The invention discloses a high-frequency minimally invasive surgery instrument for vascular melt closed cutting, which comprises a claw beam assembly with the diameter of 10-12mm/5-8mm and a control grip assembly, wherein a fast plugging mechanism is arranged between the claw beam assembly and the control grip assembly; the claw beam assembly can be exchanged; the claw beam assembly comprises clamping forceps, a fork frame, a claw beam, a lock drum/conductive ring, a jaw steering thumb wheel, a clamping opening/closing drive mechanism, a cutter drive mechanism and a disposable control mechanism; and the control grip assembly comprises a grip housing, a clamping forceps control mechanism, a cutter control mechanism, a current/signal switch and conduction device, a claw beam assembly exchange/lock mechanism, and a cutting safety mechanism. The high-frequency minimally invasive surgery instrument has the beneficial effects that the disposable using method for exchanging the claw beam is adopted; the purposes of reducing the surgery cost and preventing a patient from being threatened by cross infection are achieved, and the high-frequency minimally invasive surgery instrument is positively significant for the development of the minimally invasive medical career in China.