81 results about "Live animal" patented technology

A sensor (e.g., an optical sensor) that may be implanted within a living animal (e.g., a human) and may be used to measure an analyte (e.g., glucose or oxygen) in a medium (e.g., interstitial fluid, blood, or intraperitoneal fluid) within the animal. The sensor may include a sensor housing, an analyte indicator covering at least a portion of the sensor housing, and one or more compounds having dithio-, thio- or mercapto-containing moieties that reduce degradation of the analyte indicator.

The invention mainly relates to the technical field of Internet of Things, and provides a control device, system and method based on Wi-Fi HaLow and LTE redundancy mechanisms in order to ensure that a main gateway fails, monitoring devices in a region can automatically switch gateway nodes and ensure normal uploading of monitoring data. The main control module starts the camera module to shoot monitoring data and uploads the data through Wi-Fi HaLow, when data transmission based on the Wi-Fi HaLow is interrupted, any node in the Mesh network is converted into a gateway through the pluggable LTE module, the monitoring data is retransmitted, it can be ensured that when a main gateway breaks down, monitoring equipment in a Halow Mesh network area can automatically switch the gateway node, and the monitoring efficiency is improved. Normal uploading of monitoring data is ensured, and the system is especially suitable for monitoring remote areas with poor signal conditions.

The invention relates to the technical field of intelligent detection and customs clearance management, in particular to a living animal intelligent detection and customs clearance management system based on millimeter wave radar, which comprises a millimeter wave radar array module, a data processing and analysis module, a luggage sorting control module, a quarantine process management module, an alarm response module and a system management platform. The millimeter-wave radar array module acquires biological characteristics of a living body by adopting a multi-band fusion detection technology, and the data processing and analysis module identifies the living body and outputs a confidence score by applying algorithms such as an improved double-flow convolutional neural network; and the system management platform is linked with each module based on a detection result to realize luggage dynamic sorting, grading alarm, quarantine resource intelligent distribution and whole-process closed-loop control. According to the invention, hidden living animals can be effectively identified, biological invasion and epidemic disease transmission are prevented, and through automatic and intelligent management, the customs clearance efficiency is significantly improved, the manual intervention cost is reduced, and the traceability and safety of the clearance data are ensured.

An instrument for high-throughput scanning of live anesthetized animals, incorporating a robotic scanning device, a multi-slot animal loading dock, and an automatically controlled gas anesthesia delivery unit such that: when a subject test animal is present in a slot of said animal loading dock, gas anesthesia is delivered uninterruptedly to said test animal in the loading dock; when said test animal is being manipulated and / or scanned with said robotic scanning device, gas anesthesia is delivered uninterruptedly to said test animal.

The application provides a drug hepatotoxicity prediction method, device, system and medium, the method comprising: sequencing human liver cells after being contacted with a drug to be predicted to obtain a genome expression profile of the human liver cells after being contacted with the drug to be predicted; calculating the sum of the absolute values of the fold changes of the genes in the current gene pathway as the toxicity score of the current gene pathway according to the expression profile; calculating the Z value of the current gene pathway according to the toxicity score of the current gene pathway, the average value and the standard deviation value of the toxicity scores of the gene pathways calculated multiple times by a plurality of preset gene pathways; and predicting that the drug to be predicted has hepatotoxicity when the Z value is greater than 1.5. Therefore, the application can accurately, timely, effectively and sensitively predict drug hepatotoxicity without a large number of living animals as an experimental basis, and has good advantages in safety, environmental protection and animal protection. The application has the advantages of short experimental period and low cost.

The invention discloses a living body screening method of a high-throughput addiction inhibitor, which comprises the following steps: acquiring addictive nematodes with a plurality of addiction behavioral phenotypes; applying different addiction inhibitors to the addictive nematodes; the screening of the addiction inhibitors is realized according to the inhibition efficacy of the addiction inhibitors on the addiction behavioral phenotypes of the addiction nematodes, and based on the steps, the drug screening of the addiction inhibitors can be realized through the inhibition efficacy of the addiction inhibitors on the addiction behavioral phenotypes of the addiction nematodes in a high-throughput manner. Compared with the prior art, the medicine screening method of a traditional cell function system is abandoned, and medicine screening is carried out on the living animal behavioristics level in a brand new mode. Meanwhile, the advantages of easiness in large-scale culture, abundant behavioral modes and the like of the nematodes are utilized, and compared with expensive mammal feeding and experimental operation for drug screening, the method has higher cost performance, practical operability and high throughput.

A sensor (e.g., an optical sensor) that may be implanted within a living animal (e.g., a human) and may be used to measure an analyte (e.g., glucose or oxygen) in a medium (e.g., interstitial fluid, blood, or intraperitoneal fluid) within the animal. The sensor may include a sensor housing, an analyte indicator covering at least a portion of the sensor housing, and one or more compounds containing boronate or boronic acid moieties that reduce degradation of the analyte indicator.

Provided herein are compositions and methods for identifying effective delivery vehicles (DVs) for mRNA delivery to and expression in specific cells or tissues in culture (in vitro) or in live animals (in vivo) from a pool of co-administered DVs.

The present invention relates to a fixation and body temperature maintaining apparatus for fixing a small animal in order to generate a high-resolution micro image of a predetermined tissue of the small animal within a biomicroscope with an object lens, which includes: a plate heater with a heat wire installed therein, on which the small animal is enabled to be directly placed; a glass heater holder fixed to a hole of the plate heater; and a glass heater fixed to the glass heater holder, and located above the tissue of the small animal and maintaining flatness of the tissue, and increasing a temperature of the tissue itself, in which a cover glass serving to adjust a refractive index of the object lens and a heat wire heater are integrally formed. In an embodiment of the present invention, a body temperature of a live small animal which is an object to be observed with a biomicroscope is maintained to be constant.

The embodiment of the invention relates to the technical field of vehicles, and discloses a living object expelling method and device and a vehicle. The living object expelling method comprises the steps that whether a target living object exists in a vehicle blind area or not is determined based on detection data of the vehicle blind area; wherein the detection data of the vehicle blind area is used for reflecting the existence condition of living things in the vehicle blind area; the vehicle blind area refers to an area outside a driver view area and in a vehicle driving track, and the driver view area refers to a sight coverage area when a driver is in a driving position; under the condition that the target living object exists in the blind area of the vehicle, a target expelling strategy for the target living object is determined based on the living object type of the target living object and the area type of the area where the vehicle is located currently; and controlling the vehicle to execute the target expelling strategy. According to the technical scheme, the living body targets in the driving blind area can be repelled, and safety accidents are reduced.

A tool to aid in the feeding of whole animal bodies to a live reptile. The invention is designed for the use of deceased whole animal bodies, though a live animal body could be used in some instances. The tool consists of a barrel and a plunger. The barrel has an interior opening large enough to receive a whole animal body. The tip of the barrel has a beveled, angled tip which is used to assist in the opening of the reptile's mouth for feeding. The barrel may be lubricated to further assist insertion of the barrel into the reptile's mouth such as to position the animal body into the reptile esophagus. When fully depressed against the barrel, the end of the plunger will extend beyond the tip of the barrel to help push the animal body into the reptile's esophagus.

This invention relates to the field of leukemia research, specifically disclosing an animal model of CAR-T therapy for leukemia complicated by cytokine release syndrome (CRS), its preparation method, and its application. The method for preparing the animal model of CAR-T therapy for leukemia complicated by CRS includes: obtaining CD19 CAR-T cells: peripheral blood mononuclear cell isolation, T cell magnetic bead sorting, T cell activation, lentiviral infection, and CAR-T cell expansion; constructing an animal model of CRS after high- and low-dose CAR-T infusion: implanting Nalm-6 cell line into living animals to induce leukemia tumor burden, obtaining living animals with leukemia tumor burden, and injecting CD19 CAR-T cell line into the living animals with leukemia tumor burden. This invention provides a novel application for the animal model of CAR-T therapy for leukemia complicated by cytokine release syndrome. By using severely combined immunodeficient mice and inoculating them with high- and low-burden tumor cells, and infusing different doses of CAR-T cells, this invention constructs an in vivo model that can simulate clinical CRS, providing research guidance for clinically exploring more effective interventions.

The utility model discloses a small animal test post-operation wound surface shooting device, which comprises a base, a support vertical rod and an object placing table, the object placing table is arranged on the upper surface of the base, the support vertical rod is vertically fixed on the base, the support vertical rod is arranged on one side of the object placing table, a support arm assembly is arranged on the support vertical rod, and the support arm assembly is connected with the object placing table. Meanwhile, a clamping head assembly is arranged on the supporting arm assembly, a shooting instrument is clamped by the clamping head assembly, a fixing table assembly is installed on the object placing table, the device achieves effective constraint on shot living animals, the scale assembly is matched with the supporting vertical rod, the supporting arm assembly and the clamping head assembly, it is ensured that the proportions of images shot by different devices at different times are consistent, and the shooting efficiency is improved. The scale is used as a correction reference, the actual area of the wound surface can be automatically converted in software, the manual measurement error is reduced, the fixing table assembly and the fixing rod are designed in a modularized mode, 20-500 g experimental animals can be compatible, and the limitation of one mouse and one device of a traditional device is overcome.

The invention discloses a beauty instrument efficacy evaluation device and a beauty instrument efficacy evaluation method, the beauty instrument efficacy evaluation device comprises: a cell culture box, the cell culture box comprises two culture group boxes, the culture group boxes are used for culturing test cells; the beauty instrument to be tested is arranged above the cell culture box and is used for performing beauty treatment on the test cells; the beauty instrument to be detected is hung on the hanging moving assembly, and the hanging moving assembly is used for driving the beauty instrument to be detected to move. The beauty instrument efficacy evaluation device can replace a traditional in-vivo test with an in-vitro cell culture system, does not need to depend on living animals or human subjects, and avoids the problem of time consumption of experiment object screening, preparation and long observation period in the in-vivo experiment; and meanwhile, the problems of difficulty in testee recruitment and high experiment cost in a human body experiment are solved.

A sensor (e.g., an analyte sensor) that may be implanted partially or fully within a living animal (e.g., a human) and may be used to measure an analyte (e.g., glucose or oxygen) in a medium (e.g., interstitial fluid, blood, or intraperitoneal fluid) within the animal. The sensor may include a housing, a first polymer that includes analyte indicator molecules and covers at least a portion of the housing, and a second polymer that forms an interpenetrating network with the first polymer. The second polymer may prevent biological or protein interference of the sensor.

The invention provides a near-infrared fluorescence activated protein, a gene containing the near-infrared fluorescence activated protein, an expression box and a using method thereof, and a cell and a kit for generating the near-infrared fluorescence activated protein. A compound formed after the near-infrared fluorescence activated protein is combined with a corresponding fluorescent ligand has strong fluorescence, the fluorescence excitation peak wavelength is 574nm, near-infrared light with the emission peak wavelength is 680nm, and the near-infrared fluorescence activated protein has the advantages of high fluorescence quantum yield, large two-photon absorption cross section and the like, and has the advantage of high signal-to-noise ratio in vitro, living cells and living animals.

The application discloses a safety detonation method of electronic detonator, which comprises the following steps: using a UAV to perform safety identification and confirmation on a blasting danger area; if the UAV finds that the blasting danger area has personnel or live animals, a driving-off program is started; after a detonation controller completes network inspection of the electronic detonator and transmits a delay command of the electronic detonator, the UAV sends a safety confirmation instruction to a detonator; after the detonation controller receives the safety confirmation instruction, the detonation controller is unlocked and charges and detonates the electronic detonator; after the UAV sends the safety confirmation instruction, the blasting danger area is still monitored to determine whether to perform a blasting interruption operation; and the core of the method is that the detonation controller can be unlocked and charges and detonates the electronic detonator only when it is confirmed that the blasting danger area is safe, so that the deficiency of artificial safety confirmation is made up, and the possibility that a blasting safety accident occurs due to human negligence or the difficulty of confirming safety of personnel in a complex scene is prevented.

The utility model relates to the field of animal transport equipment, in particular to a living animal transport vehicle, at least two placement frames are arranged in a transport cabin of the living animal transport vehicle at intervals, each placement frame comprises at least one placement plate, and the placement plates are arranged in the horizontal direction and divide the interior of the transport cabin into a plurality of placement layers in the vertical direction; the mounting position of the placement plate on the placement frame is adjustable in the vertical direction; for animals which are small in size and suitable for being caged, the height of the placement layers can be reduced, animal cages can be placed on the placement frames as many as possible, and the placement frames are arranged at intervals, so that workers can walk and assemble and disassemble the animal cages conveniently; for animals which are large in size and not suitable for being caged, the placement frame in the transportation cabin can be detached, so that the animals are loaded in the transportation cabin, the placement frame is adjusted according to factors such as the size habits of the animals, the number of the animals capable of being loaded in the transportation cabin can be increased as much as possible, the transportation efficiency is improved, and the cost is reduced.

Provided herein are compositions and methods for identifying, from a co-administered DV pool, an effective delivery vehicle (DV) for delivery and expression of mRNA to and in a particular cell or tissue in a culture (in vitro) or in a living animal (in vivo).

The present invention relates to a smart pet collar for tracking the location of live animals, collecting their health data, and providing a warning in the event of the animal being stolen.

An animal transportation system forms a climate-controlled environment that includes one or more cage assemblies configured to accommodate one or more live animals to be transported therein. The one or more cage assemblies comprise a covering extending thereabove, a frame having a support laterally extending therefrom, and one or more doors supported spaced apart from the one or more cages by the support and movable between an open position and a closed position. One or more securement systems extend through an opening in a floor of the animal transportation system and flexibly secure the one or more cage assemblies to the floor. A circulation system is configured to affect environmental conditions of an interior of the animal transportation system. A control system may be coupled to the circulation system.

The invention discloses a double-enzyme lock activated photoacoustic probe for accurate imaging of drug-induced liver injury, a preparation method and application, the probe is named as SH-NAL, and the probe takes a sulfo-hemicyanine derivative SH-NH2 as a photoacoustic signal report group and a pseudo-peptide group as a recognition unit. A photoacoustic signal activation mechanism depends on a sequential enzyme digestion reaction of two DILI-related peptidases, and compared with single-enzyme response probes SH-NL and SH-NA, the photoacoustic signal activation mechanism has the advantage that the signal-to-noise ratio is remarkably improved. In in-vivo DILI photoacoustic imaging, the activation efficiency of the SH-NAL is far higher than that of a single lock type probe. Quantitative photoacoustic signal analysis is carried out in living animal imaging experiments and serological detection, SH-NAL can effectively distinguish DILI from liver cirrhosis, hepatitis and healthy liver tissue, and the double-enzyme lock activation strategy not only improves the diagnosis specificity, but also is expected to become a multifunctional platform for clinical research of DILI pathogenesis.

This invention relates to the field of intelligent detection and customs clearance management technology, particularly to a live animal intelligent detection and customs clearance management system based on millimeter-wave radar. The system includes a millimeter-wave radar array module, a data processing and analysis module, a baggage sorting control module, a quarantine process management module, an alarm response module, and a system management platform. The millimeter-wave radar array module uses multi-band fusion detection technology to acquire live biological characteristics. The data processing and analysis module uses algorithms such as an improved dual-stream convolutional neural network to identify live animals and output confidence scores. Based on the detection results, the system management platform links the various modules to achieve dynamic baggage sorting, tiered alarms, intelligent allocation of quarantine resources, and closed-loop control throughout the entire process. This invention can effectively identify concealed live animals, prevent biological invasion and disease transmission, and significantly improve customs clearance efficiency, reduce manual intervention costs, and ensure the traceability and security of customs clearance data through automated and intelligent management.

The invention discloses a construction method and an application of Elizabeth mileli for expressing Nanoluc luciferase. The Elizabeth mileli can be used for expressing Nanoluc luciferase. The coding gene of the Nanoluc luciferase is knocked into the genome of the Elizabeth mileli FL160902 strain in a fixed-point manner through a homologous recombination technology, so that the report strain capable of stably expressing the luciferase is successfully constructed. The reporter strain has normal growth characteristics, and the in-vitro detection sensitivity can reach 100 CFU. By utilizing a xenopus laevis infection model, the real-time dynamic tracing of the report strain in a living animal body is realized for the first time. The Nluc report strain constructed by the invention has the characteristics of strong luminescence stability, high detection sensitivity and the like, and provides a high-sensitivity visual research tool for analyzing the infection dynamic state and pathogenic mechanism of Elizabeth mileli.

A sensor (e.g., an optical sensor) that can be implanted within a living animal (e.g., a human) and used to measure an analyte (e.g., glucose or oxygen) in a medium (e.g., interstitial fluid, blood, or intraperitoneal fluid) within the animal, the sensor including a sensor housing, an analyte indicator covering at least a portion of the sensor housing, and a multi-metal protection system including multiple metals incorporated within and / or proximate to a surface of the analyte indicator that reduces deterioration of the analyte indicator.

The invention discloses a method for determining credibility of live animal assets and a related device, and relates to the technical field of live animal asset management.The method comprises the steps that two kinds of data from different sources including ear tag equipment data and camera equipment data are combined and processed through a first determination module and a second determination module respectively, and the credibility of the live animal assets is determined; and the third determination module performs comprehensive analysis, and meanwhile, based on the inventory rate prediction model of deep learning, the problem of inaccurate data caused by a single data source is effectively avoided, and the accuracy of the actual inventory rate and the predicted inventory rate of the current live animal assets is ensured. Based on the actual inventory rate of the current live animal assets and the predicted inventory rate of the current live animal assets, the inventory rate difference value of the current live animal assets is calculated, and the probability of the inventory rate difference value is calculated through a Gaussian model, so that a quantitative index is provided for the credibility of the live animal assets, and a bank can more objectively evaluate the real situation of the live animal assets. And the loan risk can be better controlled.

The present invention belongs to the field of biomedicine technology and particularly relates to a method for 129 A device and method for flow sampling of Xe magnetic resonance molecular probes, wherein the device includes a hyperpolarized Xe gas supply device, an air inlet line, an air return line, a sample tube, a liquid flow device, a liquid inlet line, and a liquid return line; one end of the air inlet line is connected to the hyperpolarized Xe gas supply device, and the other end extends into the sample tube; the sample tube is connected to the hyperpolarized Xe gas supply device through the air return line; one end of the liquid inlet line is connected to the liquid flow device, and the other end extends into the sample tube; the sample tube is connected to the liquid flow device through the liquid return line. The present invention provides a method that does not require complex live animal experiments, saves time and money, and is suitable for hyperpolarized Xe gas flow sampling. 129 Development and research of Xe magnetic resonance molecular probes for hyperpolarization 129 Device and method for flow sampling of Xe magnetic resonance molecular probe.

Disclosed is novel means that enables collection of embryos from the uterus of a living livestock animal, especially cattle, easily in a short time with the same accuracy as that achieved by a skilled technician. A livestock embryo collection apparatus of the present invention comprises: two syringes; a liquid transfer line for connecting a perfusate supply section-a syringe I-a balloon catheter-a syringe II-an embryo collection section; a liquid transfer direction control section for controlling the direction of transfer of a perfusate in the liquid transfer line; and a syringe pump control section for controlling pump operation of the two syringes. By this apparatus, injection and removal of the perfusate can be quickly carried out by simultaneous operation of the two syringes by the syringe pump control section and the liquid transfer direction control section that work in a coordinated manner, so that the working time for collection of embryos can be largely reduced, and so that embryos in the uterus of a living animal can be collected easily, quickly, and with the same accuracy as that achieved by a skilled technician.

The invention relates to an amyotrophic lateral sclerosis zebrafish model based on beta-methylamino-L-alanine induction as well as a construction method and application of the amyotrophic lateral sclerosis zebrafish model. According to the method for constructing the amyotrophic lateral sclerosis model by inducing the zebrafish through the BMAA, the non-specific fatality rate in the early stage of modeling is effectively reduced by limiting the initial development node and culture conditions of toxin exposure, and the living animal model with typical motor nerve injury phenotype and good repeatability is obtained. The method is short in construction period and relatively low in experiment cost, can objectively reflect sporadic ALS pathological characteristics induced by environmental factors, and is suitable for being used as an in-vivo biological carrier for high-throughput preliminary screening of anti-ALS drugs and related neurotoxicological researches.

The invention relates to the technical field of optical molecular imaging, and particularly discloses a small animal three-dimensional fast tomography method which comprises the following steps: S1, firstly, putting a living body gathering animal on the upper surface of an electric rotating platform for vertical fixation, and then fixing an optical CCD camera and a fluorescent CCD camera which are aligned with the height center line of the living body gathering animal; an optical CCD camera and a fluorescent CCD camera are fixed and connected with a computer, and an electric rotating platform which accurately rotates for thirty-six times is matched to drive a focused living animal to accurately rotate, so that the optical CCD camera and the fluorescent CCD camera can quickly shoot every time the focused living animal rotates, and the accuracy of the focused living animal is improved. After shooting for thirty-six times, synthesizing an optical three-dimensional model and a fluorescent three-dimensional model through computer software, and then rotating one of the three-dimensional models to coincide, thereby completing the most accurate and rapid three-dimensional fluorescent tomography work.