188 results about "Live animal" patented technology

A sensor (e.g., an optical sensor) that may be implanted within a living animal (e.g., a human) and may be used to measure an analyte (e.g., glucose or oxygen) in a medium (e.g., interstitial fluid, blood, or intraperitoneal fluid) within the animal. The sensor may include a sensor housing, an analyte indicator covering at least a portion of the sensor housing, and one or more compounds containing boronate or boronic acid moieties that reduce degradation of the analyte indicator.

The utility model discloses a live animal gastric juice sampling device for a pharmaceutical analysis experiment. The live animal gastric juice sampling device comprises a fixing plate, a fixing unit, an injector unit and an extraction unit, a first fixing frame is fixedly connected to the left side of the upper end of the fixing plate. The fixing unit comprises second fixing frames, first threaded rods, an arc-shaped fixing plate, a rubber pad and a rotating handle, the left side of the upper end of the fixing plate is fixedly connected with the two second fixing frames, the upper end of each second fixing frame is in threaded connection with the first threaded rod, and one end of the inner side of each first threaded rod is rotationally connected with the arc-shaped fixing plate; the inner side of each arc-shaped fixing plate is fixedly connected with a rubber pad, and the other end of the first threaded rod is fixedly connected with a rotating handle. During sampling, the injector can stably form negative pressure, meanwhile, when the sampling device is operated, the positions of the injector and the sampling pipeline do not need to be controlled at the same time, and meanwhile, the sampling pipeline can reduce the blocking condition.

The transportable xenogenic organ transplantation donor animal experiment shelter comprises an outer cabin and an inner cabin, the outer cabin is a transport box, the inner cabin is arranged in the middle area in the outer cabin, and the areas on the two sides in the outer cabin are arranged as equipment rooms; the inner cabin is provided with a barrier area and a common area, a changing room, a feeding room and a dissecting room are arranged in the barrier area, and a preparation room, a first transfer cabinet, a feed room, a clean water room, a waste water collecting room, a second transfer cabinet and a decompression bin are arranged in the common area; a personnel circulation channel and an article and animal circulation channel are arranged in the inner cabin; the controller is arranged in the preparation room, and the controller is connected with the air conditioner, the waste gas treatment device and the generator set; living animals are transported to an organ transplantation site in the square cabin, experimental animals with organs to be removed can live in the square cabin, are in a standby state all the time, are removed after the operation of a patient is prepared, and are quickly implanted into the body of the patient, so that the problems existing in long-distance transportation of xenogenic organ transplantation at present are solved.

A sensor (e.g., an optical sensor) that may be implanted within a living animal (e.g., a human) and may be used to measure an analyte (e.g., glucose or oxygen) in a medium (e.g., interstitial fluid, blood, or intraperitoneal fluid) within the animal. The sensor may include a sensor housing, an analyte indicator covering at least a portion of the sensor housing, and one or more compounds having dithio-, thio- or mercapto-containing moieties that reduce degradation of the analyte indicator.

A method for stunning and killing animals, suitable for poultry, pigs, chinchillas, mustelids, rabbits and fur-bearing animals is provided. The method involves introducing live animals to be slaughtered into a sealed chamber of a slaughter plant, adding to the sealed chamber at least one gas suitable for causing the animals to lose consciousness, performing a stunning stop so that the animals in the sealed chamber are at least partially stunned, creating a vacuum inside the sealed chamber until a predefined killing pressure is achieved, performing a killing stop so that the stunned animals in the sealed chamber are killed, opening the sealed chamber and extracting the killed animals. The gas insertion step may be preceded by a pre-suction step of air from the sealed chamber. The method minimizes damages caused by convulsive phenomena occurring in traditional slaughter methods.

The invention mainly relates to the technical field of Internet of Things, and provides a control device, system and method based on Wi-Fi HaLow and LTE redundancy mechanisms in order to ensure that a main gateway fails, monitoring devices in a region can automatically switch gateway nodes and ensure normal uploading of monitoring data. The main control module starts the camera module to shoot monitoring data and uploads the data through Wi-Fi HaLow, when data transmission based on the Wi-Fi HaLow is interrupted, any node in the Mesh network is converted into a gateway through the pluggable LTE module, the monitoring data is retransmitted, it can be ensured that when a main gateway breaks down, monitoring equipment in a Halow Mesh network area can automatically switch the gateway node, and the monitoring efficiency is improved. Normal uploading of monitoring data is ensured, and the system is especially suitable for monitoring remote areas with poor signal conditions.

The invention relates to the technical field of intelligent detection and customs clearance management, in particular to a living animal intelligent detection and customs clearance management system based on millimeter wave radar, which comprises a millimeter wave radar array module, a data processing and analysis module, a luggage sorting control module, a quarantine process management module, an alarm response module and a system management platform. The millimeter-wave radar array module acquires biological characteristics of a living body by adopting a multi-band fusion detection technology, and the data processing and analysis module identifies the living body and outputs a confidence score by applying algorithms such as an improved double-flow convolutional neural network; and the system management platform is linked with each module based on a detection result to realize luggage dynamic sorting, grading alarm, quarantine resource intelligent distribution and whole-process closed-loop control. According to the invention, hidden living animals can be effectively identified, biological invasion and epidemic disease transmission are prevented, and through automatic and intelligent management, the customs clearance efficiency is significantly improved, the manual intervention cost is reduced, and the traceability and safety of the clearance data are ensured.

The purpose of the present disclosure is to provide a nicotinamide adenine dinucleotide (NAD) production promoter derived from a novel material, and a method for producing the NAD production promoter. The technology disclosed herein relates to an NAD production promoter and is characterized by containing a Euglena-derived substance, which is a component derived from microalgae belonging to the genus Euglena. It is confirmed that the NAD production promoter has an NAD-production-promoting action on a living animal body. Because NAD production promoter uses microalgae belonging to Euglena as a material, the NAD production promoter can be stably supplied by means of culturing.

The invention belongs to the technical field of molecular biotechnology and molecular markers, and particularly relates to an SNP molecular marker associated with back fat thickness and eye muscle area characters of pigs and application of the SNP molecular marker. A high-throughput sequencing technology is utilized to identify the SNP site related to the pig meat production performance, on one hand, the influence of the SNP site on the meat production efficiency is explored, and on the other hand, an available molecular marker is provided for improving new application of pig genetic breeding. The marker corresponds to a site 7061212 of a No.1 chromosome of a pig of an international reference genome Sscrofa11.1 version. A Cgt exists at the 84bp position of the first exon region of LOC106508795, and a Cgt exists at the 84bp position of the first exon region of The base substitution of A results in single nucleotide polymorphism. Genetic typing is carried out on the SNP site, and correlation analysis shows that AA genotype individuals have excellent characters of thin back fat, large eye muscle area and the like of living bodies with the weight of 100 kg.

The utility model discloses a sepsis animal model data analysis device based on machine learning, which relates to the animal model field, and comprises a machine body, a fixing mechanism and a supporting mechanism, the top end of the machine body is provided with an observation box, the top end of the observation box is provided with a ventilation fan, the supporting mechanism is welded on the outer wall of the machine body, and the fixing mechanism is fixed on the machine body. A keyboard is placed at the top end of the supporting mechanism, an analyzer is placed at the top end of the supporting mechanism, a display screen is placed at the top end of the analyzer, and the outer wall of the display screen is sleeved with a protective sleeve. By arranging the fixing mechanism, when the living animal model is observed, after the living animal model is placed on the fixing plate of the fixing mechanism, the fixing ring is fixed on the fixing plate through the fixing rod, and the body of the living animal model is fixed by using the fixing ring, so that the animal is prevented from moving to influence the observation; and meanwhile, the fixing ring does not cause harm to the body of the living animal model.

An instrument for high-throughput scanning of live anesthetized animals, incorporating a robotic scanning device, a multi-slot animal loading dock, and an automatically controlled gas anesthesia delivery unit such that: when a subject test animal is present in a slot of said animal loading dock, gas anesthesia is delivered uninterruptedly to said test animal in the loading dock; when said test animal is being manipulated and / or scanned with said robotic scanning device, gas anesthesia is delivered uninterruptedly to said test animal.

The invention discloses a method for constructing a transgenic zebrafish model of hypoxia response. The method comprises the following steps: firstly assembling an sv40mp promoter after a hypoxia response element HRE sequence and cloning the promoter into a pT2AL200R150G plasmid carrying green fluorescent protein (GFP), then microinjecting the recombinant plasmid and transposase mRNA into zebrafish embryos, and inserting the recombinant sequence into the genome of F0 generation zebrafish by Tol2 transposon technology; raising the F0 generation fish to adult fish, hybridizing with wild-type zebrafish to produce F1 generation, hybridizing the F1 generation with the wild-type fish again to produce single-copy transgenic zebrafish F2 generation, self-pollinating male and female sibling zebrafish of the F2 generation, and screening out transgenic zebrafish Tg (HRE-sv40mp:GFP) of hypoxia response of F3 generation that can be stably inherited. The transgenic zebrafish Tg(HRE‑sv40mp:GFP) constructed in the present invention can be used as a simple and efficient hypoxia response model for biological research in hypoxia-related fields, as well as for screening molecular targeted drugs for HIF‑1α, providing a living animal screening model for the development of anti-tumor drugs.

The application provides a drug hepatotoxicity prediction method, device, system and medium, the method comprising: sequencing human liver cells after being contacted with a drug to be predicted to obtain a genome expression profile of the human liver cells after being contacted with the drug to be predicted; calculating the sum of the absolute values of the fold changes of the genes in the current gene pathway as the toxicity score of the current gene pathway according to the expression profile; calculating the Z value of the current gene pathway according to the toxicity score of the current gene pathway, the average value and the standard deviation value of the toxicity scores of the gene pathways calculated multiple times by a plurality of preset gene pathways; and predicting that the drug to be predicted has hepatotoxicity when the Z value is greater than 1.5. Therefore, the application can accurately, timely, effectively and sensitively predict drug hepatotoxicity without a large number of living animals as an experimental basis, and has good advantages in safety, environmental protection and animal protection. The application has the advantages of short experimental period and low cost.

The invention discloses a living body screening method of a high-throughput addiction inhibitor, which comprises the following steps: acquiring addictive nematodes with a plurality of addiction behavioral phenotypes; applying different addiction inhibitors to the addictive nematodes; the screening of the addiction inhibitors is realized according to the inhibition efficacy of the addiction inhibitors on the addiction behavioral phenotypes of the addiction nematodes, and based on the steps, the drug screening of the addiction inhibitors can be realized through the inhibition efficacy of the addiction inhibitors on the addiction behavioral phenotypes of the addiction nematodes in a high-throughput manner. Compared with the prior art, the medicine screening method of a traditional cell function system is abandoned, and medicine screening is carried out on the living animal behavioristics level in a brand new mode. Meanwhile, the advantages of easiness in large-scale culture, abundant behavioral modes and the like of the nematodes are utilized, and compared with expensive mammal feeding and experimental operation for drug screening, the method has higher cost performance, practical operability and high throughput.

A sensor (e.g., an optical sensor) that may be implanted within a living animal (e.g., a human) and may be used to measure an analyte (e.g., glucose or oxygen) in a medium (e.g., interstitial fluid, blood, or intraperitoneal fluid) within the animal. The sensor may include a sensor housing, an analyte indicator covering at least a portion of the sensor housing, and one or more compounds containing boronate or boronic acid moieties that reduce degradation of the analyte indicator.

The invention provides a method for crosslinking and marking biomolecules in living animals based on photocatalysis. According to the method, the hydrophilic up-conversion nano composite material and the photosensitizer are in contact with the biological sample to be detected, and the target position of the biological sample to be detected is subjected to near-infrared light irradiation, so that the RNA-RNA binding protein compound is formed in situ at the target position of the biological sample to be detected, and the biological sample is obtained. Especially in situ crosslinking of RNA and RNA binding proteins in an organism. On the basis of the cross-linking method, marking, enrichment and analysis of all kinds of RNA-RNA binding protein compounds and RNA binding proteins can be realized by further matching with a compound as shown in a formula 1, and the method has broad spectrum; meanwhile, pollution caused by cross-linking of protein and protein and cross-linking of DNA and protein is effectively avoided, and high specificity is achieved.

Provided herein are compositions and methods for identifying effective delivery vehicles (DVs) for mRNA delivery to and expression in specific cells or tissues in culture (in vitro) or in live animals (in vivo) from a pool of co-administered DVs.

The purpose of the present invention is to provide a technique for imaging the brain of a live animal and application of the technique. A radiolabeled dibenzoazepine derivative, which shows excellent brainparmeability, high receptor selectivity and high quantitativity, is used for imaging a live animal body. A dibenzoazepine derivative is used for treating a disease in which hM4D receptor or hM3D receptor participates. Further, a radiolabeled dibenzoazepine derivative is used for imaging an axonal end which is innervated by a nerve cell.

The present invention relates to a fixation and body temperature maintaining apparatus for fixing a small animal in order to generate a high-resolution micro image of a predetermined tissue of the small animal within a biomicroscope with an object lens, which includes: a plate heater with a heat wire installed therein, on which the small animal is enabled to be directly placed; a glass heater holder fixed to a hole of the plate heater; and a glass heater fixed to the glass heater holder, and located above the tissue of the small animal and maintaining flatness of the tissue, and increasing a temperature of the tissue itself, in which a cover glass serving to adjust a refractive index of the object lens and a heat wire heater are integrally formed. In an embodiment of the present invention, a body temperature of a live small animal which is an object to be observed with a biomicroscope is maintained to be constant.

The invention provides an intelligent prompting method and system for a turning of a vehicle, and the method comprises the steps: obtaining a real-time lane image of each lane through a camera disposed at the turning, obtaining the number of real-time moving objects on each lane according to the real-time lane image, and enabling the moving objects to be vehicles and pedestrians; whether the number of real-time moving objects on at least one lane is larger than 0 or not at the current turning position is judged, and if yes, a reminding device at the current turning position is controlled to conduct reminding according to the number of the real-time moving objects on each lane. When moving objects exist on the lane at the turning position, reminding is conducted through the reminding device at the turning position, so that a vehicle can conduct deceleration observation in advance according to the reminding device, and the driving accident risk at the turning position is effectively reduced.

The embodiment of the invention relates to the technical field of vehicles, and discloses a living object expelling method and device and a vehicle. The living object expelling method comprises the steps that whether a target living object exists in a vehicle blind area or not is determined based on detection data of the vehicle blind area; wherein the detection data of the vehicle blind area is used for reflecting the existence condition of living things in the vehicle blind area; the vehicle blind area refers to an area outside a driver view area and in a vehicle driving track, and the driver view area refers to a sight coverage area when a driver is in a driving position; under the condition that the target living object exists in the blind area of the vehicle, a target expelling strategy for the target living object is determined based on the living object type of the target living object and the area type of the area where the vehicle is located currently; and controlling the vehicle to execute the target expelling strategy. According to the technical scheme, the living body targets in the driving blind area can be repelled, and safety accidents are reduced.

A tool to aid in the feeding of whole animal bodies to a live reptile. The invention is designed for the use of deceased whole animal bodies, though a live animal body could be used in some instances. The tool consists of a barrel and a plunger. The barrel has an interior opening large enough to receive a whole animal body. The tip of the barrel has a beveled, angled tip which is used to assist in the opening of the reptile's mouth for feeding. The barrel may be lubricated to further assist insertion of the barrel into the reptile's mouth such as to position the animal body into the reptile esophagus. When fully depressed against the barrel, the end of the plunger will extend beyond the tip of the barrel to help push the animal body into the reptile's esophagus.

This invention relates to the field of leukemia research, specifically disclosing an animal model of CAR-T therapy for leukemia complicated by cytokine release syndrome (CRS), its preparation method, and its application. The method for preparing the animal model of CAR-T therapy for leukemia complicated by CRS includes: obtaining CD19 CAR-T cells: peripheral blood mononuclear cell isolation, T cell magnetic bead sorting, T cell activation, lentiviral infection, and CAR-T cell expansion; constructing an animal model of CRS after high- and low-dose CAR-T infusion: implanting Nalm-6 cell line into living animals to induce leukemia tumor burden, obtaining living animals with leukemia tumor burden, and injecting CD19 CAR-T cell line into the living animals with leukemia tumor burden. This invention provides a novel application for the animal model of CAR-T therapy for leukemia complicated by cytokine release syndrome. By using severely combined immunodeficient mice and inoculating them with high- and low-burden tumor cells, and infusing different doses of CAR-T cells, this invention constructs an in vivo model that can simulate clinical CRS, providing research guidance for clinically exploring more effective interventions.

A sensor (e.g., an optical sensor) that may be implanted within a living animal (e.g., a human) and may be used to measure an analyte (e.g., glucose or oxygen) in a medium (e.g., interstitial fluid, blood, or intraperitoneal fluid) within the animal. The sensor may include a sensor housing, an analyte indicator covering at least a portion of the sensor housing, and a multiple metal protective system including multiple metals incorporated in and / or in close proximity to a surface of the analyte indicator that reduce deterioration of the analyte indicator.

The utility model discloses a small animal test post-operation wound surface shooting device, which comprises a base, a support vertical rod and an object placing table, the object placing table is arranged on the upper surface of the base, the support vertical rod is vertically fixed on the base, the support vertical rod is arranged on one side of the object placing table, a support arm assembly is arranged on the support vertical rod, and the support arm assembly is connected with the object placing table. Meanwhile, a clamping head assembly is arranged on the supporting arm assembly, a shooting instrument is clamped by the clamping head assembly, a fixing table assembly is installed on the object placing table, the device achieves effective constraint on shot living animals, the scale assembly is matched with the supporting vertical rod, the supporting arm assembly and the clamping head assembly, it is ensured that the proportions of images shot by different devices at different times are consistent, and the shooting efficiency is improved. The scale is used as a correction reference, the actual area of the wound surface can be automatically converted in software, the manual measurement error is reduced, the fixing table assembly and the fixing rod are designed in a modularized mode, 20-500 g experimental animals can be compatible, and the limitation of one mouse and one device of a traditional device is overcome.

The invention discloses a beauty instrument efficacy evaluation device and a beauty instrument efficacy evaluation method, the beauty instrument efficacy evaluation device comprises: a cell culture box, the cell culture box comprises two culture group boxes, the culture group boxes are used for culturing test cells; the beauty instrument to be tested is arranged above the cell culture box and is used for performing beauty treatment on the test cells; the beauty instrument to be detected is hung on the hanging moving assembly, and the hanging moving assembly is used for driving the beauty instrument to be detected to move. The beauty instrument efficacy evaluation device can replace a traditional in-vivo test with an in-vitro cell culture system, does not need to depend on living animals or human subjects, and avoids the problem of time consumption of experiment object screening, preparation and long observation period in the in-vivo experiment; and meanwhile, the problems of difficulty in testee recruitment and high experiment cost in a human body experiment are solved.

The embodiment of the present invention provides a method for identifying live commodities on a street stall, the method comprising: obtaining a captured image and an infrared image of a target street stall, the captured image including a target stall owner and a target commodity, the captured image and the infrared image having the same size resolution; performing image recognition processing on the captured image to obtain the behavior information of the target stall owner and the appearance information of the target commodity; performing image recognition processing on the infrared image to obtain the infrared information of the target commodity; based on the behavior information of the target stall owner, the appearance information of the target commodity and the infrared information of the target commodity, judging whether the target stall owner has engaged in the sale of live commodities. The present invention can automatically identify stalls that have engaged in the sale of live commodities, improve the management efficiency of stalls that sell live animals, and improve the recognition accuracy of the sale of live commodities by combining the infrared information of the target commodity.

A digital augmented reality system and method configured to generate and project a digital overlay over a static hunting target or live animal wherein the overlay includes a digital representation of the internal anatomy of the target and further detect and display where a projectile striking the target or animal would pass through the digital overlay.

A sensor (e.g., an analyte sensor) that may be implanted partially or fully within a living animal (e.g., a human) and may be used to measure an analyte (e.g., glucose or oxygen) in a medium (e.g., interstitial fluid, blood, or intraperitoneal fluid) within the animal. The sensor may include a housing, a first polymer that includes analyte indicator molecules and covers at least a portion of the housing, and a second polymer that forms an interpenetrating network with the first polymer. The second polymer may prevent biological or protein interference of the sensor.

The invention provides a near-infrared fluorescence activated protein, a gene containing the near-infrared fluorescence activated protein, an expression box and a using method thereof, and a cell and a kit for generating the near-infrared fluorescence activated protein. A compound formed after the near-infrared fluorescence activated protein is combined with a corresponding fluorescent ligand has strong fluorescence, the fluorescence excitation peak wavelength is 574nm, near-infrared light with the emission peak wavelength is 680nm, and the near-infrared fluorescence activated protein has the advantages of high fluorescence quantum yield, large two-photon absorption cross section and the like, and has the advantage of high signal-to-noise ratio in vitro, living cells and living animals.