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63 results about "Immune recognition" patented technology
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Immune Recognition is a modified compilation of an experimental leukocyte culture conference about various aspects of macrophage and lymphocyte biology in relation to the eponymous central theme. The book is divided into nine sections. Section I covers non-antigenic signals and receptors for lymphocyte activation;
Determining Antigen Recognition through Barcoding of MHC Multimers
PendingUS20170343545A1Improve understandingMicrobiological testing/measurementBiological material analysisSingle sampleVaccination
The present invention describes the use of nucleic acid barcodes as specific labels for MHC multimers to determine the antigen responsiveness in biological samples. After cellular selection the barcode sequence will be revealed by sequencing. This technology allows for detection of multiple (potentially >1000) different antigen-specific cells in a single sample. The technology can be used for T-cell epitope mapping, immune-recognition discovery, diagnostics tests and measuring immune reactivity after vaccination or immune-related therapies.
Owner:IMMUDEX APS +1
Immunogenic composition and method of developing a vaccine based on factor H binding sites
InactiveUS20050112139A1Rapid decrease in viremiaEasy to copyVirus peptidesPharmaceutical delivery mechanismBinding siteAutoimmune responses
An immunogenic composition able to provide an immune response to Human Complement Factor H binding on one or more HIV glycoproteins is disclosed, which is characterized by at least one binding site epitope of the glycoproteins. Such immunogenic composition wherein the glycoprotein comprises gp120, gp41, or both glycoproteins gp120 and gp41 is hereby disclosed. Sialic acid is removed to enhance immune recognition of the composition and to impair Factor H binding. A medication having an inhibitive action on autoimmune response by specific inhibition of the cleavage of C3b by Factor H into inactive cell fragments.
Owner:KARP NELSON M
Signal-enhancement type immunochromatographic gold-labeled test strip and preparation method thereof
InactiveCN102507929AReduced Quantitative DetectionHigh sensitivityMaterial analysisImmune recognitionImmunity
The invention discloses a signal-enhancement type immunochromatographic gold-labeled test strip and a preparation method thereof. The preparation method of the gold-labeled test strip comprises the following steps of: (1) combining colloidal gold nanometer particles with different particle diameters; (2) preparing a colloidal gold immunity detection probe; (3) preparing a colloidal gold signal enhancement probe; (4) mounting signal-enhancement type test paper; and (5) establishing a detection method of the signal-enhancement type test paper. The signal-enhancement type immunochromatographic gold-labeled test strip, disclosed by the invention, can be applied to field fast ultra-sensitive detection without needing other auxiliary instruments, and has the following advantages that: a detection operation can be finished within 10-15 minutes and a detection result can be obtained; the sensitivity of the traditional test paper detection method can be remarkably improved, and the ultra-sensitive detection of a low-concentration appointed target object which is not realized by the traditional test paper is realized; and as long as an antibody of the immunity identification probe of the test paper is correspondingly replaced, the detection of other target objects can be realized; the specificity is high, the stability is good, the application range is wide, the cost is low and the like; in addition, the signal-enhancement type immunochromatographic gold-labeled test strip and the preparation method thereof, disclosed by the invention, are easy to promote and apply.
Owner:HEFEI UNIV OF TECH
Photoelectric chemical detection method of zearalenone based on TiO2 mesocrystal
InactiveCN106383156AHigh porosityFast transmissionMaterial electrochemical variablesImmune recognitionPhotocurrent
The invention discloses a photoelectric chemical detection method of zearalenone based on a TiO2 mesocrystal. According to the method, a polydopamine-sensitized rutile type TiO2 mesocrystal is used as a photoelectric active substrate material and is applied to an immobilization zearalenone antibody; a mesoporous cobaltosic oxide marked zearalenone secondary antibody is used as a signal probe; a photoelectric chemical sensor based on a sandwich immune recognition mode is prepared by using a signal amplification effect of the probe on the substrate material and is applied to quantitative detection of zearalenone; based on stability and high conductivity of polydopamine, polydopamine and an RTM composite can accelerate transferring speed of photoinduced electrons and increasing photocurrent signals; through a sandwich immune recognition process, OMCO with competitive light-harvesting capability is introduced into a sensing interface; and high-sensitivity detection on zearalenone in a concentration range of 1x10<-6>ng / Ml-20ng / mL can be achieved.
Owner:FUJIAN NORMAL UNIV
Immune complex vaccination as a strategy to enhance immunity in the elderly and other immune compromised populations
InactiveUS20080311135A1Reduced responseEnhance antibody responseAntibody ingredientsImmunoglobulinsImmune compromisedVaccination
The present invention generally concerns methods and compositions for improving the immune system of an individual that is an immune-compromised individual. In particular aspects, the immune-compromised individual is elderly or is immunosuppressed, such as from chemotherapy or immunosuppressants following organ or tissue transplantation. In specific embodiments, the invention relates to delivery to the immune-compromised individual of immune complexes harboring an antigen and an antibody that immunologically recognizes the antigen. The antigen may be viral, bacterial, or fungal, for example.
Owner:BAYLOR COLLEGE OF MEDICINE
Preparation and application of adjacent hybridization dual-mode immunosensor based on MXene nanosheet photo-thermal amplification
ActiveCN110716040AIncrease analytical capacityGood biocompatibilityBiological material analysisBiological testingDeoxyribonucleic acid probeImmune recognition
The invention discloses preparation and application of an adjacent hybridization dual-mode immunosensor based on MXene nanosheet photo-thermal amplification. Polyethyleneimine (PEI) modified TiO2 disc-shaped nanoparticles are used as a substrate, and a large amount of capture substrate deoxyribonucleic acids are fixed on a sensing interface through electrodeposition of gold. Two deoxyribonucleic acid probes are both labeled with a human epididymis protein 4 (HE4) antibody of a target object, and after the deoxyribonucleic acid probes as a recognition part of HE4 are captured by DNA3, the HE4 induces adjacent hybridization between primary antibody-labeled DNA1 and secondary antibody-labeled DNA2 by immunorecognition. An MXene nanosheet is loaded with a large amount of thionine, so that theMXene nanosheet can be effectively intercalated into a double-stranded DNA groove formed by hybridization, can be used as a signal probe for electrochemical-temperature dual modes, and realizes amplification of electrochemical signals due to temperature rise generated by the photo-thermal effect. Under the irradiation of an 808 nm infrared laser device, high-sensitivity detection of the HE4 is realized.
Owner:FUJIAN NORMAL UNIV
Difunctional composite nanosphere and method for rapidly detecting food-borne pathogenic bacteria
InactiveCN104749365AAchieve secondary amplificationShorten detection timeNanosensorsMicroballoon preparationFood borneMagnetite Nanoparticles
The invention provides a difunctional composite nanosphere and a method for rapidly detecting food-borne pathogenic bacteria. The difunctional composite nanosphere is characterized in that silicon dioxide is adopted and quantum dots and magnetic nanoparticles are embedded simultaneously to construct the composite nanosphere having the optical property and the superparamagetism. The corresponding quantum dot and the nanosphere are connected with a monoclonal antibody capable of specifically recognizing food-borne pathogenic bacteria, and an immune quantum dot probe capable of carrying out antigen-antibody reaction with antigens on the surface of the bacteria and an immune composite nanosphere probe are acquired. The composite nanosphere with the composite structure can be used as a carrier for immunologically recognizing and separating the pathogenic bacteria and also can be used as a signal enhancer element of the immune quantum dot probe, secondary amplification of a detection signal is realized, and target microorganisms of a sample to be detected are acquired by adopting an optical detection method. According to the method, the detection time less than or equal to 2h can be greatly shortened, the sensitivity (102cfu / mL) is improved, and the method is suitable for on-site rapid detection of foods and environment samples and can be popularized and applied in grass roots.
Owner:SHANGHAI INST OF MICROSYSTEM & INFORMATION TECH CHINESE ACAD OF SCI
Method for proteomic analysis utilizing immune recognition and cumulative subtraction
InactiveUS20080008699A1Promote accumulationSimple and noninvasive collectionSnake antigen ingredientsImmunoglobulins against animals/humansBiological bodyImmune recognition
Owner:THE BOARD OF TRUSTEES OF THE UNIV OF ILLINOIS
The DNA vaccine of an anti-infection of hepatitis C virus
InactiveCN1943789AEasy to makeGood effectGenetic material ingredientsDigestive systemImmune recognitionMutant
The invention relates to preparation and application of DNA vaccine that can resist to the infection of hepatitis C virus. The invention constructed a recombinant DNA vaccine that can express HCV enveloped glycoprotein E1 with molecular cloning techniques, on this basis constructed six N-glycosylation mutants M1-M6 of the E1 and select N-glycosylation mutant M2 as DNA vaccine that resist to infection of hepatitis C virus and application in the preparation of DNA vaccine that prevent the HCV virus infection. The advantages of the invention are : experiments reveal that N-sugar chain of HCV E1 enveloped glycoprotein can limit the host's cellular immune responses, its glycosylation may shield the T and B cell epitope of virus, thereby enable the virus to evade immune recognition; with E1 glycosylate mutants M2 may be used as DNA vaccines that are HCV therapeutic and preventive and enhance the immunogenicity, besides preparation of mutants M2 E1 glycosylate is simple, convenient and effective, and has good application prospect.
Owner:WUHAN UNIV
Product and method for treatment of conditions associated with receptor-desensitization
InactiveUS7825224B2Prolongs and enhances timeSensitizing receptorSenses disorderNervous disorderNK-receptorCellular antigens
Particular members of the multisubunit immune recognition receptor (MIRR) family of receptors, specifically, the B cell antigen receptor (BCR), the pre-B cell receptor (pre-BCR), the pro-B cell receptor (pro-BCR), Ig Fc receptors (FcR), and NK receptors, can be physically uncoupled from their associated transducers. The invention describes regulatory compounds and methods for mimicking such dissociation / destabilization for the purposes of receptor desensitization and for treatment of conditions in which receptor desensitization or alternatively, enhanced or prolonged receptor sensitization, is desirable. Compounds and methods for enhancing or prolonging receptor sensitization are also disclosed, as are methods for identifying regulatory compounds suitable for use in the present methods.
Owner:NAT JEWISH HEALTH
Preparation method of photoelectrochemical immunosensor for detecting procalcitonin
ActiveCN110501393AImprove photoelectric conversion efficiencyFast transferMaterial electrochemical variablesSemiconductor materialsAcetylcholine Iodide
The invention relates to a preparation method of a photoelectrochemical immunosensor for detecting procalcitonin. Through a split-type photoelectrochemical sensor construction mode, immune recognitionanalysis and photoelectric response test analysis of an inorganic semiconductor material are separated to achieve a purpose that the photoelectric test can be realized without damaging the immune recognition process of biomolecules; a bismuth stannate nano-material modified a cadmium sulfide nano-material is used as a substrate material to provide basic photoelectric response, and band gap structures of the two are matched, so that visible light utilization efficiency can be well improved; in the antigen and antibody specific immune recognition process in a 96 microwell plate, acetylcholin esterase is firmly bound to a procalcitonin secondary antibody through an aminated aldehyde silicon dioxide material, and the compound marks the procalcitonin secondary antibody as a marker; after acetylcholine iodide is dropped into the 96-microwell plate, the acetylcholine esterase has catalytic reaction with the acetylcholine iodide to obtain a product thiocholine, which serves as an electron donor to capture holes in the material caused by light excitation, so that light current is improved to different degrees, and sensitive detection of the procalcitonin is realized; and the detection limit of the procalcitonin is 0.20 pg / mL.
Owner:UNIV OF JINAN
Hapten, artificial antigen and monoclonal antibody for tylosin and preparation methods and applications thereof
InactiveCN102827222AQuick filterImprove detection efficiencySugar derivativesOvalbuminImmune profilingMetabolite
The invention discloses a hapten, an artificial antigen and a monoclonal antibody for tylosin and preparation methods and applications thereof. The hapten contains a common structural part of tylosin, tilmicosin, acetyl-isovaleryl tylosin and a tylosin metabolin, i.e., cladinose-removed tylosin; and in the preparation process of a tylosin artificial antigen, introduced carboxyl is connected with a carrier protein, i.e., the common structural part is kept far away from the carrier protein and is fully exposed to an immunological recognition of animals. A broad-spectrum specific antibody which can be used for recognizing the tylosin, tilmicosin, the acetyl-isovaleryl tylosin and the tylosin metabolin, i.e., cladinose-removed tylosin simultaneously can be obtained by taking the artificial antigen as an immunogen immune animal. When the broad-spectrum specific antibody is used for rapidly immunologically analyzing and sieving, the detection efficiency is increased, the detection time is shortened, and the detection cost is lowered.
Owner:HEBEI AGRICULTURAL UNIV.
Hapten, artificial antigen and monoclonal antibody for phenothiazine medicaments, preparation methods of hapten and artificial antigen and application of monoclonal antibody
The invention discloses a hapten, an artificial antigen and a monoclonal antibody for phenothiazine medicaments, preparation methods of the hapten and the artificial antigen and the application of the monoclonal antibody. The hapten contains a common structure of the phenothiazine medicaments and is connected with a carrier protein through introduced carboxyl in a preparation process of the artificial antigen for the phenothiazine medicaments, namely, the common structure is far away from the carrier protein and is completely exposed to an immunological recognition system of an animal. Therefore, a broad-spectrum specific antibody capable of recognizing a plurality of phenothiazine medicaments can be obtained when the artificial antigen is used for immunizing the animal as an immunogen, and is used for quickly realizing immunoassay and screening to improve the detection efficiency, shorten the detection time and lower the detection cost.
Owner:HEBEI AGRICULTURAL UNIV.
Method of developing an immunogenic composition and HIV vaccine
InactiveUS20050112143A1Broad antigenic responseEasy to produceVirus peptidesPharmaceutical delivery mechanismImmune recognitionComplement factor I
An antigenic and immunogenic composition of predetermined inactivated strains of human immunodeficiency virus (HIV) is disclosed. Inactivation is through psoralen and ultraviolet radiation; the composition is rendered more effective by the removal of structural features of HIV that interfere with immune response. In particular, sialic acid is removed to enhance immune recognition of the composition and to impair Complement Factor H binding. CD55 and CD59 are also removed to prevent the binding of Complement Factor H. Determination of strains for inactivation may be though immunotherapeutic genotyping or probabilistic assessment of risk of exposure.
Owner:KARP NELSON M M D
Diamondback moth peptidoglycan recognition protein, preparation method and application thereof
The present invention discloses diamondback moth peptidoglycan recognition protein, a preparation method and an application thereof, wherein the nucleotide sequence of the diamondback moth peptidoglycan recognition protein gene is represented by SEQIDNO:1-2, and semi-quantitative RT-PCR is adopted to detect temporal and spatial expression of diamondback moth PGRP-S1 in the body. According to the present invention, isaria fumosorosea is adopted to treat diamondback moth larva, quantitative RT-PCR is adopted to detect an immune recognition effect of the diamondback moth PGRP-SA gene on fungi paecilomyces fumosoroseus isaria, and the PGRP-S1 is the innate immune recognition receptor of diamondback moth, activates innate immunity, regulates antibacterial peptide expression, and provides a new target for prevention and control of diamondback moth from immunology.
Owner:SOUTH CHINA AGRI UNIV
Immune memory learning control based wet coagulation bath temperature control process for carbon fiber precursor
InactiveCN103399490AImprove intelligenceImprove controlTemperatue controlAdaptive controlTemperature controlFiber
The invention provides an immune memory learning control based wet coagulation bath temperature control process for a carbon fiber precursor. The process route is as follows: polyacrylonitrile original liquid is extruded into a coagulation bath tank through a spinneret plate, the temperature of coagulating liquid in the coagulation bath tank is subjected to real-time detection by a temperature detecting element and is fed back to a controller, the controller carries out current control quantity calculation according to the current and historical data of set value input, control quantity and feedback output and outputs a current control quantity to a controlled object, a coagulation bath is heated, and finally, the actual temperature of the coagulation bath reaches a set temperature. The controller is an intelligent temperature controller based on immune memory learning and is used for simulating an immune recognition, response and memory mechanism of a human body immune system, the traditional iterative learning control algorithms are improved, interference is taken as an antigen and is subjected to recognition, elimination and feature memory, and a control system can quickly respond and accurately control interference when the same interference occurs again, so that the stability and interference immunity of the control system are further improved.
Owner:DONGHUA UNIV
Construction of live attenuated Shigella vaccine strains that express CFA/I antigens (CfaB and CfaE) and the B subunit of heat-labile enterotoxin (LTB) from enterotoxigenic E. coli
ActiveUS7759106B2Reduce intrusionBacterial antigen ingredientsBacteriaHeterologousMucosal Immune Responses
Owner:UNITED STATES OF AMERICA THE AS REPRESENTED BY THE SEC OF THE ARMY
Intelligent power distribution network fault recovery method based on organism immune mechanism
ActiveCN112865090AQuick responseContigency dealing ac circuit arrangementsCharacter and pattern recognitionGrid faultIslanding
The invention relates to an intelligent power distribution network fault recovery method based on an organism immune mechanism, and the method specifically comprises the following steps: S1, an immune recognition module obtains information of a power distribution network through monitoring, judges the fault state, and extracts a characteristic quantity; S2, an immune matching module matches the characteristic quantity with a characteristic quantity in a fault state recorded in a power distribution network fault characteristic library in an immune memory module, if matching succeeds, the step S3 is executed, or otherwise, the step S4 is executed; S3, an immune response module performs secondary power grid fault response and executes a corresponding fault recovery scheme; S4, the immune response module performs primary power grid fault response, judges whether a fault downstream load has an interconnection switch for transfer, if so, performs load transfer and checks power flow, or otherwise, performs island division on a fault downstream area; and S5, a fault recovery scheme is generated according to the fault processing flow in the step S4, and the fault recovery scheme is recorded to a grid fault feature library. Compared with the prior art, the method has the advantages of improving the response speed of power grid fault recovery and the like.
Owner:SHANGHAI UNIVERSITY OF ELECTRIC POWER
Method for constructing spiral immunization assembly sensor for determining neomycin
The invention discloses a method for constructing a spiral immunization assembly sensor for determining neomycin, belonging to the technical field of material chemistry. The method comprises the following steps: preparing a water-soluble spiral polymer, modifying the spiral polymer with semi-antigen, coupling gold nano particles with antibody, and constructing a neomycin sensor. The invention provides a water-soluble spiral polymer, that is, poly(4-isocyano-benzoic acid). According to the invention, by immunization identification (neomycin semiantigen modified spiral polymer) and gold nanoparticle (coupled with antibody) assembly, the circular dichroism spectrum (CD) signals generated by the assembly detect the neomycin.
Owner:MEIZHENG BIO TECH CO LTD
Human Antibodies Cross-Reacting With A Bacterial And A Self Antigen From Atherosclerotic Plaques
InactiveUS20120165211A1Library screeningImmunoglobulins against animals/humansBacteroidesADAMTS Proteins
The present invention refers to human antibodies derived from human antibody libraries prepared from atherosclerotic plaques. It further refers to human antibodies able to immunologically recognize both human transgelin or fragments thereof and a protein with at least 50% similarity to OmpK36 (Outer membrane protein, Klebsiella, K36; GI: 295881594) or fragments thereof. Human transgelin is preferably transgelin 1 (Accession N° Q01995, GI:48255907). The antibodies further recognize an antigen in the atherosclerotic plaque and are useful for the preparation of immunodiagnostic reagents or assays to detect atherogenic diseases. The invention also relates to the use of anti-TAGLN monoclonal antibodies, showing cross-reactivity with a bacterial antigen having at least 50% similarity with OmpK36, for detecting antigens in the atherosclerotic plaque or as atherosclerotic related reagents in an immuno-competition assay.
Owner:BRACCO IMAGINIG SPA
Zwitterionic polypeptide, derivatives thereof and nano-drug based on zwitterionic polypeptide and derivatives thereof
ActiveCN111560049AExcellent and stable ability to entrap hydrophobic drugsFacilitated releaseOrganic active ingredientsPeptide preparation methodsTumor targetTumor targeting
The invention discloses a zwitterionic polypeptide, a derivative of the zwitterionic polypeptide and a nano-drug based on the zwitterionic polypeptide. Nano-drugs can be prepared on the basis of the zwitterionic polypeptide or derivatives thereof, the secondary structure of the zwitterionic polypeptide has excellent conversion capability before and after drug release, and release of the drugs in cells can be accelerated. The obtained nano-drug can be used for tumor targeted therapy; unexpected tumor targeting performance is obtained; and the nano-drug has excellent blood compatibility, has thecapability of avoiding immune recognition, tumor targeting, intracellular transformation and entering into cell nuclei, can reduce the distribution in liver, kidney, spleen, lung, heart and other organs rich in reticuloendothelial tissues, and finally realize the capability of efficiently inhibiting tumor growth and the in-vivo low-toxicity targeting tumor treatment effect.
Owner:ZHEJIANG UNIV
Glycoprotein dynamic light scattering immunization method based on phenylboronic acid cross-linking agent
ActiveCN113687063AReduce demandRealize highly sensitive detectionScattering properties measurementsBiological testingProtein targetImmune recognition
The invention relates to a glycoprotein dynamic light scattering immunization method based on a phenylboronic acid cross-linking agent. The phenylboronic acid cross-linking agent and the magnetic carrier marked by the immune recognition element are used as a dynamic light scattering signal enhancement probe to form a multilayer sandwich structure by taking target glycoprotein as a bridge, and the average hydration kinetic particle size change of the solution before and after the multilayer sandwich structure is used as a dynamic light scattering signal to be output; and the content of glycoprotein in the to-be-detected sample is determined by utilizing the diameter change of hydration kinetics. According to the glycoprotein dynamic light scattering immunization method based on the phenylboronic acid cross-linking agent, the operation steps are simple, high-sensitivity detection of glycoprotein in a complex sample can be achieved in a short time, the prepared immunomagnetic beads can separate and enrich target protein from a complex sample matrix, and interference of the sample matrix on follow-up detection is effectively eliminated. The problem that the paired antibody is difficult to prepare can be solved, the glycoprotein can be simply, conveniently, rapidly and timely detected, and the method is worthy of being further popularized and used.
Owner:NANCHANG UNIV
Mixed polypeptide vaccine, its preparation and application
InactiveCN1535727ASimple processPrevent invasionPeptide/protein ingredientsAntipyreticChemical synthesisAuto immune disease
The present invention provides a mixed polypeptide vaccine, it can induce body interior to produce antibody directed against self-body several different inflammatory chemotatic factors, and it is made up by mixing hybrid peptides of different species, in which the hybrid peptide of every species is made up by covalently connecting amino tail end of fragment of specific chemotatic factor and immunological recognition fragment. The invention also provides preparation method of these products, specially adopts chemical synthetic production method and provides test method of the product. Said invented mixed vaccine is easily prepared, and is suitable for curing auto immune diseases long-term dependent on medicine.
Owner:龚小迪
An Isomorphism Recognition Method of Mechanism Kinematic Chain Based on Immune Genetic Hybrid Algorithm
InactiveCN103324983BOvercome the disadvantage of easy convergence to local optimumDiversity guaranteedGenetic modelsSpecial data processing applicationsAlgorithmImmune recognition
The inventiondiscloses a mechanism kinematic link isomorphism identification method based on the immunity genetic hybrid algorithm. The mechanism kinematic link isomorphism identification method includes the steps of (1) forming a topological graph corresponding to a mechanism kinematic link according to the structural mode of the mechanism kinematic link, (2) setting a genetic code of an adjacent matrix according to the topological graph, (3) taking adjacent matrixes, to be determined, of the two topological graphs, determining an objective function, (4) generating the initial antibody population at random, calculating adaptability of each individual, sequencing the individuals according to the adaptability, (5) taking the optimal saving strategy on the initial antibody population, (6) calculating the concentration of each individual, enabling the each individual concentration to be equal to a value obtained by dividing the total individual number in a population by the adjacent individual sum, (7) taking the optimal interaction strategy on the antibody population obtained in the step (5), (8) conducting the mutation operation, adopting the inverse operator to achieve the mutation operation, (9) combining the local search operator and the genetic algorithm, (10) forming the immunity genetic hybrid algorithm, and conducting the isomorphism identification operation on the mechanism kinematic link. The mechanism kinematic link isomorphism identification method overcomes the shortcoming that the immunity genetic hybrid algorithm can be easily restrained to local optimum.
Owner:JIANGSU UNIV
Method to augment immune system in response to disease or injury
InactiveUS20140065098A1Microbiological testing/measurementAntibody ingredientsImmune recognitionLymphocyte
In one example, the present invention comprises a deliberate insult or the recognition that an insult has occurred in a patient, which insult induces an immune recognition event. The T cell repertoire is catalogued from samples of the patient's lymphocytes from before and after the insult in order to detect and sequence the TCR alpha and beta loci of highly expanded T cell clonotypes. In some examples, this information is used in turn to generate autologous T cells or to create autologous genetically-engineered T cells, either of which include TCR sequences that target the individual's disease or injury, resulting in cure or amelioration of symptoms.
Owner:BARKEN ISRAEL +1
Diamondback moth peptidoglycan recognition protein, preparation method and application thereof
The present invention discloses diamondback moth peptidoglycan recognition protein, a preparation method and an application thereof, wherein the nucleotide sequence of the diamondback moth peptidoglycan recognition protein gene is represented by SEQIDNO:1-2, and semi-quantitative RT-PCR is adopted to detect temporal and spatial expression of diamondback moth PGRP-S1 in the body. According to the present invention, isaria fumosorosea is adopted to treat diamondback moth larva, quantitative RT-PCR is adopted to detect an immune recognition effect of the diamondback moth PGRP-SA gene on fungi paecilomyces fumosoroseus isaria, and the PGRP-S1 is the innate immune recognition receptor of diamondback moth, activates innate immunity, regulates antibacterial peptide expression, and provides a new target for prevention and control of diamondback moth from immunology.
Owner:SOUTH CHINA AGRI UNIV
Product and method for treatment of conditions associated with receptor-desensitization
InactiveUS20080064103A1Prolongs and enhances timeSensitizing receptorSenses disorderNervous disorderNK-receptorCellular antigens
Particular members of the multisubunit immune recognition receptor (MIRR) family of receptors, specifically, the B cell antigen receptor (BCR), the pre-B cell receptor (pre-BCR), the pro-B cell receptor (pro-BCR), Ig Fc receptors (FcR), and NK receptors, can be physically uncoupled from their associated transducers. The invention describes regulatory compounds and methods for mimicking such dissociation / destabilization for the purposes of receptor desensitization and for treatment of conditions in which receptor desensitization or alternatively, enhanced or prolonged receptor sensitization, is desirable. Compounds and methods for enhancing or prolonging receptor sensitization are also disclosed, as are methods for identifying regulatory compounds suitable for use in the present methods.
Owner:NAT JEWISH HEALTH
Grass carp bacteria small peptide recognition receptor as well as preparation method and application thereof
PendingCN114671945AHave binding activityAntibacterial agentsCell receptors/surface-antigens/surface-determinantsBiotechnologyAntimicrobial drug
The invention discloses a grass carp bacteria small peptide recognition receptor and a preparation method and application thereof, the grass carp bacteria small peptide recognition receptor is grass carp NOD2-LRR protein, the amino acid sequence is as shown in SEQ ID NO.1, and the cDNA sequence of the coding gene is as shown in SEQ ID NO.2. The preparation method of the grass carp bacterium small peptide recognition receptor comprises the following steps: cloning a grass carp NOD2 gene, expressing, purifying and renaturating. In the invention, an immune recognition model of grass carp NOD2 on bacterial MDP is established by using a molecular docking method for the first time, NOD2-LRR protein is successfully obtained by using a prokaryotic expression system, and the result shows that the NOD2-LRR protein has binding activity on bacterial MDP, can specifically recognize bacterial MDP, and plays an important role in immune recognition of bacterial MDP; the method has potential application value in the aspects of developing novel antibacterial agents, immunopotentiators, feed additives and the like.
Owner:CHANGSHA UNIVERSITY
Hepatitis B virus enrichment fluorescent PCR (polymerase chain reaction) detection method
PendingCN114200127AEasy to storeEasy to transportMicrobiological testing/measurementBiological material analysisSuperparamagnetic beadsHepatitis B immunization
The invention relates to a hepatitis B virus enrichment fluorescent PCR (polymerase chain reaction) detection method which comprises the following steps: S1, preparation of immunomagnetic beads: coupling hepatitis B virus antibodies to carboxyl modified superparamagnetic beads to obtain the immunomagnetic beads coupled with the hepatitis B virus antibodies, s2, enrichment of hepatitis B virus: mixing and incubating hepatitis B virus positive serum or plasma with the immunomagnetic beads coupled with the hepatitis B virus antibody; s3, separating the immunomagnetic bead-virus compound by using a magnetic tool, resuspending the immunomagnetic bead-virus compound in a salt ion buffer solution, and heating and cracking; and S4, separating the magnetic beads by using a magnetic tool to obtain enriched and concentrated hepatitis B virus, and directly detecting liquid in a split product by using a fluorescent PCR reagent. According to the invention, the detection sensitivity is greatly improved due to enrichment and concentration, the specificity is strong due to immune recognition and gene recognition, and the fluorescent PCR detection time is short due to the use of a rapid PCR reagent.
Owner:杭州丹威生物科技有限公司
Recombinant plasmid with human cytomegalovirus UL140 gene and genetic engineering bacterium and application thereof
InactiveCN108300730AReduce in quantityImprove immune recognitionBacteriaVirus peptidesImmune recognitionPolyclonal antibodies
The invention discloses a recombinant plasmid with human cytomegalovirus UL140 gene and a genetic engineering bacterium and application thereof. The recombinant plasmid with human cytomegalovirus UL140 gene is established by inserting an UL140 gene into an expression type vector pET32a, the recombinant plasmid is further transferred into an expression bacterium BL21, then a genetic engineering bacterium for expressing a poly-histidine tag HCMV UL140 fusion protein can be established, and a corresponding HCMV UL140 fusion protein can be established through expression of the engineering bacterium. The fusion protein disclosed by the invention can be applied to affinity chromatography purification to prepare a polyclonal antibody, then the avoiding mechanism that a chemotactic factor proteinHCMV UL140 avoids a host immune system can be studied, the number of HCMV dormant infection host cells can be reduced, and the immune recognition of a body can be improved.
Owner:JINAN UNIVERSITY
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