The invention discloses a manufacturing process suitable for tungsten and steel connection of first wall part of a fusion reactor, belonging to the welding field of metal diffusion welding. The process comprises the following steps: 1, processing tungsten, steel and interlayer material workpieces according to requirements, and finishing a to-be-welded surface; 2, after processing, decontaminating and cleaning the workpieces by ultrasonic waves, and carrying out vacuum sealing; 3, manufacturing a stainless steel sheath; 4. putting the workpieces into the sheath in sequence, and sealing the sheath by electron beam welding or argon arc welding; 5, welding the sealed workpieces and sheath in a hot isostatic pressure machine, adopting high-purify argon gas by pressurizing gas, maintaining the temperature for 1.5-6h in the welding environment at 600-1080 DEG C and under the pressure of 100-300MPa, carrying out furnace cooling, and discharging from the furnace when the temperature is lower than 150 DEG C; and 6, carrying out necessary hot processing. According to the manufacturing process, the problem of poor connection performance of tungsten and steel caused by large difference of coefficients of thermal expansion can be solved, the connection strength and reliability of tungsten and steel can be improved.