61results about How to "Improve dialysis efficiency" patented technology

The present invention relates to a method and a device for the measurement of pressure signals in a blood treatment system, whereby system changes can be identified and can be differentiated additionally reliably between system changes in blood flow direction and in transmembrane direction in order to enable a targeted action.

A dialysis unit includes both an inlet for guiding dialysis fluid in a direction of flow to a dialyser membrane and an outlet for discharging dialysate from the dialyser membrane. A heat pump configured to exchange thermal energy between a heat reservoir and the dialysis fluid in the inlet is coupled to the inlet.

The invention belongs to the fields of membrane surface engineering and bioseparation engineering and aims at providing a method for preparing a low-density lipoprotein affinity adsorption hemodialysis membrane material. The method provided by the invention comprises the following steps: prewashing the hemodialysis membrane material; placing the prewashed hemodialysis membrane material into a plasma processor cavity; introducing inert gas and activated gas until atmosphere ingredients are constant and then carrying out plasma processing; immersing into a heparin solution; adding a coupling agent to carry out an oscillation reaction; carrying out oscillation washing by utilizing a PBS (Phosphate Buffer Solution); and repeatedly washing with clean water and perform filter drying to obtain the low-density lipoprotein affinity adsorption hemodialysis membrane material. In the method provided by the invention, active reaction groups are introduced into by utilizing a constant-pressure and low-temperature plasma activation modification processing method; the reaction is only carried out on the surface of the material, the body performance of the material is not influenced, and simultaneously the method has the characteristics of high efficiency, low cost, low energy consumption, environmental friendliness and the like; the hydrophilia and blood compatibility of the surface of a macromolecule separation membrane material can be greatly improved; and the blockage effect caused by membrane pollution in the hemodialysis course can be effectively reduced.

A blood purification method that purifies blood taken from a body by blood dialysis or by hemodiafiltration includes the step of changing an osmotic pressure of the blood to an increasing condition until a blood volume (BV level) attains a standard blood volume, in a former part of a blood purification process and the step of maintaining a standard blood volume and periodically changing the osmotic pressure of the blood in a later part of the blood purification process.

The invention discloses a polyester anticoagulation blood dialysis membrane. The dialysis membrane takes a polyester material as a main body. The polyester anticoagulation blood dialysis membrane is prepared from 10 to 24 parts of polyester material, 5 to 9 parts of polysulfone, 4 to 9 parts of polymethyl methacrylate, 6 to 9 parts of protein fiber, 15 to 20 parts of protein mixed material, 5 to 9parts of peptidoglycan, 3 to 8 parts of glycerol and 8 to 15 parts of anticoagulant. The invention further discloses a preparation method of the polyester anticoagulation blood dialysis membrane. Thepreparation method comprises the following steps: S1, mixing silk making materials; S2, removing air bubbles; S3, mixing the anticoagulant; S4, spinning. The polyester anticoagulation blood dialysismembrane has the advantages of good anticoagulation effect, higher flexibility and high retention rate of micromolecular proteins.

A dialysis unit includes both an inlet for guiding dialysis fluid in a direction of flow to a dialyzer membrane and an outlet for discharging dialysate from the dialyzer membrane. A heat pump configured to exchange thermal energy between a heat reservoir and the dialysis fluid in the inlet is coupled to the inlet.

The invention discloses a hemodialysis device for kidney internal medicine. The hemodialysis device comprises a shell, a blood inlet and outlet device is connected to the shell, a wire rack is installed outside the shell, the blood inlet and outlet device includes an arterial needle and a venous needle, the arterial needle and the venous needle are connected with a blood outlet vessel and a bloodreturn vessel respectively, the blood outlet vessel is connected with a blood pump, the blood pump is connected with a dialysis device through an intermediate tube, the dialysis device is installed inthe shell, an anticoagulant injector and a one-way valve are respectively installed at the top side and right end of the intermediate tube, and a blood insulation device is installed in the blood return vessel. According to the hemodialysis device, the hemodialysis preparation time is short, medical hollow fibers have good quality and high filtration efficiency for blood of a patient and can be washed through a cleaning tube, long-term high-efficiency hemodialysis can be effectively performed, the blood in the blood return vessel is similar to the blood temperature in the body of the patientafter insulation, the blood flow is smooth, and the patient is more comfortable.

The invention provides a membrane dialysis sample processing device for detecting melamine in milk and milk products, which mainly comprises a water-bath heating unit and a purification unit, wherein the water-bath heating unit is provided with an electronic temperature sensor and a digital display electronic temperature controller, and has temperature adjustment and automatic temperature control functions; and the purification unit has a two-layer nested structure, the wall of a liner has a window covered by a dialysis membrane, and a cavity between a shell and the liner is used for accommodating received liquid and test solution. The device has a good purification effect; the purified solution can be directly used for an assay by a developing process, liquid phase-mass-spectrography, high performance liquid chromatography and an electrochemical process; the structure is compact; the operation is convenient; the manufacturing is easy; and the manufacturing cost is low. The device can also be used for purification treatment of other detected substances.

A method is described for the treatment of hypotension, e.g., intra-dialytic hypotension, which is based on the administration to a patient, e.g. a dialysis patient during dialysis, of midodrine or a midodrine metabolite which will increase a lowered blood pressure in the patient or relieve a symptom caused by the dialysis procedure.

The invention provides a novel alkali recovery technology during viscose fiber production, which is characterized by comprising the steps that pretreated waste alkali liquor and de-mineralized water at a flow ratio of (1-2):1 enter a membrane module by a pump, and are conveyed to a diffusion dialysis membrane module device; the outflowed waste alkali liquor passes through an anode chamber of electrodialysis; dilute alkali liquor serves as an electrolyte and passes through a cathode chamber; and densified alkali obtained by the cathode chamber is recovered, wherein a concentration of sodium hydroxide of the pretreated waste alkali liquor is 50-200g / L, and the content of hemicellulose is 20-150g / L. According to the characteristic that high-concentration waste alkali containing the hemicellulose is generated during a viscose fiber production course, by using a diffusion dialysis and electrodialysis combined method, an optimized technological parameter is selected, so that the novel alkali recovery technology has the advantages of high alkali recovery rate, low energy consumption and stability in operation.

The interval adjustable crystal colloid and its preparing method relate to an interval adjustable crystal colloid and its preparing method, whose spectrum spectrum can be 20-900nm. Concretely, the preparing method is: place the spheroidal particle whose diameter is 80-250nm into the water with high pressure for dialysis, and renew the water at least for ten minutes in each dialysis until the electric conductivity is 0.1-10ª–s / cm through the supersonic wave, the colloid (dispersed) being colloid (dispersed) is diluted by monomer solution of neutral hydrogel polymer (including ultraviolet light (acrylamide monomer and as the cross linker) ), in which the initiator of ultraviolet light (acrylamide monomer and as the cross linker) is added into the deprivate O2 and CO2, the crystal colloid is generated by ultraviolet light (acrylamide monomer and as the cross linker) raying.

The invention provides a fully-automatic solution dialysis experiment device which comprises a shell, a sample injection unit, an operation control system, an operation display interface, a sample solution input shunt controller and conduit line device, a dialysis device, a power supply system, a dialysis retention solution output unit, a dialysate output valve and a sample solution output shunt controller and conduit line device; the sample injection unit, the operation control system and the operation display interface are arranged on the shell; the dialysis device is arranged in the shell; the dialysis retention solution output unit, the dialysate output valve and the power supply system are arranged on the shell; the sample injection unit is connected with an inlet of the dialysis device through the sample solution input shunt controller and conduit line device; an outlet of the dialysis device is connected with the dialysis retention solution output unit through the sample solution output shunt controller and conduit line device. The fully-automatic solution dialysis experiment device provided by the invention is simple and novel in structure, high in degree of automation, high in dialysis efficiency and suitable for the dialysis and purification processes of medium and small scale batch samples.

The invention provides a dialysis device comprising a driving mechanism which comprises a vertically-arranged air cylinder, wherein the air cylinder can rotate along the central axis of the air cylinder, and a plurality of transverse rods are symmetrically arranged at the top of the air cylinder; a clamping mechanism which is arranged at the end of the cross rod and comprises a clamping air cylinder capable of rotating on the vertical plane, wherein a clamping head is connected on the top end of the clamping air cylinder; and a dialysis mechanism which is arranged below the clamping mechanismand comprises a plurality of magnetic stirrers arranged in the circumferential direction of the air cylinder, wherein the magnetic stirrers can move in the radial direction of the air cylinder, dialysis cups are arranged on the magnetic stirrers, and rotors are arranged in the dialysis cups. A dialysis bag is clamped through the clamping head, the dialysis bag is completely immersed into dialysatewhen the air cylinder contracts, dialysis efficiency is improved, the dialysis bag is immersed into different dialysis cups gradually through rotation and lifting of the air cylinder, and automatic multi-stage dialysis is achieved.

The invention discloses a hemodialysis resource management and service system and method based on multi-objective optimization. The system comprises an information acquisition and transmission device,a data processing center, a central control host device and a client. The central control host device stores and backs up data, predicts the time when devices can be used again, integrates all hemodialysis mechanisms around a patient, adopts a multi-objective optimization mode, optimize time, distance and the device utilization rate according to weights, generates three dialysis arrangements withoptimal resources, and sends the dialysis arrangements to a client; and the client receives the dialysis schedule, collects patient information and transmits the patient information to the data center. The invention provides the hemodialysis resource management and service system and method based on multi-objective optimization, so that the patient does not need to wait in a hospital to waste time and energy, and the awkward situation of high dialysis pressure of the hospital is relieved to a certain extent.

The invention discloses a hemodialysis tube, which relates to the field of medical equipment. The hemodialysis tube provided by the present invention includes a dialysis part and a connection part, the connection part is connected to the dialysis part; the dialysis part includes an outer dialysis tube, an inner dialysis tube and a dialysis membrane, and the outer dialysis tube is sleeved on the periphery of the inner dialysis tube and is connected with the inner dialysis tube There is a gap between the dialysis membrane and the outer wall of the inner dialysis tube; the inner dialysis tube has a U-shaped or V-shaped structure, and the openings are the liquid inlet and the liquid outlet respectively; the liquid inlet and the liquid outlet pass through the connecting part ; Nano-silver is fixed in the pipes of the outer dialysis tube and the inner dialysis tube. The dialysis part of the dialysis device is small in size, and is directly placed in the human artery for hemodialysis, without the need to draw blood out of the body and then through the machine for hemodialysis, so that it has no effect on human blood pressure, and is more economical, safer and less traumatic than extracorporeal hemodialysis ; It can be left in the blood vessels for multiple use, and the patient is continuously on hemodialysis.

The present invention discloses a biological antibody automatic dialysis purification device. The table surface of a working table is sequentially provided with a dialysis tank I, a dialysis tank II and a purification tank from right to left; the dialysis tank I and the dialysis tank II are fixedly connected through a connecting bent pipe I; the dialysis tank II and the purification tank are fixedly connected through a connecting bent pipe II; a dialysis buffer solution is introduced into the dialysis tank I and the dialysis tank II through dialysis liquid pipelines, and a to-be-purified biological antibody material is introduced into a dialysis bag through an external input pipe on the side surface of the dialysis tank I, so that dialysis purification of a biological antibody in the dialysis bag by the dialysis tank I is realized; in the dialysis process of the dialysis tank I, a stirring shaft I is driven by a motor I to rotate, and the stirring shaft I drives a stirring blade I to stir the solution in the dialysis tank I, so that the dialysis purification efficiency is improved; and hot air flow is input into the dialysis tank I by a heating pipeline, so that the flow rate of macromolecules in the dialysis bag is increased and the dialysis efficiency is improved.

The invention discloses a hemodialysis system with a built-in dialysis tube, which relates to the field of medical equipment. The hemodialysis system with built-in dialysis tube of the present invention includes a dialysate container, a dialysis tube, a peristaltic pump and a waste liquid tank connected in sequence; the dialysis tube includes an outer dialysis tube, an inner dialysis tube and a dialysis membrane, and the outer dialysis tube is sleeved on the inner dialysis tube There is a gap between the outer periphery and the dialysis inner tube, and the dialysis membrane is wrapped on the outer wall of the dialysis inner tube; the dialysis inner tube is U-shaped or V-shaped, and the openings are respectively the liquid inlet and the liquid outlet; the dialysate container passes through the liquid inlet tube Connected to the liquid inlet, the peristaltic pump is connected to the liquid outlet through the liquid outlet pipe; it also includes a connecting part, the liquid inlet and the liquid outlet pass through the connecting part respectively, and the connecting part is provided with a regulating valve to open or close the liquid inlet and / or outlet and adjust the flow rate. The dialysis tube is placed in the human artery without taking blood out of the body for hemodialysis, so it has no effect on the blood pressure of the human body, and is safe, economical and less traumatic; it is indwelling in the blood vessel for multiple uses and continues to perform hemodialysis.

An automatic peritoneal dialysis machine comprises a dialyzate bag, a heater, a waste liquid bag, a safety detector, a first valve, a second valve and a third valve. Dialyzate in the dialyzate bag is heated to the set temperature through the heater, the first valve and the second valve are opened, the third valve is closed, the heated dialyzate flows into an abdominal cavity of a patient, when the pouring amount of the dialyzate reaches the preset value, the first valve is closed, the dialyzate stays in the abdominal cavity of the patient to conduct dialysis and diffusion, when the time that the dialyzate stays in the abdominal cavity of the patient reaches the preset time, the first valve and the third valve are opened, the dialyzate exchanged in the abdominal cavity is led out of the waste liquid bag, and after the amount of the led-out dialyzate is consistent with the amount of the poured dialyzate, the first valve and the third valve are closed. The safety detector leads out the dialyzate exchanged in the abdominal cavity and conducts blood leakage detection on the dialyzate exchanged in the abdominal cavity. The machine effectively ensures the safety state of the patient in the dialysis process, and improves the dialysis efficiency.

The invention discloses a dialysis tube built-in type blood hemodialysis system. The system comprises a dialysis container, a dialysis tube, a power pump and a collecting vat which are sequentially connected. The dialysis tube comprises a dialysis outer tube, a dialysis inner tube and a dialysis film. The outer wall of the dialysis inner tube is coated with the dialysis film, the dialysis container is connected to a liquid inlet through a liquid inflow tube, and the power pump is connected to a liquid outlet through a liquid outflow tube. The dialysis tube comprises a fixed base and a jacket,the fixed base is a hollow cylinder, the jacket is clamped on the outer side wall of the fixed base, and holes corresponding in position are formed in the outer side wall of the fixed base and the jacket. During use, the dialysis film is spread and clamped between the outer side wall of the fixed base and the jacket. A first magnetic stirrer is mounted at the inner bottom of the fixed base. By theadoption of the dialysis tube built-in type blood hemodialysis system, the dialysis efficiency is improved, and by means of a dialysis film fixing device, a sample can be kept in a sterile state in the dialysis and transfer processes.

The invention relates to the technical field of medical instruments, and discloses a peritoneal dialysis monitoring device which comprises a telescopic rod, a flow stopper is arranged on the outer wall of the bottom end of the telescopic rod and comprises a supporting lantern ring, the supporting lantern ring is fixedly arranged on the outer wall of the bottom end of the telescopic rod in a sleeving mode, and a temperature control box body is fixedly connected to the top face of the telescopic rod. A temperature guide device is arranged in the temperature control box body and comprises a temperature guide plate, the left face and the right face of the temperature guide plate are fixedly connected to the left inner wall and the right inner wall of the bottom end of the temperature control box body respectively, sliding grooves are formed in the top ends of the left inner wall and the right inner wall of the temperature control box body, an infusion support is arranged between the two sliding grooves, and a temperature monitor is arranged below the temperature control box body. The temperature monitor comprises a fixing frame A, the right face of the fixing frame A is fixedly connected with a fixing seat, a clamping plate is attached to the front portion of the fixing seat, the top side wall of the right end of the rear-end metal lantern ring is fixedly connected with a thermometer, the temperature of peritoneal dialysis liquid can be monitored more accurately, and the safety of peritoneal dialysis is effectively improved.

The invention provides a dialysis method of a recombinant human tissue type plasminogen kinase derivative inclusion body enhancement solution, and application. The invention adopts ultrafilter dialysis, compared with dialysis bag dialysis, dialysis efficiency is obviously improved, dialysis time is shortened into 1 / 5 of original dialysis time, a use amount of dialysis external liquid is reduced to1 / 20 of an original use amount, the dialysed rPA solution is clear and transparent, and small molecule substances, including guanidine hydrochloride, reductant DTT and the like, can be more thoroughly removed; and after the ultrafilter dialysis, the obtained rPA solution is processed by subsequent steps, and the integral yield of produced rPA protein is improved by 20%. The invention provides a convenient and efficient method for renaturation purification of a large-scale industrial inclusion body, especially the inclusion body containing more disulfide bonds.

The invention discloses a hematodialysis element. The hematodialysis element comprises a dialysis room, a dialysate inlet, a dialysate outlet, a blood lumen and a blood lumen tube, wherein the dialysis room is of a square plate type structure and is provided with a dialysis cavity defined by two plate surfaces and four side surfaces; the dialysate inlet and the dialysate outlet are correspondingly formed in the two opposite side surfaces of the dialysis room and form a dialysate lumen together with the dialysis cavity; the blood lumen is distributed on the dialysis cavity along the direction of one side of a square plate type structure, and a semipermeable membrane for dialysis is arranged on the wall of the blood lumen; the blood lumen tube is provided with a blood inlet and a blood outlet which are formed in the two opposite side surfaces of the dialysis room and are used for communicating the corresponding tube and the blood lumen. According to the hematodialysis element, the dialysis efficiency is high, and the negative effect of the hematodialysis element on blood is small.

An ultrasonic percutaneous dialysis equipment suitable for dialysis therapy or medicinal bath therapy is composed of a dialysis pool and an ultrasonic emitting head. Its advantages are high dialysis efficiency, short time, high curative effect and low cost.

The invention belongs to the field of automatic control, and particularly relates to a dialysis automatic water replacing system which comprises a dialysis tank, a dialysis bag lifting device, a sensor and an automatic water replacing control system. A water inlet with a water inlet valve is formed in the upper end of the dialysis tank, and a water outlet with a water outlet valve is formed in thebottom end of the dialysis tank. The dialysis bag lifting device comprises a fixing ring and an electric lifting rod, wherein a dialysis bag fixing clamp is arranged on the fixing ring, and the lowerend of the electric lifting rod is fixed to the fixing ring through a fixing rod. The sensor is arranged at the lower end of the fixing ring. The automatic water replacing control system comprises aninformation collecting module, an information processing module and an instruction executing module. Through the cooperation of the automatic water replacing control system and the sensor, the wateroutputting, the water inputting and the lifting of a dialysis bag are automatically controlled, the automatic replacing of water (or buffering liquid) is realized according to the conditions of impurities in the water or buffering liquid in the dialysis tank, the dialysis efficiency is improved, labor is saved, and meanwhile it is avoided that a dialysis semipermeable membrane is damaged by manualoperation.

The invention discloses a hemodialyzer which comprises two dialysis tubes. The two dialysis tubes are connected into a Y shape, and the two dialysis tubes are communicated with each other at the joint and provided with a middle connector; the end, away from the middle connector, of each dialysis tube is provided with a blood interface and a dialysis fluid interface; a hollow fiber membrane is arranged in each dialysis tube; the whole hollow fiber membranes are arranged in the two dialysis tubes respectively, and the diameter of a hollow fiber membrane bundle in each dialysis tube is reduced under the condition that the number of the whole hollow fiber membranes is unchanged, so that sufficient dialysis is conducted on blood in the dialysis tubes and dialysis fluid; blood needs to flow back in the Y-shaped hemodialyzer, so that the blood flow distance and time are increased, and the dialysis efficiency is improved; when a patient feels uncomfortable, the blood can only flow out from the middle connector by means of one dialysis tube, so that the pre-congestion amount during dialysis is reduced, the discomfort of the patient is relieved, and the dialysis process does not need to be interrupted. The invention further discloses a hemodialysis device and method using the hemodialyzer.

The present invention provides an in vitro simulator which can simulate digestion and absorption processes of feed nutrient in the chicken alimentary tract, including maw and peptic digest chamber, small intestine digesting chamber and constant temperature system etc. The feed nutrient is completed by the maw and peptic digest chamber under the digesting course of the maw and peptic; chyme is converted to the small intestine digesting chamber continuously digested after the period of maw and peptic digestion, completing the digestion of the nutrient in the small intestine and the absorption of the digested nutrient, finally achieving the simulation of the digestion and absorption processes of the feed nutrient in the chicken alimentary tract in vitro; the constant temperature system provides heat preservation and vibrating mixture functions for the digestion course of the chyme in the maw, peptic digest chamber, small intestine digesting chamber, simulating the environment temperature of the chicken alimentary tract, gastrointestinal peristalsis and chyme mixture. The chicken in vitro simulating digestion device of the invention has a lower cost, simple operation, quick performance and better palingenesis.

The invention belongs to the fields of membrane surface engineering and bioseparation engineering and aims at providing a method for preparing a low-density lipoprotein affinity adsorption hemodialysis membrane material. The method provided by the invention comprises the following steps: prewashing the hemodialysis membrane material; placing the prewashed hemodialysis membrane material into a plasma processor cavity; introducing inert gas and activated gas until atmosphere ingredients are constant and then carrying out plasma processing; immersing into a heparin solution; adding a coupling agent to carry out an oscillation reaction; carrying out oscillation washing by utilizing a PBS (Phosphate Buffer Solution); and repeatedly washing with clean water and perform filter drying to obtain the low-density lipoprotein affinity adsorption hemodialysis membrane material. In the method provided by the invention, active reaction groups are introduced into by utilizing a constant-pressure and low-temperature plasma activation modification processing method; the reaction is only carried out on the surface of the material, the body performance of the material is not influenced, and simultaneously the method has the characteristics of high efficiency, low cost, low energy consumption, environmental friendliness and the like; the hydrophilia and blood compatibility of the surface of a macromolecule separation membrane material can be greatly improved; and the blockage effect caused by membrane pollution in the hemodialysis course can be effectively reduced.

The invention discloses nephrology department dialysis equipment convenient to move. The equipment comprises an air cylinder, a placing plate, a bottom plate, universal wheels, a filtering layer, a first filtering box, a second filtering box, a first one-way valve and a second one-way valve. A piston is driven by the air cylinder to move downwards, so that the speed of blood passing through the filtering layer in the first filtering box is increased, the hemodialysis efficiency is improved, and the practicability of the equipment is improved. When the filtering of the filtering layer is saturated, the second one-way valve is further closed, and the first one-way valve is opened to enable the blood to enter the second filtering box through a first liquid guide pipe, so that the continuous filtering of the blood is realized, the hemodialysis efficiency and effect are further ensured, and the practicability of the equipment is improved. A mounting plate is welded to the side face of the placing plate, an illuminating lamp is fixedly mounted on the mounting plate through bolts, the equipment can still move in a dark environment with the illuminating lamp, and the practicability of theequipment is improved.

The invention provides a portable blood dialysis device, comprising a box body and back straps, wherein the box body includes a peristaltic pump that assists in discharging blood from the artery, a dialysis component having the feed end connected with the discharge end of the peristaltic pump, a vein connected with the discharge end of the dialysis component, a cleaning component control circuit board for cleaning the dialysis component and a battery, wherein the box body is provided with a hook that is arranged between the peristaltic pump and the feed end of the dialysis component for hanging a normal saline bottle. The portable blood dialysis device is characterized in that the dialysis component includes a dialysis unit for receiving blood from the artery and treating the blood, ultrasonic generators staggered on two sides of the dialysis unit and operating at intervals to increase of the speed of moving metabolic wastes and excessive electrolyte in the blood out of the body, and adialysis shell for holding the dialysis unit and the ultrasonic generator. The portable blood dialysis device is simple in structure and low in cost and facilitates long-term treatment.

The invention discloses a micro-flow control chip for membrane-free dialysis. The chip comprises a blood inlet, a dialysate inlet, a straight working flow channel, reflection columns, an arc-shaped working flow channel, a chip shell, a blood outlet and a dialysate outlet, the blood inlet, the dialysate inlet, the straight working flow channel, the reflection column, the arc-shaped working flow channel, the blood outlet and the dialysate outlet are all mounted in the chip shell; the blood inlet and the dialysate inlet are symmetrically formed in an inlet of the straight working flow channel; the blood outlet and the dialysate outlet are symmetrically formed in an outlet of the straight working flow channel; the straight working flow channel is tangentially connected with the arc-shaped working flow channel; and the reflection columns are respectively arranged in the straight working flow channel and the arc-shaped working flow channel. According to the technical scheme, the problems that an existing dialysis membrane is low in efficiency and pollutes blood are solved, and cell loss in membrane-free dialysis is effectively reduced.