The invention discloses a machining and manufacturing method for spiral weld defects of pipelines. The machining and manufacturing method includes marking a metal plate which is required to be cut off and contains a spiral weld joint on the surface of a pipeline by a marking pen, and cutting off the metal plate containing the spiral weld joint by a cutting machine; machining a penetrating defect with a preset length and a preset width at the position corresponding to the spiral weld joint of the metal plate by means of cutting, grinding and polishing, then filling a brass strip with the size the same with that of the designed defect to the position with the defect, performing backing weld for two sides of the defect buried by the brass strip or one side of the opening defect, and performing filling welding until the shape of the metal plate is normal; and finally welding the metal plate containing the machined spiral weld defect onto the pipeline, and grinding excess weld metal of the weld joint welded back to the pipeline so as to complete machining and manufacturing for the weld defect. By the machining and manufacturing method, machining and manufacturing of the spiral weld defects with different sizes and at different positions can be performed, the machining and manufacturing method can be used for traction experiments, calibration of detectors and verification for performance indexes can be completed, and the accuracy of pipeline integrity assessment results is improved.