18 results about "Skin ulcer" patented technology

The present invention relates to the use of lemon exosomes in the preparation of a drug for preventing, alleviating, or treating skin ulcers. The invention creatively extracts and purifies exosomes from lemons and studies their physiological effects. Lemon exosomes can reduce the expression of inflammatory factors in macrophages, promote the healing of skin ulcers, lower blood sugar, and promote skin angiogenesis. Lemon exosomes have the advantages of good efficacy, simple raw material acquisition, and minimal toxic and side effects.

Disclosed herein is a method for treating skin wounds in a patient in need of such treatment, comprising applying a foamed composition comprising nitric oxide to the area of skin requiring such treatment. The wound may be selected from the group consisting of skin ulcers, including diabetic foot ulcers (DFUs), venous leg ulcers (VLUs), arterial ulcers, decubitus (pressure) ulcers or other pressure injuries, deep tissue injuries (DTIs), burns, abrasions, skin tears, or bruises.

The present invention relates to the technical field of traditional Chinese medicine, and provides a Chinese medicine composition for treating skin lesions and scars, and a preparation method and application thereof, which is mainly used to treat skin lesions and scars caused by carbuncle and ulcer. The Chinese medicine composition of the present invention comprises the following raw materials: Vaccaria segetalis, Astragalus membranaceus, Bletilla striata, Morus alba bark, Angelica dahurica, White Ampelopsis Root, Dictamni Cortex, Rhizoma Cyperi, Rhizoma Bletillae, Bletilla striata Rhizoma, Bletilla striata Rhizoma, Bletilla striata Rhizoma, Bletilla striata Rhizoma, Bark of Bombyx batryticatus, Magnolia officinalis, Pueraria root, Eucommia bark, Dipsacus asper, Smilax glabra, Honeysuckle vine, Chuanxiong, Angelica sinensis, Ephedra sinica, and Cinnamomum cassia. The Chinese medicine composition of the present invention has the effects of dispelling wind and relieving itching, relieving swelling and relieving pain, promoting pus and detoxifying, and reducing color and eliminating scars. It is mainly used to treat skin lesions and scars caused by carbuncle and ulcer, and is significantly effective for treating skin ulcers, swellings, and furuncles. It also treats pruritus caused by deep infected wounds and psoriasis lesions, and reduces the use of antibiotics.

[Problem] To do not have a gene introduction method that has high gene introduction efficiency and high specificity to skin, subcutaneous tissue, skin ulcer surfaces and constituent cells thereof. More generally, it is difficult to achieve high gene introduction efficiency in gene introduction into a living body. The skin appendages are difficult to regenerate in form and function; when the tip tissues (upper arms, forearms, hands, fingers, thighs, shanks, feet, toes) of the upper limbs and the lower limbs are lost, regeneration is difficult. The solution is that: a novel AAV (AAV is an abbreviation of an adeno-associated virus) capsid having high gene introduction efficiency and high specificity to cells of skin / subcutaneous tissues and skin ulcer surfaces, and a novel AAV capsid having high gene introduction efficiency and high specificity to epidermal tissues and cells constituting the epidermal tissues, namely keratinocytes; disclosed is a novel tissue-specific promoter having high gene expression and high specificity against epidermal tissue and keratinocytes constituting the epidermal tissue, and a pharmaceutical product having improved gene introduction efficiency by using a steroid together with gene introduction in a living body. The present invention relates to a pharmaceutical product for inducing regeneration, regeneration and function improvement of a skin appendage by introducing a gene into a living body in order to achieve sufficient skin appendage functions, a research and development platform for developing a regeneration method for peripheral tissues and defective tissues of upper and lower limbs, and a pharmaceutical product for regeneration, and more particularly, to a pharmaceutical product for regeneration for inducing regeneration, regeneration and function improvement of the skin appendage by introducing a gene into the living body in a state where the function of the skin appendage is reduced. Thus, a method for solving the above problem is provided.

The utility model relates to the technical field of medical instruments, and provides a device for supporting and fixing a trachea cannula, which comprises a headgear main body, the headgear main body comprises a plurality of fixing bands, the fixing bands are respectively wound on the head and the neck of a patient, and the fixing bands are provided with elastic lock catches; the intubation tube supporting part is in a mask shape, the two sides of the intubation tube supporting part are fixed to the head sleeve body respectively and can be detached, a head opening is formed between the intubation tube supporting part and the head sleeve body, and the intubation tube supporting part is provided with a supporting groove; the intubation tube fixing part comprises a first fixing block, the first fixing block and the intubation tube supporting part are fixed and can be detached, the first fixing block is provided with a fixing groove, and the fixing groove and the supporting groove jointly form an intubation tube fixing hole. The head sleeve main body can be adjusted through the elastic lock catch, so that the head sleeve can be suitable for different patient head types and is well fixed, skin ulcers or medical instrument related pressure injuries are avoided, a trachea cannula can be more stable, and medical negligence caused by displacement is avoided.

The invention provides a preparation method and application of a pomegranate rind extract, and the preparation method comprises the following steps: crushing pomegranate rind by a crusher, sieving, soaking in double distilled water, boiling with big fire, boiling with small fire for 20-60 minutes, and concentrating with big fire to obtain the pomegranate rind extract. Compared with the prior art, the pomegranate peel single Chinese herbal medicine aqueous extract prepared by the invention has a remarkable inhibition effect on apostichopus japonicus skin ulcer pathogenic bacteria photobacterium damsonii, is relatively low in toxicity, and can be used for preventing and controlling apostichopus japonicus skin ulcer syndrome caused by the photobacterium damsonii. Moreover, a proper amount of pomegranate peel aqueous extract is mixed with bait to feed the apostichopus japonicus, so that the capability of resisting photobacterium damsonii subspecies infection of the apostichopus japonicus can be remarkably enhanced, and the survival rate of the apostichopus japonicus is increased.

The present invention provides a skin ulcer dressing, comprising a dressing layer made from a mixture of polyethylene glycol and lithospermum, an adhesive layer, a breathable layer, a water-absorbing layer, and a protective layer. Also provided is an apparatus for preparing a skin ulcer dressing, comprising an apparatus body having a preparation cavity within the apparatus body, and a plurality of rotating motors disposed on either side of the apparatus body, each of which is offset and correspondingly positioned. The output shafts of the rotating motors are perpendicularly connected to horizontal plates, and the plurality of horizontal plates have grooves for preparing the dressing layer, the adhesive layer, the breathable layer, the water-absorbing layer, and the protective layer. The present invention utilizes the material properties of the dressing layer made from a mixture of polyethylene glycol and lithospermum, while simultaneously coordinating the adhesive layer, the breathable layer, the water-absorbing layer, and the protective layer, thereby improving wound repair properties. The present invention prepares the raw materials, pours them into the plurality of grooves, shapes them within the grooves, removes them before they are completely solidified, and then stacks and compacts them.

The application discloses a kind of self-adhesive drug carrier temperature-sensitive hydrogel dressings, it includes temperature-sensitive matrix and imine polymer.The present application poloxamer F127 is used as temperature-sensitive matrix, and imine polymer formed by chitooligosaccharide and dopamine is used as self-adhesion component and also is the bacteriostatic oxygen molecule controlled-release system of buffer-controlled carrier, forms unique buffer-controlled release oxygen system, and a kind of composite hydrogel dressings with self-adhesion, self-healing, antibacterial, controlled release and other multiple specific functions is constructed, can be used for daily disinfection, wound healing, scar repair, the treatment of diabetic foot skin ulcer, acne and acne and the treatment of herpes skin damage;The product of the present application has good antibacterial property, water solubility, biological safety, biocompatibility, can be injected or processed into shape, can be used for rapid hemostasis, can partially replace suture, fast close wound.

The application discloses a post-cesarean section anti-slipping wound compression hemostasis device and belongs to the technical field of medical devices. The device comprises an elastic band, a third air bag installed on the inner side of the elastic band, and a compression mechanism located on the outer wall of the elastic band and used for expanding the third air bag to stop bleeding of a patient's wound. The compression mechanism comprises an auxiliary component arranged on the outer wall of the elastic band. The third air bag is flexibly connected to the surface of the wound and has no sharp edges or hard points, so that friction and tearing of the sutured wound and damaged skin can be avoided, the integrity of the wound surface is protected, skin ulcer and nerve damage (such as the "local pressure sores" risk of a traditional hemostasis band) caused by excessively high local pressure can be avoided, the third air bag can be inflated to be attached to the curved surface of the human body, the problem of poor attachment and pressure dead angle caused by rigid compression is solved, and the recovery effect of the incision of the patient after the cesarean section is improved.

[Problem] There is no gene transduction method with high efficiency and high specificity for skin, subcutaneous tissue, skin ulcer surfaces, and their constituent cells. More generally, achieving high gene transduction efficiency in vivo is challenging. Additionally, it is difficult to morphologically and functionally regenerate skin appendages and to regenerate lost peripheral tissues of the upper and lower limbs (upper arm, forearm, hand, fingers, thigh, lower leg, foot, toes).[Solution] This invention provides solutions to these challenges through a novel AAV (adeno-associated virus) capsid with high gene transduction efficiency and high specificity for skin, subcutaneous tissue, and skin ulcer surface cells, as well as a novel AAV capsid with high gene transduction efficiency and high specificity for epidermal tissue and its constituent keratinocytes. Additionally, the invention provides a novel tissue-specific promoter with high gene expression efficiency and high specificity for epidermal tissue and its constituent keratinocytes, and a pharmaceutical composition that enhances gene transduction efficiency by co-administering steroids alongside in vivo gene transduction. The invention further includes a pharmaceutical composition that promotes the regeneration, neogenesis, and functional enhancement of skin appendages through in vivo gene transduction, thereby compensating for functional impairments of skin appendages. Additionally, it provides a research and development platform for developing methods to regenerate peripheral and missing tissues of the upper and lower limbs, as well as a pharmaceutical composition for achieving tissue regeneration. Thus, the present invention provides methods for overcoming these challenges.

The invention relates to the technical field of traditional Chinese medicine, in particular to pure traditional Chinese medicine external smearing oil for treating intractable skin ulcer and a preparation method. The problems that intractable skin ulcers formed in the common technology are not healed for a long time, and new muscles are not generated in a skin grafting operation for a long time and are unsuccessful are solved. The formula comprises the following main components by mass: 20 g of coptis chinensis, 20 g of golden cypress, 20 g of lithospermum, 20 g of sanguisorba officinalis, 50 g of gypsum, 30 g of oyster, 30 g of fossil fragments, 200-250 g of rapeseed oil and 10 g of edible salt. The traditional Chinese medicine composition is natural in components, has an obvious astringency effect on yellow tissue fluid continuously exuded around fester skin in clinical use, has an obvious promotion effect on growth of new skin, and is non-irritant to skin, safe and free of toxic and side effects.

The present invention relates to a composition for preventing or treating inflammatory diseases induced by an autoimmune response, the composition comprising a peptide or peptide mixture as an active ingredient. More specifically, a composition comprising peptides P1 to P5 or a mixture thereof as an active ingredient can be provided as a therapeutic agent for inflammatory diseases induced by an autoimmune response. This is because, as a result of intraperitoneal injection or external application of peptides P1 to P5 or a mixture thereof to mouse animal models of psoriasis and inflammatory bowel disease (inflammatory diseases induced by an autoimmune response), it was confirmed that skin ulcers and skin inflammation in the mouse model of psoriasis and inflammatory bowel disease were alleviated, and inflammatory symptoms in the model of bowel inflammation were alleviated.

The application provides a trachea cannula fixing device, which comprises a mouthpiece and a plurality of clamping mechanisms; the mouthpiece is connected with the trachea cannula; a plurality of clamping mechanisms are arranged on the length direction of the mouthpiece; each clamping mechanism comprises a clamping piece and a driving assembly; two clamping pieces are oppositely arranged, and the clamping pieces are slidably connected with the mouthpiece along the axis direction of the mouthpiece; the driving assembly can control the two clamping pieces to slide oppositely to clamp or move away from the teeth. The mouthpiece is used to prevent the patient from flattening the trachea cannula through the teeth; the driving assembly is used to control the two clamping pieces to slide oppositely, so that the two clamping pieces clamp the teeth, the mouthpiece is fixed, and the fixing mode of the adhesive tape is replaced, so that the patient's uncomfortable feeling caused by the adhesive tape, the inflammation or the skin ulcer caused by the stimulation of the skin and the like can be avoided; and the connection is not firm caused by the weakening or loss of the adhesive property of the adhesive tape and the like can be avoided.

A method for measuring the conformability of a dressing (D) to a wound bed comprising: - a step of preparing a physical model (16) which simulates the irregular surface of a skin lesion, for example a skin ulcer, wherein the model defines a cavity (17), - a step of filling the cavity (17) with a liquid (L) which simulates the presence of exudate, - a step of positioning the dressing (D) on the model (16) so that the dressing (D) covers the cavity (17), - a step of detecting and processing images of the model (16) to determine a numerical value representative of the conformability.

The invention provides a traditional Chinese medicine composition and traditional Chinese medicine powder for treating burns and scalds, skin ulcers and / or edema as well as a preparation method and application, and belongs to the technical field of traditional Chinese medicine compositions. The traditional Chinese medicine composition comprises the following raw materials: phaseolus calcaratus, astragalus membranaceus, sticky rice, muskmelon pedicel, asarum heterotropoides and liquorice, the phaseolus calcaratus is used as a monarch drug, the astragalus membranaceus and the sticky rice are used as ministerial drugs, the muskmelon pedicel and the asarum heterotropoides are used as adjuvant drugs, and the liquorice is used as a The traditional Chinese medicine composition disclosed by the invention has the advantages of remarkable curative effect, short wound healing time, difficulty in infection, difficulty in formation of scar tissues after healing, no toxic or side effect, safety in use and low price.

The application provides a gelatin / polyacrylamide drug-loaded hydrogel dressing, a construction method and application thereof, and belongs to the fields of tissue engineering, material science and biology. A novel double-network interpenetrating hydrogel GEMC is prepared based on gelatin grafting dopamine GEDA, acrylamide and nanoclay NC as raw materials, and combined with curcumin nanomedicine CCNPs. The prepared GEMC hydrogel has good oxidation resistance, excellent mechanical properties (tensile, compression and viscoelasticity), excellent tissue adhesion (human, pig skin and glass) and good biocompatibility. In addition, the GEMC can be used as a drug release platform and can visually track the drug. The skin ulcer model caused by radiotherapy of mice proves that the GEMC hydrogel dressing can promote the skin regeneration of the radiotherapy wound, promote angiogenesis and reduce the inflammatory response. The current research results have great application potential in the treatment of skin ulcer caused by local radiotherapy of breast cancer.

The invention discloses a traditional Chinese medicine ointment for healing sore, promoting tissue regeneration and relieving pain and a preparation method thereof, and belongs to the technical field of medicines. The traditional Chinese medicine composition is prepared from the following raw materials: 30 to 60g of radix angelicae sinensis, 15 to 30g of radix angelicae dahuricae, 15 to 30g of radix arnebiae seu lithospermi, 15 to 30g of raw liquorice root, 15 to 20g of dragon's blood, 10 to 20g of herba menthae, 200 to 300g of sesame oil and 180 to 300g of The traditional Chinese medicine composition disclosed by the invention is based on compatibility combination of promoting blood circulation to remove blood stasis, cooling blood and detoxifying, removing stasis and diminishing swelling, and astringing sores and promoting tissue regeneration, and is prepared by summarizing clinical experience for many years according to a fixed dosage ratio. The traditional Chinese medicine composition is reasonable in formula, simple to prepare and convenient to use, and the obvious effective rate of the traditional Chinese medicine composition in treatment of pressure sores, herpes zoster, incontinence dermatitis, haemorrhoids and radioactive skin ulcers is up to 90% or above through clinical application verification for many years.

The invention relates to application of FeSO4 in preparation of drugs or feeds for promoting apostichopus japonicus coelomocyte phagocytosis activity, and belongs to the field of aquaculture, the application method is as follows: ferrous sulfate is added in the drugs or feeds to improve expression of hsp70 and c3 genes in apostichopus japonicus bodies, so that the pathogen removal capacity of apostichopus japonicus is improved, and the apostichopus japonicus coelomocyte phagocytosis activity of apostichopus japonicus is improved. Meanwhile, by adjusting a tlr3 gene mediated immune signal channel, the recognition capability of the stichopus japonicus on exogenous pathogens is promoted, so that the non-specific immunity of the stichopus japonicus can be remarkably enhanced. The stichopus japonicus skin ulcer syndrome is prevented by utilizing the function and the killing function of FeSO4 on vibrio splendidus in a water body.