9 results about "Molecular Transport" patented technology

A physical method for regulating molecular transport in the extracellular space of the brain includes applying an external pressure to the brain tissue of an animal, and the rhythm of applying the external pressure is associated with the automaticity of the animal. A device for regulating molecular transport in the extracellular space of the brain includes a detection mechanism, a pressure mechanism, and a control mechanism. The detection mechanism is capable of detecting the automaticity of the animal. The pressure mechanism is capable of applying an external pressure to the brain tissue of the animal. The control mechanism is capable of controlling the pressure mechanism based on the detection result of the detection mechanism such that the rhythm of applying the external pressure of the pressure mechanism is associated with the automaticity of the animal. The method and device can effectively regulate molecular transport in the extracellular space of the brain.

To provide a selection platform that exploits the physiology of the choroid plexus to identify molecular transport system (MTS) peptides capable of holding various functional cargos in the cerebrospinal fluid and distributing the cargos to cells of the CNS.SOLUTION: Provided are MTS peptides or targeting peptides comprising a specific amino acid sequence. Provided are compositions comprising a peptide, the peptide comprising a first MTS peptide conjugated to a cargo. Methods of using the MTS peptides are also provided. For example, provided is a method for transporting cargo to the CNS, the method comprising administering one or more of the disclosed compositions to a subject in need thereof, the peptide conjugated to the cargo entering the CNS.SELECTED DRAWING: None

This document discloses MTS peptides or targeting peptides. MTS peptides comprising the amino acid sequence of any one of SEQ ID NO: 1-12 are disclosed. Compositions comprising peptides, wherein the peptides comprise a first MTS peptide conjugated to a cargo, are disclosed. Methods of using MTS peptides are also disclosed. For example, a method of transporting cargo to a CNS is disclosed, the method comprising administering one or more of the disclosed compositions to a subject in need, wherein the cargo-conjugated peptide enters the CNS.

This invention relates to the field of biomedical technology, specifically disclosing a modular interactive organ-on-a-chip and its application method. The chip body includes an inlet and an outlet, a flow channel at the bottom of the chip body connecting the inlet and outlet, multiple chambers on the chip body, an endothelial barrier installed within each chamber, and an organoid culture device. The bottoms of the multiple chambers are connected to the flow channel. The inlet, outlet, and chambers form a dynamic circulation system. This invention effectively achieves physiological coupling between organs, establishing bidirectional feedback regulation between organs; it also supports the large-scale expansion of multiple culture chambers to form more complex multi-organ networks; it enables the construction of a cross-chip microphysiological communication network covering multiple human systems; and by achieving cross-scale parameter monitoring from molecular transport to organ function, it provides highly scalable and efficient measurement capabilities for pathophysiological research of complex multi-organ systems and high-throughput drug screening.

The invention discloses a hybrid polyamide membrane containing an intrinsic microporous polymer as well as a preparation method and application of the hybrid polyamide membrane, and belongs to the technical field of membrane separation. The preparation method comprises the following steps: soaking a porous support base membrane in an aqueous phase monomer solution containing an intrinsic microporous polymer, and then soaking in an organic phase monomer solution for reaction to prepare the hybrid polyamide membrane containing the intrinsic microporous polymer. A unique nano-pore channel of the self-contained microporous polymer can construct a nano-channel beneficial to molecular transport in the membrane, so that the permeability of the membrane is improved; the self-contained microporous polymer can be covalently crosslinked and anchored in the membrane, so that the non-selective defect of the interface is reduced, and the stability of the membrane structure in the operation process is improved; the introduction of the self-contained microporous polymer can improve the hydrophilicity of the membrane and strengthen the selective transmission of water. The preparation process is simple and convenient, the prepared membrane is applied to pervaporation ethanol-water separation, and the permeation flux and separation factors of the membrane can be improved.

Disclosed herein are MTS peptides or targeting peptides. Disclosed are MTS peptides comprising the amino acid sequence of any one of SEQ ID NOs: 1-12. Disclosed are compositions comprising a peptide, wherein the peptide comprises a first MTS peptide conjugated to a cargo. Also disclosed are methods of using the MTS peptides. For example, disclosed are methods of transporting cargo to the CNS comprising administering one or more of the disclosed compositions to a subject in need thereof, wherein the peptide conjugated to cargo enters the CNS.

This invention belongs to the field of membrane preparation and application technology, and relates to a method for preparing an anion-supported MOF-based microporous polymer mixed matrix membrane for efficient separation of n-butane and isobutane. This invention selects anion-supported MOF with a size similar to that of n-butane and isobutane as the porous filler, and prepares a mixed matrix membrane with a microporous polymer. Utilizing the unique pore size of the anion-supported MOF combined with the high free volume of the microporous polymer, it is beneficial to control the microporous structure and molecular transport behavior within the membrane, accurately sieving n-butane and isobutane gas molecules, improving the permeation performance of n-butane, thereby enhancing the permeation difference between n-butane and isobutane, and improving the separation capability of n-butane and isobutane. The preparation method is simple and effectively overcomes the shortcomings of low permeation performance and insufficient selectivity improvement in the separation of n-butane and isobutane by mixed matrix membranes, achieving a synergistic improvement in the selective permeation performance of n-butane and isobutane.

A physical method for regulating molecular transport in the extracellular space of the brain of an animal, comprising applying external pressure to the brain tissue of the animal, the rhythm of the application of the external pressure being correlated with the animal's spontaneous rhythmicity. An apparatus for regulating molecular transport in the extracellular space of the brain of an animal, comprising a detecting mechanism (10), a pressurizing mechanism (30), and a control mechanism (50). The detecting mechanism (10) is capable of detecting the spontaneous rhythmicity of the animal. The pressurizing mechanism (30) is capable of applying external pressure to the brain tissue of the animal. The control mechanism (50) is capable of controlling the pressurizing mechanism (30) in accordance with the detection result of the detecting mechanism (10), so that the rhythm of the application of the external pressure by the pressurizing mechanism (30) is correlated with the spontaneous rhythmicity of the animal. The method and apparatus can effectively regulate molecular transport in the extracellular space of the brain.

Methods and devices are disclosed for rapid, multiplex molecular detection of diverse nucleic acid target molecules. The invention features an electrophoretic array with immobilized hydrogel microgel deposits. Each deposit comprises a three-dimensional, cross-linked polymer matrix containing an immobilized affinity-binding molecule and a porogen-derived pore network. This structure is configured for rapid molecular transport of nucleic acids (e.g., up to 800 bp), providing a localized environment for target capture, ligation of linear Rolling Circle Amplification (RCA) probes, and RCA. Target-specific components are anchored within distinct microgels for multiplexing. Electric fields enhance transport, reaction kinetics, and amplicon concentration. Detection is achieved in under 20 minutes. The specifically structured and fabricated microgels improve detection speed, sensitivity, and applicability to multiple different targets.