A flux-cored nickel-based alloy wire contains, based on the total mass of the wire, 3 to 11 percent by mass of TiO2, 0.2 to 1.3 percent by mass of SiO2, 1 to 3 percent by mass of ZrO2, and 0.3 to 1.0 percent by mass of manganese oxides in terms of MnO2, contains of a total of 0.2 to 1.0 percent by mass in terms of Na, K and Li of sodium compounds, potassium compounds, and lithium compounds. The flux has a ratio (([TiO2]+[ZrO2])/[SiO2]) of the total of the TiO2 and ZrO2 contents to the SiO2 content of 5.0 to 14.5, in which [TiO2], [SiO2] and [ZrO2] represent TiO2, SiO2 and ZrO2 contents. The wire shows excellent weldability in welding of all positions typically on 9% nickel steels and nickel-based alloy steels and gives a weld metal having good pitting resistance, bead appearance, and resistance to hot cracking.