Periodontitis gel containing hyaluronic acid and preparation method thereof
A technology of hyaluronic acid and sodium hyaluronate, which is applied in the field of medicine, can solve the problems of short retention time, limited application, and easy biodegradation of natural sodium hyaluronate, and achieve the effect of promoting regeneration, repair and healing
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Embodiment 1
[0028] A periodontitis gel containing hyaluronic acid, comprising the following components in mass percentage: sodium hyaluronate derivatives (0.5%), enzyme-cleaved oligomeric hyaluronate sodium (0.5%), glycerin (5%), honeysuckle Water Extract (3%), Recombinant Human Bone Morphogenetic Protein (rhBMP-2) (0.08%), Basic Fibroblast Growth Factor (b-FGF) (0.06%), Pentylene Glycol (0.03%), Caprylyl Glycol (0.02%), methylparaben (0.1%), and purified water were added to 100%.
[0029] The molecular weight of small molecular weight sodium hyaluronate is 9000Da.
[0030] The preparation method of the periodontitis gel containing hyaluronic acid comprises the following steps:
[0031] (1) Preparation of sodium hyaluronate derivatives.
[0032] (2) Mix sodium hyaluronate derivatives and sodium hyaluronate with an appropriate amount of water, soak at room temperature, homogenize for 3 minutes, and stir at a speed of 300 r / min for 30 minutes to fully swell and disperse evenly, as compone...
Embodiment 2
[0038] A periodontitis gel containing hyaluronic acid, comprising the following components in mass percentage: sodium hyaluronate derivatives (0.8%), enzyme-cleaved oligomeric hyaluronate sodium (0.4%), glycerin (10%), honeysuckle Water extract (2%), recombinant human bone morphogenic protein (rhBMP-2) (0.06%), basic fibroblast growth factor (b-FGF) (0.1%), pentanediol (0.03%), octanediol (0.03%), methylparaben (0.2%), and purified water were added to 100%.
[0039] The molecular weight of small molecular weight sodium hyaluronate is 7000Da.
[0040] The preparation method of the periodontitis gel containing hyaluronic acid comprises the following steps:
[0041] (1) Preparation of sodium hyaluronate derivatives.
[0042](2) Mix sodium hyaluronate derivatives and sodium hyaluronate with an appropriate amount of water, soak at room temperature, homogenize for 3 minutes, and stir at a speed of 300 r / min for 30 minutes to fully swell and disperse evenly, as component 1;
[004...
Embodiment 3
[0048] A periodontitis gel containing hyaluronic acid, comprising the following components in mass percentage: sodium hyaluronate derivatives (1.2%), enzyme-cleaved oligomeric hyaluronate sodium (0.3%), glycerin (12%), honeysuckle Water extract (4%), recombinant human bone morphogenic protein (rhBMP-2) (0.15%), basic fibroblast growth factor (b-FGF) (0.1%), pentanediol (0.02%), octanediol (0.04%), methylparaben (0.15%), and purified water were added to 100%.
[0049] The molecular weight of small molecular weight sodium hyaluronate is 5000Da.
[0050] The preparation method of the periodontitis gel containing hyaluronic acid comprises the following steps:
[0051] (1) Preparation of sodium hyaluronate derivatives.
[0052] (2) Mix sodium hyaluronate derivatives and sodium hyaluronate with an appropriate amount of water, soak at room temperature, homogenize for 3 minutes, and stir at a speed of 300 r / min for 30 minutes to fully swell and disperse evenly, as component 1;
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