampness and relieves pain, and is targeted at those with exterior pathogenic factors and dampness obscuring the clear orifices).

[0030] Assistant herbs assist in dispelling exterior pathogens while clearing away damp-heat, preventing exterior pathogens from turning into heat and entering the interior. They include Bupleurum (which harmonizes exterior and interior, relieves liver qi and depression, and drives pathogens out, helping the monarch herbs to dispel exterior pathogens and reduce fever), Scutellaria baicalensis, Coptis chinensis, and Phellodendron chinense (Scutellaria baicalensis clears damp-heat in the upper burner, Coptis chinensis clears excess fire in the middle burner, and Phellodendron chinense clears damp-heat in the lower burner. The three herbs are used together to clear damp-heat in the three burners, targeting the internal heat symptoms that may be associated with colds), and Rhubarb (which clears the bowels and eliminates heat, conducts heat downward, and works together with Scutellaria baicalensis and Coptis chinensis to clear interior heat).

[0031] Auxiliary drugs regulate qi and eliminate dampness, harmonize qi, open the orifices and eliminate phlegm, and restrain the overly warm and dry or bitter and cold nature of the monarch and ministerial drugs, including dried tangerine peel, pinellia, poria, and oriental water chestnuts (the above 4 drugs regulate qi and strengthen the spleen, dry dampness and eliminate phlegm, promote diuresis and eliminate dampness, and are aimed at chest tightness, nausea, and excessive sputum caused by dampness blocking the spleen), costus root and aurantium (the above 2 drugs promote qi and relieve fullness, eliminate bloating and remove stagnation, strengthen the regulation of qi, and relieve abdominal distension), platycodon and aurantium (platycodon promotes lung function and relieves sore throat, aurantium descends qi and relieves fullness, one ascending and one descending, restoring the function of lung qi), pig's tooth soap and peppermint (pig's tooth soap eliminates phlegm and opens the orifices, peppermint dispels wind-heat, and assists in dispelling exterior pathogens and resolving phlegm), asarum (warms the meridians and dispels cold, opens the orifices and relieves pain, and assists the monarch drug in dispelling cold).

[0032] It harmonizes the properties of the drugs, guides the efficacy directly to the site of the disease, and has the functions of detoxification and opening the orifices, including licorice (tonic qi, clearing away heat and detoxifying, harmonizing various drugs, and alleviating the conflict between pungent and warm drugs and bitter and cold drugs in the prescription), realgar, and musk (realgar detoxifies and dries dampness (small doses can prevent poisoning), musk opens the orifices and refreshes the mind, and both are used in trace amounts to guide the meridians and enhance the efficacy of the drugs to reach the site of the disease).

[0033] The present invention takes "clearing away heat and detoxifying, removing dampness and resolving phlegm, and strengthening the body and eliminating pathogenic factors" as its general principle, and can prevent and treat mixed toxic pathogens (heat toxins, damp toxins, and cold toxins) caused by viruses (such as influenza viruses), bacteria, and fungal infections. Its core pharmacological effects are shown in the following table: The pharmacology of the prescription corresponding to the symptoms of the present invention is as follows: In terms of pharmacological mechanisms, the herbs in this compound work synergistically: Patchouli, Angelica dahurica, Tangerine Peel, and Mentha have aromatic properties for dehumidifying, dispelling exterior pathogenic cold, and dispelling cold; Gleditsia sinensis, Platycodon grandiflorum, Pinellia ternata, and Asarum have expectorant, antitussive, soothing, and soothing properties; Scutellaria baicalensis, Coptis chinensis, and Phellodendron chinense clear away heat and toxins, and eliminate dampness; Poria cocos and Alisma orientalis promote diuresis and eliminate dampness; and Rhubarb has a purgative, heat-clearing, and detoxifying effect. The combined use of these herbs comprehensively regulates the body's immune function, enhancing resistance while directly inhibiting the growth of pathogenic microorganisms.

[0034] In addition, the present invention also relates to the use of the traditional Chinese medicine composition in the preparation of a medicament for preventing or treating fever, respiratory diseases (symptoms of cough, swollen throat, shortness of breath), digestive tract diseases (symptoms of vomiting, diarrhea) or myocarditis (systemic symptoms, palpitations, lockjaw) caused by one or more of viruses, bacteria and fungi.

[0035] The components of the traditional Chinese medicine composition are powdered and mixed to obtain mixed powder, and the mixed powder is filled into capsule shells to obtain capsules.

[0036] When preparing an oral liquid medicament, the preparation method of the medicament comprises the following steps: 1) Patchouli, Gleditsia sinensis, Angelica dahurica, Tangerine peel, Menthol, Licorice root, Platycodon grandiflorum, Costus root, Saposhnikovia root, Pinellia ternata, Asarum (optional), Bletilla striata, Notopterygium wilfordii, Bupleurum root, Scutellaria baicalensis, Coptis chinensis, Phellodendron chinense, Poria cocos, Alisma orientalis, Citrus aurantium, Radix Rehmanniae, and Rhubarb are weighed and mixed according to weight, extracted with boiling water, and filtered to obtain an aqueous extract; 2) The aqueous extract is concentrated and then added with realgar and musk at room temperature (18-30° C.) to obtain the pharmaceutical agent.

[0037] Preferably, the material-liquid mass ratio of the boiling water extraction is 1:5-1:10, the number of extractions is 2-3 times, each extraction time is 1-2 hours, and the extracts are combined and filtered.

[0038] When preparing a medicament in other dosage forms, the preparation of the medicament includes the following steps: S1. Weigh the mixture of fangfeng, qianghuo, bupleurum, and angelica, add 8 times the amount of purified water and perform step distillation: distillation at 100 ° C for 1.5h to collect the light volatile oil, distillation at 120 ° C for 2h to collect the heavy volatile oil, and combine the light volatile oil and the heavy volatile oil to form a mixed volatile oil; S2. The residue was mixed with Patchouli, Gleditsia sinensis, Tangerine peel, Licorice, Platycodon grandiflorum, and Aucklandia lappa, 12 times the amount of water was added, extracted at a low boiling temperature of 85 ± 2 ° C for 2 h, filtered through a 300-mesh filter cloth, and the first filtrate and residue were collected; S3. The residue was added 8 times water at 90 ° C and refluxed for 1.5h, and the second filtrate was collected; S4. The first filtrate and the second filtrate were combined and concentrated under reduced pressure to collect the clear paste; S5. Weigh and mix Scutellaria baicalensis, Coptis chinensis, Phellodendron amurense, Poria cocos, Alisma orientalis, Citrus aurantium, Radix Rehmanniae, Radix Rehmanniae, Rhubarb, Mentha arvense, Pinellia ternata, Asarum sieboldii (optional), and Radix Ampelopsis pilosulae. Extract the mixture using 70% ethanol at a solid-liquid ratio of 1:10. Perform three-stage countercurrent extraction for 45 minutes per stage. Filter the extract and collect the concentrate. S6. The clear paste and the concentrated solution are mixed in a ratio of 3:1, musk and realgar are added and mixed, vacuum dried, crushed, granulated, sprayed with the mixed volatile oil, mixed, and excipients are added to prepare powder, nebulizer inhalation, and sublingual rapid film preparation respectively.

[0039] The present invention provides a variety of different administration forms for different symptom types, such as a nebulizer inhaler for severe respiratory tract disease; a sublingual rapid film preparation for acute laryngeal swelling; an intestinal targeted capsule for diarrheal infection, etc.

[0040] The beneficial effects of the present invention are: 1. Broad-spectrum antiviral: covers respiratory and digestive tract viral and drug-resistant bacterial infections, with indications ranging from common cold to severe pneumonia.

[0041] 2. Multi-target synergy: combining the effects of eliminating pathogens (antiviral / antibacterial) with strengthening the body (immunomodulation) to reduce the risk of drug resistance from single drug use.

[0042] 3. Rapidly relieve symptoms: Clear the bowels and dissipate heat, with a fever reduction rate of over 70% within 48 hours. DETAILED DESCRIPTION

[0043] The technical solutions of the present invention will be described clearly and completely below with the aid of embodiments. Obviously, the embodiments described are only some of the embodiments of the present invention, not all of them. All other embodiments derived by persons of ordinary skill in the art based on the embodiments of the present invention without inventive effort are also within the scope of protection of the present invention.

[0044] Example 1: A traditional Chinese medicine composition is prepared from the following traditional Chinese medicine raw materials in parts by weight: 10 parts of Patchouli, 6 parts of Gleditsia sinensis, 10 parts of Angelica dahurica, 10 parts of dried tangerine peel, 6 parts of mint, 6 parts of liquorice, 10 parts of Platycodon grandiflorum, 6 parts of costus root, 10 parts of Saposhnikovia divaricata, 6 parts of Pinellia ternata, 2 parts of Asarum, 0.3 parts of realgar, 10 parts of Bletilla striata, 0.1 parts of musk, 10 parts of Notopterygium wilfordii, 10 parts of Bupleurum chinense, 10 parts of Scutellaria baicalensis, 6 parts of Coptis chinensis, 10 parts of Phellodendron amurense, 10 parts of Poria cocos, 10 parts of Alismatis rhizome, 10 parts of Citrus aurantium, 10 parts of Radix Rehmanniae, and 6 parts of Rhubarb.

[0045] The Chinese medicine composition in this embodiment has the effects of clearing away heat and detoxifying, dispelling wind and cold, and removing dampness and soothing the stomach, and is suitable for treating symptoms such as fever, cough, and sore throat. The effects of various Chinese medicinal materials work synergistically to effectively inhibit viral replication and enhance the body's immunity.

[0046] Mixed toxic pathogens caused by viral (such as influenza), bacterial, and fungal infections present with variable symptoms, a mixture of cold and heat, lingering or rapidly progressive illness, and systemic manifestations of toxic pathogens, primarily manifesting as confusion, a dull complexion, and jaundice. These symptoms are often complicated by pathological products such as "stasis," "phlegm," and "wind." Patients must be between 18 and 60 years old and present within 48 hours of onset. All patients with these symptoms are considered eligible for selection.

[0047] Specific symptoms of mixed toxic pathogens (heat, dampness, and cold) caused by viral (such as influenza virus), bacterial, and fungal infections include mild pneumonia, influenza combined with bacterial pneumonia, viral enteritis, fungal pneumonia, bacterial dysentery, and viral myocarditis. Western medicine diagnostic standards are consistent with the diagnostic standards in the "Standards for Diagnosis and Efficacy of Traditional Chinese Medicine Diseases and Syndromes" (2024 edition). Traditional Chinese medicine syndrome differentiation refers to the "Guiding Principles for Clinical Research of New Chinese Medicines." This preparation has been used in clinical medicine and the following treatment cases have been obtained: Case 1: Mild pneumonia (heat toxin attacking the lungs) Patient: Male, 35 years old, fever 38.5℃, dry cough, sore throat, CT showed ground-glass shadows in both lungs. Medication: Take this prescription in capsule form (3g / time, 3 times / day). Results: Fever subsided in 1 day, cough eased after 15 minutes, and CT shadow absorption rate was 60% after 15 days.

[0048] Case 2: Influenza combined with bacterial pneumonia Patient: Female, 50 years old, high fever 40℃, cough with purulent sputum. Dosage: Inhale this prescription through aerosol and take the capsules orally, 3g each time, 3 times a day. Expectoration will decrease 30 minutes after taking the medicine. Results: Fever subsided in 18 hours and lung rales disappeared in 7 days.

[0049] Case 3: Viral enteritis (cold-dampness toxicity syndrome) Patient: Male, 28 years old, watery diarrhea 10 times / day, vomiting, white greasy tongue coating. Dosage: Take this capsule, 3g each time, 3 times a day, for 3 days.

[0050] Result: Diarrhea stopped and vomiting stopped within 24 hours.

[0051] Case 4: Fungal pneumonia.

[0052] Patient: Male, 60 years old, long-term hormone treatment, fever and lung nodules. Dosage: Inhalation of this prescription by nebulization, combined with oral administration of this prescription capsule. 3g each time, 3 times a day Results: The body temperature returned to normal after 3 days and the GM test turned negative.

[0053] Case 5: Bacillary dysentery (damp-heat toxicity syndrome) Patient: Male, 32 years old, with bloody stools, tenesmus, and abdominal pain. Dosage: Take this prescription in capsule form, 5g each time, twice a day. Results: The bloody stool disappeared in 3 days and the symptoms were relieved in 5 days. Case 6: Viral Myocarditis (Heat Toxin Invading the Heart) Patient: Female, 22 years old, with palpitations, chest tightness, and phlegm in the throat that is difficult to cough up. Dosage: Take this prescription capsule, 3g each time, 3 times a day.

[0054] Result: The palpitations were relieved in 5 days. Case 7: Severe pneumonia.

[0055] Patient: Male, 70 years old, tachypnea (RR 35 times / min), bilateral lung consolidation. Dosage: Inhalation of this prescription by nebulization plus oral administration of this prescription capsule, 5g each time, 3 times a day.

[0056] Results: Inflammatory markers decreased over 7 days. Case 8: Drug-resistant bacterial infection (MRSA pneumonia) Patient: A 55-year-old male patient presented with fever and multidrug-resistant bacterial infection, with poor efficacy of vancomycin. Dosage: Inhale this prescription by nebulization, and take this prescription capsule orally, 3g each time, 3 times a day. Results: The body temperature returned to normal within 5 days and the bacterial clearance rate was 80%. The preparation method of the capsule in the above case is: grind the components of the traditional Chinese medicine composition into powder and mix them to obtain mixed powder, and then fill the mixed powder into a capsule shell to obtain the capsule.

[0057] Other dosage forms are prepared using the following preparation methods: S1. Weigh the mixture of fangfeng, qianghuo, bupleurum, and angelica, add 8 times the amount of purified water and perform step distillation: distillation at 100 ° C for 1.5h to collect the light volatile oil, distillation at 120 ° C for 2h to collect the heavy volatile oil, and combine the light volatile oil and the heavy volatile oil to form a mixed volatile oil; S2. The residue was mixed with Patchouli, Gleditsia sinensis, Tangerine peel, Licorice, Platycodon grandiflorum, and Aucklandia lappa, 12 times the amount of water was added, extracted at a low boiling temperature of 85 ± 2 ° C for 2 h, filtered through a 300-mesh filter cloth, and the first filtrate and residue were collected; S3. The residue was added 8 times water at 90 ° C and refluxed for 1.5h, and the second filtrate was collected; S4. The first filtrate and the second filtrate were combined and concentrated under reduced pressure to collect the clear paste; S5. Weigh scutellaria baicalensis, coptis chinensis, phellodendron, poria, zedoaria, fructus aurantii, radix polygoni ginseng, rhubarb, mint, pinellia ternata, asarum, and ampelopsis pilosula, mix them, use 70% ethanol as solvent, with a solid-liquid ratio of 1:10, perform three-stage countercurrent extraction, each stage for 45 minutes, and collect the concentrate by filtration; S6. The clear paste and the concentrated solution are mixed in a ratio of 3:1, musk and realgar are added and mixed, vacuum dried, crushed, granulated, sprayed with the mixed volatile oil, mixed, and excipients are added to prepare capsules, nebulizer inhalation, and sublingual rapid film preparation respectively.

[0058] Example 2: The Chinese medicine preparation is made from the following Chinese medicine raw materials in parts by weight: 10 parts of Patchouli, 6 parts of Gleditsia sinensis, 10 parts of Angelica dahurica, 10 parts of dried tangerine peel, 6 parts of mint, 6 parts of liquorice, 10 parts of Platycodon grandiflorum, 6 parts of costus root, 10 parts of saposhnikovia divaricata, 6 parts of Pinellia ternata, 0 part of asarum, 0.3 part of realgar, 10 parts of white ampelopsis, 0.1 part of musk, 10 parts of Notopterygium wilfordii, 10 parts of Bupleurum chinense, 11 parts of Scutellaria baicalensis, 6 parts of Coptis chinensis, 10 parts of Phellodendron amurense, 10 parts of Poria cocos, 10 parts of Alismatis rhizome, 10 parts of Citrus aurantium, 10 parts of Yuanshen, and 6 parts of rhubarb.

[0059] The difference between this embodiment and the first embodiment is that the amount of Asarum is reduced from 2 parts to 0 parts, and the amount of Scutellaria baicalensis is increased from 10 parts to 11 parts. This adjustment in the formula is mainly due to the fact that Asarum is warm and dry in nature, which may aggravate the heat symptoms in some patients with a hot constitution, while Scutellaria baicalensis has the effects of clearing heat and dampness, purging fire and detoxifying. Increasing its amount can enhance the heat-clearing and detoxifying effects, making it more suitable for patients with obvious heat symptoms.

[0060] The preparation method is the same as that of Example 1.

[0061] Example 3 The Chinese medicine preparation is made from the following Chinese medicine raw materials in parts by weight: 10 parts of Patchouli, 6 parts of Gleditsia sinensis, 10 parts of Angelica dahurica, 10 parts of dried tangerine peel, 6 parts of mint, 6 parts of liquorice, 10 parts of Platycodon grandiflorum, 6 parts of costus root, 10 parts of saposhnikovia divaricata, 6 parts of Pinellia ternata, 0 part of asarum, 0.1 part of realgar, 10 parts of white ampelopsis, 0 part of musk, 10 parts of Notopterygium wilfordii, 10 parts of Bupleurum chinense, 12 parts of Scutellaria baicalensis, 4 parts of Coptidis rhizome, 10 parts of Phellodendron chinense, 10 parts of Poria cocos, 10 parts of Alismatis rhizome, 10 parts of Citrus aurantium, 10 parts of Yuanshen, 6 parts of rhubarb, 12 parts of honeysuckle, and 12 parts of forsythia.

[0062] The difference between Example 3 and Example 1 is that the amount of Asarum is reduced from 2 parts to 0 parts, the amount of Realgar is reduced from 0.3 parts to 0.1 parts, the amount of Musk is reduced from 0.1 parts to 0 parts, the amount of Scutellaria baicalensis is increased from 10 parts to 12 parts, the amount of Coptis chinensis is reduced from 6 parts to 4 parts, and the newly added medicinal materials are: 12 parts of Honeysuckle and 12 parts of Forsythia suspensa. Asarum is warm and dry in nature, and prolonged use can deplete Qi and damage Yin. Its complete removal can avoid adverse effects on patients with Yin deficiency, internal heat, or those with a dry constitution. Realgar contains arsenic compounds, so reducing its dosage reduces the risk of toxic accumulation while retaining its detoxifying properties. Musk is a potent herb and a scarce resource, so its removal expands its applicable population (for example, it is contraindicated for pregnant women) and reduces costs. Scutellaria baicalensis has the properties of clearing heat and dampness, purging fire and detoxifying. Increasing its dosage synergizes with the additions of honeysuckle and forsythia to enhance its antiviral and antipyretic effects. Coptis chinensis is bitter and cold, and can damage stomach Qi. Reducing its dosage can alleviate gastrointestinal irritation, while maintaining overall heat-clearing efficacy by adding Scutellaria baicalensis. The adjusted formula is more suitable for cold patients with heat-toxin accumulation (symptoms include high fever, sore and swollen throat, and thick yellow sputum). While clearing heat and detoxifying, it also balances safety and spleen and stomach protection. It is particularly suitable for the common pathogenesis of "external heat and toxic exogenous infection" in modern patients.

[0063] The preparation method is the same as that of Example 1.

[0064] Finally, it should be noted that the above embodiments are only used to illustrate the technical solutions of the present invention, rather than to limit it. Although the present invention has been described in detail with reference to the aforementioned embodiments, those skilled in the art should understand that they can still modify the technical solutions described in the aforementioned embodiments, or make equivalent replacements for some of the technical features therein. However, these modifications or replacements do not deviate the essence of the corresponding technical solutions from the spirit and scope of the technical solutions of the various embodiments of the present invention.

Claims

1. A Chinese medicine composition, characterized in that: The traditional Chinese medicine composition comprises the following raw materials by weight: 8-12 parts of Patchouli, 4-8 parts of Gleditsia sinensis, 8-12 parts of Angelica dahurica, 8-12 parts of dried tangerine peel, 4-8 parts of mint, 4-8 parts of liquorice, 8-12 parts of Platycodon grandiflorum, 4-8 parts of costus root, 8-12 parts of siler, 4-8 parts of pinellia tuber, 0.1-0.5 parts of realgar, 8-12 parts of white ampelopsis, 8-12 parts of Notopterygium wilfordii, 8-12 parts of bupleurum, 8-12 parts of scutellaria baicalensis, 4-8 parts of coptis chinensis, 8-12 parts of phellodendron amurense, 8-12 parts of poria, 8-12 parts of oriental rhizome, 8-12 parts of fructus aurantii, 8-12 parts of Radix Rehmanniae, and 4-8 parts of rhubarb.

2. The Chinese medicine composition according to claim 1, wherein: Also includes 1-3 parts of Asarum.

3. The Chinese medicine composition according to claim 1, characterized in that: It also contains 0.05-0.2 parts of musk.

4. The Chinese medicine composition according to claim 1, wherein: The Chinese medicine composition is composed of the following raw materials by weight: 10 parts of Patchouli, 6 parts of Gleditsia sinensis, 10 parts of Angelica dahurica, 10 parts of dried tangerine peel, 6 parts of mint, 6 parts of liquorice, 10 parts of Platycodon grandiflorum, 6 parts of costus root, 10 parts of siler, 6 parts of pinellia tuber, 0.3 parts of realgar, 10 parts of white ampelopsis, 0.1 parts of musk, 10 parts of Notopterygium wilfordii, 10 parts of bupleurum, 11 parts of scutellaria baicalensis, 6 parts of coptis chinensis, 10 parts of phellodendron amurense, 10 parts of poria, 10 parts of oriental rhizome, 10 parts of fructus aurantii, 10 parts of yuanshen, and 6 parts of rhubarb.

5. The Chinese medicine composition according to claim 1, characterized in that: The Chinese medicine composition is composed of the following raw materials by weight: 10 parts of Patchouli, 6 parts of Gleditsia sinensis, 10 parts of Angelica dahurica, 10 parts of dried tangerine peel, 6 parts of mint, 6 parts of liquorice, 10 parts of Platycodon grandiflorum, 6 parts of costus root, 10 parts of Saposhnikovia divaricata, 6 parts of Pinellia ternata, 2 parts of Asarum, 0.3 parts of realgar, 10 parts of Bletilla striata, 0.1 parts of musk, 10 parts of Notopterygium wilfordii, 10 parts of Bupleurum chinense, 10 parts of Scutellaria baicalensis, 6 parts of Coptis chinensis, 10 parts of Phellodendron amurense, 10 parts of Poria cocos, 10 parts of Alismatis rhizome, 10 parts of Citrus aurantium, 10 parts of Radix Rehmanniae, and 6 parts of Rhubarb.

6. The Chinese medicine composition according to claim 1, characterized in that: The Chinese medicine composition is composed of the following raw materials by weight: 10 parts of Patchouli, 6 parts of Gleditsia sinensis, 10 parts of Angelica dahurica, 10 parts of dried tangerine peel, 6 parts of mint, 6 parts of liquorice, 10 parts of Platycodon grandiflorum, 6 parts of costus root, 10 parts of Saposhnikovia divaricata, 6 parts of Pinellia ternata, 0.1 part of realgar, 10 parts of Bletilla striata, 10 parts of Notopterygium wilfordii, 10 parts of Bupleurum chinense, 12 parts of Scutellaria baicalensis, 4 parts of Coptis chinensis, 10 parts of Phellodendron chinense, 10 parts of Poria cocos, 10 parts of Alismatis rhizome, 10 parts of Citrus aurantium, 10 parts of Radix Rehmanniae, 6 parts of Rhubarb, 12 parts of Honeysuckle, and 12 parts of Forsythia suspensa.

7. The use of the Chinese medicine composition according to any one of claims 1 to 6, characterized in that: The Chinese medicine composition is used in the preparation of a medicament for preventing or treating fever, respiratory diseases, digestive tract diseases and myocarditis caused by one or more of viruses, bacteria and fungi.

8. The use according to claim 8, characterized in that: The preparation method of the medicine comprises the following steps: grinding the components of the traditional Chinese medicine composition into powder and mixing them to obtain mixed medicine powder, and then filling the mixed medicine powder into a capsule shell to obtain a capsule.

9. The use according to claim 8, characterized in that: The preparation of the medicament comprises the following steps: S1. Weigh the mixture of fangfeng, qianghuo, bupleurum, and angelica, add 8 times the amount of purified water and perform step distillation: distillation at 100 ° C for 1.5h to collect the light volatile oil, distillation at 120 ° C for 2h to collect the heavy volatile oil, and combine the light volatile oil and the heavy volatile oil to form a mixed volatile oil; S2. The residue was mixed with Patchouli, Gleditsia sinensis, Tangerine peel, Licorice, Platycodon grandiflorum, and Aucklandia lappa, 12 times the amount of water was added, extracted at a low boiling temperature of 85 ± 2 ° C for 2 h, filtered through a 300-mesh filter cloth, and the first filtrate and residue were collected; S3. The residue was added 8 times water at 90 ° C and refluxed for 1.5h, and the second filtrate was collected; S4. The first filtrate and the second filtrate were combined and concentrated under reduced pressure to collect the clear paste; S5. Weigh scutellaria baicalensis, coptis chinensis, phellodendron, poria, oriental rhizome, fructus aurantii, radix polygoni ginseng, rhubarb, mint, pinellia ternata, and ampelopsis pilosula, mix them, use 70% ethanol as solvent, with a solid-liquid ratio of 1:10, perform three-stage countercurrent extraction, each stage for 45 minutes, and collect the concentrate by filtration; S6. The clear paste and the concentrated solution are mixed in a ratio of 3:1, realgar alone is added, or musk and realgar are added and mixed, vacuum dried, crushed, granulated, sprayed with the mixed volatile oil, mixed, and excipients are added to prepare powders, nebulized inhalers, and sublingual rapid film preparations respectively.

10. The use according to claim 9, characterized in that: In step S5, asarum is also added and mixed.

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