Topical spray for treating intractable skin ulcer

Abstract

The invention discloses a topical spray for treating intractable skin ulcer. The topical spray is prepared from puerarin, sophora flavescens, golden cypress, golden larch bark, oldenlandia diffusa, gallnut, divaricate saposhnikovia roots, borneol and recombinant human basic fibroblast growth factor powder. The topical spray is prepared by the following steps of firstly crushing the raw materials and then adding 95% ethanol for percolation to prepare a traditional Chinese medicine extract solution; adding the recombinant human basic fibroblast growth factor powder for mixing evenly; dissolving taken menthol by using 75% ethanol to serve as a corrigent; and adding tween-80 for solubilizing and then mixing evenly to obtain a finished product spray. An advanced modern medicine preparation technology is used, new components are scientifically added on the basis of reserving effective components of a traditional Chinese medicine preparation, traditional dosage and ratios of the raw materials are changed, the new components are matched with the added oldenlandia diffusa, gallnut, divaricate saposhnikovia roots and the like, so that the therapeutic effects of resisting bacteria, relieving pain, clearing heat and dry dampness of the topical spray are strengthened; and meanwhile, western medicine components are added, so that the prepared topical spray is more convenient to use, fast to take effect and more lasting in medicinal effect.

Description

technical field [0001] The invention relates to a medicine for treating skin ulcers, in particular to an external spray for treating stubborn skin ulcers. Background technique [0002] For chronic skin ulcers, traditional Chinese medicine believes that exuberant evil qi is the external cause, and lack of righteousness is the internal cause. Prolonged illness is deficient, qi and blood stagnation, nutrition and health are not smooth, and the skin is not nourished; the treatment should be to strengthen the body to drive away evil spirits, clear away heat and detoxify, nourish qi and nourish blood , Eliminate putrefaction and promote granulation as the principle. Western medicine theory believes that intractable skin ulcer is a kind of body surface disease caused by skin tissue defect, liquefaction, infection and necrosis, and is clinically characterized by long-term non-healing of skin ulcer. Because the sore surface is difficult to heal and consumes a lot, it causes great pa...

AI Technical Summary

Problems solved by technology

When administering Chuangyangling powder, according to its instructions for use, a layer of about 1 mm thick should be spread on the sore surface, but in the actual operation process, it is difficult to meet the requirements of the instructions: because the powder is fine and smooth, It is easy to disperse, and it is difficult to achieve a uniform distribution of the drug on the sore surface when spraying the medicine, resulting in thicker adhesion of the medicine powder on the local sore surface, and then absorbing too much exudate, affecting healing and causing waste of medicine, while less medicine powder adheres to the sore surface The concentration of the drug cannot be reached, especially for skin ulcers in the sagging part, the powder is more likely to fall off, and it is difficult to achieve a long-lasting effect, resulting in the inability of the drug to reach an effective concentration in the damaged part; another dosage form of Chuangyangling—ointment, when applied, the drug Contact with an infected wound can easily cause wound bacteria to contaminate the ointment, causing secondary infection and affecting the re-use of the ointment

Because the commercially available Chuangyangling not only has certain disadvantages in the dosage form, but also in clinical use, the applicant also found that the compound Chinese medicine has a milder medicinal property, and its therapeutic effect on the skin ulcers with a large area and difficult to heal for a long time not ideal