7 results about "Auto immune disease" patented technology

The present invention pertains to the treatment of diseases associated with a dysregulated immune response such as auto immune disorders, inflammatory diseases or pathological immune responses as adverse effects of medical treatments. In particular the invention provides a combined use of inhibitors of Receptor-interacting serine / threonine-protein kinase (RIPK1) and inhibitors of Inhibitor of κB (IκB) Kinase (IKK) in subjects suffering from such disorders. The invention provides such inhibitory compounds and their combinations for use in medical applications, as well as pharmaceutical compositions comprising the compounds of the invention.

The invention discloses a traditional Chinese medicine composition for eliminating edema, killing cancer cells and improving human immunity, and belongs to the technical field of traditional Chinese medicine preparations. The traditional Chinese medicine composition is prepared from the following raw material medicines in parts by weight: 8-12 parts of pokeberry root, 2-4 parts of radix euphorbiae lantu, 12-18 parts of poria cocos, 0.3-0.7 part of leech, 25-35 parts of wild buckwheat rhizome, 25-35 parts of polygonum cuspidatum, 25-35 parts of astragalus membranaceus, 10-14 parts of lucid ganoderma, 8-12 parts of glossy privet fruit and 9-13 parts of scutellaria baicalensis. According to the traditional Chinese medicine, the pokeberry root and the radix euphorbiae lantu are used for diminishing swelling and inducing diuresis, the wild buckwheat rhizome and the polygonum cuspidatum are used for killing cancer cells, the astragalus membranaceus, the lucid ganoderma and the glossy privet fruit are used for improving immunity, the poria cocos is used for tonifying spleen and excreting dampness, the leech is used for promoting blood circulation and removing blood stasis, and the scutellaria baicalensis is used for clearing away heat and toxic materials, so that triple effects of eliminating edema, killing cancer cells and reconstructing immune homeostasis are achieved.

The application generally relates to a therapy comprising at least two therapeutic agents, a first therapeutic compound being an antagonist of IL-7 or CD127 and a second therapeutic compound being an antagonist of IL12, IL-23, IL-12R or IL-23R, or comprising a bifunctional molecule targeting IL-7 or CD127 and IL12, IL-23, IL-12R or IL-23R. The combination therapy or the bifunctional molecule is provided for use in the treatment of a patient suffering from an inflammatory disease or an auto-immune disease.

The present invention relates to novel polycyclic compounds of general Formula (I) wherein X represents N-R5, O, S, or S(O)2; Y represents optionally substituted aryl or heteroaryl; and R1, R2, R3, R4 and R5 represent various groups. The compounds of the invention are useful as inhibitors of the MTHFD2 enzyme, in particular for use in the treatment of diseases associated with MTHFD2 enzyme such as, for example, auto-immune diseases, inflammatory diseases, and proliferative diseases.

This invention provides a nitrogen-containing heterocyclic protein inhibitor compound, its stereoisomers, tautomers, or pharmaceutically acceptable salts, and also provides the preparation of nitrogen-containing heterocyclic compounds and their uses. Drugs prepared using these compounds have a wide range of applications in treating diseases, including various types of autoimmune diseases such as multiple sclerosis, rheumatoid arthritis, inflammatory bowel disease, lupus erythematosus, neurodermatitis, dermatitis, psoriasis, psoriatic arthritis, Crohn's disease, Sjögren's syndrome, and scleroderma.

The invention relates to lipid-based nanoparticles comprising mRNA molecule(s) encoding membrane interleukin 35 (IL-35), and their use to treat inflammatory and / or auto-immune diseases.

The present disclosure relates to a composition comprising a first compound A comprising or consisting of an amino acid sequence of SEQ ID No.: 1 and a low amount of epimer impurities, a method of manufacturing thereof, a compound prepared by said method, an intermediate of said compound, and the use of such composition in medicine, such as in the treatment or prevention of an auto immune disease, diabetes, obesity, parodontitis and / or tissue transplant rejection.