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Absorptive bone hemostatic agent

A hemostatic agent and modified technology, applied in the field of bone hemostatic agents, can solve the problems of bone wax not being absorbed by the human body, hindering the regeneration of new bone, non-union of fractures, etc., achieving no irritating inflammatory reaction, good compatibility, and sticking good attachment effect

Active Publication Date: 2009-11-04
成都迪康中科生物医学材料有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] However, the above-mentioned bone wax has poor compatibility with human tissue, and there are different degrees of inflammatory reactions, and the bone wax is not absorbed by the human body. Once it is pressed on the bone wound surface, it will become a permanent foreign body in the human body, which will hinder the regeneration of new bone. , more serious consequences can cause fracture nonunion

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0021] Example 1 Dissolve 3 grams of carboxymethylated konjac glucomannan in 20 milliliters of distilled water, and add 5 grams of carboxymethylated chitosan powder. After stirring and mixing evenly, seal it with a plastic bag, and then store it in an oven at 40°C for 24 hours to obtain soft, water-insoluble cement.

Embodiment 2

[0022] Example 2 Dissolve 3 grams of carboxymethyl-modified konjac glucomannan in 18 milliliters of distilled water, and add 5 grams of chitosan powder. After stirring and mixing evenly, seal it with a plastic bag, and then store it in an oven at 40°C for 24 hours to obtain soft, water-insoluble cement.

Embodiment 3

[0023] Example 3 4 grams of konjac glucomannan and 3 grams of carboxymethylated chitosan powder were dissolved in 22 milliliters of distilled water. After stirring and mixing evenly, seal it with a plastic bag, and store it in an oven at 50° C. for 24 hours to obtain soft, water-insoluble cement.

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PUM

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Abstract

The invention discloses an absorbable bone hemostatic agent used in surgery or orthopedic operations, which mainly includes 20-95 parts of chitosan or modified chitosan, konjac glucomannan or carboxymethylated modified 5-80 parts of konjac glucomannan, water is 50%-500% of the total weight of the solid. It is prepared by mixing solid powder or aqueous solution with another solid powder or aqueous solution. The hemostatic agent of the invention is easy to operate, has good compatibility, has no stimulating inflammation reaction, and can induce bone growth.

Description

technical field [0001] The invention relates to a bone hemostatic agent used in surgical or orthopedic operations, which is mainly made of absorbable biological materials. Background technique [0002] Most of the bone hemostatic agents used in neurosurgery or orthopedic surgery use bone wax to achieve the purpose of hemostasis on bone wounds through the mechanical force filling effect of the bone wax's unique hardness, toughness and viscosity at a certain temperature. Bone wax is mainly composed of beeswax, vegetable oil, etc. It is dark yellow and is generally produced for self-use. When in use, take an appropriate amount of bone wax with your fingers, knead it into a certain shape, and press it on the bleeding surface of the bone to achieve hemostasis. However, this type of product can sometimes fail to achieve the hemostatic effect of the bone during use, and cannot stop the momentum of the bone oozing blood. After mixing with the blood, it becomes loose and falls off l...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L15/42A61K31/722A61P7/04
CPCA61L2400/04A61L2430/02
Inventor 熊成东周崇林张德云
Owner 成都迪康中科生物医学材料有限公司
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