Biodegradable Mg-Gd-Zn-Ag-Zr series magnesium alloy and preparation method thereof

A magnesium alloy and biological technology, applied in the field of biodegradable implant materials, can solve problems such as uneven local degradation, achieve good mechanical compatibility, refine grains, and increase corrosion potential

Inactive Publication Date: 2013-07-03
JIANGSU KONSUNG MEDICAL EQUIPMENT CO LTD +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Its disadvantages are: the degradation rate of magnesium is too fast, and it is prone to the problem of uneven local degradation. The current magnesium alloy can not meet the clinical requirements.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0025] Use pure magnesium (the purity of Mg is greater than or equal to 99.95%), a Mg-Gd master alloy with a mass percentage of Gd of 20% (the content of impurities such as Fe, Ni, and Cu is less than 0.05%), and pure zinc (the purity of Zn is greater than or equal to 99.99%), a Mg-Sr master alloy with a mass percentage of Sr of 20% (Fe, Ni, Cu and other impurities are less than 0.01%), a Mg-Zr master alloy with a mass percentage of Zr of 20% (Fe, Ni, Cu, etc. Ni, Cu and other impurities are less than 0.01%), according to the alloy composition ratio of Mg-8Gd-1Zn-0.3Sr-0.4Zr (mass fraction), that is, the mass percentages are Mg90.3%, Gd8%, Zn 1 %, Sr 0.3%, Zr 0.4% (reasonable impurities are not considered in this mass percentage content, when selecting raw materials, raw materials with less impurities should be selected as much as possible).

[0026] When smelting, first add pure magnesium to the resistance furnace to melt, and the temperature of the furnace rises to 300 °C an...

Embodiment 2

[0028] Pure magnesium ingots, Mg-Gd master alloy (Gd mass percentage is 30%), pure zinc, Mg-Sr master alloy (Sr mass percentage in this master alloy is 30%), Mg-Zr master alloy ( The mass percent content of Zr in this master alloy is 30%) as the raw material, according to the alloy composition ratio of Mg-8Gd-1Zn-0.3Sr-0.4Zr (mass fraction), that is, the mass percentages are Mg90.3%, Gd8 %, Zn 1%, Sr 0.3%, Zr 0.4%, according to the proportion relationship, it is converted into the amount of raw materials, weighed and smelted.

[0029] When smelting, first put pure magnesium ingots into the resistance furnace to melt, and the furnace temperature rises to 300 °C and starts to introduce CO 2 and SF 6 Mixed gas, CO 2 and SF 6The amount of gas used is 10:1; when the temperature rises to 750 ℃, add Mg-Gd master alloy, after it melts, start the automatic stirrer to stir for 5 minutes, then add pure Zn, Mg-Sr and Mg-Zr master alloy, stir After 5-10 minutes, let it stand for 20-40 ...

Embodiment 3

[0031] Pure magnesium ingots, Mg-Gd master alloy with 50% Gd by mass, pure zinc powder, Mg-Sr master alloy with 80% by mass Sr, Mg-Gd with 50% by mass Zr Zr master alloy, according to the alloy composition ratio of Mg-5Gd-0.5Zn-0.1Sr-0.1Zr (mass fraction), that is, the mass percentage content is Mg94.3%, Gd5%, Zn 0.5%, Sr 0.1%, Zr 0.1%.

[0032] When smelting, first add pure magnesium to the resistance furnace to melt, and the temperature of the furnace rises to 300 °C and starts to introduce CO 2 and SF 6 Mixed gas as shielding gas, CO 2 and SF 6 The gas consumption is 5:1, when the temperature rises to 750 ℃, add the Mg-Gd master alloy, after it melts, start the automatic stirrer to stir for 5 minutes, then add pure zinc powder, Mg-Sr master alloy and Mg-Zr master alloy The alloy is stirred for 5-10 minutes, left to stand for 20-40 minutes, and then cast into a metal mold at 720° C. under the protection of a protective gas to obtain a Mg-Gd-Zn-Sr-Zr series magnesium allo...

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PUM

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Abstract

The invention relates to biodegradable Mg-Gd-Zn-Ag-Zr series magnesium alloy and a preparation method thereof in the technical field of medical alloy. The alloy consists of Gd, Zn, Ag, Zr and Mg in percentage by weight: 5-10 percent of Gd, 0.5-3 percent of Zn, 0.1-1 percent of Ag, 0.1-1 percent of Zr and the balance of Mg. Through reasonably designing the alloy elements, a long-period stacking order structure (LPSO structure) is formed in an alloy structure; and with the adoption of the structure, the alloy can be strengthened and toughened, and the corrosion resistance and the local corrosion resistance of the alloy can be improved. Through deformation processing and heat treatment, the strong toughness and the corrosion resistance of the magnesium alloy can be further improved. The magnesium alloy provided by the invention is uniformly corroded in simulated body fluid, so that the overall failure of an implant material due to local corrosion is avoided, and no obvious cytotoxicity exists. The biodegradable Mg-Gd-Zn-Ag-Zr series magnesium alloy can be used as a bone plate, a bone nail and other fixing and implant materials in the orthopeadic surgery.

Description

technical field [0001] The invention relates to a medical alloy and a preparation method thereof, in particular to an alloy used in the field of biodegradable implant materials and a preparation method thereof. Background technique [0002] At present, the orthopedic implant materials in clinical application are mainly stainless steel and titanium alloy materials. However, stainless steel and titanium alloys are biologically inert materials, which are not degradable in the body and are prone to produce soluble ions, which can easily cause biotoxicity, local allergies or inflammation; after bone healing, a second operation is required to remove the implant material, which increases the pain of the patient , psychological and economic burdens. In addition, the elastic modulus of stainless steel and titanium alloy is much higher than that of human bone, which has a great "stress shielding" effect on local bone tissue, which may lead to the possibility of natural bone function ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C22C23/06C22C1/03C22F1/06
Inventor 章晓波王强王章忠巴志新甄睿
Owner JIANGSU KONSUNG MEDICAL EQUIPMENT CO LTD
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