The present invention belongs to the field of biomedical
imaging technology, and specifically relates to a magnetic
nanoparticle imaging
system and method based on pre-polarization, aiming to solve the problems that existing magnetic
nanoparticle imaging devices rely on differential receiving coils and are not robust to background interference signals. The present invention includes: a group of pre-polarizing coils, a group of gradient and horizontal scanning coils, a group of excitation and vertical scanning coils, and a group of non-differential receiving coils, which are used for pre-polarizing
magnetic nanoparticles to a semi-saturated state, exciting a
magnetic field and spatially encoding along the
horizontal and vertical directions, and inducing changes in
magnetization intensity; a
signal acquisition and image reconstruction module, which is used to acquire the
induced voltage signals of a group of non-differential receiving coils during the three-dimensional tomographic scanning of the imaging target, and perform magnetic
nanoparticle imaging reconstruction. The present invention realizes the detection of
magnetization pulse signals without background interference and magnetic nanoparticle imaging, and the
system has strong robustness.