8 results about "Biological unit" patented technology

Disclosed are methods for trapping and barcoding discrete biological units in a hydrogel. Also disclosed are methods for analyzing gene expression, genotype, haplotype or epigenome in discrete biological units, as well as kits for implementing the methods of the present disclosure.

The application provides a simulation device for nitrogen migration and transformation, which comprises an input unit, a simulation unit, a biological unit, a regulation unit and a data processing unit, the input unit is used to simulate the migration of nitrogen source input from a downstream river to a surrounding area; the simulation unit comprises a river channel simulation mechanism, a confluence triangular area simulation tank, a first side bank simulation tank of a main stream and a second side bank simulation tank of the main stream, the biological unit controls aerobic / anaerobic partition and nitrification / denitrification partition by regulating carbon source, oxygen and controlling soil structure / particle, the regulation unit is arranged in the confluence triangular area simulation tank, the first side bank simulation tank of the main stream and the second side bank simulation tank of the main stream, and is used to regulate dissolved oxygen, PH and conductivity, and the data processing unit is used to give a prediction result. The application solves the problem that a traditional water tank cannot simulate the interaction of two rivers, and improves the accuracy of simulation experiment.

Methods and kits for trapping and barcoding discrete biological units in a hydrogel are disclosed. The kits provide barcode units possessing unique identifiers and a moiety for binding biological units. Also included is a hydrogel solution or monomers for preparing a hydrogel solution, and reagents for molecular biology assays. In certain versions, the barcode units are beads that may be pre-bound to a support. The platform facilitates forming complexes between biological units—such as cells, nuclei, or DNA fragments—and the barcode units, then embedding these complexes within a polymerized hydrogel matrix. This enables analyzing gene expression, genotype, haplotype, or the epigenome by allowing reagent diffusion while keeping the biological units and their unique barcodes spatially associated.

The present invention provides a bio-ink based on inkjet printing and its preparation method and application, wherein the bio-ink is obtained by mixing the components in the bio-ink composition, and the composition includes a dispersion medium and a biological unit; the dispersion medium includes a hydrogel cross-linking precursor and a hydrogel adhesion enhancer. The viscosity of the bio-ink of the present invention can be adjusted in a large range, which can ensure the printing performance of high-precision ink droplets (micrometer level) and trace amounts (nanoliter level); it is suitable for printing on the surface and inside of various materials (such as hydrogels, water, polymers, etc.); the ink composition is liquid at 0-40°C, suitable for printing at 0-40°C, and will not clog the needle when printing at 0-40°C, which can reduce printing costs; it can realize the printing of points, lines, surfaces, and bodies; it can realize the printing of various patterns.

System for the non-invasive, field-based detection of resonance signals between biological units, characterized in that physiological parameters (e.g., electromagnetic, acoustic, or biophotonic signals) are detected and evaluated for patterns of synchronization or coupling, including subtle resonance phenomena that go beyond known physical forces and can be interpreted in the context of a postulated fifth force.