86results about How to "Induced growth" patented technology

Methods and compositions for treatment, diagnosis, and prevention of a virus comprise administering to a patient antibodies which react with regions of viral proteins and result in neutralization of infectivity and inactivation of functionally essential events in the life cycle of the virus. The antibodies recognize viral epitopes which fail to elicit an immune response in man when encountered through infection or naturally through the environment. In a preferred embodiment, the invention provides compositions and methods useful in the treatment and diagnosis of human immunodeficiency virus (HIV) infections.

The invention relates to a medical alloy material, in particular to a uniformly degradable orthopedic implant magnesium alloy material. The orthopedic implant magnesium alloy material comprises the following components in percentage by weight: 0-5% of Gd, 1-5% of Nd, more than 0-2% of Sr, 0-0.5% of Zn, more than 0-1% of Zr and the balance of Mg. Due to the addition of magnesium alloy elements Gd and Nd, the strength and the corrosion resistance of the magnesium alloy are improved. In addition, a small amount of Gd and Nd are better in bio-safety; Sr has the effect of inducing growth of osteoblasts; Zn is a human necessary micronutrient element, and the ductility and the corrosion resistance of the alloy can be improved due to the addition of the Zn; and Zr has the effects of refining crystal grains and improving the strength and the corrosion resistance of the alloy and can enable the magnesium degrading speed to be more uniform, and no cell toxicity exists after a small amount of Zr is added.

The invention relates to an artificial knee joint bone fusion prosthesis. The artificial knee joint bone fusion prosthesis comprises a femur condyle prosthesis, a tibia platform prosthesis and a joint pad, wherein the femur condyle prosthesis comprises a joint surface, a condyle combination surface, a intercondylar combination surface, a positioning body, a femur intramedullary stem and a femur intramedullary extending stem; the tibia platform prosthesis comprises a platform body, a tibia combination surface, a wing plate or a positioning body, a tibia intramedullary stem and a tibia intramedullary extending stem; the femur intramedullary stem, the femur intramedullary extending stem, the tibia intramedullary stem and the tibia intramedullary extending stem are hollow, the surfaces of the intramedullary stems and the extending stems have porous or mesh structure so as to ensure that the hollow parts in the stem body can be communicated with the external part; when in use, autograft or allograft crushed bone particles are filled in the hollow parts of the intramedullary stems and the intramedullary extending stems, and after the external bone tissue fuses and grows together with the crushed bone particles filled in the intramedullary stems, the overall elastic modulus can be very close to that of the human bone, thus reaching the aim of effectively preventing the loose between the artificial knee joint bone fusion prosthesis and the sclerotin for long time.

The invention provides a preparation method of a multifunctional layered joint cartilage support. The multifunctional layered joint cartilage support capable of simulating the biological property andthe mechanical property of natural cartilage is prepared by taking hydrogel as a support material, taking mesenchymal stem cells, cartilage cells and osteoblasts as inducing and developing objects andby adopting a 3D printing technology. The multifunctional layered joint cartilage support can accurately simulate the internal tissue form and the contour of each layer of the natural cartilage and can realize that different layers have different mechanical and biological characteristics. The prepared artificial cartilage support cells are derived from patients, the support serves as a degradablehydrogel material and the rejection reaction after implantation is greatly reduced. Various nutritional substances and growth factors are mixed in the hydrogel support, so that the sustained releaseeffect can be achieved and regulation and control of the growth and development of the artificial cartilage can be realized.

The invention discloses a method for preparing ordered ferriferrous oxide/chitosan nanometre composite material comprising the following steps, making chitosan solution from chitosan powder with thin acid solution, charging FeCl2 and FeCl3 solution into the chitosan solution, forming ferriferrous oxide / chitosan precursor solution, loading the precursor solution into a mould with a layer of pure chitosan film internally, placing into freeze liquid, removing the mould and applying magnetic field onto the two ends of the gel composite material for material forming, flushing to neutral with distilled water and drying.

The invention relates to an acetabular bone deformity filler which comprises a bone deformity filler, a screw hole, reinforcing ribs and a reinforcing plate and is made into a three-dimensional porous dictyosome structure by adopting medical metals or biological ceramics. The surface and the interior of the three-dimensional porous dictyosome are provided with a plurality of mutually communicated pore canals, the acetabular bone deformity filler is provided with a screw hole in a suitable position and also provided with a bone-planting hole for containing bone-planting particles or bone meal in a suitable position, all or partial surface of the acetabular bone deformity filler is provided with a hydroxyapatite coating, and the acetabular bone deformity filler can be effectively prevented from loosening for a long time when external osseous tissue permeates and grows in the three-dimensional porous dictyosome and melts and grows with the bone-planting particles or the bone meal filled in the bone-planting hole into a whole after operational planting.

Embodiments of a mask for sequential lateral solidification are disclosed herein. In some embodiments, a mask of the present disclosure comprises a transmission region including a first slit column having a plurality of first slits separated from one another by a predetermined interval, and a second slit column having a plurality of second slits separated from one another by a predetermined interval and disposed adjacent to and offset from the first slit column. An irradiated laser beam is substantially completely transmitted through the transmission region. In some embodiments, the mask includes a semi-transmission region including a first opening pattern disposed at least partially between adjacent first slits and having a plurality of first openings formed into a desired shape, and a second opening pattern disposed at least partially between adjacent second slits and having a plurality of second opening formed into a desired shape. A portion of less than all of the laser beam is transmitted through the semi-transmission region. A method of performing the sequential lateral solidification using the mask is also disclosed herein.

A bowel extension device implantable into a body for treatment of short bowel syndrome. The bowel extension device comprises a housing and a displaceable member coupled to the housing. The bowel extension device is configured to apply a tensile force sufficient to promote bowel growth without causing damage to the bowel. In some embodiments, the bowel extension device can be completely contained with the body.

The invention discloses a traditional Chinese medicine cancer toxin prescription for treating liver cancer and application thereof in the preparation of medicaments for resisting liver cancer. The cancer toxin prescription is prepared in accordance with the cancer toxin theory proposed by traditional Chinese medicine master Professor Zhou Zhongying, and is prepared from hedyotidis herba, muscardine silkworm, centipede, akebia fruit, pseudostellaria root, dwarf lilyturf root and rhizoma pleionis according to a certain weight ratio. The prescription has the main functions of eliminating pathogens, eliminating cancer and detoxicating and the auxiliary function of strengthening healthy qi. By using mice with liver cancer H22 transplantation tumor as materials, the pharmacological experiment result shows the cancer resistance effect of the cancer toxin prescription: the tumor inhibition rates of a low-dose group, an intermediate-dose group and a high-dose group are respectively 24.5%, 42.8% and 21.1%, thereby showing the effect of inhibiting the growth of H22 tumor mass; the tumor mass cell apoptosis rates of the low-dose group, the intermediate-dose group and the high-dose group are respectively 47.16%, 60.52% and 57.59%, thereby showing the effect of inducing tumor cells to die; and the cancer toxin prescription can block the high expression of TLR4, block the MyD88 dependent pathway of TLR4 intracellular signal transduction and inhibit the expression of downstream NF-kB proteins. Experiment shows that the cancer toxin prescription can be used for preparing medicaments for resisting liver cancer.

The present invention relates to a surface porous bioactive implant and a preparation method thereof, a microporous implant with the aperture diameter of 10-250 mum is prepared from pure titanium powder or titanium alloy powder by 3D printing technology; the microporous implant is degreased and cleaned; 5mol / L NaOH is used for alkali heat treatment at 80 DEG C, and after sintering, the furnace cooling is performed; the obtained implant is placed in the simulated body fluid for mineralization at the processing temperature of 37.5 DEG C for 1-10 days to form a hydroxyapatite coating with the thickness of 0.01 to 20 mum on the surface; finally the obtained implant is ultrasonically cleaned for 5min by purified water, after flushing, the cleaning and packaging are performed; the complicated preparation process problem is solved, the three dimensional printing technology is simple, and the aperture diameter is adjustable and precise.

The invention relates to a method for preparing a carbon catalyst based on carbon template-induced Fe-N growth and the carbon catalyst. The preparation method of the catalyst comprises the following steps of 1) dispersing a carbon material into a solvent A, and then performing wet ball milling, freezing and drying to obtain a carbon template; 2) dissolving a Fe compound and an N compound into a solvent B, and then adding the carbon template, performing uniform mixing and drying to obtain a catalyst precursor; and 3) performing high-temperature pyrolysis on the catalyst precursor in gas atmosphere to obtain the Fe and N co-doped carbon catalyst. Compared with the prior art, the preparation method disclosed in the invention can suppress generation of non-active or weak active metal Fe particles, Fe carbide and the like by virtue of introduction of the carbon template, so as to promote conversion of the metal Fe particles, Fe carbide and the like to strong active Fe-N<x> species to inducegrowth of Fe-N<x> strong active sites and the like; and in addition, interaction can be generated between the carbon template and the Fe-N<x> active sites and the like, so that the electronic structure can be regulated and enhancement of the inherent activity can be improved.

A bowel extension device implantable into a body for treatment of short bowel syndrome. The bowel extension device comprises a housing and a displaceable member coupled to the housing. The bowel extension device is configured to apply a tensile force sufficient to promote bowel growth without causing damage to the bowel. In some embodiments, the bowel extension device can be completely contained with the body.

The invention relates to periodontitis gel containing hyaluronic acid and a preparation method thereof. The periodontitis gel is prepared from the following ingredients in mass percent: 0.1% to 1.5% of sodium hyaluronate derivative, 0.05% to 1.0% of enzyme-digested oligomerized sodium hyaluronate, 5% to 15% of glycerinum, 1.5% to 4.5% of honeysuckle flower aqueous extractive, 0.02% to 0.2% of recombinant human bone morphogenetic protein-2 (rhBMP-2), 0.02% to 0.2% of base fibroblast growth factor (b-FGF), 0.02% to 0.04% of pentanediol, 0.02% to 0.04% of octylene glycol, 0.1% to 0.3% of methylparaben and purified water added to 100%. The gel disclosed by the invention can be applied to treating gingivitis and periodonititis and has an obvious treating effect.

The invention provides tetrakaidecahedron metal hydroxystannate and a preparation method and application thereof. The molecular formula of the tetrakaidecahedron metal hydroxystannate is MSn(OH)6, wherein M is Ca, Mg, Co, Ni, Mn or Cu. The preparation method includes: mixing equal-mole tin salt solution and metal salt solution, stirring, adding regulator, stirring for 10 minutes to 3 hours, dropwisely adding alkaline solution, and transferring to a hydrothermal kettle for reaction for 5-24 hours to obtain the tetrakaidecahedron metal hydroxystannate, wherein the reaction temperature is 25-120 DEG C. The tetrakaidecahedron metal hydroxystannate is widely applicable to the technical field of photocatalysis, and the light degradation effect of tetrakaidecahedron light is better than that of hexahedron light during methylene blue degradation using photocatalysis.

The invention provides a preparation method of a bone tissue engineering porous ceramics scaffold, belongs to the technical field of medical apparatus and instruments, and is capable of effectively solving the uniform distribution problem of drug carrying chitosan microspheres coating the surface of the bone tissue engineering porous ceramics scaffold. The preparation method comprises the steps of firstly preparing a porous scaffold, then preparing a drug carrying microspheres, and then preparing a ceramics scaffold coated with alginic acid. After obtaining the ceramics scaffold of which the surface is coated with the alginic acid, the drug carrying microspheres is needed to be combined with the ceramics scaffold: uniformly dispersing the prepared drug carrying microspheres into a centrifuge tube filled with deionized water, soaking the ceramics scaffold coated with the alginic acid into the centrifuge tube filled with the drug carrying microspheres, placing at the temperature of 37 DEG C, vibrating in a constant-temperature vibration box with the rotation speed of 60 to 120r/min for 1 to 3h, taking out the ceramics scaffold, repeatedly washing by using the deionized water, and then performing vacuum drying to obtain the bone tissue engineering porous ceramics scaffold which is coated with the alginic acid and provided with the uniformly-distributed drug carrying microspheres. The bone tissue engineering porous ceramics scaffold is mainly used for human bone tissue repair.

The invention provides a method for improving the osteogenesis ability of mesenchymal stem cells, which comprises the following steps: inoculating the mesenchymal stem cells into an alpha-MEM culturemedium containing 10% of fetal calf serum, culturing, digesting and subculturing by 0.2% of pancreatin when the fusion degree of the mesenchymal stem cells is 80-85%, inoculating the obtained mesenchymal stem cells into an alpha-MEM culture medium containing 10% of fetal calf serum for culture, and adding osteogenesis induction liquid and a metformin aqueous solution for induction when the densityof the mesenchymal stem cells is greater than 90% for induction for 14-21 days. The metformin acts on the mesenchymal stem cells, alizarin red staining results show that the metformin can significantly improve the calcium mineralization nodule degree of the cells, and it is indicated that the metformin has a significant induction effect on mesenchymal stem cell osteogenic differentiation, the metformin can significantly improve the expression of the mesenchymal stem cell osteogenic differentiation related genes SIRT1, ALP, COL1A1, RUNX2 and BGLAP, and the improvement of the osteogenic differentiation capacity of the mesenchymal stem cells is of great significance to stem cell transplantation and bone biology research.

The invention discloses multifunctional injectable hydrogel for tumor photo-thermal treatment and bone tissue repair and a preparation method, and belongs to the field of biomedical materials. The preparation method comprises the following steps of firstly, synthesizing micro-nano carbon spheres by adopting a hydrothermal carbonization method; secondly, adding the micro-nano carbon spheres into achitosan solution, and performing uniform stirring to obtain a solution A; thirdly, simultaneously dissolving beta-sodium glycerophosphate and sodium hyaluronate in deionized water, and performing sufficient stirring to obtain a solution B; and finally, in an ice bath environment, adding the solution B into the solution A, uniformly stirring the solutions, and performing sterilizing and disinfection for 24 hours by using an ultraviolet lamp to obtain the injectable composite hydrogel. The injectable hydrogel has good biocompatibility; the injectable hydrogel is in a liquid state at the room temperature, can be directly injected into a bone tumor focus, and can rapidly form gel in situ in an environment with the body temperature of 37 DEG C, so that effective fixation of a photothermal agent and rapid filling of bone defects are realized; and bone tumor cells can be killed through local photo-thermal treatment, meanwhile bone tissue repair can be effectively promoted, and all-dimensional treatment of bone tumors is achieved.

The invention discloses an anisotropic magnetoresistive permalloy buffer layer preparation method. The method comprises the steps that a substrate which is thoroughly cleaned is put into a vacuum cavity, argon gas is provided in the whole process, a buffer layer is deposited by adopting the pulse radio frequency as a sputtering power source, then a NiFe layer is deposited, and finally a covering layer is deposited. The pulse radio frequency technology is adopted, power is supplied to a target gun at intervals during thin film deposition, time is provided for migration of material atoms on the surface of the substrate due to pulse radio frequency interval deposition, and the thin film flatness is improved, so that the crystalline degree of the thin film is enhanced, and the material AMR value is increased; by means of the pulse radio frequency deposition technology, the deposition atoms can sufficiently migrate on the surface of the substrate, the surface flatness of the buffer layer is improved, growth of the NiFe thin film structure can be better induced at normal temperature, and the crystalline grain diameter is increased, so that the permalloy thin film AMR value is increased, the coercive force is lowered, and the thin film sensitivity becomes better.

The invention discloses a composite polypropylene mesh. The composite polypropylene mesh is bonded by a polypropylene mesh and a fibroblast growth factor through polydopamine. In the premise condition of not changing the mechanical strength and the surface structure of the original polypropylene mesh, the fibroblast growth factor is grafted on the surface of the polydopamine after the polydopamine is grafted on the surface of the polypropylene mesh, and the composite mesh separation phenomenon cannot be generated. Simultaneously the fibroblast growth factor is hard to degrade in the body, the fibroblast growth can be induced and then the fascia reconstruction is induced.