40 results about "Hedyotis diffusa" patented technology

The invention belongs to the technical field of pharmacy, and mainly relates to a traditional Chinese medicine composition ointment for treating bacterial fungal infection and dermatitis and a preparation method thereof. The traditional Chinese medicinal materials such as the sophora flavescens, the blackberry lily, the cortex dictamni, the gallnut, the fructus cnidii, the aloe, the cortex pseudolaricis, the fructus kochiae, the cortex phellodendri, the typhonium giganteum, the radix stemonae, the hedyotis diffusa, the spina gleditsiae and the rhizoma smilacis glabrae which are subjected to biological fermentation can inhibit the growth of fungi and also can relieve itching and relieve swelling; the traditional Chinese medicine has small side effects; ti / ZIF-8 is also added, so that the antibacterial effect is more obvious; the traditional Chinese medicine composition can be used for treating acute and chronic dermatitis, eczema, dermatophytosis, tinea manuum, foot sweat, fungal infection, skin itch, papule, plaque papule, erythroderma and intractable skin stubborn dermatitis caused by various bacteria and fungi, red swelling and itching caused by mosquito bite, and inhibiting candida albicans, staphylococcus aureus and the like. In general, the method has a very wide application prospect in the field.

The present application relates to the technical field of traditional Chinese medicine composition, and provides a traditional Chinese medicine composition for treating fire-evil type acne as well as a preparation method and application thereof.The traditional Chinese medicine composition comprises the following raw materials in parts by weight: 18-22 parts of purple flower ground ivy, 12-14 parts of gotu kola, 12-14 parts of mulberry bark, 5-7 parts of white flower snake tongue grass, 2-3 parts of honeysuckle, 5-7 parts of loquat leaf, and 3-5 parts of coix seed.The traditional Chinese medicine composition of the present application uses pure natural medicinal materials as raw materials, has controllable cost, is convenient to popularize, has no obvious side effects, can effectively reduce the burden and pain of patients, reduces the influence on the body and psychology of people, and has wide application prospect.

The application belongs to the technical field of traditional Chinese medicine, and particularly relates to a traditional Chinese medicine composition for improving systemic lupus erythematosus and a preparation method thereof. The traditional Chinese medicine composition comprises the following raw materials in parts by weight: 15-30 parts of dry rehmannia, 12-26 parts of calcined turtle shell, 13-25 parts of chicken tendon ginseng, 11-18 parts of red peony root, 10-20 parts of white flower snake tongue grass, 6-18 parts of small rosmarinus officinalis, 4-15 parts of artemisia annua, 5-10 parts of centella asiatica, 4-12 parts of cimicifuga foetida, 3-10 parts of coix seed, 2-9 parts of bergamot slice, and 3-7 parts of raw licorice. Test results show that the traditional Chinese medicine composition for improving systemic lupus erythematosus prepared by the application can inhibit the expression of IL-10 and IL-17 in serum, reduce anti-dsDNA antibodies in serum, significantly improve the clinical symptoms of systemic lupus erythematosus, and has a wide application prospect.

This invention discloses a medicinal mud for treating blood stasis and heat-induced arthralgia, its preparation method, and its application. The medicinal mud is composed of the following raw materials in parts by weight: 30-70 parts of *Hedyotis diffusa*, 30-70 parts of *Caesalpinia sappan*, 30-70 parts of *Gardenia jasminoides*, 30-70 parts of *Rheum palmatum* (processed with wine), 15-45 parts of *Stephania tetrandra*, 10-30 parts of *Sparganium stoloniferum*, 10-30 parts of *Curcuma zedoaria*, 10-30 parts of *Ligusticum chuanxiong*, 10-30 parts of *Smilax glabra*, 10-30 parts of *Geranium wilfordii*, 10-30 parts of *Polygonum cuspidatum*, 5-15 parts of *Cinnamomum cassia*, 5-15 parts of *Cyperus rotundus*, and 5-15 parts of *Citrus reticulata* (green tangerine peel). The above-mentioned treatment method scientifically combines a large number of heat-clearing, blood-cooling, and detoxifying herbs such as gardenia bark, rhubarb, Japanese knotweed, and smilax glabra with powerful blood-breaking and stasis-removing herbs such as sparganium rhizome, turmeric rhizome, sappanwood, and sclerotium tsao-ko. It is also supplemented with herbs that dispel dampness, unblock the meridians, promote qi circulation, and relieve pain. This method directly targets the three core elements of "blood stasis and heat arthralgia": "heat," "stasis," and "congestion." It treats internal diseases from the outside, with significant curative effects, and avoids the systemic toxic side effects of oral medications.

This invention provides an extract of *Hedyotis diffusa*, its preparation method, and its uses. When the extract is measured under reversed-phase high-performance liquid chromatography, the peak area A of 6''-malonyl *Hedyotis diffusa* I is... M Peak area A with cypermethrin I B The ratio is less than 0.1, and the peak area A of free kaempferol is... K With A B The ratio shall not exceed 0.15. The preparation method includes: adjusting the pH of the aqueous extract of *Kaempferia galanga* to 11-13.5, and performing alkaline hydrolysis at 25-65°C for 20-60 minutes. This invention utilizes the difference in stability of malonyl bonds and glycosidic bonds under alkaline conditions to achieve the selective conversion of 6''-malonylkaempferol I to kaempferol I, increasing the content of kaempferol I while maintaining the integrity of the glycosidic bonds and inhibiting or controlling the formation of free kaempferol. The resulting extract can be used to prepare anti-inflammatory and antioxidant drugs or health foods.

The invention provides a preparation method of anti-cancer health-preserving Chinese herbal medicine Qu liquor, and relates to the technical field of functional distilled liquor. According to the method, firstly, heat-clearing and detoxifying medicinal materials such as huechys sanguinea and hedyotis diffusa, blood-activating medicinal materials such as ligusticum wallichii and salvia miltiorrhiza, tonifying medicinal materials such as ginseng, polygonatum kingianum and cistanche deserticola and blood-cooling medicinal materials such as radix aconiti preparata, radix rehmanniae and cortex lycii radicis are subjected to procedures of soaking, decocting and the like in groups to be prepared into four kinds of liquid medicine respectively; and mixing the four liquid medicines with borneol, fermenting with rice flour, and baking to prepare the special Chinese herbal medicine starter. And finally, mixing the prepared Chinese herbal medicine koji with the cooked sorghum and glutinous rice, and sequentially saccharifying, fermenting and distilling to finally obtain the finished wine. According to the method, the effects of composite traditional Chinese medicines are deeply combined with a traditional wine brewing process, so that the finished wine has anti-cancer and comprehensive health-preserving functions.

The present application belongs to the field of Chinese medicine preparation, and relates to a quality detection method of a Chinese medicine compound composition for benefiting kidney and dispelling wind. The Chinese medicine compound composition for benefiting kidney and dispelling wind comprises the following components in weight fractions: 9-30 parts of raw astragalus, 6-12 parts of wine holly fruit, 3-6 parts of scorpion, 5-10 parts of fried cantharis, 9-30 parts of prince salvia, 6-12 parts of fried atractylodes, 6-30 parts of pyrrosia, 3-10 parts of safflower, 3-10 parts of chuanxiong, 15-30 parts of white flower snake tongue, 15-30 parts of poria bark, and 9-30 parts of plantago seed. The quality detection method of the Chinese medicine compound composition adopts thin layer chromatography to identify astragalus and wine holly fruit, and further improves the comprehensiveness and reliability of the quality monitoring of the Chinese medicine compound composition by determining the content of calycosin-7-glucoside, and more perfectly characterizes the effective active components and quality of the medicine, which is beneficial to the comprehensive monitoring of the active components and further guarantees the stability, consistency, controllability, safety and effectiveness of the Chinese medicine compound composition.

The invention relates to the technical field of medicines, in particular to a traditional Chinese medicine composition for treating chronic atrophic gastritis and a preparation method thereof. Comprising the following raw materials in parts by weight: 25-35 parts of honey-fried astragalus membranaceus, 10-15 parts of roasted rhizoma atractylodis macrocephalae, 8-10 parts of ginseng, 5-8 parts of elecampane, 2-4 parts of fructus amomi, 12-18 parts of codonopsis pilosula, 12-18 parts of poria cocos, 8-10 parts of vinegar-processed curcuma zedoary, 2-4 parts of pseudo-ginseng, 8-12 parts of oldenlandia diffusa, 10-15 parts of medlar, 8-10 parts of pericarpium citri reticulatae, 5-7 parts of ginger processed pinellia, 0.08-0.12 part of naringin and 5-7 parts of liquorice. The traditional Chinese medicine composition disclosed by the invention takes spleen invigorating and qi supplementing, qi regulating and blood activating, precise regulation and control and mucous membrane repairing as the core, specifically solves the pathogenesis of spleen deficiency and qi stagnation type CAG with deficiency in root and excess in excess, inhibits the progression of precancerous lesions, and improves the treatment effectiveness and safety.

The invention discloses an agilawood moxibustion cigarette and a manufacturing method thereof, and belongs to the field of cigarettes, the agilawood moxibustion cigarette comprises a paper cigarette tube, a filter tip and combustion filler, the combustion filler comprises agilawood leaves, lucid ganoderma, rhizoma polygonati, ginseng, anoectochilus formosanus, gynostemma pentaphylla, anoectochilus formosanus, phellinus igniarius, hedyotis diffusa, five-element tea, folium artemisiae argyi, folium eriobotryae and momordica grosvenori; the filter tip is a safe and environment-friendly filter tip made of degradable fibers, and the degradable fibers are more than one of cellulose acetate fibers, activated carbon fibers, bamboo fibers and straw fibers. According to a common smoking mode, smoke generated after combustion can be inhaled into the lung, nicotine is not contained, and the traditional Chinese medicine composition has the effects of clearing lung viscera, regulating intestines and stomach, discharging stubborn stool, strengthening yang, guiding qi downward, dissipating binds, ventilating the lung, clearing damp, expelling cold, discharging stasis and beautifying the face.

The invention relates to the field of medical treatment and public health, in particular to a traditional Chinese medicine formula ointment for treating osteoarthrosis pain. The first prescription is mainly composed of the following medicines: unprocessed radix aconiti, unprocessed radix aconiti kusnezoffii, asarum, artemisia rupestris, radix achyranthis bidentatae, loranthus parasiticus, cortex acanthopanacis, herba epimedii, kadsura pepper stem, cortex illicii, zaocys dhumnade, centipede, berchemia lanceolata, caesalpinia cucullata, ardisia mamillata, philippine flemingia root, whorlleaf stonecrop herb, ajuga parviflora, centella asiatica, physalis alkekengi, fructus psoraleae, rhizoma drynariae, cassia twig, rubia cordifolia and caulis spatholobi; the component II is mainly prepared from the following medicines: frankincense, myrrh, flos daturae, borneol and ferula asafetida; the invention relates to a preparation method of a traditional Chinese medicine formula ointment for treating osteoarthrosis pain. The preparation method comprises the following steps: pulverizing and filtering by using a powder screen in a formula I and a formula II, and preparing raw ointment and cooked ointment. The pharmaceutical ointment disclosed by the invention has a good curative effect, and particularly has a better treatment effect on symptoms such as swelling and pain of waist joints, neck joints, leg joints and hand joints; the traditional Chinese medicine composition is reasonable in composition, simple to use, remarkable in treatment effect and curative effect, few in side effect and environment-friendly.

The invention provides a traditional Chinese medicine composition with an anti-tumor function and application thereof, and belongs to the technical field of traditional Chinese medicines. The traditional Chinese medicine composition is prepared from the following raw materials in parts by weight: 8-12 parts of radix scutellariae, 12-18 parts of radix paeoniae alba, 8-12 parts of ginger processed cortex magnoliae officinalis, 8-12 parts of fructus aurantii, 8-12 parts of pericarpium citri reticulatae, 8-12 parts of radix puerariae, 8-12 parts of radix bupleuri, 8-12 parts of liquorice, 12-18 parts of codonopsis pilosula, 25-35 parts of radix astragali, 25-35 parts of actinidia valvata, 25-35 parts of oldenlandia diffusa, 25-35 parts of radix actinidiae chinensis, 25-35 parts of herba patriniae and 25-35 parts of semen coicis. The traditional Chinese medicine composition has direct anti-tumor activity, can significantly enhance the treatment effect of chemotherapeutic drugs and / or immune checkpoint inhibitors, and provides an effective means for comprehensive treatment of tumors.

The invention provides a traditional Chinese medicine preparation for treating esophageal cancer and a preparation method thereof, and relates to the technical field of traditional Chinese medicine pharmacy, the traditional Chinese medicine preparation is composed of radix clematidis, salvia chinensis, kelp, radix actinidiae chinensis, glabrous sarcandra herb, lotus leaf base, chaff, adenophora stricta, aspongopus, persimmon calyx, airpotato yam, tangerine pith and nidus vespae; the esophageal cancer resisting effect and safety of the traditional Chinese medicine preparation are systematically verified through in-vitro and in-vivo experiments: the in-vitro experiment shows that the traditional Chinese medicine preparation can remarkably reduce the levels of TNF-alpha, IL-1beta and IL-8 in supernatant of esophageal cancer cells Eca-109, and the anti-tumor effect is achieved by adjusting the inflammation microenvironment; in-vivo experiments show that the traditional Chinese medicine preparation can inhibit the growth of esophageal cancer EC9706 cell nude mouse transplantation tumor; the immune balance of the organism can be remodeled by bidirectionally regulating the immune cell subpopulation, and the anti-tumor immunity is enhanced; meanwhile, liver and kidney injuries to nude mice are not caused under the effective dosage, and a new scheme with safety and effectiveness is provided for clinical treatment of esophageal cancer.

The invention discloses a traditional Chinese medicine composition for treating liver cancer and a preparation method thereof, the traditional Chinese medicine composition takes turtle shell as a monarch drug, astragalus membranaceus, curcuma zedoary, oyster and nightshade as ministerial drugs, radix pseudostellariae for tonifying qi and nourishing yin, lucid ganoderma for nourishing qi and blood and enhancing the effect of astragalus membranaceus for tonifying healthy qi, oldenlandia diffusa for clearing away heat and toxic materials, akebia fruit for regulating qi, activating blood and removing stasis, and the traditional Chinese medicine composition has the effects of clearing heat and removing toxicity. The capacities of the monarch drug and the ministerial drug for removing stasis toxin and dissipating abdominal mass are enhanced; raw liquorice is used as a conductant drug for regulating the drug property. The traditional Chinese medicine composition has the effects of soothing the liver, strengthening the spleen, tonifying qi and activating blood for liver cancer patients, and can also soften hard lumps, dissipate stagnation, clear away heat and toxic materials, nourish yin, promote salivation, clear deficiency heat and improve the life quality of the patients. The Chinese herbal medicine composition disclosed by the invention is simple in preparation method, easy to popularize, high in compliance in the aspect of anti-liver cancer use, high in tumor inhibition rate, exact in curative effect and safe in clinical application, and has important significance in treatment of liver cancer.

The invention discloses a traditional Chinese medicine compound composition and application thereof in treating chronic kidney disease related pruritus, and belongs to the field of pruritus disease treatment. The traditional Chinese medicine compound composition is prepared from the following raw materials in parts by mass: 45 parts of radix sophorae flavescentis, 45 parts of cortex dictamni, 30 parts of herba schizonepetae, 30 parts of rhizoma alismatis, 30 parts of salted semen plantaginis, 20 parts of oldenlandia diffusa, 20 parts of folium mori, 20 parts of angelica sinensis, 20 parts of ligusticum wallichii, 20 parts of radix polygoni multiflori preparata, 20 parts of astragalus membranaceus, 20 parts of semen coicis and 15 parts of pogostemon cablin. After decoction and rotary evaporation, the traditional Chinese medicine compound composition can be used for lotion / ointment for treating chronic kidney disease related pruritus, and the lotion / ointment is smeared on pruritus parts for treatment; the lotion / ointment is obvious in effect, low in cost, free of toxic and side effects, wide in medicine source and simple and feasible in treatment method.

The invention provides a traditional Chinese medicine composition for treating thyroid nodules, which is prepared from twelve medicinal materials including poria cocos, roasted rhizoma atractylodis macrocephalae, rhizoma pinellinae praeparata, honey-fried licorice root, radix bupleuri, radix paeoniae alba, moutan bark, radix scrophulariae, raw oyster shell, vinegar turtle shell, platycodon grandiflorum and semen armeniacae amarae, and a specific process that the raw oyster shell and the vinegar turtle shell are crushed to 3-5mm and then decocted is adopted. According to the treatment principle of tonifying spleen and reducing phlegm, soothing liver and regulating qi, lifting and guiding and softening hardness to dissipate stagnation, platycodon grandiflorum is used for opening and diffusing lung qi carrying medicine to ascend, semen armeniacae amarae is used for depressing qi and reducing phlegm and guiding qi to descend, qi movement thrust of ascending and descending is formed, and the hardness softening medicine can efficiently reach the neck focus; meanwhile, spleen strengthening and healthy energy protection are achieved, and bitter cold is prevented from hurting middle- Through clinical observation of 120 thyroid nodule patients, the total effective rate is 96.7%, the obvious effective rate is 90.0%, pharyngeal foreign body sensation disappears in 7-14 days on average, the nodule volume average reduction rate is 75.8%, the recurrence rate is only 3.3% after 6 months, and the occurrence rate of anorexia and loose stool of the patients is 0%. A contrast experiment further proves that the nodule reduction rate is only 45.5% after the platycodon grandiflorum and the bitter apricot kernels are removed. The traditional Chinese medicine composition can quickly soften and reduce nodules, thoroughly dissolve phlegm stasis, protect healthy qi and reduce relapse, and overcomes the defects of spleen deficiency, excessive phlegm, anorexia, loose stool and drug withdrawal and relapse which are easily caused by traditional bitter and cold prescriptions of selfheal, seaweed and the like.

This invention relates to the field of veterinary medicine technology and provides a traditional Chinese medicine composition for treating coccidiosis in chickens, along with its preparation method. The composition is prepared from a combination of raw materials including *Gnaphalium affine*, *Hedyotis diffusa*, *Dendrobium nobile*, *Hemiberlesia argyi*, and *Thalictrum sylvestris*. This pure traditional Chinese medicine preparation exhibits no drug resistance, no drug residues, no toxic side effects, and no palatability issues. It also possesses advantages such as significant efficacy, rational formulation, simple preparation, low cost, and environmental friendliness. The traditional Chinese medicine composition of this invention has the effects of stopping diarrhea and killing parasites, clearing heat and drying dampness, and tonifying the middle and replenishing qi. It has a significant effect against coccidiosis in chickens, effectively preventing abnormal feces, intestinal bleeding, and intestinal ulcers caused by coccidiosis, and rapidly restoring the production performance of chicken flocks, thus improving breeding profits.

The invention discloses a traditional Chinese medicine composition for treating toxic diffuse goiter and a preparation method of the traditional Chinese medicine composition, and relates to the technical field of traditional Chinese medicines. Comprising the following raw materials: 10-25 parts of oldenlandia diffusa, 10-25 parts of verbena, 8-20 parts of rhizoma pinellinae praeparata, 8-15 parts of amomum tsao-ko, 3-10 parts of rhizoma acori graminei, 8-20 parts of paris polyphylla, 8-15 parts of peach kernel, 8-15 parts of pogostemon cablin, 8-15 parts of eupatorium fortunei and 3-8 parts of liquorice. Through a specific ratio and a preparation process of monarch drugs, ministerial drugs, adjuvant drugs and conductant drugs, drug compatibility and dosage ratio are optimized, and the traditional Chinese medicine composition integrates functions of reducing phlegm and resolving masses, clearing away heat and toxic materials, promoting blood circulation and removing blood stasis, promoting diuresis and dissolving turbidity, and tonifying spleen and strengthening body resistance, and aims to dissipate goiter nodules caused by Graves diseases, eliminate pathological products, improve internal environment, relieve symptoms and recover viscera functions. The traditional Chinese medicine composition can effectively regulate the immune function and improve clinical symptoms, and has the advantages of improving the treatment effect and reducing adverse reactions.

The invention discloses a traditional Chinese medicine composition for treating atrophic gastritis and a preparation method of the traditional Chinese medicine composition for treating atrophic gastritis. The traditional Chinese medicine composition is prepared from the following raw materials in parts by weight: 3-10 parts of angelica sinensis, 3-10 parts of ligusticum wallichii, 10-30 parts of radix paeoniae alba, 5-20 parts of dandelion, 10-30 parts of herba ecliptae, 5-20 parts of sculellaria barbata, 5-20 parts of semen litchi, 5-20 parts of fructus aurantii, 10-30 parts of lily, 5-20 parts of mangnolia officinalis, 5-20 parts of radices trichosanthis, 10-30 parts of oriental wormwood, 3-10 parts of endothelium corneum gigeriae galli, 10-30 parts of oldenlandia diffusa, 10-30 parts of honeysuckle and 2-10 parts of liquorice. The traditional Chinese medicine composition can well treat atrophic gastritis, and is remarkable in effect, safe and reliable.

The invention relates to the technical field of traditional Chinese medicines, and particularly discloses a traditional Chinese medicine composition for treating pulmonary nodules and a preparation method of the traditional Chinese medicine composition. The active component is prepared from the following raw materials in parts by mass: 30 to 36 parts of rhizoma fagopyri dibotryis, 16 to 20 parts of herba hedyotidis diffusae, 12 to 14 parts of rhizoma arisaematis, 8 to 10 parts of bulbus fritillariae thunbergii, 6 to 9 parts of rhizoma corydalis, 6 to 7 parts of rhizoma polygonati, 1 to 2 parts of rhizoma dioscoreae, 4 to 5 parts of poria cocos, 3 to 4 parts of radix angelicae and 1 to 2 parts of liquorice root; in the preparation process, a synergistic accelerant is added, and the synergistic accelerant is prepared by mixing honeysuckle, burdock, hawthorn and seaweed according to a certain proportion and then performing enzymolysis; the combination of the four medicines can guide and improve the overall efficacy by optimizing the immune microenvironment, multi-target immune regulation and other ways, and ensures the pertinence and effectiveness of the traditional Chinese medicine composition for treating pulmonary nodules.

The application discloses a traditional Chinese medicine composition for treating chronic atrophic gastritis with low-grade intra-epithelial neoplasia and a preparation method and application thereof. The traditional Chinese medicine composition is prepared from raw materials including radix astragali 10-15 parts, rhizoma atractylodis macrocephalae 8-10 parts, poria cocos 10-15 parts, pericarpium citri reticulatae 8-10 parts, rhizoma pinelliae 5-8 parts, cyperus rotundus 12-15 parts, panax notoginseng 3-5 parts, radix curcumae 10-12 parts, root of actinidia 15-20 parts, herba hedyotis diffusae 15-20 parts and herba scorpiuridis 10-15 parts. The traditional Chinese medicine composition has good effects of improving gastric mucosa atrophy and low-grade intra-epithelial neoplasia, and has important application prospects for development of drugs for simple chronic atrophic gastritis and chronic atrophic gastritis combined with low-grade intra-epithelial neoplasia.

This invention relates to the field of biomedicine. It provides a compound astragalus and ganoderma preparation with anti-cancer properties, its preparation method, and its application. The preparation is made from the following raw materials in parts by weight: 200-500 parts ganoderma, 200-500 parts astragalus, 50-100 parts ganoderma spore powder, 30-60 parts Panax notoginseng, 30-60 parts Salvia miltiorrhiza, 50-100 parts Atractylodes macrocephala, 150-300 parts Smilax glabra, 100-200 parts Hedyotis diffusa, 20-40 parts Bombyx mori, and 20-40 parts Glycyrrhiza uralensis. The compound astragalus and ganoderma preparation of this invention has anti-tumor effects and improves the effects of radiotherapy and chemotherapy on leukopenia and thrombocytopenia, as well as adverse reactions caused by anti-tumor treatment.

This invention discloses a traditional Chinese medicine compound for liver protection in aquatic animals, its preparation method, and its application, belonging to the field of liver protection and prevention in aquatic animals. The compound comprises the following ingredients: rhubarb, dried tangerine peel, perilla, artemisia capillaris, *Hedyotis diffusa*, forsythia, poria cocos, codonopsis, and licorice. The method of using this compound is to mix it with feed during the rapid growth period of aquatic animals, administering it for 3-5 consecutive days, followed by a 2-3 day break, constituting one course of treatment. It is used to treat symptoms such as liver enlargement, atrophy, and abnormal color caused by spoiled feed and certain bacterial infections. The medicine is safe to use, leaves no harmful residues, and meets national standards for pollution-free food safety.

The invention discloses a telomere Plus compound which is prepared by the following steps: step 1, preparing an extraction composition used by the telomere Plus compound from the following raw materials in parts by weight: 6-10 parts of green soy beans, 6-10 parts of broccoli, 6-10 parts of cabbages, 4-8 parts of cucumbers, 8-12 parts of avocados, 5-9 parts of avocados, 8-12 parts of mushrooms, 3-7 parts of tomatoes, 3-7 parts of hedyotis diffusa and 5-9 parts of peanuts; and 9-13 parts of grapes. The preparation method has the beneficial effects that the telomere concentrated essence from a natural fermentation extraction source is adopted, an international patent membrane carrier formula is applied to quickly and powerfully absorb to form a complex, and a targeted biological liposome carrier technology is applied to prepare the telomere Plus compound, so that the defects of the traditional plant extraction telomere enzyme are well overcome, and the preparation method is simple and convenient. The detention time of the telomere Plus compound in the body of a patient can be prolonged, so that the treatment effect is improved, the toxic and side effects are reduced, and meanwhile, the pain of a patient with advanced cancer in the treatment process is remarkably reduced.

This invention provides a traditional Chinese medicine preparation for treating Hashimoto's thyroiditis and its preparation method, belonging to the field of traditional Chinese medicine pharmaceutical technology. The preparation is made from Curcuma zedoaria, oyster shell, Eclipta prostrata, Ligustrum lucidum, Sargassum, processed Aconitum carmichaelii, Cremastra appendiculata, Duchesnea indica, Hedyotis diffusa, Artemisia capillaris, Oroxylum indicum, and cinnamon. The formula is meticulously formulated, closely addressing the core pathogenesis of Hashimoto's thyroiditis: "phlegm and blood stasis, spleen and kidney deficiency, and nutritional imbalance." It focuses on "eliminating masses and dispersing nodules, promoting qi and blood circulation," fully embodying the TCM diagnostic and treatment approach of "differentiating syndromes and treating accordingly, addressing both the root cause and symptoms." This invention's preparation has a good therapeutic effect on Hashimoto's thyroiditis, effectively improving thyroid autoimmune disorders, regulating thyroid function, and alleviating symptoms of local thyroid inflammation in experimentally induced Hashimoto's thyroiditis rats. Further clinical observation studies have found that this preparation significantly improves the overall effective rate of clinical treatment for Hashimoto's thyroiditis patients, providing a new approach to the treatment of this condition.

The invention belongs to the technical field of plant extract preparations, and discloses a plant disinfectant and a preparation method thereof. The preparation method comprises the following preparation steps: (1) mixing and crushing dried liquorice, fructus forsythiae, radix isatidis, honeysuckle, dandelion, golden cypress, cyrtomium fortunei, andrographis paniculata and oldenlandia diffusa, and then adding into hot water for standing and soaking treatment; and (2) filtering the mixture soaked in the step (1), filling a percolation column with a wet solid material, and performing low-temperature percolation extraction at the temperature of 0-30 DEG C by adopting an ethanol water solution as an extraction solvent to obtain the plant disinfectant. The preparation method of the plant disinfectant is simple, the process conditions are easy to control, and the production cost is low. Through verification, good killing effects on candida albicans, staphylococcus aureus, escherichia coli, pseudomonas aeruginosa, tortoise mycobacterium abscess subspecies, natural bacteria, human coronavirus and influenza A virus can be achieved.

A composition for administration to a subject is disclosed. The composition comprises at least one plant-active component. The plant-active component is present in the composition in an amount that effectively inhibits xanthine oxidase (XO) in the subject. The plant-active component comprises at least one extract selected from the group consisting of: i) an extract of *Potentilla fruticosa*; ii) an extract of *Hedyotis diffusa*; and iii) a combination of i) and ii). The composition may also comprise one or more supplementary extracts. The composition may be in the form of an oral composition, for example, for ingestion. The composition may also be in the form of a topical composition, for example, for topical application. A method for inhibiting xanthine oxidase (XO) in a subject is also provided. The method comprises administering an effective amount of the composition to the subject.

This invention discloses a traditional Chinese medicine composition and its preparation for rheumatic arthralgia. The composition consists of nine herbs: *Hedyotis diffusa*, earthworm, *Eupolyphaga sinensis*, centipede, silkworm, scorpion, dung beetle, *Sinomenium acutum*, and *Zaocys dhumnades*. The composition exerts its efficacy through specific weight ratios, and is particularly suitable for treating joint pain and deformities caused by rheumatoid arthritis and osteoarthritis. The key to this invention lies in the heavy use of multiple insect-derived medicinal materials, which can penetrate deep into the meridians and collaterals, exerting a powerful effect of dispelling wind, clearing the meridians, relieving dampness and pain, and breaking up blood stasis and dissipating nodules in stubborn rheumatic arthralgia. Simultaneously, specific processing techniques are specified for the key insect-derived medicinal materials, such as wine-processing, salt-processing, roasting, and wheat bran-frying, to reduce toxicity, enhance efficacy, and ensure medication safety. The traditional Chinese medicine composition of this invention can be further prepared into various modern dosage forms such as powders, granules, and capsules, facilitating patient administration and clinical application.

The invention discloses rhodobryum roseum polysaccharide as well as a preparation method and application thereof. The molar content of glucose in monosaccharide composition of the rhodobryum roseum polysaccharide is not lower than 97%, and the rhodobryum roseum polysaccharide contains terminal and 1-6, 1-4, 1-4, 6, 1-3 and 6 connected glucose residues. The preparation method comprises the following steps: degreasing a rhodobryum roseum medicinal material with acetone, adding hot water, carrying out ethanol gradient precipitation, Sevag-method deproteinization and dialysis impurity removal on an extracting solution, and purifying through a DEAE-52 cellulose column and a Sephadex G-75 gel column in sequence to obtain the rhodobryum roseum extract. Experiments prove that the polysaccharide can remarkably improve spleen and thymus indexes and serum IgA, IgG and IgM levels of immunosuppressed mice and shows excellent humoral immune enhancement activity, and the action mechanism of the polysaccharide is related to regulation and control of signal channels such as PI3K / Akt. The invention also provides application of the polysaccharide in preparation of an immunomodulator and a pharmaceutical composition.

This invention discloses the application of a traditional Chinese medicine composition in the preparation of drugs for the prevention and treatment of gastritis. The composition comprises the following ingredients: Astragalus membranaceus, ginseng, Atractylodes macrocephala, fermented Cordyceps militaris powder, Lycium barbarum, Hedyotis diffusa, Fagopyrum dibotrys, Bistorta officinalis, Panax notoginseng, and Caesalpinia sappan. This invention is the first to discover and confirm that this traditional Chinese medicine composition can be used to prevent or treat chronic gastritis, especially chronic atrophic gastritis. Experiments have verified that it can significantly prevent or improve the pathological state of the gastric mucosa in rats with chronic atrophic gastritis. Specifically, it can significantly increase the serum pepsinogen I / II ratio, decrease gastrin-17 levels, reverse gastric gland atrophy, and repair the morphological structure of the gastric mucosa, achieving a systematic repair of the function and structure of the CAG gastric mucosa. Furthermore, the ingredients in this traditional Chinese medicine composition are rationally combined, and no obvious toxic side effects were observed under experimental conditions, demonstrating good safety and potential for long-term use.

This invention discloses a traditional Chinese medicine composition for treating lung cancer, prepared from the following raw materials in parts by weight: 15-30 parts of raw Astragalus membranaceus, 10-15 parts of Adenophora stricta, 10-15 parts of Asparagus cochinchinensis, 10-15 parts of Ophiopogon japonicus, 10-15 parts of Poria cocos, 15-30 parts of Selaginella tamariscina, 15-30 parts of Hedyotis diffusa, 15-30 parts of Paris polyphylla, 15-30 parts of Cremastra appendiculata, 15-30 parts of Prunella vulgaris, 15-30 parts of Houttuynia cordata, and 10-15 parts of Ligustrum lucidum. This traditional Chinese medicine composition can inhibit the proliferation of lung cancer cells and promote their apoptosis. Simultaneously, it exerts an anti-invasion and metastatic effect on lung cancer by intervening in exosomes, improving clinical symptoms in cancer patients, regulating functional immune function, and improving quality of life.