163 results about "Atrial septum" patented technology

Interatrial shunts are described herein that are designed to benefit both the left side of the heart and the right side of the heart. The interatrial shunt is anchored in the atrial septum to permit blood to flow between atrial heart chambers across the atrial septum. In accordance with some aspects, the lumen of the shunt has an effective orifice area selected to permit blood flow across the atrial septum to unload the patient's left ventricle with beneficial effects on the patient's right ventricle. The shunts are structured to be suitably anchored at the atrial septum for long-term implantation. Further, the shunts preferably have insignificant late lumen loss. The interatrial shunts are expected to treat pathologies such as heart failure and pulmonary hypertension.

Systems for delivering a device for regulating blood pressure across a patients atrial septum are provided. The delivery apparatus may include a first catheter, a hub having one or more engagers disposed thereon, the one or more engagers configured to releasably engage with a first expandable end of the shunt in a contracted delivery state within a lumen of a sheath, and an second catheter extending through a center lumen of the first catheter and the hub, wherein the first catheter, the hub, and the second catheter are independently moveable relative to the sheath. The inventive devices may reduce left atrial pressure and left ventricular end diastolic pressure, increase cardiac output, increase ejection fraction, relieve pulmonary congestion, and lower pulmonary artery pressure, among other benefits. The inventive devices also may be used to treat subjects having heart failure, pulmonary congestion, or myocardial infarction, among other pathologies.

Devices are provided with an internal dimension that can be reduced and increased in vivo. In one example, an interatrial shunt for placement at an atrial septum of a patient's heart includes a body. The body includes first and second regions coupled in fluid communication by a neck region. The body includes a shape-memory material. The body defines a passageway through the neck region for blood to flow between a first atrium and a second atrium. The first and second regions are superelastic at body temperature, and the neck region is malleable at body temperature. A flow area of the passageway through the neck region may be adjusted in vivo.

The invention relates to an atrial septum puncture system, and belongs to the technical field of medical instruments. The atrial septum puncture system comprises a conveying sheath assembly, a dilator assembly and a puncture guide wire. The dilator assembly comprises a dilator, a puncture needle and a control handle. The conveying sheath assembly, the dilator assembly and the puncture guide wire are combined into the atrial septum puncture system, puncture operation is more convenient and safer, and the puncture guide wire and a puncture needle do not need to be frequently exchanged in the puncture operation process; according to the dilator assembly, the control handle comprises the moving part and the limiting part, the moving part is fixedly connected with the near end of the puncture needle, the moving part is used for driving the puncture needle to move in the axial direction of the moving part, and a user can control the puncture needle conveniently; the limiting step is arranged on the outer wall of the moving part, and the axial distance between the near end of the limiting part and the limiting step is 0.5-10 mm, so that the distance of a puncture needle extending out of the dilator can be limited, and the safety of puncture operation can be guaranteed.

Systems and methods for delivering a device for regulating blood pressure across a patient's atrial septum are provided. The delivery apparatus may include a first catheter, a hub having one or more engagers disposed thereon, the one or more engagers configured to releasably engage with a first expandable end of the shunt in a contracted delivery state within a lumen of a sheath, and an second catheter extending through a center lumen of the first catheter and the hub, wherein the first catheter, the hub, and the second catheter are independently moveable relative to the sheath. The inventive devices may reduce left atrial pressure and left ventricular end diastolic pressure, increase cardiac output, increase ejection fraction, relieve pulmonary congestion, and lower pulmonary artery pressure, among other benefits. The inventive devices also may be used to treat subjects having heart failure, pulmonary congestion, or myocardial infarction, among other pathologies.

An inner conveying catheter is movably arranged in an inner cavity of an outer conveying catheter in a penetrating mode, the inner conveying catheter comprises a first main body catheter section and a first bending adjusting catheter section in the axial direction of the inner conveying catheter, the far end of the first main body catheter section is connected with the near end of the first bending adjusting catheter section, and the first bending adjusting catheter section has the bendable function; the inner control silk thread is connected with the first bending adjusting pipe section and used for controlling the first bending adjusting pipe section to be bent actively, and the pushing inner core rod piece is movably arranged in an inner cavity of the inner conveying guide pipe in a penetrating mode. Therefore, the artificial valve ring has good regulation and delivery performance, the multi-angle space regulation performance of the artificial valve ring effectively improves the success rate of a mitral valve replacement operation, the mitral valve replacement operation can be carried out in various ways such as femoral artery, atrial septum (femoral vein) and cardiac apex, the release paths of the artificial valve ring are diversified, and the artificial valve ring has good application prospects. The operation range is greatly widened, the operation method is simple and easy to learn, and the learning curve and the operation duration of an operator can be effectively shortened.

The invention discloses an atrial septum puncture training model and method, and belongs to the technical field of medical instruments. The puncture needle is connected with the puncture sheath, the puncture needle is connected with the wire, the binocular camera is connected with the control element and the display screen, the 3D heart model comprises a left atrium, a right atrium, a ventricle, a magnetic iron block and an electromagnetic coil, a port of the 3D heart model is composed of a ferromagnet and three red mark points, and the binocular camera and the white light light source are placed above the 3D heart model. A trumpet-shaped opening and an electromagnet catheter are placed at an ideal puncture point of the 3D heart model and used for simulating the force in the puncture process, and the binocular camera and the puncture point interface are connected with the controller and the screen. By simulating the anatomical structure and physiological environment of a real human body, a safe practice platform capable of being repeatedly operated is provided for medical staff.

Systems and methods for implanting a shunt for regulating blood pressure between a patient's left and right atria are provided. The shunt comprises an anchor having a neck region, first and second end regions, and a conduit affixed with the anchor formed of a biocompatible material that is resistant to transmural and translation tissue ingrowth and that reduces a risk of paradoxical embolism. The shunt may be advanced through the sheath until the first region protrudes from the sheath and self-expands within the left atrium. The shunt and the sheath may then be retracted until the first region contacts the left side of the atrial septum. The sheath may further be retracted until the counterforce exerted by shunt tension on the atrial septum overcomes the friction of the retained portions of the shunt such that the second region is exposed from the sheath and self-expands within the second atrium.

The invention discloses a left atrial appendage occlusion simulation method and system based on a CT image, and the method comprises the steps: reading CT image data of a patient, segmenting a left atrium and a left atrial appendage from the CT image data, and obtaining corresponding binary three-dimensional image data; reading a left auricle opening mark point set by a user, and calculating geometric parameters of the left auricle opening in combination with the binary three-dimensional image data; reading the opening of the inferior vena cava set by the user and another arbitrary point on the inferior vena cava, calculating the optimal atrial septum puncture site and the rotation angle of the left auricle occluder conveying sheath after entering the left atrium, calculating the corresponding conveying sheath movement track curve, and outputting or visualizing the calculation result. By utilizing the embodiment of the invention, more accurate left atrial appendage parameter acquisition, surgical path planning and three-dimensional simulation of the surgical process under the three-dimensional condition can be realized, and a doctor is helped to evaluate the surgical process before the surgery.

The present disclosure relates to a method and a device for treating heart failure by normalizing elevated blood pressure in the left and right atria of a heart of a mammal. The present disclosure includes methods for creating and maintaining an opening in the atrial septum. Tools for making an opening and enlarging the opening are also disclosed. Use of the techniques and tools described herein prolongs the patency of an intra-atrial pressure relief opening.

The utility model provides an atrial septum puncture needle and an atrial septum puncture system, the atrial septum puncture needle comprises a needle tube and a needle tip, and the needle tip is connected to the far end of the needle tube; the needle point has a first puncture mode and a second puncture mode, the needle point is electrically connected with energy source equipment in the first puncture mode, a target object is punctured through discharging, and the needle point mechanically punctures the target object in the second puncture mode; a height difference exists at the joint of the needle tube and the needle tip, the surface of the needle tube is covered with an insulating layer, and the thickness of the insulating layer is matched with the height difference. Therefore, pure physical atrial septum puncture can be completed when facing normal atrial septum tissue, an energy source can be used for assisting in completing stoma when facing specific diseased tissue, meanwhile, during puncture, the atrial septum puncture needle is in smooth transition, no abrupt step exists, and the puncture process can be smooth.

The application discloses a heart chamber pressure regulating device, which is a cylindrical structure and comprises, in the axial direction of the cylindrical structure, an atrial septum passage and an outflow tract arranged in sequence along the blood flow direction; the side of the atrial septum passage, which is opposite to the outflow tract, is provided with an inflow port; a one-way open valve is arranged in the outflow tract; and the cylindrical structure is provided with a first positioning part and a second positioning part which are respectively arranged on the two sides of the atrial septum. The heart chamber pressure regulating device can form a one-way open valve structure on the atrial septum, is stable in position when cooperating with the atrial septum, can be recycled when the release position is improper, and can be released again.

The application relates to a degradable occluder implantation system, which comprises an occluder body composed of an upper disc, a lower disc and a hollow waist, the upper disc, the lower disc and the waist are formed by weaving wires made of degradable materials, an upper connecting piece comprises an upper connecting part and an upper combining part, a lower connecting piece comprises a lower connecting part and a lower combining part, a conveying device comprises a core connecting piece, a sleeve connecting piece and an outer sheath, the sleeve connecting piece is coaxially movably arranged in the outer sheath, a channel is formed in the middle of the sleeve connecting piece, the core connecting piece is movably arranged in the channel, the upper end of the core connecting piece is detachably connected with the upper connecting part, and the sleeve connecting piece is detachably connected with the lower connecting part. The application pulls the upper connecting piece to move in the inner side of the waist through the core connecting piece, so that the upper connecting piece and the lower connecting piece are close to and combined together, the upper disc and the lower disc are unfolded and attached to the atrial septum, the problem of poor occlusion effect of the degradable occluder is solved, and the risk of thrombus shedding is reduced.

Disclosed are various configurations of electrodes with accompanying extensions and wires configured to be attached at or near the left atrium of a heart to allow the device to be held snug against the endocardium and out of the blood flow for low energy defibrillation of the atria in response to atrial fibrillation or other atrial arrhythmias. The portion of the lead internal to the atrium (e.g., the left atrium) is restrained against the endocardium of the left atrium by way of a restraint mechanism. In one example, the electrode is configured to attach to the atrial septum, with wires containing memory-shaped metal to keep the wires against the heart wall. In yet another example, the electrode is configured to be part of a mitral valve device.

The invention discloses a double-disc-shaped integrally-formed degradable heart atrial septum foramen ovale plugging device which comprises a first disc part, a second disc part and a plugging part, the first disc part and the second disc part are connected to the two axial ends of the plugging part, and the first disc part, the second disc part and the plugging part are integrally-formed pieces. And the first disc part and the second disc part are elastic pieces capable of automatically restoring to original shapes. The plugging device is an integrally-formed degradable part and provides a temporary bridge for self-repairing of the heart, so that self cell tissues can climb and grow, and then the plugging device is degraded and absorbed in the body. Long-term complications and potential safety hazards caused by metal remaining in a human body can be avoided, the plugging device is high in structural integrity, the degradation rate of the plugging device in the human body is uniform, no structural disintegration risk exists, all the defects of an existing plugging device of a woven structure can be overcome, and surgical operation can be simplified.

A mechanical device for voluntarily creating a remedial atrial septal defect, a sheathed vascular dilator that includes the mechanical device, and methods of voluntarily creating a remedial atrial septal defect in an atrial septum using the mechanical device. The mechanical device includes leading and trailing flanges separated by a circular gap with a circular sharp on the leading flange projecting towards the circular gap.

To provide a device and method for creating a perforation in the atrial septum while using the curvature of a distal portion of the device to automatically stop the delivery of energy to the atrial septum upon completion of a puncture.SOLUTION: A puncturing device configured to create a puncture in a tissue comprises an elongate member comprising a proximal portion defining a longitudinal axis along the length of the elongate member. The elongate member further comprises a flexible distal portion that curves away from the longitudinal axis, and a distal tip configured to deliver energy to the tissue. A sensing element placed on the flexible distal portion of the elongate member detects the curvature of the distal portion. Thereby, when the flexible distal portion of the elongate member is straightened, energy is delivered to the distal tip; and, when the flexible distal portion of the elongate member is curved, energy is not delivered to the distal tip.SELECTED DRAWING: Figure 1

A medical material makes it possible to perform less invasive treatment of atrial septal defect and is unlikely to cause problems in the late post-treatment period. A medical material includes a substantially middle portion and two tubular portions (first tubular portion, second tubular portion) having a mesh structure formed of a bioabsorbable linear material and includes a proximal connecting part connected to a first end and a distal connecting part connected to a second end and threaded to a delivery cable. The proximal connecting part and the distal connecting part are configured to reversibly or irreversibly achieve a locked state and an unlocked state, the locked state being a state in which the proximal connecting part and the distal connecting part remain united, the unlocked state being a state in which the proximal connecting part and the distal connecting part do not remain united. When the distal connecting part is inserted into the proximal connecting part, the engaging portion of the distal connecting part engages with the engaged portion of the proximal connecting part to cause the medical material to transition from the unlocked state to the locked state.

A closure device for sealing an atrial septal defect is provided. The closure device includes a distal closure portion and a proximal closure portion. The distal closure portion includes a distal membrane covering a plurality of distal fingers that extend in a distal plane. The proximal closure portion includes a proximal membrane covering a plurality of proximal fingers that extend in a proximal plane. The closure device also includes a waist section extending axially between the plurality of distal fingers and the plurality of proximal fingers. The distal closure portion is configured to sealingly engage one of the left or right side of a septal wall, the proximal closure portion is configured to sealingly engage the other of the left or right side of the septal wall, and the waist section is configured to be positioned and centered in an atrial septal defect between the left and the right septal wall.

This invention relates to the field of congenital heart disease treatment technology, and discloses the application of sapropterin in the prevention and treatment of bisphenol fluorene-induced congenital heart disease in fetuses. The congenital heart disease includes cardiac structural defects, heart failure, or cardiomyocyte lesions, specifically selected from ventricular septal defects, atrial septal defects, tetralogy of Fallot, myocardial hypertrophy, decreased cardiac ejection fraction, decreased short-axis contraction rate, cardiomyocyte ferroptosis, myocardial tissue inflammatory infiltration, or myocardial collagen fibrosis. Sapropterin is used as a direct supplement to biological tetrahydropterin (BH4). Through exogenous intervention, it precisely reverses the endogenous BH4 deficiency caused by bisphenol fluorene exposure, restores the expression of GTP cyclase 1 (GCH1) and the dynamic balance of RNA m6A, and upregulates the level of YTH domain family protein 2 (YTHDF2), thereby blocking ferroptosis signal transduction, reducing oxidative stress and inflammatory response, and inhibiting the process of myocardial tissue fibrosis at the molecular level.

The invention relates to the technical field of medical images, in particular to an X-ray image visual prompt system for atrial septum puncture surgery, which comprises a data acquisition and preprocessing module for acquiring preoperative X-ray video to obtain an anatomical structure segmentation mask; the data analysis and generation module is used for constructing a puncture point decision model, outputting a puncture area probability graph and generating candidate puncture points based on the puncture area probability graph; the data processing module is used for tracking the anatomical structure segmentation mask, determining a space average value, optimizing a space-time model through a trajectory-semantic decoupling mechanism, obtaining a trajectory consistency loss function and outputting a prediction result; the data prediction module is used for constructing a safety puncture area probability graph and generating a dynamic visual prompt graph; the data enhancement and decision-making module is used for superposing and displaying the dynamic visual prompt graph and the safety puncture area probability graph, and real-time feedback is carried out by a computing terminal, so that collaborative operation of people and the system is realized; and through AI auxiliary analysis and suggestion, the reliability of the puncture operation is improved.

The invention relates to an atrial septal stoma system, and belongs to the technical field of medical instruments. According to the application, the cutter movably penetrating through the sheathing canal body is arranged, the pushing rod of the capturing device movably penetrates through the cutter, and the traction part of the storage device movably penetrates through the pushing rod, so that the atrial septum tissue can be captured through the capturing device, and the capturing device and the captured atrial septum tissue can be tightened in the storage cavity of the capturing device through the storage device; in addition, the captured atrial septum tissue can be cut through the cutter to form a stoma, and the cut atrial septum tissue is bound through cooperation of the capturing claw and the storage part, so that the cut tissue can be conveniently withdrawn out of the body along with the system, and the cut tissue is prevented from falling off and being left in the atrium.

A hole closing material achieves less invasive treatment for atrial septal defect with no or little possibility of problems in the late post-treatment period. The hole closing material includes two tubular bodies (first tubular portion and second tubular portion) having a mesh structure formed of a bioabsorbable linear material, and includes: a proximal connecting part connected to a first end; and a distal connecting part connected to a second end and screwed to a delivery cable. The proximal connecting part and the distal connecting part are capable of selectively achieving: “locked” in which the proximal connecting part and the distal connecting part remain united; and “unlocked” in which the proximal connecting part and the distal connecting part do not remain united. The delivery cable passes through the substantially middle portion, is inserted into a hollow tube of the proximal connecting part, and passes out of the hole closing material in a direction from the second end to the first end.

The present disclosure relates to a method and a device for treating heart failure by normalizing elevated blood pressure in the left and right atria of a heart of a mammal. The present disclosure includes methods for creating and maintaining an opening in the atrial septum. Tools for making an opening and enlarging the opening are also disclosed. Use of the techniques and tools described herein prolongs the patency of an intra-atrial pressure relief opening.

The invention discloses an atrial septum puncture needle tracking method and system based on Transform and a program product, and aims to track the position of a puncture needle in real time through transesophageal echocardiography and improve the tracking precision, robustness and real-time performance of the puncture needle in an operation so as to ensure the safety and efficiency of the atrial septum paracentesis. The atrial septum puncture needle tracking method comprises the steps of data preprocessing, feature extraction, Transform coding, position prediction, trajectory generation and the like. According to the method, by learning a large amount of training data, the tracking robustness is improved, and the method can better adapt to anatomical structure differences and image noise of different patients; a self-attention mechanism is introduced to learn the context relation of the puncture needle in time and space, and the tracking precision is further improved; the real-time performance is improved through parallel computing, and the position of the puncture needle can be tracked in real time in a real-time TEE image sequence.

The present application relates to a kind of tissue defect plugging device and tissue defect plugging device.Tissue defect plugging device includes plugging device body, plugging device body is memory material.When plugging device body is in natural relaxed state, all clamping ring is in the same plane, or, adjacent two clamping ring is provided with gap in the direction of straight line perpendicular to its plane, can produce original shape restoring torque, so that the first atrial septum and the second atrial septum produce mutual close tendency, and then make the first atrial septum and the second atrial septum mutually close and close, finally reach the purpose of closing foramen ovale, plugging effect is better, while operation is relatively simple.In addition, because the caliber of clamping ring is different, so as to cancel the flow blocking film, simple structure, also obtain the effect of plugging foramen ovale;In addition, using the above structure design form, the metal material implanted in body is less, can avoid the complication of thrombosis, i.e. not easy to cause adverse reaction.

The application discloses an ostomy device and an ostomy system, and relates to the technical field of medical devices, in particular to an ostomy device and an ostomy system. The ostomy device comprises a puncture assembly, a cutting assembly and a sheath tube assembly. The puncture assembly comprises a mandrel and a puncture part, and the puncture part is arranged at the distal end of the mandrel. The cutting assembly is arranged around the mandrel and at the proximal end of the puncture part. The sheath tube assembly is arranged around the puncture assembly and the cutting assembly, and the distal end of the sheath tube assembly is provided with a receiving tube section. The opening caliber of the distal end of the receiving tube section is adjustable. The distal end of the sheath tube assembly of the ostomy device is provided with the receiving tube section, the opening caliber of the distal end of the receiving tube section is adjustable, and the distal end can form an outwardly expanding horn-shaped opening. When the cutting assembly cuts the atrial septum tissue from the distal end to the proximal end, the receiving tube section can receive the cut tissue, so that the cut tissue cannot escape into the blood circulation and cause thrombosis.

This application relates to a coronary sinus and left atrium shunt system, belonging to the field of medical device technology. The system described in this application, by setting up a puncture component and a shunt component including a cutter, allows for the cutting of a portion of myocardial tissue between the coronary sinus and the left atrium, forming a shunt orifice. This establishes a shunt channel between the coronary sinus and the left atrium, effectively avoiding the embolism risk associated with atrial septal shunts and improving coronary artery blood perfusion, potentially benefiting myocardial recovery.

The invention provides a mitral valve clip operation simulator which comprises a bottom plate, and a first side of the bottom plate is provided with a first storage groove and a second storage groove; the first module is provided with an atrial septum simulation part and a mitral valve simulation part, and the first module is arranged on the bottom plate in the mode that the first module can be switched between an unfolded state and a folded state; the second module is provided with a lower cavity tube used for simulating the inferior vena cava, and the second module is arranged on the bottom plate in a mode of being capable of being switched between an unfolded state and a folded state; when the first module is in an unfolded state, the atrial septum simulation part and the mitral valve simulation part protrude out of the bottom plate, and the positions of the atrial septum simulation part and the mitral valve simulation part form an analogue simulation position; when the second module is in an unfolded state, the lower cavity tube protrudes out of the bottom plate to form a surgical instrument access path; when the first module is in the folded state, the first module is integrally contained in the first containing groove, and when the second module is in the folded state, the second module is integrally contained in the second containing groove.