This invention discloses a compound
bilayer sustained-release formulation for treating arrhythmia, belonging to the field of
pharmaceutical technology. The formulation uses two purified active monomers from natural plants as its core
active components, employing a rapid-release and sustained-release
bilayer structure design with strictly controlled dosages for each layer of active monomers. The two active monomers of this invention have clearly defined primary and secondary pharmacological functions, possessing both core targeted therapeutic
efficacy and complementary secondary pharmacological effects. One component primarily regulates myocardial
electrophysiology and intervenes in arrhythmias, while also exhibiting auxiliary activities such as coronary
artery dilation and myocardial protection. The other component primarily functions for myocardial protection,
microcirculation optimization, and myocardial
damage repair, while also assisting in stabilizing heart
rhythm. Furthermore, the first active
monomer possesses
dose-dependent cardiovascular pharmacological characteristics. This invention features a scientifically formulated, mild, and stable and sustained
drug release, simultaneously achieving both
rhythm regulation and myocardial protection. It solves the problems of existing formulations, such as single target, low safety, and limited therapeutic systems. The preparation process is simple and controllable, showing promising prospects for industrialization.