173 results about "Biospecimen" patented technology

Provided herein are methods of characterizing tumors or a region of interest in a biological sample.

A system for automated extraction of biological samples from a set of biological samples has a small footprint and minimal movement of consumable sets, thereby reducing potential contamination during the extraction process. The extraction system includes a set of reaction tubes, a storage unit for storing a set of consumables, a sample preparation unit, a sample extraction unit, a waste unit, a plurality of robots for moving the tubes, samples, and cassettes, and a programmable control system programmed to process the samples in a serial mode in which a series of samples are processed sequentially in time one after another, thereby maintaining a continuous mode. Thus, a fixed processing turnaround time for each sample is maintained regardless of when the sample starts processing.

The invention relates to the technical field of infectious disease detection, and discloses a new respiratory infectious disease early warning method, which comprises the following steps: S1, specimen collection and data collection: collecting biological samples of new respiratory infectious disease virus infected individuals and other respiratory infectious disease virus infected individuals, the biological sample comprises a blood sample and a swab sample; meanwhile, basic information of the individuals is collected, wherein the basic information comprises gender, age and respiratory symptom duration; s2, quantitative detection: the biological sample is subjected to quantitative detection by adopting reagents of various respiratory infectious disease viruses, the detection content comprises antigens and antibodies, and the antibodies comprise an I gM antibody, an I gG antibody and an I gA antibody; according to the invention, basic information of individuals and antigen-antibody detection reagent resources of various respiratory infectious disease viruses are deeply integrated, so that the recognition capability of new respiratory infectious disease virus infected individuals is effectively improved.

The present disclosure provides systems and methods for the generation of a virtually stained image of an unstained biological specimen based on an acquired image of the unstained biological specimen, where the virtually stained image manifests the appearance of the unstained biological specimen as if it were chemically stained with a morphological stain.

The disclosed invention provides a cartridge, method and cartridge processing systems for molecular tests that include extracting one or more biological materials from a tissue. The cartridge includes a base having a receptacle inside the base, a lid placed over the receptacle, and a gasket in the base. The base includes a transparent window placed under the receptacle, and the receptacle contains a slide on which the tissue is disposed. A film is disposed on an inner surface of the lid, and the film is suitable to extract the one or more biological materials from the tissue. The gasket surrounds the slide, and the lid creates a sealed chamber around the gasket that encloses the slide, and vacuum suction is applied through a port of the base to press the film against the tissue on the slide.

A biological sample collection system including a containment vessel; a sample collection reservoir disposed toward a first end of the containment vessel and a valve disposed in a sample receiving area. The valve includes a closed configuration, such that when the valve is in the closed configuration the biological sample is retained in the sample collection reservoir, and an open configuration, such that when the valve is in the open configuration the biological sample is released from the sample collection reservoir into a sample storage chamber of the containment vessel. A cap includes a pusher. When the biological sample collection system is closed by engagement of the containment vessel with the cap, the pusher engages with the valve thereby moving the valve from the closed configuration to the open configuration to permit the biological sample to be released from the sample collection reservoir into the containment vessel.

The invention relates to the technical field of online monitoring, in particular to a biological sample whole-course tracing and safety supervision method and system.The method specifically comprises the steps that an area needing biological sample supervision is divided into a plurality of sub-sample library subareas, and the total value of activity attenuation equivalents of historical samples in the sub-sample library subareas is extracted; meanwhile, extracting position data of cold chain monitoring nodes in subareas of the sub-sample library, obtaining regional representative monitoring nodes, and calculating an aging fluctuation coefficient and a cold chain deviation coefficient; substituting the aging fluctuation coefficient and the cold chain deviation coefficient into a sub-sample library partition activity risk total value estimation strategy to estimate a sub-sample library partition sample activity risk total value; allocating cold chain resources according to the pre-estimated sub-sample library partition sample activity risk total value; the problem that the decay risk of the biological sample is mismatched with the space environment in the prior art is solved.

The invention provides a full-process automatic all-in-one machine for DNA extraction, amplification and sequencing. The full-process automatic all-in-one machine comprises a cabin body, the cabin body is internally provided with a first space, and the first space is internally provided with a biological sample extraction workbench for realizing the whole process of DNA extraction, amplification and sequencing; the top of the cabin is provided with an air inlet duct, the side surface or / and the bottom of the cabin is provided with an air outlet duct, and the air inlet duct and the air outlet duct form negative pressure in the cabin; an amplification area is arranged on the biological sample extraction workbench, a cooling base used for reducing pollutants generated in the amplification process is arranged in the amplification area, and an air suction plate is arranged on the side face of the amplification area; the air suction plate is communicated with the air outlet channel, and pollutants generated in the amplification area are discharged out of the cabin body through the air outlet channel. Pollutants generated in the cabin body can be effectively prevented from facing three positions outside from gaps or cabin door lamps of the cabin body, so that pollution to the surrounding environment is avoided, and the safety of biological experiments is further improved. In addition, the integrated cabin is provided, and the requirement for the operation space of the biological experiment is effectively reduced.

A biological sample collection system and dispensing system is described. The biological sample collection system provides for collection and processing of a biological sample (i.e. bodily fluids collected from nose, throat, or other mucosal membrane of an animal or human). The biological sample collection system includes a sample collector and a collection tube. The sample collector provides a structure for sealing the biological sample in the collection tube for further processing without opening the collection tube, and may provide a structure for collecting the biological sample. When the sample collector and collection tube are removably attached the dispensing system is formed. The dispensing system provides for further processing of the biological sample without opening the collection tube (i.e. without un-securing or removing the plug from the collection tube). The dispensing system further provides dispensing of the processed biological sample without opening the collection tube).

The invention relates to the technical field of cryopreservation equipment, in particular to a control method of a sample access system and the sample access system, and aims to solve the problem that an existing sample access system is low in storage, transfer and access efficiency of biological samples. In order to achieve the purpose, the sample access system comprises a storage device, and the storage device comprises a storage bin and a first interface communicated with the storage bin; the delivery equipment comprises a temporary storage bin, and a second interface and a manual pick-and-place port which are communicated with the temporary storage bin; the transfer equipment can transfer the sample containers to the storage equipment and the delivery equipment through the first interface and the second interface respectively, and can transfer the sample containers between the storage equipment and the delivery equipment; the control method comprises the steps of obtaining a task instruction; selectively executing a warehouse-out task and / or a warehouse-in task according to the task instruction; and a plurality of warehouse-in / warehouse-out tasks can be executed in sequence according to the types and the storage sequence of the warehouse-in / warehouse-out samples.

1. Name of the product in this design: Reagent Card. 2. Purpose of this design: This design is used for the analysis and processing of biological samples. 3. The key design feature of this product is its shape. 4. The picture or photo that best illustrates the key design points: Design 1 3D diagram 1. 5. No design highlights, left view of each design omitted; no design highlights, right view of each design omitted; the back of the product is a part that is not easily seen or not easily seen during use, rear view of each design omitted. 6. Design 1 is designated as the basic design.

1. The name of the design product: storage tank. 2. The use of the design product: the design product is used for storing biological samples. 3. The design points of the design product: the combination of shape and pattern. 4. The picture or photo that best indicates the design points: perspective view 1.

The invention relates to the technical field of automatic treatment of biological samples, in particular to an automatic space and single-cell multi-omics sample preparation and analysis method and system. In several examples, a continuous flexible sample strip is released from a strip dispensing assembly by a rotation mechanism. A prepared biological sample is fixed on the sample receiving surface of the flexible sample strip to generate a continuous length of prepared sample strip, and space and single cell multiomics data corresponding to the fixed biological sample is generated based on the continuous length of prepared sample strip. In some embodiments, the methods and systems are useful for preparing and analyzing solid phase biological samples, such as OCT embedded frozen tissue blocks or FFPE tissue blocks. In other embodiments, the methods and systems are suitable for preparing and analyzing liquid phase biological samples.

The disclosed system discussed herein may include systems and methods for the automated intake and analysis of biological samples. The system may receive, by a drawer of a testing device, a sample holder comprising a biological sample. The system may transport, by a robotic manipulator, the sample holder from the sample drawer to a slot within a repository. The system may maintain a predefined temperature within the repository during a growth period of the biological sample. The system may move the sample holder to an optic assembly. The system may remove, by the robotic manipulator, a coverslip from the sample holder. The system may capture, an image of the biological sample. The system may determine one or more characteristics of the biological sample. The system may execute, based on the one or more characteristics, one or more actions.

The present application relates to the technical field of biological sample bank equipment management and laboratory safety, in particular to a low-temperature storage equipment shifting system for a biological sample bank and an application method thereof, which comprises a shifting bearing platform, an environment maintaining module, a safety monitoring module and a cooperative control module.The shifting bearing platform is used for bearing and moving the equipment; the environment maintaining module is used for adjusting the internal environment information of the equipment; the safety monitoring module is used for monitoring and obtaining monitoring information, including the posture information, position information and speed information of the shifting bearing platform, the environment information within the preset range of the equipment, the internal environment information of the equipment and the path obstacle information; the cooperative control module is used for moving path planning, controlling the moving range and coordinating the work of the environment maintaining module according to the monitoring information, and performing risk analysis, triggering risk warning and emergency disposal.The present application realizes smooth movement in the shifting process, whole-process low-temperature maintenance, multi-dimensional state monitoring and active risk warning through the integrated and intelligent shifting system, and guarantees the activity of samples and the safety of equipment.

The invention discloses a biological sample microelement digestion and detection method, and relates to the technical field of microelement analysis and testing. According to the method, the biological sample is digested by jointly treating the biological sample through the functional additive and the digestion acid system in combination with optimization of the digestion temperature and the digestion time. After the biological sample is digested, the sample is cooled to the room temperature, deionized water is used for fixing the volume, and after water membrane filtration, the content of 12 trace elements in the sample is determined by adopting inductively coupled plasma mass spectrometry (ICP-MS). The digestion and detection method provided by the invention is simple and convenient to operate, short in digestion time, low in equipment cost, capable of effectively avoiding element volatilization loss, suitable for large-batch sample detection and capable of providing accurate pretreatment and detection technical support for heavy metal exposure evaluation.

A biological specimen of a subject is handled and tracked for a procedure involving that specimen. Prior to initiation of the procedure, a first procedure data structure (PDS) is generated. The first PDS binds an identifier corresponding to the subject with an indicator of a procedure to be performed on the specimen and identifiers of a specimen container and a specimen holder that physically contacts the biological specimen, as well as a scheduled time for the procedure. A schedule of a plurality of PDSs including the first PDS, is displayed on a display device of a graphical user interface. Following initiation of the procedure, the first PDS is updated based on user input, and after the procedure, at least a portion of the first PDS, as updated, is stored in a database in conjunction with other PDSs respectively associated with other completed procedures.

The utility model provides a biological sample collecting swab which is characterized in that the biological sample collecting swab comprises a swab head, a connecting rod and a handheld part, and the swab head is located at one end of the connecting rod and used for collecting a biological sample; the handheld part is located at the other end of the connecting rod, the width of the handheld part is equal to or larger than that of the connecting rod, and handheld is facilitated; the surface of the swab head is further provided with color-changeable flocking, after the biological sample is detected, the surface of the swab head changes color, and the effectiveness of sample collection can be judged conveniently.

The invention provides a DNA souvenir and a biological sample DNA extraction and packaging method, and belongs to the technical field of biological products. The biological sample DNA extraction and encapsulation method provided by the invention is efficient and safe in extraction process, and is suitable for various non-invasive or minimally invasive samples; a stable packaging technology can realize long-term preservation of DNA under a normal temperature condition and prevent degradation; the finished DNA souvenir has unique biological feature recognition value, meets personalized and emotional souvenir requirements, and has wide commercial popularization potential.

Disclosed herein are devices that permit easier handling of organisms such as mice during animal handling. The disclosed devices gain faster and greater control when handling, dosing, or manipulating a model organism as well as permitting gaining greater handling confidence in a shorter period than traditional methods. The disclosed devices further create less stress for both the research animal and the handler. The disclosed devices are portable and can be fixed into position using securing devices. The disclosed devices comprise a platform that allows for an organism to grasp the platform when placed on the platform. Furthermore, the devices are configured to be portable.

The utility model relates to the technical field of refrigeration houses, in particular to a biological sample refrigeration house with a stacking mechanism, which comprises a refrigeration house main body, a lofting mechanism is arranged in the refrigeration house main body, the lofting mechanism comprises a buffer compartment, and the buffer compartment is positioned in the refrigeration house main body. A plurality of sealing cabin doors are mechanically connected between the buffer compartment and the refrigeration house main body, a plurality of sample storage mechanisms are arranged in the refrigeration house main body, each sample storage mechanism comprises an ultra-low temperature storage room, and storage goods shelves are fixed to the two sides of the inner walls of the ultra-low temperature storage rooms through bolts; and stacking machine equipment is slidably connected to the interior of the ultralow-temperature storage room. According to the utility model, through the mutual cooperation of internal parts of the lofting mechanism, a worker does not need to enter a refrigeration house, biological samples can be moved to the lower part of stacking machine equipment through the sample platform, and through the mutual cooperation of internal parts of the sample storage mechanism, the biological samples can be taken and stored in a storage shelf.

Disclosed herein are detectable moieties and detectable conjugates comprising one or more detectable moieties. In some embodiments, the disclosed detectable moieties have a narrow wavelength and are suitable for multiplexing. Also disclosed are methods of labeling one or more targets within a biological specimen using any of the detectable conjugates and / or detectable moieties described herein.

A system to store specimen containers in a temperature controlled environment includes at least a first temperature sensor positioned to sense a temperature in a first region of the temperature controlled environment in an interior of the cryogenic storage tank and at least a first level sensor positioned to sense a level of a cryogenic medium within the temperature controlled environment in the interior of the cryogenic storage tank. A method of storing specimen containers in a temperature controlled environment includes monitoring one or more parameters within the temperature controlled environment to prevent exposure of biological samples within the specimen containers to parameters that put the viability of the biological samples at risk.

The utility model discloses a device for extracting and detecting a biological sample, which relates to the technical field of detection devices and comprises a sampling barrel, a sampling and wiping rod is inserted in the sampling barrel, a detection reagent is arranged in the sampling barrel, a mixing tube is fixed and connected in the sampling barrel in a penetrating manner, a piston is connected in the mixing tube in a sliding manner, and the piston is connected with the sampling barrel in a sliding manner. One end of the piston is fixedly connected with a connecting rod, and the bottom side of the mixing pipe is fixedly connected with a liquid inlet pipe in a penetrating manner; the connecting rod enables the piston to move up and down, when the piston moves upwards, a mixed solution of a detection reagent and a sample is extracted through the liquid inlet pipe to enter the mixing pipe, and the piston moves downwards to discharge the mixed solution of the detection reagent and the sample out of the mixing pipe through the liquid outlet pipe. Then the detection box is inserted into the insertion groove, so that a mixed solution of a detection reagent and a sample in the sampling barrel drips into the detection box through the fixed pipe, and the detection of the sample is completed.

The present teachings generally include techniques for characterizing the health of an animal (e.g., gastrointestinal health) using image analysis (e.g., of a sample of an exudate such as mucus) as a complement, alternative, or a replacement to traditional laboratory analyses of biological specimens. The present teachings may further include techniques for personalizing a health and wellness plan (including, but not limited to, a dietary supplement such as a customized formula based on a health assessment), where such a plan may be based on one or more of the health characterization techniques described herein. The present teachings may also or instead include techniques or plans for continuous care for an animal, e.g., by executing health characterization and heath planning techniques in a cyclical fashion. A personalized supplement system (e.g., using a personalized supplement, personalized dosing device, and personalized packaging) may also or instead be created using the present teachings.

To provide a cryopreservation device with an integrated tracking device chamber.SOLUTION: Provided is an RFID tag as the tracking device which can be placed in the cryopreservation device as part of the procedure for vitrification of a biological specimen. The cryopreservation device maintains its integrity and keeps the RFID tag securely in the chamber at both ambient conditions when the specimen is collected and under liquid nitrogen where the specimen is stored. The cryopreservation device with an integrated tracking device chamber allows for each individual biological sample to have its own tracking device for monitoring during cryogenic storage.SELECTED DRAWING: Figure 2a

A biological sample collection system is provided, the system comprising: a containment vessel; a sample collection reservoir disposed toward a first end of the containment vessel and comprising a valve disposed in a sample receiving area, the valve comprising: a closed configuration, wherein when the valve is in the closed configuration the biological sample is retained in the sample collection reservoir, and an open configuration, wherein when the valve is in the open configuration the biological sample is released from the sample collection reservoir into a sample storage chamber of the containment vessel; and a cap comprising a pusher; wherein, when the biological sample collection system is closed by engagement of the containment vessel with the cap, the pusher engages with the valve thereby moving the valve from the closed configuration to the open configuration to permit the biological sample to be released from the sample collection reservoir into the containment vessel.