A method of operating a cardiac
rhythm management (CRM)
system includes: measuring a baseline
PR interval of cardiac
depolarization; measuring one or both of the heart sound and the heart depolarized QRS width; delivering pacing stimulation according to atrial sensing of a
ventricular pacing interval (AsVp interval), and measuring one or both of a heart sound and a QRS width of the AsVp interval, where the pacing stimulation is delivered using a conducted
system pacing (CSP) vector comprising electrodes positioned in the
interventricular septum; delivering a pacing stimulus according to an
atrial pacing to
ventricular pacing interval (ApVp interval) and measuring one or both of a heart sound and a QRS width of the ApVp interval; and generating a recommended atrial-to-ventricular
delay setting for the CSP based on one or both of the measured heart sound and the QRS width.