12 results about "Biological unit" patented technology

Disclosed are methods for trapping and barcoding discrete biological units in a hydrogel. Also disclosed are methods for analyzing gene expression, genotype, haplotype or epigenome in discrete biological units, as well as kits for implementing the methods of the present disclosure.

The application provides a simulation device for nitrogen migration and transformation, which comprises an input unit, a simulation unit, a biological unit, a regulation unit and a data processing unit, the input unit is used to simulate the migration of nitrogen source input from a downstream river to a surrounding area; the simulation unit comprises a river channel simulation mechanism, a confluence triangular area simulation tank, a first side bank simulation tank of a main stream and a second side bank simulation tank of the main stream, the biological unit controls aerobic / anaerobic partition and nitrification / denitrification partition by regulating carbon source, oxygen and controlling soil structure / particle, the regulation unit is arranged in the confluence triangular area simulation tank, the first side bank simulation tank of the main stream and the second side bank simulation tank of the main stream, and is used to regulate dissolved oxygen, PH and conductivity, and the data processing unit is used to give a prediction result. The application solves the problem that a traditional water tank cannot simulate the interaction of two rivers, and improves the accuracy of simulation experiment.

The present invention discloses a biological unit imaging system for acquiring image information of a biological unit, comprising: an image acquisition mechanism and a drift compensation mechanism; wherein: the drift compensation mechanism is used to compensate for the drift amount of the biological unit so that the biological unit is kept at a constant position; the image acquisition mechanism is used to acquire an image of the biological unit after drift compensation by the drift compensation mechanism. The present invention eliminates the influence of biological drift on the subsequent image analysis process by adding a drift compensation mechanism, so that researchers can obtain more real and accurate analysis data on the biological unit.

The present invention discloses a fixing device for observing biological units, comprising a screw-on assembly and a retaining assembly; the screw-on assembly comprises: a sleeve having an external thread; a cover having an external thread matching the internal thread and a hollow portion formed in the middle; wherein: the cover clamps a glass slide between the cover and the upper end of the sleeve by screwing the internal thread with the external thread; the screw-on assembly is fixed on an observation platform by the retaining assembly. The present invention clamps the glass slide between the cover and the sleeve, thereby limiting the horizontal drift of the glass slide relative to the observation platform, so as to avoid the influence of the drift of the glass slide on the observation during the observation of biological cells under a microscope.

The multifunctional microbial unit culture apparatus according to an embodiment of the present invention includes a main module that generates a mixed gas by mixing carbon dioxide and oxygen and controls the temperature and humidity of the mixed gas, and a cultivation module that includes a cultivation unit for cultivating microorganisms using the mixed gas supplied from the main module, wherein the mixed gas can circulate between the main module and the cultivation module.

Methods and kits for trapping and barcoding discrete biological units in a hydrogel are disclosed. The kits provide barcode units possessing unique identifiers and a moiety for binding biological units. Also included is a hydrogel solution or monomers for preparing a hydrogel solution, and reagents for molecular biology assays. In certain versions, the barcode units are beads that may be pre-bound to a support. The platform facilitates forming complexes between biological units—such as cells, nuclei, or DNA fragments—and the barcode units, then embedding these complexes within a polymerized hydrogel matrix. This enables analyzing gene expression, genotype, haplotype, or the epigenome by allowing reagent diffusion while keeping the biological units and their unique barcodes spatially associated.

The present invention discloses a fixing device for stabilizing biological units, which is used for fixing glass slides. The fixing device for stabilizing biological units includes an assembly component and a retaining component; the assembly component is fixed on an observation platform by means of the retaining component; the assembly component includes: a sleeve, the upper end of which forms a matching surface, the glass slide is placed on the matching surface, and the middle of the outer surface of the sleeve forms an upward annular step; a cover body, which has a hollow structure, and the cover body is used to buckle on the upper end of the sleeve body; a magnet pair, which includes a first magnet arranged on the annular step and a second magnet arranged on the edge of the cover body and opposite to the first magnet, and the magnetic force between the first magnet and the second magnet enables the cover body to press against the glass slide. The fixing device for stabilizing biological units not only achieves the purpose of quickly fixing the glass slide, but also in the process of fixing the glass slide, the glass slide will not rotate, so that the glass slide and its biological unit can obtain a horizontal posture consistent with that when placed.

The present invention provides a bio-ink based on inkjet printing and its preparation method and application, wherein the bio-ink is obtained by mixing the components in the bio-ink composition, and the composition includes a dispersion medium and a biological unit; the dispersion medium includes a hydrogel cross-linking precursor and a hydrogel adhesion enhancer. The viscosity of the bio-ink of the present invention can be adjusted in a large range, which can ensure the printing performance of high-precision ink droplets (micrometer level) and trace amounts (nanoliter level); it is suitable for printing on the surface and inside of various materials (such as hydrogels, water, polymers, etc.); the ink composition is liquid at 0-40°C, suitable for printing at 0-40°C, and will not clog the needle when printing at 0-40°C, which can reduce printing costs; it can realize the printing of points, lines, surfaces, and bodies; it can realize the printing of various patterns.

System for the non-invasive, field-based detection of resonance signals between biological units, characterized in that physiological parameters (e.g., electromagnetic, acoustic, or biophotonic signals) are detected and evaluated for patterns of synchronization or coupling, including subtle resonance phenomena that go beyond known physical forces and can be interpreted in the context of a postulated fifth force.