The invention discloses a
lindera aggregata compound with an antagonistic effect for
inflammatory bowel diseases and an application thereof. The
lindera aggregata compound is prepared by mixing
lindera aggregata extract with
dendrobium officinale polysaccharides, wherein the weight of the
lindera aggregata extract is 1%-99% of the weight of the
lindera aggregata compound. A preparation method forthe
lindera aggregata extract comprises the following steps: adding a lindera aggregata tablet into ethyl
alcohol in
volume concentration of 50-90%, heating, performing
reflux extraction and concentrating, thereby acquiring the lindera aggregata extract. The preparation method for the
dendrobium officinale polysaccharides comprises the following steps: adding
dendrobium officinale into ethyl
alcohol, performing
water extraction and performing
alcohol precipitation. The compound has the effects of relieving the
weight loss of
enteritis model rat, obviously relieving colon congestion
edema, intestinal wall expansion and
mucosal ulcer injury, reducing intestinal index and intestinal weight per unit length, regulating intestinal immunologic derangement, restraining
intestinal inflammation medium expression, relieving
intestinal inflammation response, relieving histopathological change of colon, maintaining intestinal tract state, and the like, and can be used for preparing a
drug for preventing and controlling
inflammatory bowel diseases.