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Preparation method and application of nanocomposite of silver, chitosan and/or derivative thereof

A technology of chitosan derivatives and nanocomposites, which is applied in the direction of drug combinations, medical preparations with no active ingredients, medical preparations containing active ingredients, etc., can solve the problems of preparation methods and applications that have not been reported, and achieve Uniform particle size effect

Inactive Publication Date: 2010-01-06
LIAOCHENG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The preparation method and application of silver-chitosan and its derivatives nanocomposite powder with chitosan and its derivatives as carrier, dispersant and protective agent have not been reported

Method used

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  • Preparation method and application of nanocomposite of silver, chitosan and/or derivative thereof
  • Preparation method and application of nanocomposite of silver, chitosan and/or derivative thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0053] A kind of silver, chitosan nanocomposite, preparation method step is as follows:

[0054] (1) 10g chitosan is ground into fine powder;

[0055] (2) 0.005g silver nitrate is ground into fine powder;

[0056] (3) Mix chitosan fine powder and silver nitrate fine powder, fully grind for 1 hour;

[0057] (4) Add 0.005 g of ascorbic acid, and continue to fully grind for 2 hours to obtain a silver-chitosan nanocomposite (sample 1) with a silver particle size of 1-100 nm.

Embodiment 2

[0059] A nanocomposite of silver and chitosan derivatives, the preparation method steps are as follows:

[0060] (1) 10g carboxymethyl chitosan is ground into fine powder;

[0061] (2) 0.005g silver nitrate is ground into fine powder;

[0062] (3) Carboxymethyl chitosan fine powder and silver nitrate fine powder were mixed, fully ground for 2 hours;

[0063] (4) Add 0.005 g of glucose and continue to grind thoroughly for 2.5 hours to obtain a silver-chitosan derivative nanocomposite (sample 2) with a silver particle size of 1-100 nm.

Embodiment 3

[0065] A nanocomposite of silver, chitosan and chitosan derivatives, the preparation method steps are as follows:

[0066] (1) 7g chitosan and 3g hydroxypropyl chitosan are ground into fine powder;

[0067] (2) 0.005g silver nitrate is ground into fine powder;

[0068] (3) Chitosan and hydroxypropyl chitosan fine powder are mixed with silver nitrate fine powder, fully ground for 2 hours;

[0069] (4) Add 0.005 g of N-acetylglucosamine and continue to grind thoroughly for 6 hours to obtain silver, chitosan and chitosan derivative nanocomposites with a silver particle size of 1-100 nm.

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Abstract

The invention discloses a nanocomposite of silver, chitosan and / or a chitosan derivative and a preparation method thereof. The preparation method comprises the steps of evenly mixing the chitosan and / or the chitosan derivative fine powder with silver nitrate fine powder and fully grinding for 1-3 hours with the weight proportion of the chitosan and / or the chitosan derivative to the silver nitrate of 100: 0.0005-0.5; adding a reducing agent with the reduction equivalence ratio of the reducing agent to the silver nitrate of 1: 1-2: 1 and fully grinding for 2-6 hours, thereby obtaining the nanocomposite of the silver, chitosan and / or the chitosan derivative with the silver particle size of 1-100nm. The nanocomposite has the effects of promoting wound healing, stopping bleeding, alleviating pain, anti-inflammation and sterilization, can be used for treating female vaginitis, cervicitis, cervical erosion, bedsores, skin ulcers, burns, scalds, trauma and other skin inflammation, tinea manus and pedis and the like, and can also be used for preparing a variety of trauma dressings, such as thin films, sponges, gynecological suppositories, patches and the like.

Description

technical field [0001] The invention relates to the technical fields of chemical industry and medicine, in particular to a preparation method of silver, chitosan and / or chitosan derivative nanocomposite powder and its application in the treatment of female vaginitis, cervicitis, cervical erosion, bedsore, skin Ulcers, burns, scalds, wounds, and other skin inflammations, tinea pedis and other pharmaceutical applications, and can also be used to prepare various trauma dressings such as films, sponges, gynecological suppositories, films, etc. Background technique [0002] Chitosan is the deacetylation product of chitin, and it is a basic amino polysaccharide existing in nature. In recent years, studies by scholars at home and abroad have shown that chitosan and its derivatives have hemostasis, pain relief, regulation of macrophage and fibroblast growth and extensive antibacterial effects, and have good biocompatibility, so , Many scholars use it as an accelerator of wound heal...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K33/38A61K47/36A61P15/00A61P17/02A61P17/00A61P31/04A61P31/10A61L15/28A61L15/44A61K31/722
Inventor 桑青秦东风付式州玄红专张辉
Owner LIAOCHENG UNIV
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