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3 results about "Auto immune disease" patented technology
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An autoimmune disease is a condition in which your immune system mistakenly attacks your body. The immune system normally guards against germs like bacteria and viruses. When it senses these foreign invaders, it sends out an army of fighter cells to attack them.
Combinations of RIPK1- and IKK-inhibitors for the prevention or treatment of immune diseases
The present invention pertains to the treatment of diseases associated with a dysregulated immune response such as auto immune disorders, inflammatory diseases or pathological immune responses as adverse effects of medical treatments. In particular the invention provides a combined use of inhibitors of Receptor-interacting serine / threonine-protein kinase (RIPK1) and inhibitors of Inhibitor of κB (IκB) Kinase (IKK) in subjects suffering from such disorders. The invention provides such inhibitory compounds and their combinations for use in medical applications, as well as pharmaceutical compositions comprising the compounds of the invention.
Owner:UNIVERSITY OF COLOGNE
Polycyclic mthfd2 inhibitors and uses thereof
PCT designated stageWO2026132447A1Organic active ingredientsOrganic chemistryPolycyclic compoundBiochemistry
The present invention relates to novel polycyclic compounds of general Formula (I) wherein X represents N-R5, O, S, or S(O)2; Y represents optionally substituted aryl or heteroaryl; and R1, R2, R3, R4 and R5 represent various groups. The compounds of the invention are useful as inhibitors of the MTHFD2 enzyme, in particular for use in the treatment of diseases associated with MTHFD2 enzyme such as, for example, auto-immune diseases, inflammatory diseases, and proliferative diseases.
Owner:IKTOS
A class of pyridine compounds containing nitrogen heterocycles
This invention provides a nitrogen-containing heterocyclic protein inhibitor compound, its stereoisomers, tautomers, or pharmaceutically acceptable salts, and also provides the preparation of nitrogen-containing heterocyclic compounds and their uses. Drugs prepared using these compounds have a wide range of applications in treating diseases, including various types of autoimmune diseases such as multiple sclerosis, rheumatoid arthritis, inflammatory bowel disease, lupus erythematosus, neurodermatitis, dermatitis, psoriasis, psoriatic arthritis, Crohn's disease, Sjögren's syndrome, and scleroderma.
Owner:SHANGHAI ZHEYE BIOTECH LLC