Periodontitis gel containing hyaluronic acid and preparation method thereof

A technology of hyaluronic acid and sodium hyaluronate, which is applied in the field of medicine, can solve the problems of short retention time, limited application, and easy biodegradation of natural sodium hyaluronate, and achieve the effect of promoting regeneration, repair and healing

Inactive Publication Date: 2018-06-29
NANJING TZONE BIOLOGICAL SCI & TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] Natural sodium hyaluronate is easily biodegradable, has a short residence time in the organism, and its hardness and mechanical strength are not large enough, which limits its clinical application and requires chemical modification

Method used

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  • Periodontitis gel containing hyaluronic acid and preparation method thereof
  • Periodontitis gel containing hyaluronic acid and preparation method thereof
  • Periodontitis gel containing hyaluronic acid and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0028] A periodontitis gel containing hyaluronic acid, comprising the following components in mass percentage: sodium hyaluronate derivatives (0.5%), enzyme-cleaved oligomeric hyaluronate sodium (0.5%), glycerin (5%), honeysuckle Water Extract (3%), Recombinant Human Bone Morphogenetic Protein (rhBMP-2) (0.08%), Basic Fibroblast Growth Factor (b-FGF) (0.06%), Pentylene Glycol (0.03%), Caprylyl Glycol (0.02%), methylparaben (0.1%), and purified water were added to 100%.

[0029] The molecular weight of small molecular weight sodium hyaluronate is 9000Da.

[0030] The preparation method of the periodontitis gel containing hyaluronic acid comprises the following steps:

[0031] (1) Preparation of sodium hyaluronate derivatives.

[0032] (2) Mix sodium hyaluronate derivatives and sodium hyaluronate with an appropriate amount of water, soak at room temperature, homogenize for 3 minutes, and stir at a speed of 300 r / min for 30 minutes to fully swell and disperse evenly, as compone...

Embodiment 2

[0038] A periodontitis gel containing hyaluronic acid, comprising the following components in mass percentage: sodium hyaluronate derivatives (0.8%), enzyme-cleaved oligomeric hyaluronate sodium (0.4%), glycerin (10%), honeysuckle Water extract (2%), recombinant human bone morphogenic protein (rhBMP-2) (0.06%), basic fibroblast growth factor (b-FGF) (0.1%), pentanediol (0.03%), octanediol (0.03%), methylparaben (0.2%), and purified water were added to 100%.

[0039] The molecular weight of small molecular weight sodium hyaluronate is 7000Da.

[0040] The preparation method of the periodontitis gel containing hyaluronic acid comprises the following steps:

[0041] (1) Preparation of sodium hyaluronate derivatives.

[0042](2) Mix sodium hyaluronate derivatives and sodium hyaluronate with an appropriate amount of water, soak at room temperature, homogenize for 3 minutes, and stir at a speed of 300 r / min for 30 minutes to fully swell and disperse evenly, as component 1;

[004...

Embodiment 3

[0048] A periodontitis gel containing hyaluronic acid, comprising the following components in mass percentage: sodium hyaluronate derivatives (1.2%), enzyme-cleaved oligomeric hyaluronate sodium (0.3%), glycerin (12%), honeysuckle Water extract (4%), recombinant human bone morphogenic protein (rhBMP-2) (0.15%), basic fibroblast growth factor (b-FGF) (0.1%), pentanediol (0.02%), octanediol (0.04%), methylparaben (0.15%), and purified water were added to 100%.

[0049] The molecular weight of small molecular weight sodium hyaluronate is 5000Da.

[0050] The preparation method of the periodontitis gel containing hyaluronic acid comprises the following steps:

[0051] (1) Preparation of sodium hyaluronate derivatives.

[0052] (2) Mix sodium hyaluronate derivatives and sodium hyaluronate with an appropriate amount of water, soak at room temperature, homogenize for 3 minutes, and stir at a speed of 300 r / min for 30 minutes to fully swell and disperse evenly, as component 1;

[0...

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Abstract

The invention relates to periodontitis gel containing hyaluronic acid and a preparation method thereof. The periodontitis gel is prepared from the following ingredients in mass percent: 0.1% to 1.5% of sodium hyaluronate derivative, 0.05% to 1.0% of enzyme-digested oligomerized sodium hyaluronate, 5% to 15% of glycerinum, 1.5% to 4.5% of honeysuckle flower aqueous extractive, 0.02% to 0.2% of recombinant human bone morphogenetic protein-2 (rhBMP-2), 0.02% to 0.2% of base fibroblast growth factor (b-FGF), 0.02% to 0.04% of pentanediol, 0.02% to 0.04% of octylene glycol, 0.1% to 0.3% of methylparaben and purified water added to 100%. The gel disclosed by the invention can be applied to treating gingivitis and periodonititis and has an obvious treating effect.

Description

technical field [0001] The invention relates to a periodontitis gel containing hyaluronic acid and a preparation method thereof, belonging to the field of medicine. Background technique [0002] Periodontitis refers to chronic inflammation that occurs in the gums, periodontal ligament, cementum, and alveolar bone. Most cases develop from long-standing gingivitis, forming periodontal pockets and alveolar bone absorption symptoms. Due to the slow course of the disease, the early symptoms do not cause obvious pain, and patients often do not seek medical treatment in time. The longer the inflammation, the damage to the supporting tissue will gradually increase, which will eventually lead to the loss of teeth, and at the same time become an important cause of pathological changes in other organs and tissues of the body. potential risk factors. It is listed by the World Health Organization as one of the three major diseases that endanger human health. Periodontitis not only inte...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K38/18A61K9/06A61P1/02A61K36/355A61K31/728
CPCA61K9/006A61K9/06A61K31/728A61K36/355A61K38/1825A61K38/1875A61K2236/331A61K2236/39A61K2236/51A61K2300/00
Inventor 金玉
Owner NANJING TZONE BIOLOGICAL SCI & TECH
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