3results about How to "High target accuracy" patented technology

The invention discloses a xanthene nitroreductase-responsive fluorescent dye compound as well as a preparation method and application thereof, and belongs to the technical field of xanthene derivatives. The fluorescent dye compound can be used for quickly and specifically recognizing overexpressed nitroreductase in tumor cells; after the fluorescent probe acts with nitroreductase, the fluorescence intensity of the fluorescent probe at 718 nm is obviously enhanced, and the fluorescent probe has excellent targeting capability on mitochondria; meanwhile, under the excitation of illumination with the specific wavelength of 660 nm, an acting product of the fluorescent dye compound and nitroreductase can efficiently generate reactive oxygen species (ROS), and then the effect of specifically killing tumor cells is achieved. The xanthene nitroreductase response type fluorescent dye compound provided by the invention can achieve the goal of integration of diagnosis and treatment of solid tumors, and has important clinical application value.

The present application relates to the field of oil and gas field development research, and provides a method for improving target radius in drilling, comprising the following steps: step 1, determining the main layer of the target block, and determining the production capacity of the main layer; step 2, determining the sweet spot distribution of the well site deployment area based on at least the production capacity of the main layer, and determining the main layer plane and the longitudinal distribution trend of the main layer of the well site deployment area; step 3, determining the well point position based on at least the main layer plane and the longitudinal distribution trend of the main layer of the well site deployment area, and determining the well pattern; step 4, determining the target area range based on at least the well pattern, designing the target point, and designing the target point with the depth of the main layer as the target area range; and step 5, determining the directional well trajectory. The present application takes the depth of the main layer as the design target point, and considers the regular well pattern, so that the directional error of the well trajectory can be effectively reduced, the target accuracy can be improved, the well trajectory can be optimized, the footage can be further reduced, the drilling cycle can be shortened, the field operation efficiency can be improved, and the investment can be saved.

This invention discloses a composition for treating ABC type diffuse large B-cell lymphoma and its application, belonging to the field of biomedical technology. The composition comprises chidamide and psyllium phosphate. This invention constructs a synergistic therapeutic system of chidamide and psyllium phosphate, precisely overcoming the treatment challenges of ABC type diffuse large B-cell lymphoma. By targeting the dual key targets of HDAC3 and PIM1, this composition achieves synergistic effects of epigenetic regulation and signaling pathway inhibition, significantly improving anti-tumor efficacy. This invention successfully overcomes the bottleneck of poor efficacy and high relapse rate of existing R-CHOP regimens in the treatment of ABC subtype lymphoma, providing a novel, highly specific treatment strategy for relapsed or refractory ABC type diffuse large B-cell lymphoma, with broad clinical application prospects.