The present invention discloses a pulse stimulation device capable of effectively avoiding atrial vulnerable period pacing, comprising an atrial sensing module, a pacing control module, an
atrial pacing module, a
clock / timing module and a storage module; the atrial sensing module senses and sends an atrial self-activity
signal to the pacing control module; when the pacing control module identifies the atrial self-activity
signal as an atrial sensing event in the
refractory period, the
clock / timing module is controlled to perform timing of the sequentially adjacent T1 period and T2 period according to the sequentially adjacent T1 period and T2 period stored in the storage module; when the pacing control module determines that the expected
atrial pacing event occurs in the T2 period, the
atrial pacing module is inhibited from issuing the atrial pacing event, so as to solve the problem of the risk of
atrial fibrillation caused by atrial vulnerable period pacing.