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Preparation method for essential oil sustained-release capsule

A technology of sustained-release capsules and essential oils, applied in the field of biomedicine, can solve problems such as changes in sensory properties and skin care functions, difficulties in producing stable and dispersed dosage forms, inconvenient storage and use, etc., to meet the requirements of production and application, low production costs, good stability effect

Inactive Publication Date: 2021-03-09
SHANGHAI NAT ENG RES CENT FORNANOTECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Due to its general volatility, many components are easily lost and oxidized during production, storage and transportation, resulting in changes in the sensory properties of its fragrance components and skin care functions. difficulty
Bring a lot of inconvenience to its storage and use

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0019] A slow-release capsule of lavender essential oil, which wraps lavender essential oil with cyclodextrin, adds a solubilizer and a cosolvent at the same time, increases the solubility of the essential oil in the cyclodextrin, and makes an inorganic powder material of the essential oil, and finally obtains the essential oil The capsules are prepared as follows:

[0020] (1) Dissolve cyclodextrin in sodium hydroxide alkaline aqueous solution with a pH value of 11 to make a cyclodextrin solution with a mass ratio of 20%, and add 50% lavender essential oil and 10% fluorocarbon Compound FC-77 and 1% co-solvent were reacted at 4°C for 24 hours under stirring conditions, and the reaction solution was placed at 4°C and stood for 24 hours. After precipitation, centrifuged, water and absolute ethanol Wash the precipitated product, and dry the product in a vacuum oven at room temperature for 12 hours to obtain a white solid powder;

[0021] (2) Take 100 grams of the powder obtained...

Embodiment 2

[0024] A kind of rose essential oil sustained-release capsule, similar to the step of embodiment 1, prepared according to the following steps:

[0025] (1) Dissolve cyclodextrin in sodium carbonate alkaline aqueous solution with a pH value of 8 to make a cyclodextrin solution with a mass ratio of 30%, adding 70% rose essential oil, 15% solubilizer PFOB and 10 % Co-solvent ethyl acetate, under stirring conditions, react at 4°C for 24 hours, after the reaction, put the reaction solution at 8°C, let it stand for 24 hours, after the precipitation, centrifuge, use water and absolute ethanol Wash the precipitated product, and dry the product in a vacuum oven at room temperature for 12 hours to obtain a white solid powder;

[0026] (2) Take 100 grams of the powder obtained in step (1), add 5-20 grams of wetting agent, mix to make a soft material, granulate, sieve, dry, sterilize, and fill into capsules to obtain the rose essential oil sustained-release capsules .

[0027] The slow-...

Embodiment 3

[0029] A pomelo essential oil sustained-release capsule, similar to the steps of Example 1, is prepared as follows:

[0030] (1) Dissolve cyclodextrin in an alkaline aqueous solution with a pH value of 11 to make a cyclodextrin solution with a mass ratio of 50%, add grapefruit essential oil with a mass ratio of 70%, and a mass ratio of 20% as a solubilizer FC -77 and a mass ratio of 10% diethyl ether as a co-solvent, reacted at 4°C for 24 hours under stirring conditions, after the reaction was completed, put the reaction solution at 4°C, let it stand for 24 hours, and centrifuged after precipitation. Wash the precipitated product with water and absolute ethanol, and dry the product in a vacuum oven at room temperature for 12 hours to obtain a white solid powder;

[0031] (2) Take 100 grams of the powder obtained in step (1), add 20 grams of wetting agent, mix to make a soft material, granulate, sieve, dry, sterilize, and then fill capsules to obtain the essential oil sustained...

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PUM

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Abstract

The invention relates to a preparation method for an essential oil sustained-release capsule. According to the preparation method, cyclodextrin is wrapped around essential oil, a solubilizer and a cosolvent are added to enhance the solubility of the essential oil in the cyclodextrin, an inorganic powder material of the essential oil is prepared, and finally the essential oil capsule is obtained. The preparation method has the advantages that a process is simple, the production cost is low, an obtained inclusion compound is good in stability, and the requirements of production and application can be further met; the preparation method is simple and high in operability and can further meet the requirements of production and application; the inclusion compound prepared through the preparationmethod is of a nano structure, is beneficial to sustained release and control of the essential oil, and has good physical and chemical stability; and according to the capsule prepared through the preparation method, the volatility of the essential oil can be reduced, the stability can be improved, in addition, the essential oil can be pulverized, so that the essential oil can be conveniently prepared into various dosage forms, and the application range of the essential oil can be expanded.

Description

technical field [0001] The invention relates to a preparation method of essential oil sustained-release capsules, in particular to the use of cyclodextrin to wrap essential oil molecules to form solid phase powder and then prepare capsules, which belongs to the field of biomedicine. Background technique [0002] Essential oil is a natural plant essence, usually extracted from plant roots, stems, leaves, flowers, peels or resins, and is a multifunctional aromatic substance with skin care functions. Due to its general volatility, many components are easily lost and oxidized during production, storage and transportation, resulting in changes in the sensory properties of its fragrance components and skin care functions. At the same time, low water solubility also makes it difficult to produce stable, dispersed dosage forms difficulty. Bring inconvenience to its storage and use. [0003] The inclusion of essential oil is an effective means to solve the above problems. Generall...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/52A61K47/69
CPCA61K9/1652A61K47/6951
Inventor 崔大祥朱君周海玲林琳邬淑红
Owner SHANGHAI NAT ENG RES CENT FORNANOTECH
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