The invention relates to the technical field of first aids, and discloses an adjustable labor-saving pressing mechanism for biological cardiac resuscitation. The pressing mechanism comprises a fixingbottom plate, wherein a supporting frame is clamped to the top of the fixing bottom plate, a fixing bayonet lock is slidably connected to the outer side of the supporting frame, and a rotating shaft is rotatably connected to the back of the supporting frame. According to the adjustable labor-saving pressing mechanism for biological cardiac resuscitation, the rotating shaft drives a planet wheel torotate, the planet wheel drives a connecting rod to rotate, the connecting rod drives a supporting rod to displace, the supporting rod drives a connecting plate to displace, the connecting plate drives a pressing assembly to displace, and then an adjusting rod and other mechanisms are used in cooperation, so that mechanical pressing is more labor-saving; the effect of the pressing depth can be freely adjusted, a rotating crank is driven to rotate through a rotating flange, and drives a compression plate to rotate, and then a compression bin, an air inlet pipe, an air outlet pipe, a positioning mask and other mechanisms are used in cooperation, so that the effects of air pressurization and automatic oxygen supply are achieved.