237 results about "Skin ulcerations" patented technology

Provided is a method of treating skin ulcers and related complications in patients by administering an oxidative reduction potential (ORP) water solution that is stable for at least twenty-four hours.

The present invention generally relates to the improvement of tissue health by increasing local blood flow. In some aspects of the invention, increased local blood flow is effected by the transdermal delivery of the nitric oxide precursor L-arginine and/or its derivatives alone, or optionally in conjunction with an adjunct such as theophylline. The transdermal delivery is effected, in certain embodiments through the means of a hostile biophysical environment, such as that created by a high ionic strength environment. Various pathological states caused by, or occurring in conjunction with, insufficient blood flow, can be treated using the systems and methods of the invention as described herein. In other embodiments, increased blood flow using the systems and methods of the invention may result in enhanced healing, for example, through greater availability of the constituents of the blood. Examples of conditions which may benefit from increased blood flow include, but are not limited to, erectile dysfunction, hair loss, female sexual dissatisfaction, sagging facial or other body tissue, peripheral vascular disease including claudication, neuropathy, skin ulcers, bone healing, wound healing, viral and bacterial infection, and skin grafting.

A chair having reclining capabilities is provided for use with infirm or geriatric patients. The chair includes a fabric seat and back which is formed from woven elastomeric yarns which allow by directional strips. The woven fabric provides air circulation to the patient to help prevent skin ulcerations and other ailments produced by prolonged contact. The woven fabric also allows for quick draining and drying due to liquid contact. The seat and back in the preferred embodiment are formed from extruded aluminum members which engage the fabric in a taut condition i.e. by resilient lateral supports.

An iontophoresis device operable to deliver active agent to a biological interface such as skin or mucous membranes includes the combination of a hydrogel-based wound covering with an iontophoresis device to deliver antibiotic to biological interfaces. The effective concentration of antibiotics from oral or intravenous administration rarely reaches poorly perfused tissues such as cartilage or skin ulcerations resulting in entrenched and difficult to treat infections. Local deliver of additional antibiotic would serve to maintain the effective concentration of drug to the target tissues. Combining an iontophoresis device with a hydrogel-based wound covering to deliver localized antibiotic allows faster wound healing and prevent infection.

The invention relates to an application of nocardia rubra-cell wall skeleton in the preparation of the medicines used for treating skin injury and furuncles, including skin ulcer and ulceration.

[Problems] To provide a novel external agent for treatment of skin ulcer which has an excellent healing effect on intractable skin ulcer such as bedsore, diabetic skin ulcer and ischemic skin ulcer.

[Means for Solving Problems] The agent is characterized in that it comprises a composition containing at least one selected from the group consisting of granulocyte colony stimulating factor (G-CSF), stromal cell-derived factor-1 (SDF-1) and CD41-positive cells, and a hydrophilic high molecular substance.

The invention is directed to a method for treating ulcers, including ulcers of the lower leg, by topical plus oral administration of proanthocyanidins to a patient.

The invention relates to a stem cell preparation for repairing skin ulcer. The stem cell preparation consists of mesenchymal stem cells and exogenous cell factors. The stem cell preparation is prepared from the mesenchymal stem cells in combination with the exogenous cell factors, so that the directional differentiation of the mesenchymal stem cells towards endothelial cells is promoted; and through the paracrine of the mesenchymal stem cells as well as the exogenous cell factors, the growth of the endothelial cells is stimulated, fibroblast and capillary growth as well as collagen synthesis and granulation in a wound surface are enhanced, and the proliferation of skin keratinocytes and endothelial cells is improved, so that the purpose of rapidly and effectively repairing skin with ulcer injury is achieved.

The present invention relates to Periplaneta Americana or its ethanol extract for the treatment of inflammation. Specifically, said inflammation includes cervical erosion, ulcerative colitis, skin ulcer, mucosal ulcer and postoperative condyloma acuminatum. Treating said disorders by Periplaneta Americana or its ethanol extract has the advantages of effectively reducing bleeding, shortering healing time, significant curative effect, no adverse reactions and low cost. Periplaneta Americana or its ethanol extract provides a new selection for the clinical treatment of cervical erosion, ulcerative colitis and postoperative condyloma acuminatum.

Disclosed are a medicament for the treatment of burns and sore and ulcer diseases, and a wound plaster made of the same. The invention belongs to the technical field of traditional Chinese medicine, and specifically relates to a medicament for the treatment of burns and sore and ulcer diseases. The medicament mainly comprises, by weight, 35 to 65 parts of rosin, 20 to 40 parts of borneol, 30 to 90 parts of beeswax and 500 to 1000 parts of sesame oil. All the components in the invention are in reasonable allocation and complement each other. The utilization of the invention enables effective treatment of burns and scalds and skin ulcer, alleviating pains of patients.

The invention discloses a preparation method of medical temperature-sensitive hydrogel. The preparation method comprises the following steps: taking carboxymethyl chitosan, polyvinyl alcohol, sodium alginate and silver nitrate as raw materials; dissolving and mixing; then adding an ascorbic acid water solution and glutaraldehyde; obtaining crude gel by adopting a microwave radiation method; washing the crude gel with diluted acetic acid and water; drying the crude gel in vacuum at 40 DEG C until the weight is constant, so as to obtain the medical temperature-sensitive hydrogel. The medical temperature-sensitive hydrogel disclosed by the invention has a relatively good antibacterial effect, has a wide antibiotic spectrum and no cell toxicity and has high efficiency and low toxin; after the medical temperature-sensitive hydrogel is uniformly sprayed, one layer of a gel thin film is formed on the surface of a wound and has a lasting antibacterial effect and good air permeability and moisture retention; the medical temperature-sensitive hydrogel has the effects of promoting wound healing, stopping bleeding, stopping pain, resisting inflammation and sterilizing, can be used for large-area irregular traumas including burns, scalds, traumas and the like and can also be used for other skin inflammations including bedsores, skin ulcers, tinea manus and pedis, female vaginitis, cervicitis, cervical erosion and the like.

Pharmaceutical compositions including tetrasilver tetroxide (Ag₄O₄), such as in crystalline form, and methods of using such compositions for the prevention, treatment, and management various of dermatological skin conditions and diseases. In one embodiment, these compositions are substantially free of added persulfates. These dermatological conditions and diseases that may be prevented, treated, or managed with the compositions of the invention vary and include, but are not limited to, eczema, psoriasis, dermatitis, disease-induced skin ulcers, undefined tropical diseases, shingles, rashes, bedsores, cold sores, blisters, boils, herpes simplex, acne, pimples, skin chafing, skin cracking, itchiness, skin peeling, and warts.

The invention discloses a medicine for treating skin ulceration and relates to a Chinese medicine. The medicine is prepared by the following raw materials of certain weight portions: 5 to 10 portions of borneol, 5 to 10 portions of dragon's blood and 30 to 60 portions of pearl. 2 to 10 portions of notoginseng and 1 to 5 portions of common bletilla rubber can also be added. The preparation method is as follows: the raw materials are ground into fine powder, mixed uniformly, sterilized, dried and packaged. The medicine prepared by the method of the invention has good effect on skin ulceration caused by erosion of vulva (decubitus ulcer and eczema), burn and scald, etc.

Disclosed is a natural hirudin ointment, wherein the formula contains natural hirudin and conventional ointment matrix, and each 100g of the ointment contains natural hirudin 100-200000 international units. The ointment can be used for treating thrombotic phlebitis, burns, skin cracks, skin ulcer, chilblain, acne, acne and hemorrhoid.

The invention relates to a TCM compound external liniment liquid for antiphlogosis and sterilization and a preparation method, and belongs to the technical field of Chinese medicines. TCM active ingredients that are honeysuckle, scutellaria, safflower, Astragalus roots, rhizoma ligustici wallichii, myrobalam, rhubarb and blood of dragon are mixed and then decocted with water, so that the TCM compound external liniment liquid is made; wherein, the components has the weight as follows: the honeysuckle is 12 to 18g, the scutellaria is 9 to 15g, the safflower is 8 to 15g, the Astragalus roots is 12 to 24g, the rhizoma ligustici wallichii is 8 to 15g, the myrobalam is 12 to 18g, the rhubarb is 12 to 20g, and the blood of dragon is 3 to 6g. The invention has the preparation method for preparing the external liniment liquid that: the medicinal materials are mixed by weight rate, decocted, concentrated and filtered after being stood to cold, and then are added with anionic surfactant that is sodium dodecyl sulfate and broad-spectrum antibacterial preservative that is nipagin esters; the solution is stirred uniformly after dissolution, and then is potted and sterilized, so that the external liniment liquid is made. The TCM compound external liniment liquid is adopted to sterilize and diminish inflammation without allergic reaction, so as to lead the wound to close up rapidly; the TCM compound external liniment liquid is used for skin ulcer and bedsore, and is more particularly applied to the patients suffered from combined multiple skin ulcer of diabetes mellitus.

A novel polypeptide, and an antibacterial agent, antifungal agent and/or antiseptic containing as an effective ingredient the polypeptide are disclosed. The polypeptide of this invention has an amino acid sequence shown in SEQ ID NOs:1 to 12 and 13 to 31. This antibacterial agent, antifungal agent and/or antiseptic is useful for the prevention, amelioration or treatment of diseases such as burn, decubitus, wound, skin ulcer, leg ulcer, diabetic ulcer, occlusive arterial disease and arteriosclerosis obliterans, cellulitis, acute lymphangitis, lymphadenitis, erysipelas, skin abscess, necrotizing subcutaneous infection, staphylococcal scalded skin syndrome (SSSS), folliculitis, facial furuncle, suppurative hidradenitis, carbuncle, infectious paronychia, erythrasma and severe infection (sepsis).

The invention relates to a Chinese herbal medicine compound bait, as well as a preparation method and application of the Chinese herbal medicine compound bait. The Chinese herbal medicine compound bait comprises the following Chinese herbal medicine components by weight percent: 20-30% of radix pseudostellariae, 5-10% of cordyceps sinensis, 10-15% of lycium chinense, 10-15% of clove, 10-15% of honeysuckle, 10-15% of radix bupleuri, 5-10% of liquorice, 5-10% of radix astragali, 1-5% of poria cocos and 1-5% of borneol; and the Chinese herbal medicine compound bait comprises the following basic bait components by weight percent: 30-35% of sea mud, 10-15% of kelp meal, 4-6% of shell powder, 10-15% of sargassum thunbergii powder, 0.5-1% of spiral seaweed, 3-5% of fish meal, 3-5% of vegetable protein, 1-3% of shrimp meal, 2-3% of scallop skirt, 0.6-0.8% of yeast tablets, 2-2.2% of composite mineral salt and 1.8-2% of multivitamin. The Chinese herbal medicine components are mixed into the basic bait components according to the ratio of 2-5%, and the mixture has the particle size of 250-300 meshes. The Chinese herbal medicine compound bait provided by the invention is capable of obviously increasing the weight gain rate and survival rate of stichopus japonicus, reducing the splanchnic ratio, and improving the immunity of the stichopus japonicus; and the Chinese herbal medicine compound bait is free from toxic and side effects, can be used for remarkably improving the 'skin ulceration syndrome' resistance of the stichopus japonicus and has the advantages of reducing the food coefficient as well as NH3-N content and chemical oxygen demand (COD) content in aquaculture water, and the like, thus having good guiding significance for increasing the yield of stichopus japonicus aquaculture and the prevention and treatment of diseases.

The present invention provides a Chinese medicine and Western medicine combined liniment for external application for curing the diseases of chronic intractable dermatitis, dermophytosis, tinea cruris, tinea manuum, tinea pedis, psoriasis, ulcer of skin, infection of skin, scabies, pruritus cutanea, tinea unguium and leuconychia, etc. with obvious therapeutic effect. Said medicine preparation is made up by using the Chinese medicinal materials of cnidium seed, stemona root, sulfur, shrubalthea bark, mylabris, camphor and salicylic acid. Besides, said invention also provides the concrete steps of its preparation process.

A system and method for facilitating the healing of a skin ulcer, such as a diabetic ulcer, on a treatment region of a body. Ultrasound waves are transmitted to the treatment region. Interferential electrical stimulation is applied to the treatment region, simultaneously with the ultrasound transmission. The treatment region may be massaged with a massaging device during the treatment session. A gel may be applied onto the treatment region to facilitate the ultrasound transmission and electrical stimulation. A measurement system may be used to obtain accurate measurements of the skin ulcer, to provide a quantitative determination of the healing progression.

The invention discloses application of histatin 1 (Hst1) polypeptide in preparation of composite materials for promoting repair of large-area skin defects. The Hst1 polypeptide is found to have the characteristics of promoting cell adhesion and vascularization and inhibiting inflammatory response. The Hst1 polypeptide can be loaded on a variety of biological materials, and can be prepared into dressing, injection, ointment, powder, hydrogel, membranes, sponges, fiber scaffold materials and the like, which can effectively promote the healing of the large-area skin defects, by being compounded with bioactive composite materials, wherein large-area skin defects include traumas, burns, skin ulcer caused by tumor resection or diabetes, and the like. The Hst1 polypeptide provided by the invention is human-derived polypeptide, and has good biocompatibility and biosafety. When being used for the preparation of the composite materials for promoting the repair of the large-area skin defects, theHst1 polypeptide has an important medical value and a good industrialization prospect.