4 results about "Skin ulcer" patented technology

The application discloses a kind of self-adhesive drug carrier temperature-sensitive hydrogel dressings, it includes temperature-sensitive matrix and imine polymer.The present application poloxamer F127 is used as temperature-sensitive matrix, and imine polymer formed by chitooligosaccharide and dopamine is used as self-adhesion component and also is the bacteriostatic oxygen molecule controlled-release system of buffer-controlled carrier, forms unique buffer-controlled release oxygen system, and a kind of composite hydrogel dressings with self-adhesion, self-healing, antibacterial, controlled release and other multiple specific functions is constructed, can be used for daily disinfection, wound healing, scar repair, the treatment of diabetic foot skin ulcer, acne and acne and the treatment of herpes skin damage;The product of the present application has good antibacterial property, water solubility, biological safety, biocompatibility, can be injected or processed into shape, can be used for rapid hemostasis, can partially replace suture, fast close wound.

The application discloses a post-cesarean section anti-slipping wound compression hemostasis device and belongs to the technical field of medical devices. The device comprises an elastic band, a third air bag installed on the inner side of the elastic band, and a compression mechanism located on the outer wall of the elastic band and used for expanding the third air bag to stop bleeding of a patient's wound. The compression mechanism comprises an auxiliary component arranged on the outer wall of the elastic band. The third air bag is flexibly connected to the surface of the wound and has no sharp edges or hard points, so that friction and tearing of the sutured wound and damaged skin can be avoided, the integrity of the wound surface is protected, skin ulcer and nerve damage (such as the "local pressure sores" risk of a traditional hemostasis band) caused by excessively high local pressure can be avoided, the third air bag can be inflated to be attached to the curved surface of the human body, the problem of poor attachment and pressure dead angle caused by rigid compression is solved, and the recovery effect of the incision of the patient after the cesarean section is improved.

[Problem] There is no gene transduction method with high efficiency and high specificity for skin, subcutaneous tissue, skin ulcer surfaces, and their constituent cells. More generally, achieving high gene transduction efficiency in vivo is challenging. Additionally, it is difficult to morphologically and functionally regenerate skin appendages and to regenerate lost peripheral tissues of the upper and lower limbs (upper arm, forearm, hand, fingers, thigh, lower leg, foot, toes).[Solution] This invention provides solutions to these challenges through a novel AAV (adeno-associated virus) capsid with high gene transduction efficiency and high specificity for skin, subcutaneous tissue, and skin ulcer surface cells, as well as a novel AAV capsid with high gene transduction efficiency and high specificity for epidermal tissue and its constituent keratinocytes. Additionally, the invention provides a novel tissue-specific promoter with high gene expression efficiency and high specificity for epidermal tissue and its constituent keratinocytes, and a pharmaceutical composition that enhances gene transduction efficiency by co-administering steroids alongside in vivo gene transduction. The invention further includes a pharmaceutical composition that promotes the regeneration, neogenesis, and functional enhancement of skin appendages through in vivo gene transduction, thereby compensating for functional impairments of skin appendages. Additionally, it provides a research and development platform for developing methods to regenerate peripheral and missing tissues of the upper and lower limbs, as well as a pharmaceutical composition for achieving tissue regeneration. Thus, the present invention provides methods for overcoming these challenges.

The application provides a gelatin / polyacrylamide drug-loaded hydrogel dressing, a construction method and application thereof, and belongs to the fields of tissue engineering, material science and biology. A novel double-network interpenetrating hydrogel GEMC is prepared based on gelatin grafting dopamine GEDA, acrylamide and nanoclay NC as raw materials, and combined with curcumin nanomedicine CCNPs. The prepared GEMC hydrogel has good oxidation resistance, excellent mechanical properties (tensile, compression and viscoelasticity), excellent tissue adhesion (human, pig skin and glass) and good biocompatibility. In addition, the GEMC can be used as a drug release platform and can visually track the drug. The skin ulcer model caused by radiotherapy of mice proves that the GEMC hydrogel dressing can promote the skin regeneration of the radiotherapy wound, promote angiogenesis and reduce the inflammatory response. The current research results have great application potential in the treatment of skin ulcer caused by local radiotherapy of breast cancer.