The invention relates to a calcified cluster positioning method and device, computer equipment and a storage medium, and the calcified cluster positioning method is applied to a mammary gland three-dimensional tomographic image, and comprises the steps: obtaining an interested space in the mammary gland three-dimensional tomographic image; segmenting the space of interest to obtain candidate calcification points; screening out and determining a calcification point from the candidate calcification points; and clustering the determined calcification points to obtain a calcification cluster region. According to the positioning method of the calcified cluster, the interested space is selected from the mammary gland three-dimensional tomographic image; According to the method, the interested space can be segmented and screened, the calcification points are clustered after being obtained, so that positioning of the calcification clusters is achieved, only reconstructed mammary gland three-dimensional tomography image data are needed in the positioning process, scanned original data are not needed, the processed data size is reduced, and positioning of the calcification clusters is rapidand accurate.