The invention discloses a pre-embedded bag for multi-stage remediation of uranium-contaminated soil and a use method thereof, and belongs to the technical field of uranium-contaminated soil remediation. The pre-embedded bag for multi-stage remediation of uranium-contaminated soil can be pre-embedded by a soil cleaning and per-embedding manner, on the one hand, uranyl ions in the soil are transferred through a strict water-conducting network, a large amount of uranyl ions are actively and quickly collected into the pre-embedded bag to facilitate fixed-point remediation, on the other hand, a special soil remediation agent is used to greatly improve adsorption and accumulation for uranyl ions, agglomeration of uranyl ions is improved based on nano porous properties, and uranyl ions are filledin micro-pores to avoid contamination and diffusion. After the active primary remediation, uranyl ions in the uranium-contaminated soil are reduced to a certain value, then natural secondary remediation, namely heavy metal uranium enrichment plant remediation, is followed, the soil organic matter content and soil fertility are increased, a soil surface structure is improved and maintained, and asolid foundation for direct use of the soil after uranium pollution remediation is laid.