Cinnamic aldehyde series preparation and its preparation process

A preparation process, cinnamon aldehyde technology, applied in the direction of antiviral agents, active ingredients of aldehydes, cardiovascular system diseases, etc., can solve the problems of high cost, unsatisfactory curative effect, unstable content, etc., and achieve low production cost, The effect of low price and simple process

Inactive Publication Date: 2005-07-06
中国人民解放军第四军医大学药物研究所
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Problems solved by technology

It has been proved by clinical application that although the existing traditional Chinese medicine preparations have a therapeutic effect on viral myocarditis, the cost is high, the content is unstable, and the curative effect is not satisfactory. Therefore, the development of effective drugs for the treatment of viral myocarditis has become a focus of attention

Method used

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Experimental program
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Embodiment Construction

[0012] specific implementation plan

[0013] The cinnamon aldehyde series preparations use industrially synthesized cinnamon aldehyde as the raw material drug, and the preparation processes of each dosage form are as follows:

[0014] 1. The preparation process of cinnamaldehyde sustained-release tablets:

[0015] The preparation process of the cinnamon aldehyde sustained-release tablet is divided into three parts, one is cladding; the other is preparing the tablet core; the third is coating. Among them, the formula ratio of inclusion and tableting raw materials is: cinnamaldehyde 2.5%, 2-hydroxypropyl-β-cyclodextrin 29.4%, absolute ethanol 0.5%, distilled water 62.6%, 5% Eudragit RS acetone solution 1%, Dry aluminum hydroxide 1%, magnesium stearate 1%, talcum powder 1%; the material of the traditional slow-release coating solution is Eudragit RS12.5, Eudragit RL12.5, dibutyl phthalate, isobutanol / Acetone (1 / 1), Talc, Magnesium Stearate, Colour, PEG6000, Distilled Water, Is...

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Abstract

The invention provides a preparation for treating viral myocarditis, wherein the medicinal reactivity of cinnamic aldehyde for antiviral, immunity adjustment, cardiac rhythm stabilization and blood vessel amplificatus, the cinnamic aldehyde can be prepared into cinnamic aldehyde slow release tablet, cinnamic aldehyde slow release capsule and cinnamic aldehyde injection for treating viral myocarditis. The invention has the advantages of stabilized medicinal content, high biological availability, small amount of administration, high curative effect, and low toxicity.

Description

Technical field [0001] The cinnamon aldehyde series preparations of the present invention relate to slow-release tablets, slow-release capsules and injections for treating inflammation caused by various viruses and germs, ischemic cardiovascular and cerebrovascular diseases, tumors, and diabetes, and especially relate to a series of preparations for treating viral myocarditis. Background technique [0002] Cinnamon aldehyde is an active ingredient in the volatile oil of plants such as cassia twig and cinnamon. It is a colorless or light yellow oily liquid, volatile, crystallizes when it is cold, and has a strong cinnamon flavor. Miscible with alcohol, ether, chloroform and oil; slightly soluble in water. It is often used to prepare fruit flavors in soap flavors and food flavors, and is also an important pharmaceutical raw material. Now it can be artificially synthesized, chemical name: tri-phenyl-2-propenal, molecular formula: C 9 h 8 O, the content of industrial products...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/22A61K9/52A61K31/11A61P9/00A61P31/04A61P31/12
Inventor 王四旺丁媛媛谢艳华
Owner 中国人民解放军第四军医大学药物研究所
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